Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 4133
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol MAP2   Gene   UCSC   Ensembl
Aliases MAP2A, MAP2B, MAP2C
Gene name microtubule associated protein 2
Alternate names microtubule-associated protein 2, MAP-2,
Gene location 2q34 (209424046: 209734117)     Exons: 22     NC_000002.12
Gene summary(Entrez) This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
OMIM 157130

Protein Summary
Protein general information P11137  

Name: Microtubule associated protein 2 (MAP 2)

Length: 1827  Mass: 199,526

Sequence MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPYREDEEGAFGEHGSQGTYSNTKENGI
NGELTSADRETAEEVSARIVQVVTAEAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVE
EDLLTASKMEFHDQQELTPSTAEPSDQKEKESEKQSKPGEDLKHAALVSQPETTKTYPDKKDMQGTEEEKAPLAL
FGHTLVASLEDMKQKTEPSLVVPGIDLPKEPPTPKEQKDWFIEMPTEAKKDEWGLVAPISPGPLTPMREKDVFDD
IPKWEGKQFDSPMPSPFQGGSFTLPLDVMKNEIVTETSPFAPAFLQPDDKKSLQQTSGPATAKDSFKIEEPHEAK
PDKMAEAPPSEAMTLPKDAHIPVVEEHVMGKVLEEEKEAINQETVQQRDTFTPSGQEPILTEKETELKLEEKTTI
SDKEAVPKESKPPKPADEEIGIIQTSTEHTFSEQKDQEPTTDMLKQDSFPVSLEQAVTDSAMTSKTLEKAMTEPS
ALIEKSSIQELFEMRVDDKDKIEGVGAATSAELDMPFYEDKSGMSKYFETSALKEEATKSIEPGSDYYELSDTRE
SVHESIDTMSPMHKNGDKEFQTGKESQPSPPAQEAGYSTLAQSYPSDLPEEPSSPQERMFTIDPKVYGEKRDLHS
KNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPATT
PALEKAPCFPVESKEEEQIEKVKATGEESTQAEISCESPFLAKDFYKNGTVMAPDLPEMLDLAGTRSRLASVSAD
AEVARRKSVPSETVVEDSRTGLPPVTDENHVIVKTDSQLEDLGYCVFNKYTVPLPSPVQDSENLSGESGTFYEGT
DDKVRRDLATDLSLIEVKLAAAGRVKDEFSVDKEASAHISGDKSGLSKEFDQEKKANDRLDTVLEKSEEHADSKE
HAKKTEEAGDEIETFGLGVTYEQALAKDLSIPTDASSEKAEKGLSSVPEIAEVEPSKKVEQGLDFAVQGQLDVKI
SDFGQMASGLNIDDRRATELKLEATQDMTPSSKAPQEADAFMGVESGHMKEGTKVSETEVKEKVAKPDLVHQEAV
DKEESYESSGEHESLTMESLKADEGKKETSPESSLIQDEIAVKLSVEIPCPPAVSEADLATDERADVQMEFIQGP
KEESKETPDISITPSDVAEPLHETIVSEPAEIQSEEEEIEAQGEYDKLLFRSDTLQITDLGVSGAREEFVETCPS
EHKGVIESVVTIEDDFITVVQTTTDEGESGSHSVRFAALEQPEVERRPSPHDEEEFEVEEAAEAQAEPKDGSPEA
PASPEREEVALSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSIMTEQLETIPKEEKAEKEARRSSLEKH
RKEKPFKTGRGRISTPERKVAKKEPSTVSRDEVRRKKAVYKKAELAKKTEVQAHSPSRKFILKPAIKYTRPTHLS
CVKRKTTAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSGDRDENSFSLNSSISSSARR
TTRSEPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTP
PKSPATPKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTSKCGSLKNIRHRPGGGRVKI
ESVKLDFKEKAQAKVGSLDNAHHVPGGGNVKIDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSS
GSINLLESPQLATLAEDVTAALAKQGL
Structural information
Interpro:  IPR030797 IPR013588 IPR001084
Prosite:   PS00229 PS51491

Pfam:  		 PF08377 PF00418

DIP:  		 577
MINT:   1210186
STRING:   ENSP00000353508;
Other Databases GeneCards:  MAP2;  Malacards:  MAP2

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000226 microtubule cytoskeleton
organization
 IBA biological_process
GO:0001578 microtubule bundle format
ion
 IEA biological_process
GO:0002162 dystroglycan binding
 IPI molecular_function
GO:0005198 structural molecule activ
ity
 NAS molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005516 calmodulin binding
 IEA molecular_function
GO:0005730 nucleolus
 IDA cellular_component
GO:0005737 cytoplasm
 IDA cellular_component
GO:0005874 microtubule
 IEA cellular_component
GO:0005875 microtubule associated co
mplex
 TAS cellular_component
GO:0008017 microtubule binding
 IBA molecular_function
GO:0021954 central nervous system ne
uron development
 IEP biological_process
GO:0031175 neuron projection develop
ment
 IEP biological_process
GO:0043005 neuron projection
 IBA cellular_component
GO:0048813 dendrite morphogenesis
 IEP biological_process
GO:0000226 microtubule cytoskeleton
organization
 IBA biological_process
GO:0001578 microtubule bundle format
ion
 IEA biological_process
GO:0002162 dystroglycan binding
 IPI molecular_function
GO:0005198 structural molecule activ
ity
 NAS molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005516 calmodulin binding
 IEA molecular_function
GO:0005730 nucleolus
 IDA cellular_component
GO:0005737 cytoplasm
 IEA cellular_component
GO:0005737 cytoplasm
 IDA cellular_component
GO:0005856 cytoskeleton
 IEA cellular_component
GO:0005856 cytoskeleton
 IEA cellular_component
GO:0005874 microtubule
 IEA cellular_component
GO:0005875 microtubule associated co
mplex
 TAS cellular_component
GO:0008017 microtubule binding
 IEA molecular_function
GO:0008017 microtubule binding
 IBA molecular_function
GO:0015631 tubulin binding
 IEA molecular_function
GO:0021954 central nervous system ne
uron development
 IEA biological_process
GO:0021954 central nervous system ne
uron development
 IEP biological_process
GO:0031175 neuron projection develop
ment
 IEP biological_process
GO:0043005 neuron projection
 IBA cellular_component
GO:0048813 dendrite morphogenesis
 IEP biological_process
GO:0000226 microtubule cytoskeleton
organization
 IBA biological_process
GO:0002162 dystroglycan binding
 IPI molecular_function
GO:0005198 structural molecule activ
ity
 NAS molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005730 nucleolus
 IDA cellular_component
GO:0005737 cytoplasm
 IDA cellular_component
GO:0005875 microtubule associated co
mplex
 TAS cellular_component
GO:0008017 microtubule binding
 IBA molecular_function
GO:0021954 central nervous system ne
uron development
 IEP biological_process
GO:0031175 neuron projection develop
ment
 IEP biological_process
GO:0043005 neuron projection
 IBA cellular_component
GO:0048813 dendrite morphogenesis
 IEP biological_process

Diseases

Associated diseases References
Endometriosis PMID: 26604067
Platelet aggregation PMID: 17903294
Endometriosis INFBASE26604067

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26604067 Endometrio
sis
70 (30 healthy
controls, 34 wo
men with endome
triosis)
 NGF
MAP-2
and SYP
 Show abstract