Endometriosis Knowledgebase

Search Result

Gene id

4144

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

MAT2A Gene UCSC Ensembl

Aliases

MATA2, MATII, SAMS2

Gene name

methionine adenosyltransferase 2A

Alternate names

S-adenosylmethionine synthase isoform type-2, MAT 2, MAT-II, adoMet synthase 2, adoMet synthetase 2, methionine adenosyltransferase 2, methionine adenosyltransferase II, alpha, testicular tissue protein Li 121,

Gene location

2p11.2 (85538977: 85545279) Exons: 9 NC_000002.12

Gene summary(Entrez)

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

OMIM

601468

Protein Summary

Protein general information

P31153

Name: S adenosylmethionine synthase isoform type 2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT II)

Length: 395 Mass: 43,661

Tissue specificity: Detected in kidney. {ECO

Sequence

MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRA
AVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECM
PLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEK
VIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTA
AYGHFGRDSFPWEVPKKLKY

Structural information

Interpro:	IPR022631 IPR022630 IPR022629 IPR022628 IPR002133 IPR022636
Prosite:	PS00376 PS00377
Pfam:	PF02773 PF02772 PF00438
PDB:	2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I
PDBsum:	2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I
STRING:	ENSP00000303147;

Other Databases

GeneCards: MAT2A; Malacards: MAT2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004478	methionine adenosyltransf erase activity	IDA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005829	cytosol	IBA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006556	S-adenosylmethionine bios ynthetic process	IEA	biological_process
GO:0006556	S-adenosylmethionine bios ynthetic process	IDA	biological_process
GO:0006730	one-carbon metabolic proc ess	IEA	biological_process
GO:0032259	methylation	TAS	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0048269	methionine adenosyltransf erase complex	IDA	cellular_component
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IEA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IEA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IEA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IDA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005829	cytosol	IBA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006556	S-adenosylmethionine bios ynthetic process	IEA	biological_process
GO:0006556	S-adenosylmethionine bios ynthetic process	IEA	biological_process
GO:0006556	S-adenosylmethionine bios ynthetic process	IEA	biological_process
GO:0006556	S-adenosylmethionine bios ynthetic process	IDA	biological_process
GO:0006730	one-carbon metabolic proc ess	IEA	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0032259	methylation	TAS	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0048269	methionine adenosyltransf erase complex	IDA	cellular_component
GO:0004478	methionine adenosyltransf erase activity	IDA	molecular_function
GO:0004478	methionine adenosyltransf erase activity	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005829	cytosol	IBA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006556	S-adenosylmethionine bios ynthetic process	IDA	biological_process
GO:0032259	methylation	TAS	biological_process
GO:0048269	methionine adenosyltransf erase complex	IDA	cellular_component

KEGG pathways

hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
hsa00270  Cysteine and methionine metabolism

Diseases

Associated diseases	References
Cancer	PMID: 18423013
Cleft lip	PMID: 19048631
Endometriosis	PMID: 22276910
Endometriosis	INFBASE22276910
Spinal dysraphism	PMID: 19161160

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
22276910	Endometrio sis			100 (50 endomet riosis, 50 cont rols)		COX-2 BRAF NRAS CFL1 MAT2A SEPT9 ATAD3A CADM2 NAA15 and CCDC21	Show abstract