Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 4277
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol MICB   Gene   UCSC   Ensembl
Aliases PERB11.2
Gene name MHC class I polypeptide-related sequence B
Alternate names MHC class I polypeptide-related sequence B, MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog,
Gene location 6p21.33 (31494880: 31511123)     Exons: 7     NC_000006.12
Gene summary(Entrez) This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
OMIM 602436

Protein Summary
Protein general information Q29980  

Name: MHC class I polypeptide related sequence B (MIC B)

Length: 383  Mass: 42,646

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumo

Sequence MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDESVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAED
VLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQES
TVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTC
RASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKV
LVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATG
STGSTEGA
Structural information
Protein Domains
 Ig-like (207-298)
Interpro:  IPR007110 IPR013783 IPR003597 IPR011161 IPR011162
Prosite:   PS50835

Pfam:  		 PF07654 PF00129

PDB:  		 1JE6 2WY3
PDBsum:   1JE6 2WY3
STRING:   ENSP00000252229;
Other Databases GeneCards:  MICB;  Malacards:  MICB

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001913 T cell mediated cytotoxic
ity
 IBA biological_process
GO:0002429 immune response-activatin
g cell surface receptor s
ignaling pathway
 IDA biological_process
GO:0003823 antigen binding
 IBA molecular_function
GO:0005886 plasma membrane
 IBA cellular_component
GO:0005886 plasma membrane
 TAS cellular_component
GO:0006979 response to oxidative str
ess
 IDA biological_process
GO:0009408 response to heat
 IDA biological_process
GO:0009986 cell surface
 ISS cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0016032 viral process
 IEA biological_process
GO:0019835 cytolysis
 IEA biological_process
GO:0019882 antigen processing and pr
esentation
 IBA biological_process
GO:0032526 response to retinoic acid
 IDA biological_process
GO:0042267 natural killer cell media
ted cytotoxicity
 IBA biological_process
GO:0046629 gamma-delta T cell activa
tion
 IDA biological_process
GO:0046703 natural killer cell lecti
n-like receptor binding
 IDA molecular_function
GO:0050689 negative regulation of de
fense response to virus b
y host
 IDA biological_process
GO:0050689 negative regulation of de
fense response to virus b
y host
 IDA biological_process
GO:0050776 regulation of immune resp
onse
 TAS biological_process
GO:0001913 T cell mediated cytotoxic
ity
 IBA biological_process
GO:0002250 adaptive immune response
 IEA biological_process
GO:0002376 immune system process
 IEA biological_process
GO:0002429 immune response-activatin
g cell surface receptor s
ignaling pathway
 IDA biological_process
GO:0003823 antigen binding
 IBA molecular_function
GO:0005886 plasma membrane
 IBA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 TAS cellular_component
GO:0006955 immune response
 IEA biological_process
GO:0006979 response to oxidative str
ess
 IDA biological_process
GO:0009408 response to heat
 IDA biological_process
GO:0009986 cell surface
 ISS cellular_component
GO:0016020 membrane
 IEA cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0016032 viral process
 IEA biological_process
GO:0019835 cytolysis
 IEA biological_process
GO:0019882 antigen processing and pr
esentation
 IBA biological_process
GO:0032526 response to retinoic acid
 IDA biological_process
GO:0042267 natural killer cell media
ted cytotoxicity
 IBA biological_process
GO:0046629 gamma-delta T cell activa
tion
 IDA biological_process
GO:0046703 natural killer cell lecti
n-like receptor binding
 IDA molecular_function
GO:0050689 negative regulation of de
fense response to virus b
y host
 IDA biological_process
GO:0050689 negative regulation of de
fense response to virus b
y host
 IDA biological_process
GO:0050776 regulation of immune resp
onse
 TAS biological_process
GO:0001913 T cell mediated cytotoxic
ity
 IBA biological_process
GO:0002429 immune response-activatin
g cell surface receptor s
ignaling pathway
 IDA biological_process
GO:0003823 antigen binding
 IBA molecular_function
GO:0005886 plasma membrane
 IBA cellular_component
GO:0005886 plasma membrane
 TAS cellular_component
GO:0006979 response to oxidative str
ess
 IDA biological_process
GO:0009408 response to heat
 IDA biological_process
GO:0009986 cell surface
 ISS cellular_component
GO:0019882 antigen processing and pr
esentation
 IBA biological_process
GO:0032526 response to retinoic acid
 IDA biological_process
GO:0042267 natural killer cell media
ted cytotoxicity
 IBA biological_process
GO:0046629 gamma-delta T cell activa
tion
 IDA biological_process
GO:0046703 natural killer cell lecti
n-like receptor binding
 IDA molecular_function
GO:0050689 negative regulation of de
fense response to virus b
y host
 IDA biological_process
GO:0050689 negative regulation of de
fense response to virus b
y host
 IDA biological_process
GO:0050776 regulation of immune resp
onse
 TAS biological_process

KEGG pathways

hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa04650  Natural killer cell mediated cytotoxicity

Diseases

Associated diseases References
Alzheimer's disease PMID: 19691640
Asthma PMID: 16776673
Behcet's disease PMID: 16101830
Cancer PMID: 15640005
Cardiomyopathy PMID: 11169252
Celiac disease PMID: 16698444
Crohn's disease PMID: 12392511
Endometriosis PMID: 25775242
Multiple sclerosis PMID: 18588574
Endometriosis INFBASE25775242
Psoriasis PMID: 12022360
Rheumatoid arthritis PMID: 17003176
Schizophrenia PMID: 17561376
Systemic lupus erythematosus PMID: 11862397
Ulcerative colitis PMID: 16679067
Ulcerative colitis PMID: 18785505

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
25775242 Endometrio
sis
202 (121 women
with histologic
ally proven end
ometriosis, 81
endometriosis-f
ree controls )
 MICB
MICA
ULBP2
 Show abstract