Endometriosis Knowledgebase

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Gene id

4282

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

MIF Gene UCSC Ensembl

Aliases

GIF, GLIF, MMIF

Gene name

macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Alternate names

macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, phenylpyruvate tautomerase,

Gene location

22q11.23 (23894377: 23895221) Exons: 3 NC_000022.11

Gene summary(Entrez)

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

OMIM

153620

Protein Summary

Protein general information

P14174

Name: Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation inhibiting factor) (GIF) (L dopachrome isomerase) (L dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)

Length: 115 Mass: 12,476

Sequence

MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRS
YSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

Structural information

Interpro:	IPR001398 IPR019829 IPR014347
Prosite:	PS01158
Pfam:	PF01187
PDB:	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ
PDBsum:	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ
DIP:	31137
MINT:	5000040
STRING:	ENSP00000215754;

Other Databases

GeneCards: MIF; Malacards: MIF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001516	prostaglandin biosyntheti c process	IDA	biological_process
GO:0002906	negative regulation of ma ture B cell apoptotic pro cess	IEA	biological_process
GO:0004167	dopachrome isomerase acti vity	IDA	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005125	cytokine activity	IDA	molecular_function
GO:0005126	cytokine receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0006954	inflammatory response	IEA	biological_process
GO:0007166	cell surface receptor sig naling pathway	IDA	biological_process
GO:0007569	cell aging	IEA	biological_process
GO:0008283	cell proliferation	IDA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010739	positive regulation of pr otein kinase A signaling	IDA	biological_process
GO:0019752	carboxylic acid metabolic process	IDA	biological_process
GO:0030330	DNA damage response, sign al transduction by p53 cl ass mediator	IEA	biological_process
GO:0030890	positive regulation of B cell proliferation	IDA	biological_process
GO:0031666	positive regulation of li popolysaccharide-mediated signaling pathway	IEA	biological_process
GO:0031982	vesicle	IDA	cellular_component
GO:0032269	negative regulation of ce llular protein metabolic process	IEA	biological_process
GO:0033033	negative regulation of my eloid cell apoptotic proc ess	IEA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0042056	chemoattractant activity	IDA	molecular_function
GO:0042327	positive regulation of ph osphorylation	IDA	biological_process
GO:0043030	regulation of macrophage activation	NAS	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043406	positive regulation of MA P kinase activity	IEA	biological_process
GO:0043518	negative regulation of DN A damage response, signal transduction by p53 clas s mediator	IDA	biological_process
GO:0045087	innate immune response	IEA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0050178	phenylpyruvate tautomeras e activity	IDA	molecular_function
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050731	positive regulation of pe ptidyl-tyrosine phosphory lation	IDA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0050918	positive chemotaxis	IEA	biological_process
GO:0061078	positive regulation of pr ostaglandin secretion inv olved in immune response	IEA	biological_process
GO:0061081	positive regulation of my eloid leukocyte cytokine production involved in im mune response	IEA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070207	protein homotrimerization	IPI	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071157	negative regulation of ce ll cycle arrest	IDA	biological_process
GO:0090238	positive regulation of ar achidonic acid secretion	IEA	biological_process
GO:0090344	negative regulation of ce ll aging	IDA	biological_process
GO:1902166	negative regulation of in trinsic apoptotic signali ng pathway in response to DNA damage by p53 class mediator	IDA	biological_process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IEA	biological_process
GO:0001516	prostaglandin biosyntheti c process	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IEA	biological_process
GO:0002376	immune system process	IEA	biological_process
GO:0002906	negative regulation of ma ture B cell apoptotic pro cess	IEA	biological_process
GO:0004167	dopachrome isomerase acti vity	IEA	molecular_function
GO:0004167	dopachrome isomerase acti vity	IDA	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005125	cytokine activity	IDA	molecular_function
GO:0005126	cytokine receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0006954	inflammatory response	IEA	biological_process
GO:0007166	cell surface receptor sig naling pathway	IDA	biological_process
GO:0007569	cell aging	IEA	biological_process
GO:0008283	cell proliferation	IDA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010739	positive regulation of pr otein kinase A signaling	IDA	biological_process
GO:0016853	isomerase activity	IEA	molecular_function
GO:0019752	carboxylic acid metabolic process	IDA	biological_process
GO:0030330	DNA damage response, sign al transduction by p53 cl ass mediator	IEA	biological_process
GO:0030890	positive regulation of B cell proliferation	IDA	biological_process
GO:0031666	positive regulation of li popolysaccharide-mediated signaling pathway	IEA	biological_process
GO:0031982	vesicle	IDA	cellular_component
GO:0032269	negative regulation of ce llular protein metabolic process	IEA	biological_process
GO:0033033	negative regulation of my eloid cell apoptotic proc ess	IEA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0042056	chemoattractant activity	IDA	molecular_function
GO:0042127	regulation of cell prolif eration	IEA	biological_process
GO:0042327	positive regulation of ph osphorylation	IDA	biological_process
GO:0043030	regulation of macrophage activation	NAS	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043406	positive regulation of MA P kinase activity	IEA	biological_process
GO:0043518	negative regulation of DN A damage response, signal transduction by p53 clas s mediator	IEA	biological_process
GO:0043518	negative regulation of DN A damage response, signal transduction by p53 clas s mediator	IDA	biological_process
GO:0045087	innate immune response	IEA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IEA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0050178	phenylpyruvate tautomeras e activity	IEA	molecular_function
GO:0050178	phenylpyruvate tautomeras e activity	IEA	molecular_function
GO:0050178	phenylpyruvate tautomeras e activity	IDA	molecular_function
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050731	positive regulation of pe ptidyl-tyrosine phosphory lation	IEA	biological_process
GO:0050731	positive regulation of pe ptidyl-tyrosine phosphory lation	IDA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0050918	positive chemotaxis	IEA	biological_process
GO:0061078	positive regulation of pr ostaglandin secretion inv olved in immune response	IEA	biological_process
GO:0061081	positive regulation of my eloid leukocyte cytokine production involved in im mune response	IEA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070207	protein homotrimerization	IPI	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IEA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071157	negative regulation of ce ll cycle arrest	IDA	biological_process
GO:0090238	positive regulation of ar achidonic acid secretion	IEA	biological_process
GO:0090344	negative regulation of ce ll aging	IDA	biological_process
GO:1902166	negative regulation of in trinsic apoptotic signali ng pathway in response to DNA damage by p53 class mediator	IDA	biological_process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IEA	biological_process
GO:0001516	prostaglandin biosyntheti c process	IDA	biological_process
GO:0004167	dopachrome isomerase acti vity	IDA	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005125	cytokine activity	IDA	molecular_function
GO:0005126	cytokine receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0007166	cell surface receptor sig naling pathway	IDA	biological_process
GO:0008283	cell proliferation	IDA	biological_process
GO:0009986	cell surface	IDA	cellular_component
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010739	positive regulation of pr otein kinase A signaling	IDA	biological_process
GO:0019752	carboxylic acid metabolic process	IDA	biological_process
GO:0030890	positive regulation of B cell proliferation	IDA	biological_process
GO:0031982	vesicle	IDA	cellular_component
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0042056	chemoattractant activity	IDA	molecular_function
GO:0042327	positive regulation of ph osphorylation	IDA	biological_process
GO:0043030	regulation of macrophage activation	NAS	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043518	negative regulation of DN A damage response, signal transduction by p53 clas s mediator	IDA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0050178	phenylpyruvate tautomeras e activity	IDA	molecular_function
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050731	positive regulation of pe ptidyl-tyrosine phosphory lation	IDA	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070207	protein homotrimerization	IPI	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071157	negative regulation of ce ll cycle arrest	IDA	biological_process
GO:0090344	negative regulation of ce ll aging	IDA	biological_process
GO:1902166	negative regulation of in trinsic apoptotic signali ng pathway in response to DNA damage by p53 class mediator	IDA	biological_process

KEGG pathways

hsa00350 Tyrosine metabolism
hsa00360 Phenylalanine metabolism

Diseases

Associated diseases	References
Alopecia areata	PMID: 15815686
Alzheimer's disease	PMID: 15286457
Amyotrophic lateral sclerosis (ALS)	PMID: 18608101
Anemia	PMID: 19591577
Asthma	PMID: 14962818
Atopy	PMID: 14962818
Biliary atresia	PMID: 16385258
Cancer	PMID: 19773451
Chagas Disease	PMID: 19376177
Crohn's disease	PMID: 17172590
Cystic fibrosis	PMID: 16179637
Diabetes	PMID: 18853133
Ectopic endometriosis	PMID: 18710704
Endometriosis	PMID: 17658526
Female infertility	PMID: 1090165
Fertility disorders	PMID: 7039539
Gastric mucosa	PMID: 19724898
Hyperandrogenism	PMID: 20598902
Juvenile arthritis	PMID: 11508429, H01672
Male pseudohermaphroditism (MPH)	PMID: 3426164
Myocardial infarction	PMID: 15308783
Nephrotic syndrome	PMID: 16133063
Obesity	PMID: 16247506
Pancreatitis	PMID: 17495357
Polyarthritis	PMID: 14551601
Endometriosis associated infertility	INFBASE20492386
Ectopic endometriosis	INFBASE18710704
Endometriosis	INFBASE12095493
Polycystic ovary syndrome (PCOS)	PMID: 21623990
Poor ovarian response(POR)	PMID: 25083184
Psoriasis	PMID: 15304087
Recurrent miscarriage	PMID: 26368793
Rheumatoid arthritis	PMID: 12070782
Sarcoidosis	PMID: 17005573
Sepsis	PMID: 19941661
Spermatogenetic defects	PMID: 17592555
Systemic lupus erythematosus	PMID: 16724072
Testicular anomalies	PMID: 9340616
Vasculitis	PMID: 17181929

PubMed references

PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
18710704	Endometrio sis	9 women with en dometriotic les ions		MIF	Show abstract
19230876	Endometrio sis			MCP-1 MIF LEP and CA-125	Show abstract
16616746	Endometrio sis	70 (45 women wi th endometriosi s, 25 normal wo men)			Show abstract
15820792	Endometrio sis	93 (38 normal w omen, 55 women with endometrio sis)			Show abstract
15236996	Endometrio sis	76 (60 women wi th endometriosi s, 16 controls undergoing tuba l ligation)			Show abstract
12095493	Endometrio sis	93 (36 healthy women, 57 women with endometri osis)	Female infertility		Show abstract
26622394	Endometrio sis	149 (55 fertile with endometri osis, 43 infert ile with endome triosis, 47 con trols)	Female infertility		Show abstract
25439837	Endometrio sis	36 (16 normal c ontrols, 20 wom en with endomet riosis)	Female infertility	MIF CD74 and COX-2	Show abstract
19299454	Endometrio sis	593 (196 cases with pathologic ally proved end ometriosis, 397 disease-free w omen as control subjects)		COX-2 MIF	Show abstract
20829186	Endometrio sis			MIF VEGF IL-8 MCP-1	Show abstract
17997749	Endometrio sis			IL-1 MIF	Show abstract
20492386	Endometrio sis	55 (40 patients with endometri osis, 15 contro l women)			Show abstract
17658526	Endometrio sis		Female infertility		Show abstract
17706208	Endometrio sis	141 (63 women w ith II-IV endom etriosis, 78 co ntrols)		MIF MCP-1 INFG LEP CA-127	Show abstract
11836337	Endometrio sis			MIF	Show abstract