Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 4288
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol MKI67   Gene   UCSC   Ensembl
Aliases KIA, MIB-, MIB-1, PPP1R105
Gene name marker of proliferation Ki-67
Alternate names proliferation marker protein Ki-67, antigen KI-67, antigen Ki67, antigen identified by monoclonal antibody Ki-67, proliferation-related Ki-67 antigen, protein phosphatase 1, regulatory subunit 105,
Gene location 10q26.2 (128126404: 128096658)     Exons: 16     NC_000010.11
Gene summary(Entrez) This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
OMIM 176741

Protein Summary
Protein general information P46013  

Name: Proliferation marker protein Ki 67 (Antigen identified by monoclonal antibody Ki 67) (Antigen KI 67) (Antigen Ki67)

Length: 3256  Mass: 358,694

Sequence MWPTRRLVTIKRSGVDGPHFPLSLSTCLFGRGIECDIRIQLPVVSKQHCKIEIHEQEAILHNFSSTNPTQVNGSV
IDEPVRLKHGDVITIIDRSFRYENESLQNGRKSTEFPRKIREQEPARRVSRSSFSSDPDEKAQDSKAYSKITEGK
VSGNPQVHIKNVKEDSTADDSKDSVAQGTTNVHSSEHAGRNGRNAADPISGDFKEISSVKLVSRYGELKSVPTTQ
CLDNSKKNESPFWKLYESVKKELDVKSQKENVLQYCRKSGLQTDYATEKESADGLQGETQLLVSRKSRPKSGGSG
HAVAEPASPEQELDQNKGKGRDVESVQTPSKAVGASFPLYEPAKMKTPVQYSQQQNSPQKHKNKDLYTTGRRESV
NLGKSEGFKAGDKTLTPRKLSTRNRTPAKVEDAADSATKPENLSSKTRGSIPTDVEVLPTETEIHNEPFLTLWLT
QVERKIQKDSLSKPEKLGTTAGQMCSGLPGLSSVDINNFGDSINESEGIPLKRRRVSFGGHLRPELFDENLPPNT
PLKRGEAPTKRKSLVMHTPPVLKKIIKEQPQPSGKQESGSEIHVEVKAQSLVISPPAPSPRKTPVASDQRRRSCK
TAPASSSKSQTEVPKRGGRKSGNLPSKRVSISRSQHDILQMICSKRRSGASEANLIVAKSWADVVKLGAKQTQTK
VIKHGPQRSMNKRQRRPATPKKPVGEVHSQFSTGHANSPCTIIIGKAHTEKVHVPARPYRVLNNFISNQKMDFKE
DLSGIAEMFKTPVKEQPQLTSTCHIAISNSENLLGKQFQGTDSGEEPLLPTSESFGGNVFFSAQNAAKQPSDKCS
ASPPLRRQCIRENGNVAKTPRNTYKMTSLETKTSDTETEPSKTVSTANRSGRSTEFRNIQKLPVESKSEETNTEI
VECILKRGQKATLLQQRREGEMKEIERPFETYKENIELKENDEKMKAMKRSRTWGQKCAPMSDLTDLKSLPDTEL
MKDTARGQNLLQTQDHAKAPKSEKGKITKMPCQSLQPEPINTPTHTKQQLKASLGKVGVKEELLAVGKFTRTSGE
TTHTHREPAGDGKSIRTFKESPKQILDPAARVTGMKKWPRTPKEEAQSLEDLAGFKELFQTPGPSEESMTDEKTT
KIACKSPPPESVDTPTSTKQWPKRSLRKADVEEEFLALRKLTPSAGKAMLTPKPAGGDEKDIKAFMGTPVQKLDL
AGTLPGSKRQLQTPKEKAQALEDLAGFKELFQTPGHTEELVAAGKTTKIPCDSPQSDPVDTPTSTKQRPKRSIRK
ADVEGELLACRNLMPSAGKAMHTPKPSVGEEKDIIIFVGTPVQKLDLTENLTGSKRRPQTPKEEAQALEDLTGFK
ELFQTPGHTEEAVAAGKTTKMPCESSPPESADTPTSTRRQPKTPLEKRDVQKELSALKKLTQTSGETTHTDKVPG
GEDKSINAFRETAKQKLDPAASVTGSKRHPKTKEKAQPLEDLAGLKELFQTPVCTDKPTTHEKTTKIACRSQPDP
VDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGKAMHTPKPAVSGEKNIYAFMGTPVQKLDLTENLTGSKRRL
QTPKEKAQALEDLAGFKELFQTRGHTEESMTNDKTAKVACKSSQPDPDKNPASSKRRLKTSLGKVGVKEELLAVG
KLTQTSGETTHTHTEPTGDGKSMKAFMESPKQILDSAASLTGSKRQLRTPKGKSEVPEDLAGFIELFQTPSHTKE
SMTNEKTTKVSYRASQPDLVDTPTSSKPQPKRSLRKADTEEEFLAFRKQTPSAGKAMHTPKPAVGEEKDINTFLG
TPVQKLDQPGNLPGSNRRLQTRKEKAQALEELTGFRELFQTPCTDNPTTDEKTTKKILCKSPQSDPADTPTNTKQ
RPKRSLKKADVEEEFLAFRKLTPSAGKAMHTPKAAVGEEKDINTFVGTPVEKLDLLGNLPGSKRRPQTPKEKAKA
LEDLAGFKELFQTPGHTEESMTDDKITEVSCKSPQPDPVKTPTSSKQRLKISLGKVGVKEEVLPVGKLTQTSGKT
TQTHRETAGDGKSIKAFKESAKQMLDPANYGTGMERWPRTPKEEAQSLEDLAGFKELFQTPDHTEESTTDDKTTK
IACKSPPPESMDTPTSTRRRPKTPLGKRDIVEELSALKQLTQTTHTDKVPGDEDKGINVFRETAKQKLDPAASVT
GSKRQPRTPKGKAQPLEDLAGLKELFQTPICTDKPTTHEKTTKIACRSPQPDPVGTPTIFKPQSKRSLRKADVEE
ESLALRKRTPSVGKAMDTPKPAGGDEKDMKAFMGTPVQKLDLPGNLPGSKRWPQTPKEKAQALEDLAGFKELFQT
PGTDKPTTDEKTTKIACKSPQPDPVDTPASTKQRPKRNLRKADVEEEFLALRKRTPSAGKAMDTPKPAVSDEKNI
NTFVETPVQKLDLLGNLPGSKRQPQTPKEKAEALEDLVGFKELFQTPGHTEESMTDDKITEVSCKSPQPESFKTS
RSSKQRLKIPLVKVDMKEEPLAVSKLTRTSGETTQTHTEPTGDSKSIKAFKESPKQILDPAASVTGSRRQLRTRK
EKARALEDLVDFKELFSAPGHTEESMTIDKNTKIPCKSPPPELTDTATSTKRCPKTRPRKEVKEELSAVERLTQT
SGQSTHTHKEPASGDEGIKVLKQRAKKKPNPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQESLTAGK
ATKIPCESPPLEVVDTTASTKRHLRTRVQKVQVKEEPSAVKFTQTSGETTDADKEPAGEDKGIKALKESAKQTPA
PAASVTGSRRRPRAPRESAQAIEDLAGFKDPAAGHTEESMTDDKTTKIPCKSSPELEDTATSSKRRPRTRAQKVE
VKEELLAVGKLTQTSGETTHTDKEPVGEGKGTKAFKQPAKRKLDAEDVIGSRRQPRAPKEKAQPLEDLASFQELS
QTPGHTEELANGAADSFTSAPKQTPDSGKPLKISRRVLRAPKVEPVGDVVSTRDPVKSQSKSNTSLPPLPFKRGG
GKDGSVTGTKRLRCMPAPEEIVEELPASKKQRVAPRARGKSSEPVVIMKRSLRTSAKRIEPAEELNSNDMKTNKE
EHKLQDSVPENKGISLRSRRQNKTEAEQQITEVFVLAERIEINRNEKKPMKTSPEMDIQNPDDGARKPIPRDKVT
ENKRCLRSARQNESSQPKVAEESGGQKSAKVLMQNQKGKGEAGNSDSMCLRSRKTKSQPAASTLESKSVQRVTRS
VKRCAENPKKAEDNVCVKKIRTRSHRDSEDI
Structural information
Protein Domains
 FHA. (27-76)
PP1-binding. (502-549)
Interpro:  IPR000253 IPR012568 IPR029334 IPR008984
Prosite:   PS50006

Pfam:  		 PF00498 PF08065 PF15276

PDB:  		 1R21 2AFF 5J28
PDBsum:   1R21 2AFF 5J28

DIP:  		 28132
MINT:   137995
STRING:   ENSP00000357643;
Other Databases GeneCards:  MKI67;  Malacards:  MKI67

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000775 chromosome, centromeric r
egion
 IEA cellular_component
GO:0000793 condensed chromosome
 IEA cellular_component
GO:0005515 protein binding
 IPI molecular_function
GO:0005524 ATP binding
 IEA molecular_function
GO:0005634 nucleus
 IDA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0005730 nucleolus
 IDA cellular_component
GO:0005730 nucleolus
 IDA cellular_component
GO:0005737 cytoplasm
 IEA cellular_component
GO:0006259 DNA metabolic process
 IEA biological_process
GO:0007126 meiotic nuclear division
 IEA biological_process
GO:0008022 protein C-terminus bindin
g
 IPI molecular_function
GO:0008283 cell proliferation
 TAS biological_process
GO:0014070 response to organic cycli
c compound
 IEA biological_process
GO:0016020 membrane
 IDA cellular_component
GO:0030212 hyaluronan metabolic proc
ess
 IEA biological_process
GO:0031100 animal organ regeneration
 IEA biological_process
GO:0034605 cellular response to heat
 IEA biological_process
GO:0044822 poly(A) RNA binding
 IDA molecular_function
GO:0072574 hepatocyte proliferation
 IEA biological_process
GO:1990705 cholangiocyte proliferati
on
 IEA biological_process
GO:0000166 nucleotide binding
 IEA molecular_function
GO:0000775 chromosome, centromeric r
egion
 IEA cellular_component
GO:0000793 condensed chromosome
 IEA cellular_component
GO:0005515 protein binding
 IPI molecular_function
GO:0005524 ATP binding
 IEA molecular_function
GO:0005634 nucleus
 IEA cellular_component
GO:0005634 nucleus
 IEA cellular_component
GO:0005634 nucleus
 IEA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0005694 chromosome
 IEA cellular_component
GO:0005694 chromosome
 IEA cellular_component
GO:0005730 nucleolus
 IEA cellular_component
GO:0005730 nucleolus
 IEA cellular_component
GO:0005730 nucleolus
 IDA cellular_component
GO:0005730 nucleolus
 IDA cellular_component
GO:0005737 cytoplasm
 IEA cellular_component
GO:0006259 DNA metabolic process
 IEA biological_process
GO:0007049 cell cycle
 IEA biological_process
GO:0007126 meiotic nuclear division
 IEA biological_process
GO:0008022 protein C-terminus bindin
g
 IPI molecular_function
GO:0008283 cell proliferation
 IEA biological_process
GO:0008283 cell proliferation
 TAS biological_process
GO:0008283 cell proliferation
 TAS biological_process
GO:0014070 response to organic cycli
c compound
 IEA biological_process
GO:0016020 membrane
 IDA cellular_component
GO:0030212 hyaluronan metabolic proc
ess
 IEA biological_process
GO:0031100 animal organ regeneration
 IEA biological_process
GO:0034605 cellular response to heat
 IEA biological_process
GO:0044822 poly(A) RNA binding
 IDA molecular_function
GO:0072574 hepatocyte proliferation
 IEA biological_process
GO:1990705 cholangiocyte proliferati
on
 IEA biological_process
GO:0005515 protein binding
 IPI molecular_function
GO:0005634 nucleus
 IDA cellular_component
GO:0005634 nucleus
 IDA cellular_component
GO:0005730 nucleolus
 IDA cellular_component
GO:0005730 nucleolus
 IDA cellular_component
GO:0008022 protein C-terminus bindin
g
 IPI molecular_function
GO:0008283 cell proliferation
 TAS biological_process
GO:0008283 cell proliferation
 TAS biological_process
GO:0016020 membrane
 IDA cellular_component
GO:0044822 poly(A) RNA binding
 IDA molecular_function

Diseases

Associated diseases References
Adenomyosis PMID: 17208943
Alzheimer's disease PMID: 16385451
Cancer PMID: 19584075
Cardiovascular disease PMID: 19023099
Endometriosis PMID: 25194152
Jaw abnormalities PMID: 22419666
Endometriosis INFBASE26708185
Polycystic ovary syndrome (PCOS) PMID: 16361289

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
25194152 Endometrio
sis
60 (35 women wi
th endometriosi
s, 25 fertile e
umenorrheic wom
en)
 Ki67
SCF
Akt
GSK3B
 Show abstract
26708185 Endometrio
sis
33 (13 women wi
th ovarian endo
metriosis (case
s), 10 eutopic
endometria, 10
women with non
endometriotic d
iseases (contro
ls))
 HtrA1
TGFb1
pSmad and Ki67
 Show abstract
10605405 Endometrio
sis
24 and 7 endome
triosis cases
 Ki-67
ER
PR
 Show abstract