Endometriosis Knowledgebase

Search Result

Gene id

4988

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

OPRM1 Gene UCSC Ensembl

Aliases

LMOR, M-OR-1, MOP, MOR, MOR1, OPRM

Gene name

opioid receptor mu 1

Alternate names

mu-type opioid receptor, mu opiate receptor, mu opioid receptor hMOR-1a,

Gene location

6q25.2 (154010495: 154246866) Exons: 17 NC_000006.12

Gene summary(Entrez)

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

OMIM

600018

Protein Summary

Protein general information

P35372

Name: Mu type opioid receptor (M OR 1) (MOR 1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)

Length: 400 Mass: 44,779

Tissue specificity: Expressed in brain. Isoform 16 and isoform 17 are detected in brain. {ECO

Sequence

MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMA
LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDY
YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSH
PTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDH
PSTANTVDRTNHQLENLEAETAPLP

Structural information

Motifs	NPxx (334-338) in stabilizing(a-role)
Interpro:	IPR000276 IPR017452 IPR000105 IPR001418
Prosite:	PS00237 PS50262
Pfam:	PF00001
MINT:	100121
STRING:	ENSP00000394624;

Other Databases

GeneCards: OPRM1; Malacards: OPRM1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001965	G-protein alpha-subunit b inding	IDA	molecular_function
GO:0002438	acute inflammatory respon se to antigenic stimulus	IEA	biological_process
GO:0004930	G-protein coupled recepto r activity	ISS	molecular_function
GO:0004979	beta-endorphin receptor a ctivity	IMP	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	ISS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005623	cell	IEA	cellular_component
GO:0005623	cell	IEA	cellular_component
GO:0005783	endoplasmic reticulum	TAS	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0005925	focal adhesion	IEA	cellular_component
GO:0007187	G-protein coupled recepto r signaling pathway, coup led to cyclic nucleotide second messenger	TAS	biological_process
GO:0007191	adenylate cyclase-activat ing dopamine receptor sig naling pathway	IEA	biological_process
GO:0007194	negative regulation of ad enylate cyclase activity	ISS	biological_process
GO:0007200	phospholipase C-activatin g G-protein coupled recep tor signaling pathway	ISS	biological_process
GO:0007204	positive regulation of cy tosolic calcium ion conce ntration	IDA	biological_process
GO:0007218	neuropeptide signaling pa thway	IEA	biological_process
GO:0007268	chemical synaptic transmi ssion	IBA	biological_process
GO:0007600	sensory perception	NAS	biological_process
GO:0007626	locomotory behavior	IEA	biological_process
GO:0008022	protein C-terminus bindin g	IEA	molecular_function
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0009314	response to radiation	IEA	biological_process
GO:0019233	sensory perception of pai n	ISS	biological_process
GO:0019233	sensory perception of pai n	IBA	biological_process
GO:0019904	protein domain specific b inding	IEA	molecular_function
GO:0031005	filamin binding	IEA	molecular_function
GO:0031635	adenylate cyclase-inhibit ing opioid receptor signa ling pathway	IEA	biological_process
GO:0031681	G-protein beta-subunit bi nding	IBA	molecular_function
GO:0032094	response to food	IEA	biological_process
GO:0032100	positive regulation of ap petite	IEA	biological_process
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032590	dendrite membrane	IEA	cellular_component
GO:0032839	dendrite cytoplasm	IEA	cellular_component
GO:0033554	cellular response to stre ss	IMP	biological_process
GO:0038047	morphine receptor activit y	ISS	molecular_function
GO:0038047	morphine receptor activit y	IBA	molecular_function
GO:0042060	wound healing	IEA	biological_process
GO:0042220	response to cocaine	IEA	biological_process
GO:0042383	sarcolemma	IEA	cellular_component
GO:0042755	eating behavior	IEA	biological_process
GO:0042923	neuropeptide binding	IBA	molecular_function
GO:0043005	neuron projection	IBA	cellular_component
GO:0043204	perikaryon	IEA	cellular_component
GO:0043950	positive regulation of cA MP-mediated signaling	IDA	biological_process
GO:0043951	negative regulation of cA MP-mediated signaling	IDA	biological_process
GO:0044849	estrous cycle	IEA	biological_process
GO:0045019	negative regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045121	membrane raft	IEA	cellular_component
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0048149	behavioral response to et hanol	IMP	biological_process
GO:0050769	positive regulation of ne urogenesis	ISS	biological_process
GO:0051481	negative regulation of cy tosolic calcium ion conce ntration	IDA	biological_process
GO:0051930	regulation of sensory per ception of pain	IEA	biological_process
GO:0060079	excitatory postsynaptic p otential	IEA	biological_process
GO:0061358	negative regulation of Wn t protein secretion	IMP	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	ISS	biological_process
GO:0070588	calcium ion transmembrane transport	IEA	biological_process
GO:0070848	response to growth factor	IEA	biological_process
GO:0071315	cellular response to morp hine	IBA	biological_process
GO:0098794	postsynapse	IEA	cellular_component
GO:2000310	regulation of N-methyl-D- aspartate selective gluta mate receptor activity	ISS	biological_process
GO:0001965	G-protein alpha-subunit b inding	IDA	molecular_function
GO:0002438	acute inflammatory respon se to antigenic stimulus	IEA	biological_process
GO:0004871	signal transducer activit y	IEA	molecular_function
GO:0004930	G-protein coupled recepto r activity	IEA	molecular_function
GO:0004930	G-protein coupled recepto r activity	IEA	molecular_function
GO:0004930	G-protein coupled recepto r activity	ISS	molecular_function
GO:0004930	G-protein coupled recepto r activity	IEA	molecular_function
GO:0004979	beta-endorphin receptor a ctivity	IEA	molecular_function
GO:0004979	beta-endorphin receptor a ctivity	IMP	molecular_function
GO:0004985	opioid receptor activity	IEA	molecular_function
GO:0004985	opioid receptor activity	IEA	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	IEA	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	ISS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005623	cell	IEA	cellular_component
GO:0005623	cell	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005783	endoplasmic reticulum	TAS	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0005925	focal adhesion	IEA	cellular_component
GO:0007165	signal transduction	IEA	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IEA	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IEA	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IEA	biological_process
GO:0007187	G-protein coupled recepto r signaling pathway, coup led to cyclic nucleotide second messenger	TAS	biological_process
GO:0007191	adenylate cyclase-activat ing dopamine receptor sig naling pathway	IEA	biological_process
GO:0007193	adenylate cyclase-inhibit ing G-protein coupled rec eptor signaling pathway	IEA	biological_process
GO:0007194	negative regulation of ad enylate cyclase activity	IEA	biological_process
GO:0007194	negative regulation of ad enylate cyclase activity	ISS	biological_process
GO:0007200	phospholipase C-activatin g G-protein coupled recep tor signaling pathway	IEA	biological_process
GO:0007200	phospholipase C-activatin g G-protein coupled recep tor signaling pathway	ISS	biological_process
GO:0007204	positive regulation of cy tosolic calcium ion conce ntration	IDA	biological_process
GO:0007218	neuropeptide signaling pa thway	IEA	biological_process
GO:0007268	chemical synaptic transmi ssion	IBA	biological_process
GO:0007600	sensory perception	NAS	biological_process
GO:0007626	locomotory behavior	IEA	biological_process
GO:0008022	protein C-terminus bindin g	IEA	molecular_function
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0009314	response to radiation	IEA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0019233	sensory perception of pai n	IEA	biological_process
GO:0019233	sensory perception of pai n	ISS	biological_process
GO:0019233	sensory perception of pai n	IBA	biological_process
GO:0019904	protein domain specific b inding	IEA	molecular_function
GO:0030425	dendrite	IEA	cellular_component
GO:0030818	negative regulation of cA MP biosynthetic process	IEA	biological_process
GO:0031005	filamin binding	IEA	molecular_function
GO:0031635	adenylate cyclase-inhibit ing opioid receptor signa ling pathway	IEA	biological_process
GO:0031681	G-protein beta-subunit bi nding	IEA	molecular_function
GO:0031681	G-protein beta-subunit bi nding	IBA	molecular_function
GO:0032094	response to food	IEA	biological_process
GO:0032100	positive regulation of ap petite	IEA	biological_process
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032590	dendrite membrane	IEA	cellular_component
GO:0032839	dendrite cytoplasm	IEA	cellular_component
GO:0033554	cellular response to stre ss	IMP	biological_process
GO:0038003	opioid receptor signaling pathway	IEA	biological_process
GO:0038047	morphine receptor activit y	IEA	molecular_function
GO:0038047	morphine receptor activit y	ISS	molecular_function
GO:0038047	morphine receptor activit y	IBA	molecular_function
GO:0042060	wound healing	IEA	biological_process
GO:0042220	response to cocaine	IEA	biological_process
GO:0042383	sarcolemma	IEA	cellular_component
GO:0042755	eating behavior	IEA	biological_process
GO:0042923	neuropeptide binding	IBA	molecular_function
GO:0043005	neuron projection	IBA	cellular_component
GO:0043204	perikaryon	IEA	cellular_component
GO:0043278	response to morphine	IEA	biological_process
GO:0043950	positive regulation of cA MP-mediated signaling	IDA	biological_process
GO:0043951	negative regulation of cA MP-mediated signaling	IDA	biological_process
GO:0044849	estrous cycle	IEA	biological_process
GO:0045019	negative regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045121	membrane raft	IEA	cellular_component
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0048149	behavioral response to et hanol	IMP	biological_process
GO:0050769	positive regulation of ne urogenesis	IEA	biological_process
GO:0050769	positive regulation of ne urogenesis	ISS	biological_process
GO:0051481	negative regulation of cy tosolic calcium ion conce ntration	IDA	biological_process
GO:0051930	regulation of sensory per ception of pain	IEA	biological_process
GO:0060079	excitatory postsynaptic p otential	IEA	biological_process
GO:0061358	negative regulation of Wn t protein secretion	IMP	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IEA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	ISS	biological_process
GO:0070588	calcium ion transmembrane transport	IEA	biological_process
GO:0070848	response to growth factor	IEA	biological_process
GO:0071315	cellular response to morp hine	IEA	biological_process
GO:0071315	cellular response to morp hine	IBA	biological_process
GO:0098794	postsynapse	IEA	cellular_component
GO:2000310	regulation of N-methyl-D- aspartate selective gluta mate receptor activity	IEA	biological_process
GO:2000310	regulation of N-methyl-D- aspartate selective gluta mate receptor activity	ISS	biological_process
GO:0001965	G-protein alpha-subunit b inding	IDA	molecular_function
GO:0004930	G-protein coupled recepto r activity	ISS	molecular_function
GO:0004979	beta-endorphin receptor a ctivity	IMP	molecular_function
GO:0005245	voltage-gated calcium cha nnel activity	ISS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005783	endoplasmic reticulum	TAS	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0007187	G-protein coupled recepto r signaling pathway, coup led to cyclic nucleotide second messenger	TAS	biological_process
GO:0007194	negative regulation of ad enylate cyclase activity	ISS	biological_process
GO:0007200	phospholipase C-activatin g G-protein coupled recep tor signaling pathway	ISS	biological_process
GO:0007204	positive regulation of cy tosolic calcium ion conce ntration	IDA	biological_process
GO:0007268	chemical synaptic transmi ssion	IBA	biological_process
GO:0007600	sensory perception	NAS	biological_process
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0019233	sensory perception of pai n	ISS	biological_process
GO:0019233	sensory perception of pai n	IBA	biological_process
GO:0031681	G-protein beta-subunit bi nding	IBA	molecular_function
GO:0033554	cellular response to stre ss	IMP	biological_process
GO:0038047	morphine receptor activit y	ISS	molecular_function
GO:0038047	morphine receptor activit y	IBA	molecular_function
GO:0042923	neuropeptide binding	IBA	molecular_function
GO:0043005	neuron projection	IBA	cellular_component
GO:0043950	positive regulation of cA MP-mediated signaling	IDA	biological_process
GO:0043951	negative regulation of cA MP-mediated signaling	IDA	biological_process
GO:0045019	negative regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0048149	behavioral response to et hanol	IMP	biological_process
GO:0050769	positive regulation of ne urogenesis	ISS	biological_process
GO:0051481	negative regulation of cy tosolic calcium ion conce ntration	IDA	biological_process
GO:0061358	negative regulation of Wn t protein secretion	IMP	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	ISS	biological_process
GO:0071315	cellular response to morp hine	IBA	biological_process
GO:2000310	regulation of N-methyl-D- aspartate selective gluta mate receptor activity	ISS	biological_process

KEGG pathways

hsa04080  Neuroactive ligand-receptor interaction
hsa04915  Estrogen signaling pathway
hsa05032  Morphine addiction

Diseases

Associated diseases	References
Attention-deficit hyperactivity disorder (ADHD)	PMID: 11140838
Autism	PMID: 19058789
Biliary liver cirrhosis	PMID: 18709298
Cancer	PMID: 19891732
Chronic obstructive pulmonary disease (COPD)	PMID: 19625176
Coronary disease	PMID: 21347282
Crohn's disease	PMID: 19167252
Depression	PMID: 12210283
Diabetes	PMID: 18518884
Endometriosis	PMID: 15299092
Epilepsy	PMID: 12221164
Obesity	PMID: 19008867
Ovarian endometriosis	INFBASE16815388
Endometriosis	INFBASE15299092
Ovarian endometriosis	PMID: 16815388
Psychiatric disorders	PMID: 19086053

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
15299092	Endometrio sis					PDGFRA PKC beta1 JAK1 Sprouty2 MKK7 COUP-TF2 PGE2EP	Show abstract
16815388	Endometrio sis (ovari an)					PDGFRA PKCbeta1 JAK1 HSP90A COUP-TF2 MOR 17betaHSD2 Sprouty2 and PGE(2)EP3	Show abstract