Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 5047
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol PAEP   Gene   UCSC   Ensembl
Aliases GD, GdA, GdF, GdS, PAEG, PEP, PP14
Gene name progestagen associated endometrial protein
Alternate names glycodelin, PEG, PP14 protein (placental protein 14), alpha uterine protein, glycodelin-A, glycodelin-F, glycodelin-S, placental protein 14, pregnancy-associated endometrial alpha-2 globulin, progestagen-associated endometrial protein (placental protein 14, pregna,
Gene location 9q34.3 (135561623: 135566775)     Exons: 7     NC_000009.12
Gene summary(Entrez) This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
OMIM 173310

Protein Summary

Protein general information P09466  

Name: Glycodelin (GD) (Placental protein 14) (PP14) (Pregnancy associated endometrial alpha 2 globulin) (PAEG) (PEG) (Progestagen associated endometrial protein) (Progesterone associated endometrial protein)

Length: 180  Mass: 20,624

Sequence MLCLLLTLGVALVCGVPAMDIPQTKQDLELPKLAGTWHSMAMATNNISLMATLKAPLRVHITSLLPTPEDNLEIV
LHRWENNSCVEKKVLGEKTENPKKFKINYTVANEATLLDTDYDNFLFLCLQDTTTPIQSMMCQYLARVLVEDDEI
MQGFIRAFRPLPRHLWYLLDLKQMEEPCRF
Structural information
Interpro:  IPR002447 IPR012674 IPR002345 IPR022272 IPR000566
Prosite:   PS00213

Pfam:  
PF00061

PDB:  
4R0B
PDBsum:   4R0B
MINT:   1209116
STRING:   ENSP00000277508;
Other Databases GeneCards:  PAEP;  Malacards:  PAEP

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0006810 transport
IEA biological_process
GO:0006915 apoptotic process
IDA biological_process
GO:0007275 multicellular organism de
velopment
TAS biological_process
GO:0032725 positive regulation of gr
anulocyte macrophage colo
ny-stimulating factor pro
duction
IDA biological_process
GO:0036094 small molecule binding
IEA molecular_function
GO:2000667 positive regulation of in
terleukin-13 secretion
IDA biological_process
GO:2000778 positive regulation of in
terleukin-6 secretion
IDA biological_process
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0006810 transport
IEA biological_process
GO:0006915 apoptotic process
IDA biological_process
GO:0007275 multicellular organism de
velopment
TAS biological_process
GO:0032725 positive regulation of gr
anulocyte macrophage colo
ny-stimulating factor pro
duction
IDA biological_process
GO:0036094 small molecule binding
IEA molecular_function
GO:2000667 positive regulation of in
terleukin-13 secretion
IDA biological_process
GO:2000778 positive regulation of in
terleukin-6 secretion
IDA biological_process
GO:0005515 protein binding
IPI molecular_function
GO:0006915 apoptotic process
IDA biological_process
GO:0007275 multicellular organism de
velopment
TAS biological_process
GO:0032725 positive regulation of gr
anulocyte macrophage colo
ny-stimulating factor pro
duction
IDA biological_process
GO:2000667 positive regulation of in
terleukin-13 secretion
IDA biological_process
GO:2000778 positive regulation of in
terleukin-6 secretion
IDA biological_process

Diseases

Associated diseases References
Azoospermia PMID: 22182811
Endometrial receptivity PMID: 16939926
Endometriosis PMID: 23670949
Female infertility PMID: 21292383
Implantation failure PMID: 16417092
Male infertility PMID: 9755428
Oligozoospermia PMID: 22182811
Ovarian endometriosis INFBASE25797583
Endometriosis (ovarian) INFBASE25797583
Ovarian endometriosis INFBASE23461865
Dysmenorrhea INFBASE19903048
Female infertility INFBASE12810542
Implantation defects INFBASE12810542
Endometriosis INFBASE12810542
Ovarian endometriosis PMID: 25797583
Polycystic ovary syndrome (PCOS) PMID: 14764802
Recurrent implantation failure (RIF) PMID: 25747132
Retarded endometrial differentiation PMID: 8006124
Spermatogenetic defects PMID: 17482165

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
12810542 Endometrio
sis


IL-15
proline-rich protein
B61
Dickkopf-1
glycodelin
N-acetylglucosamine-6-O-sulfotransferase
G0S2 protein
purine nucleoside phosphorylase
semaphorin E
neuronal olfactomedin-related endoplasmic reticulum localized protein mRNA
Sam68-like phospho
Show abstract
18672236 Endometrio
sis

47 (24 women wi
th endometriosi
s, 23 healthy v
olunteers of si
milar age)
GdA
OPN
LPA3
HOXA10
Show abstract
18402941 Endometrio
sis

28 (11 healthy
fertile control
s, 17 patients
with endometrio
sis)
Glycodelin
Show abstract
22736326 Endometrio
sis

353 (121 contro
ls without endo
metriosis at la
paroscopy and f
rom 232 women w
ith endometrios
is (minimal-mil
d n = 148; mode
rate-severe n =
84))
Annexin V
VEGF
CA-125 and sICAM-1
glycodelin
Show abstract
19903048 Endometrio
sis

68 (41 endometr
iosis, 27 contr
ols )
IL-8
RANTES
OPG
PAPP-A
TNF-alpha and glycodelin
Show abstract
22563871 Endometrio
sis


IL-6
TNF-alpha
glycodelin A
Show abstract
23670949 Endometrio
sis

124 (75 women w
ith ovarian end
ometriosis, 49
women without e
ndometriosis )

Show abstract
25797583 Endometrio
sis (ovari
an)

98 (58 women wi
th ovarian endo
metriosis (case
s), 40 healthy
women undergoin
g sterilization
or patients wi
th benign ovari
an cysts (contr
ols))
Female infertility IL6
IL8
PAEP
LEP
Show abstract
23461865 Endometrio
sis (ovari
an)

99 (57 women wi
th ovarian endo
metriosis, 42 h
ealthy women co
ntrol)

Show abstract