Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 50616
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol IL22   Gene   UCSC   Ensembl
Aliases IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18
Gene name interleukin 22
Alternate names interleukin-22, IL-10-related T-cell-derived inducible factor, cytokine Zcyto18,
Gene location 12q15 (68253500: 68248244)     Exons: 5     NC_000012.12
OMIM 605330

Protein Summary

Protein general information Q9GZX6  

Name: Interleukin 22 (IL 22) (Cytokine Zcyto18) (IL 10 related T cell derived inducible factor) (IL TIF)

Length: 179  Mass: 20,011

Sequence MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLI
GEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKD
TVKKLGESGEIKAIGELDLLFMSLRNACI
Structural information
Interpro:  IPR009079 IPR020423 IPR020453
Prosite:   PS00520

Pfam:  
PF14565

PDB:  
1M4R 1YKB 3DGC 3DLQ 3G9V 3Q1S
PDBsum:   1M4R 1YKB 3DGC 3DLQ 3G9V 3Q1S

DIP:  
46035
MINT:   6693924
STRING:   ENSP00000329384;
Other Databases GeneCards:  IL22;  Malacards:  IL22

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005125 cytokine activity
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IC cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0006953 acute-phase response
NAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006954 inflammatory response
NAS biological_process
GO:0006955 immune response
IBA biological_process
GO:0007267 cell-cell signaling
IC biological_process
GO:0045518 interleukin-22 receptor b
inding
NAS molecular_function
GO:0046427 positive regulation of JA
K-STAT cascade
IBA biological_process
GO:0051384 response to glucocorticoi
d
IEA biological_process
GO:0005125 cytokine activity
IBA molecular_function
GO:0005125 cytokine activity
IEA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IC cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0006953 acute-phase response
NAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006954 inflammatory response
NAS biological_process
GO:0006955 immune response
IBA biological_process
GO:0007267 cell-cell signaling
IC biological_process
GO:0045518 interleukin-22 receptor b
inding
NAS molecular_function
GO:0046427 positive regulation of JA
K-STAT cascade
IBA biological_process
GO:0051384 response to glucocorticoi
d
IEA biological_process
GO:0005125 cytokine activity
IBA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IC cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0006953 acute-phase response
NAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006954 inflammatory response
NAS biological_process
GO:0006955 immune response
IBA biological_process
GO:0007267 cell-cell signaling
IC biological_process
GO:0045518 interleukin-22 receptor b
inding
NAS molecular_function
GO:0046427 positive regulation of JA
K-STAT cascade
IBA biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa04659  Th17 cell differentiation
hsa05321  Inflammatory bowel disease

Diseases

Associated diseases References
Defective endometrial receptivity PMID: 25935494
Endometriosis PMID: 24133578
Endometriosis INFBASE24133578

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
24133578 Endometrio
sis


IL-22
IL-22R1
IL-10R2)
Show abstract