Endometriosis Knowledgebase

Search Result

Gene id

5290

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

PIK3CA Gene UCSC Ensembl

Aliases

CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, PI3K-alpha, p110-alpha

Gene name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Alternate names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase p110 subunit alpha, phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform, phosphoinositide-3-kinase, catalytic, alpha polypeptide, ptdIns-3-kinase subunit p110-alpha, serine/threonine protein kinase PIK3CA,

Gene location

3q26.32 (179148113: 179240092) Exons: 23 NC_000003.12

Gene summary(Entrez)

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]

OMIM

171834

Protein Summary

Protein general information

P42336

Name: Phosphatidylinositol 4,5 bisphosphate 3 kinase catalytic subunit alpha isoform (PI3 kinase subunit alpha) (PI3K alpha) (PI3Kalpha) (PtdIns 3 kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alp

Length: 1068 Mass: 124,284

Sequence

MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQ
EAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEA
VDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAI
RKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQR
VPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPH
GLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRE
NDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEM
HNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQG
FLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQ
NQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTR
EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGG
WTTKMDWIFHTIKQHALN

Structural information

Protein Domains	PI3K-ABD. (16-105) PI3K-RBD. (187-289) C2 (330-487) PIK (517-694)
Interpro:	IPR016024 IPR000008 IPR011009 IPR000403 IPR018936 IPR003113 IPR002420 IPR000341 IPR015433 IPR001263 IPR029071
Prosite:	PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545
Pfam:	PF00454 PF00792 PF02192 PF00794 PF00613
PDB:	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR
PDBsum:	2ENQ 2RD0 3HHM 3HIZ 3ZIM 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4TUU 4TV3 4WAF 4YKN 4ZOP 5DXH 5DXT 5FI4 5ITD 5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK 5UBR
DIP:	42728
MINT:	1367228
STRING:	ENSP00000263967;

Other Databases

GeneCards: PIK3CA; Malacards: PIK3CA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001525	angiogenesis	IEA	biological_process
GO:0001889	liver development	IEA	biological_process
GO:0001944	vasculature development	TAS	biological_process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IBA	cellular_component
GO:0005942	phosphatidylinositol 3-ki nase complex	ISS	cellular_component
GO:0005943	phosphatidylinositol 3-ki nase complex, class IA	IDA	cellular_component
GO:0006006	glucose metabolic process	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological_process
GO:0010468	regulation of gene expres sion	IEA	biological_process
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological_process
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IDA	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	TAS	molecular_function
GO:0030027	lamellipodium	IEA	cellular_component
GO:0030168	platelet activation	TAS	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0030295	protein kinase activator activity	IEA	molecular_function
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031295	T cell costimulation	TAS	biological_process
GO:0032147	activation of protein kin ase activity	IEA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological_process
GO:0035004	phosphatidylinositol 3-ki nase activity	ISS	molecular_function
GO:0035004	phosphatidylinositol 3-ki nase activity	TAS	molecular_function
GO:0035005	1-phosphatidylinositol-4- phosphate 3-kinase activi ty	IBA	molecular_function
GO:0036092	phosphatidylinositol-3-ph osphate biosynthetic proc ess	IEA	biological_process
GO:0038028	insulin receptor signalin g pathway via phosphatidy linositol 3-kinase	TAS	biological_process
GO:0038095	Fc-epsilon receptor signa ling pathway	TAS	biological_process
GO:0038096	Fc-gamma receptor signali ng pathway involved in ph agocytosis	TAS	biological_process
GO:0038128	ERBB2 signaling pathway	TAS	biological_process
GO:0040014	regulation of multicellul ar organism growth	IEA	biological_process
GO:0043457	regulation of cellular re spiration	IEA	biological_process
GO:0043491	protein kinase B signalin g	IEA	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological_process
GO:0043542	endothelial cell migratio n	TAS	biological_process
GO:0043560	insulin receptor substrat e binding	IEA	molecular_function
GO:0044029	hypomethylation of CpG is land	IEA	biological_process
GO:0046854	phosphatidylinositol phos phorylation	ISS	biological_process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IBA	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	TAS	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0060048	cardiac muscle contractio n	TAS	biological_process
GO:0060612	adipose tissue developmen t	IEA	biological_process
GO:0071333	cellular response to gluc ose stimulus	IEA	biological_process
GO:0097009	energy homeostasis	IEA	biological_process
GO:0098779	mitophagy in response to mitochondrial depolarizat ion	IGI	biological_process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IEA	biological_process
GO:2000653	regulation of genetic imp rinting	IEA	biological_process
GO:2000811	negative regulation of an oikis	IMP	biological_process
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0001525	angiogenesis	IEA	biological_process
GO:0001889	liver development	IEA	biological_process
GO:0001944	vasculature development	TAS	biological_process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IBA	cellular_component
GO:0005942	phosphatidylinositol 3-ki nase complex	IEA	cellular_component
GO:0005942	phosphatidylinositol 3-ki nase complex	ISS	cellular_component
GO:0005943	phosphatidylinositol 3-ki nase complex, class IA	IDA	cellular_component
GO:0006006	glucose metabolic process	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological_process
GO:0006909	phagocytosis	IEA	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological_process
GO:0010468	regulation of gene expres sion	IEA	biological_process
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological_process
GO:0016301	kinase activity	IEA	molecular_function
GO:0016301	kinase activity	IEA	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IEA	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IDA	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	TAS	molecular_function
GO:0016310	phosphorylation	IEA	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0030027	lamellipodium	IEA	cellular_component
GO:0030168	platelet activation	TAS	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0030295	protein kinase activator activity	IEA	molecular_function
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031295	T cell costimulation	TAS	biological_process
GO:0032147	activation of protein kin ase activity	IEA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological_process
GO:0035004	phosphatidylinositol 3-ki nase activity	ISS	molecular_function
GO:0035004	phosphatidylinositol 3-ki nase activity	TAS	molecular_function
GO:0035005	1-phosphatidylinositol-4- phosphate 3-kinase activi ty	IBA	molecular_function
GO:0036092	phosphatidylinositol-3-ph osphate biosynthetic proc ess	IEA	biological_process
GO:0038028	insulin receptor signalin g pathway via phosphatidy linositol 3-kinase	TAS	biological_process
GO:0038095	Fc-epsilon receptor signa ling pathway	TAS	biological_process
GO:0038096	Fc-gamma receptor signali ng pathway involved in ph agocytosis	TAS	biological_process
GO:0038128	ERBB2 signaling pathway	TAS	biological_process
GO:0040014	regulation of multicellul ar organism growth	IEA	biological_process
GO:0043457	regulation of cellular re spiration	IEA	biological_process
GO:0043491	protein kinase B signalin g	IEA	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological_process
GO:0043542	endothelial cell migratio n	TAS	biological_process
GO:0043560	insulin receptor substrat e binding	IEA	molecular_function
GO:0044029	hypomethylation of CpG is land	IEA	biological_process
GO:0046854	phosphatidylinositol phos phorylation	IEA	biological_process
GO:0046854	phosphatidylinositol phos phorylation	ISS	biological_process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IEA	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IBA	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	TAS	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	IEA	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0060048	cardiac muscle contractio n	TAS	biological_process
GO:0060612	adipose tissue developmen t	IEA	biological_process
GO:0071333	cellular response to gluc ose stimulus	IEA	biological_process
GO:0097009	energy homeostasis	IEA	biological_process
GO:0098779	mitophagy in response to mitochondrial depolarizat ion	IGI	biological_process
GO:2000270	negative regulation of fi broblast apoptotic proces s	IEA	biological_process
GO:2000653	regulation of genetic imp rinting	IEA	biological_process
GO:2000811	negative regulation of an oikis	IMP	biological_process
GO:0001944	vasculature development	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IBA	cellular_component
GO:0005942	phosphatidylinositol 3-ki nase complex	ISS	cellular_component
GO:0005943	phosphatidylinositol 3-ki nase complex, class IA	IDA	cellular_component
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological_process
GO:0007173	epidermal growth factor r eceptor signaling pathway	TAS	biological_process
GO:0014066	regulation of phosphatidy linositol 3-kinase signal ing	TAS	biological_process
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016301	kinase activity	TAS	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	IDA	molecular_function
GO:0016303	1-phosphatidylinositol-3- kinase activity	TAS	molecular_function
GO:0030168	platelet activation	TAS	biological_process
GO:0030168	platelet activation	TAS	biological_process
GO:0031295	T cell costimulation	TAS	biological_process
GO:0031295	T cell costimulation	TAS	biological_process
GO:0035004	phosphatidylinositol 3-ki nase activity	ISS	molecular_function
GO:0035004	phosphatidylinositol 3-ki nase activity	TAS	molecular_function
GO:0035005	1-phosphatidylinositol-4- phosphate 3-kinase activi ty	IBA	molecular_function
GO:0038028	insulin receptor signalin g pathway via phosphatidy linositol 3-kinase	TAS	biological_process
GO:0038095	Fc-epsilon receptor signa ling pathway	TAS	biological_process
GO:0038096	Fc-gamma receptor signali ng pathway involved in ph agocytosis	TAS	biological_process
GO:0038128	ERBB2 signaling pathway	TAS	biological_process
GO:0043542	endothelial cell migratio n	TAS	biological_process
GO:0046854	phosphatidylinositol phos phorylation	ISS	biological_process
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	IBA	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0046934	phosphatidylinositol-4,5- bisphosphate 3-kinase act ivity	TAS	molecular_function
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	TAS	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0050900	leukocyte migration	TAS	biological_process
GO:0060048	cardiac muscle contractio n	TAS	biological_process
GO:0098779	mitophagy in response to mitochondrial depolarizat ion	IGI	biological_process
GO:2000811	negative regulation of an oikis	IMP	biological_process

KEGG pathways

hsa05200  Pathways in cancer
hsa04151  PI3K-Akt signaling pathway
hsa05206  MicroRNAs in cancer
hsa05166  HTLV-I infection
hsa05205  Proteoglycans in cancer
hsa04015  Rap1 signaling pathway
hsa04014  Ras signaling pathway
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa04510  Focal adhesion
hsa05169  Epstein-Barr virus infection
hsa05418  Fluid shear stress and atherosclerosis
hsa05161  Hepatitis B
hsa04062  Chemokine signaling pathway
hsa05224  Breast cancer
hsa05164  Influenza A
hsa04630  Jak-STAT signaling pathway
hsa04068  FoxO signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05203  Viral carcinogenesis
hsa04210  Apoptosis
hsa04668  TNF signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa05142  Chagas disease
hsa05215  Prostate cancer
hsa01522  Endocrine resistance
hsa05162  Measles
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04380  Osteoclast differentiation
hsa04932  Non-alcoholic fatty liver disease
hsa04650  Natural killer cell mediated cytotoxicity
hsa04024  cAMP signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04066  HIF-1 signaling pathway
hsa05160  Hepatitis C
hsa04722  Neurotrophin signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04360  Axon guidance
hsa04620  Toll-like receptor signaling pathway
hsa05146  Amoebiasis
hsa04660  T cell receptor signaling pathway
hsa04915  Estrogen signaling pathway
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05212  Pancreatic cancer
hsa04152  AMPK signaling pathway
hsa01524  Platinum drug resistance
hsa05222  Small cell lung cancer
hsa04917  Prolactin signaling pathway
hsa05210  Colorectal cancer
hsa04012  ErbB signaling pathway
hsa04910  Insulin signaling pathway
hsa04150  mTOR signaling pathway
hsa04931  Insulin resistance
hsa04211  Longevity regulating pathway
hsa05230  Central carbon metabolism in cancer
hsa04670  Leukocyte transendothelial migration
hsa04071  Sphingolipid signaling pathway
hsa04140  Autophagy - animal
hsa05211  Renal cell carcinoma
hsa04914  Progesterone-mediated oocyte maturation
hsa04611  Platelet activation
hsa05231  Choline metabolism in cancer
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa05142  Chagas disease
hsa05146  Amoebiasis
hsa04213  Longevity regulating pathway
hsa05165  Human papillomavirus infection
hsa05214  Glioma
hsa05169  Epstein-Barr virus infection
hsa05213  Endometrial cancer
hsa05167  Kaposi's sarcoma-associated herpesvirus infection
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05162  Measles
hsa05166  HTLV-I infection
hsa05100  Bacterial invasion of epithelial cells
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04931  Insulin resistance
hsa04930  Type II diabetes mellitus
hsa05418  Fluid shear stress and atherosclerosis
hsa05223  Non-small cell lung cancer
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05211  Renal cell carcinoma
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05214  Glioma
hsa04923  Regulation of lipolysis in adipocytes
hsa05226  Gastric cancer
hsa05225  Hepatocellular carcinoma
hsa05212  Pancreatic cancer
hsa05210  Colorectal cancer
hsa05203  Viral carcinogenesis
hsa05221  Acute myeloid leukemia
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
hsa05231  Choline metabolism in cancer
hsa05230  Central carbon metabolism in cancer
hsa05200  Pathways in cancer
hsa04213  Longevity regulating pathway - multiple species
hsa04211  Longevity regulating pathway
hsa04380  Osteoclast differentiation
hsa04360  Axon guidance
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04370  VEGF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04973  Carbohydrate digestion and absorption
hsa04750  Inflammatory mediator regulation of TRP channels
hsa05100  Bacterial invasion of epithelial cells
hsa04725  Cholinergic synapse
hsa04919  Thyroid hormone signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04926  Relaxin signaling pathway
hsa04917  Prolactin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04910  Insulin signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04062  Chemokine signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04670  Leukocyte transendothelial migration
hsa04666  Fc gamma R-mediated phagocytosis
hsa04664  Fc epsilon RI signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04625  C-type lectin receptor signaling pathway
hsa04620  Toll-like receptor signaling pathway
hsa04930  Type II diabetes mellitus
hsa04611  Platelet activation
hsa04810  Regulation of actin cytoskeleton
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04510  Focal adhesion
hsa04218  Cellular senescence
hsa04210  Apoptosis
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04152  AMPK signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04024  cAMP signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04068  FoxO signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04668  TNF signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04370  VEGF signaling pathway
hsa04012  ErbB signaling pathway
hsa04015  Rap1 signaling pathway
hsa04014  Ras signaling pathway
hsa00562  Inositol phosphate metabolism
hsa04960  Aldosterone-regulated sodium reabsorption
hsa04070  Phosphatidylinositol signaling system
hsa04973  Carbohydrate digestion and absorption
hsa00562  Inositol phosphate metabolism

Diseases

Associated diseases	References
Alzheimer's disease	PMID: 19141999
CLOVE syndrome	OMIM: 171834
Cowden syndrome 5	OMIM: 171834
Endometriosis	PMID: 20493625
Thyroid cancer	GAD15928251
Schizophrenia	GAD20691427
Retinal Neoplasms	GAD19420344
Rectal cancer	GAD19903786
Prostate cancer	GAD20407443
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	GAD19458356
Pancreatic cancer	GAD19351817
Ovarian cancer	GAD18794094
Nasopharyngeal cancer	GAD19012001
Adenocarcinoma	GAD20526288
Lung cancer	GAD17487277
Hypercholesterolemia	GAD20602615
Hepatocellular carcinoma	OMIM: 171834
Esophageal cancer	GAD19164214
Esophageal cancer	GAD16380997
Endometriosis	GAD20493625
Endometrial cancer	GAD19234438
Diabetes	GAD20571754
Colorectal cancer	GAD15994075
Colonic Neoplasms	GAD19237633
Adenocarcinoma	GAD19861897
Adenoma	GAD19440799
Carcinoma	GAD18782444
Breast Neoplasms	GAD17947469
Breast cancer	GAD17936563
Breast cancer	GAD18183466
Breast cancer	GAD20813970
Breast cancer	GAD20508983
Breast cancer	GAD20551053
Breast cancer	GAD20177704
Breast cancer	GAD20479250
Breast cancer	GAD20107891
Breast cancer	GAD19844234
Breast cancer	GAD19844788
Breast cancer	GAD19671852
Breast cancer	GAD19027487
Breast cancer	GAD19685490
Breast cancer	GAD18798071
Breast cancer	GAD18371219
Breast cancer	GAD18679714
Breast cancer	GAD16397024
Breast cancer	GAD16168105
Breast cancer	GAD16317585
Breast cancer	GAD16353168
Astrocytoma	GAD20569675
Alzheimer's disease	GAD19141999
Ovarian cancer	OMIM167000
Nonsmall cell lung cancer	OMIM211980
Nevus, epidermal	OMIM162900
Megalencephaly-capillary malformation-polymicrogyria syndrome, somatic	OMIM602501
Keratosis, seborrheic	OMIM182000
Hepatocellular carcinoma	OMIM114550
Gastric cancer	OMIM613659
Cowden syndrome 5	OMIM615108
Colorectal cancer	OMIM114500
CLOVE syndrome	OMIM612918
Breast cancer	OMIM114480
Keratosis	OMIM: 171834
Endometriosis	PubMed26920370
Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	KEGGH01912
Megalencephaly-capillary malformation syndrome	KEGGH01885
Cowden syndrome	KEGGH01222
Pituitary adenomas	KEGGH01102
Cushing's syndrome	KEGGH01431
Breast cancer	KEGGH00031
Ovarian cancer	KEGGH00027
Desmoplastic small round cell tumor	KEGGH01985
Hepatocellular carcinoma	KEGGH00048
Male infertility	PMID: 23634797
Megalencephaly-capillary malformation-polymicrogyria syndrome	OMIM: 171834
Ovarian cancer	KEGG: H00027, OMIM: 171834
Polycystic ovary syndrome (PCOS)	PMID: 17083810
Varicocele	PMID: 23634797

PubMed references

PMID	Condition	Associated_genes	Abstract
26920370	Endometrio sis	ETS1 MLH1 PRKDC PIK3CA ARID1A AMER1 ARID2 BCL11A CREBBP ERBB2 EXT1 FANCD2 MSH6 NF1 NOTCH1 NUMA1 PDE4DIP PPP2R1A RNF213 and SYNE1	Show abstract
26276776	Endometrio sis		Show abstract
25692284	Endometrio sis		Show abstract