Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 5320
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol PLA2G2A   Gene   UCSC   Ensembl
Aliases MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2
Gene name phospholipase A2 group IIA
Alternate names phospholipase A2, membrane associated, GIIC sPLA2, NPS-PLA2, group IIA phospholipase A2, non-pancreatic secretory phospholipase A2, phosphatidylcholine 2-acylhydrolase 2A, phospholipase A2, group IIA (platelets, synovial fluid),
Gene location 1p36.13 (19980438: 19975430)     Exons: 6     NC_000001.11
Gene summary(Entrez) The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
OMIM 172411

Protein Summary

Protein general information P14555  

Name: Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non pancreatic secretory phospholipase A2) (NPS PLA2) (Phosphatidylcholine 2 acylhydrolase 2A)

Length: 144  Mass: 16,083

Sequence MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLE
KRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
Structural information
Interpro:  IPR001211 IPR033112 IPR016090 IPR033113
Prosite:   PS00119 PS00118

Pfam:  
PF00068
CDD:   cd00125

PDB:  
1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I 5G3N
PDBsum:   1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I 5G3N
MINT:   1206447
STRING:   ENSP00000364252;
Other Databases GeneCards:  PLA2G2A;  Malacards:  PLA2G2A

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0004623 phospholipase A2 activity
IDA molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0005509 calcium ion binding
IEA molecular_function
GO:0005543 phospholipid binding
IDA molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006644 phospholipid metabolic pr
ocess
IDA biological_process
GO:0006654 phosphatidic acid biosynt
hetic process
TAS biological_process
GO:0010744 positive regulation of ma
crophage derived foam cel
l differentiation
TAS biological_process
GO:0016042 lipid catabolic process
IEA biological_process
GO:0030141 secretory granule
IEA cellular_component
GO:0034374 low-density lipoprotein p
article remodeling
TAS biological_process
GO:0036148 phosphatidylglycerol acyl
-chain remodeling
TAS biological_process
GO:0036149 phosphatidylinositol acyl
-chain remodeling
TAS biological_process
GO:0036150 phosphatidylserine acyl-c
hain remodeling
TAS biological_process
GO:0036151 phosphatidylcholine acyl-
chain remodeling
TAS biological_process
GO:0036152 phosphatidylethanolamine
acyl-chain remodeling
TAS biological_process
GO:0046473 phosphatidic acid metabol
ic process
IDA biological_process
GO:0047498 calcium-dependent phospho
lipase A2 activity
TAS molecular_function
GO:0048471 perinuclear region of cyt
oplasm
IEA cellular_component
GO:0050729 positive regulation of in
flammatory response
TAS biological_process
GO:0050830 defense response to Gram-
positive bacterium
TAS biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IDA biological_process
GO:0004623 phospholipase A2 activity
IEA molecular_function
GO:0004623 phospholipase A2 activity
IEA molecular_function
GO:0004623 phospholipase A2 activity
IDA molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0005509 calcium ion binding
IEA molecular_function
GO:0005543 phospholipid binding
IDA molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006629 lipid metabolic process
IEA biological_process
GO:0006644 phospholipid metabolic pr
ocess
IEA biological_process
GO:0006644 phospholipid metabolic pr
ocess
IDA biological_process
GO:0006654 phosphatidic acid biosynt
hetic process
TAS biological_process
GO:0010744 positive regulation of ma
crophage derived foam cel
l differentiation
TAS biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
IEA cellular_component
GO:0016042 lipid catabolic process
IEA biological_process
GO:0016042 lipid catabolic process
IEA biological_process
GO:0016787 hydrolase activity
IEA molecular_function
GO:0030141 secretory granule
IEA cellular_component
GO:0034374 low-density lipoprotein p
article remodeling
TAS biological_process
GO:0036148 phosphatidylglycerol acyl
-chain remodeling
TAS biological_process
GO:0036149 phosphatidylinositol acyl
-chain remodeling
TAS biological_process
GO:0036150 phosphatidylserine acyl-c
hain remodeling
TAS biological_process
GO:0036151 phosphatidylcholine acyl-
chain remodeling
TAS biological_process
GO:0036152 phosphatidylethanolamine
acyl-chain remodeling
TAS biological_process
GO:0046473 phosphatidic acid metabol
ic process
IDA biological_process
GO:0046872 metal ion binding
IEA molecular_function
GO:0047498 calcium-dependent phospho
lipase A2 activity
IEA molecular_function
GO:0047498 calcium-dependent phospho
lipase A2 activity
TAS molecular_function
GO:0048471 perinuclear region of cyt
oplasm
IEA cellular_component
GO:0050729 positive regulation of in
flammatory response
TAS biological_process
GO:0050830 defense response to Gram-
positive bacterium
TAS biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IDA biological_process
GO:0004623 phospholipase A2 activity
IDA molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0004623 phospholipase A2 activity
TAS molecular_function
GO:0005543 phospholipid binding
IDA molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005615 extracellular space
IDA cellular_component
GO:0005783 endoplasmic reticulum
IDA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006644 phospholipid metabolic pr
ocess
IDA biological_process
GO:0006654 phosphatidic acid biosynt
hetic process
TAS biological_process
GO:0010744 positive regulation of ma
crophage derived foam cel
l differentiation
TAS biological_process
GO:0034374 low-density lipoprotein p
article remodeling
TAS biological_process
GO:0036148 phosphatidylglycerol acyl
-chain remodeling
TAS biological_process
GO:0036149 phosphatidylinositol acyl
-chain remodeling
TAS biological_process
GO:0036150 phosphatidylserine acyl-c
hain remodeling
TAS biological_process
GO:0036151 phosphatidylcholine acyl-
chain remodeling
TAS biological_process
GO:0036152 phosphatidylethanolamine
acyl-chain remodeling
TAS biological_process
GO:0046473 phosphatidic acid metabol
ic process
IDA biological_process
GO:0047498 calcium-dependent phospho
lipase A2 activity
TAS molecular_function
GO:0050729 positive regulation of in
flammatory response
TAS biological_process
GO:0050830 defense response to Gram-
positive bacterium
TAS biological_process
GO:0070062 extracellular exosome
IDA cellular_component
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IDA biological_process

KEGG pathways

hsa01100  Metabolic pathways
hsa04014  Ras signaling pathway
hsa00590  Arachidonic acid metabolism
hsa04270  Vascular smooth muscle contraction
hsa04972  Pancreatic secretion
hsa00591  Linoleic acid metabolism
hsa04975  Fat digestion and absorption
hsa00564  Glycerophospholipid metabolism
hsa00565  Ether lipid metabolism
hsa00592  alpha-Linolenic acid metabolism

Diseases

Associated diseases References
Asthenozoospermia PMID: 26446356
Cancer PMID: 19692168
Chronic obstructive pulmonary disease (COPD) PMID: 19625176
Colorectal cancer OMIM: 172411
Coronary artery disease PMID: 19495570
Endometrial receptivity PMID: 19542542
Endometriosis PMID: 8150107
Male infertility PMID: 12749123
Ovarian endometriosis INFBASE25366587
Endometriosis INFBASE8150107
Endometriosis (ovarian) INFBASE25366587
Ovarian endometriosis PMID: 25366587
Ovarian endometriosis PMID: 25366587
Recurrent empty follicle syndrome PMID: 17007665
Schizophrenia PMID: 15318030

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
8150107 Endometrio
sis

24 (15 have pat
ients with endo
metriosis, 9 do
not have endom
etriosis)
PLA2
Show abstract
25446850 Endometrio
sis

57 (29 patients
with ovarian
endometriosis,
28 control heal
thy women)
Female infertility PGF2A
AKR1B1
AKR1C3
PLA2G2A
PTGS2/COX-2
ABCC4 and PTGFR
PLA2G4A and HPGD
Show abstract
25366587 Endometrio
sis (ovari
an)

116 (70 ovarian
endometriosis,
38 healthy wom
en controls, 8
patients with b
enign ovarian c
ysts)

Show abstract