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Search Result

Gene id

5728

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

PTEN Gene UCSC Ensembl

Aliases

10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1

Gene name

phosphatase and tensin homolog

Alternate names

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, mitochondrial PTENalpha, mitochondrial phosphatase and tensin protein alpha, mutated in multip,

Gene location

10q23.31 (87863437: 87971929) Exons: 10 NC_000010.11

Gene summary(Entrez)

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

OMIM

601728

SNPs

rs11202597

Strand:    Allele origin:   Allele change: A/T   Mutation type: snp

CM000672.2   g.87905433A>T
NC_000010.10   g.89665190A>C
NC_000010.10   g.89665190A>T
NC_000010.11   g.87905433A>T
NG_007466.2   g.46995A>C
NG_007466.2   g.46995A>T
NM_000314.4   c.164+11324A>C
NM_000314.4   c.164+11324A>T
NM_000314.6   c.164+11324A>C
NM_000314.6   c.164+11324A>T
NM_001304717.2   c.683+11324A>C
NM_001304717.2   c.683+11324A>T
NM_001304718.1   c.-542+11324A>C
NM_001304718.1   c.-542+11324A>T
NW_013171807.1   g.121257A>T
rs1234220

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000672.2   g.87885716A>G
NC_000010.10   g.89645473A>G
NC_000010.11   g.87885716A>G
NG_007466.2   g.27278A>G
NM_000314.4   c.80-8309A>G
NM_000314.6   c.80-8309A>G
NM_001304717.2   c.599-8309A>G
NM_001304718.1   c.-626-8309A>G
NW_013171807.1   g.101539A>G
rs17431184

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000672.2   g.87960494T>C
NC_000010.10   g.89720251T>C
NC_000010.11   g.87960494T>C
NG_007466.2   g.102056T>C
NM_000314.4   c.802-400T>C
NM_000314.6   c.802-400T>C
NM_001304717.2   c.1321-400T>C
NM_001304718.1   c.211-400T>C
NW_013171807.1   g.176283T>C
rs2299939

Strand:    Allele origin:   Allele change: A/C/T   Mutation type: snp

CM000672.2   g.87897393C>A
CM000672.2   g.87897393C>T
NC_000010.10   g.89657150C>A
NC_000010.11   g.87897393C>A
NC_000010.11   g.87897393C>T
NG_007466.2   g.38955C>A
NG_007466.2   g.38955C>T
NM_000314.4   c.164+3284C>A
NM_000314.4   c.164+3284C>T
NM_000314.6   c.164+3284C>A
NM_000314.6   c.164+3284C>T
NM_001304717.2   c.683+3284C>A
NM_001304717.2   c.683+3284C>T
NM_001304718.1   c.-542+3284C>A
NM_001304718.1   c.-542+3284C>T
NW_013171807.1   g.113217C>A
NW_013171807.1   g.113217C>T
rs2735343

Strand:    Allele origin:   Allele change: C/G   Mutation type: snp

CM000672.2   g.87945672G>C
NC_000010.10   g.89705429G>C
NC_000010.11   g.87945672G>C
NG_007466.2   g.87234G>C
NG_010870.1   g.293G>C
NM_000314.4   c.493-6446G>C
NM_000314.6   c.493-6446G>C
NM_001304717.2   c.1012-6446G>C
NM_001304718.1   c.-100+2903G>C
NW_013171807.1   g.161461G>C
rs2736627

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000672.2   g.87961337C>T
NC_000010.10   g.89721094C>T
NC_000010.11   g.87961337C>T
NG_007466.2   g.102899C>T
NM_000314.4   c.1026+219C>T
NM_000314.6   c.1026+219C>T
NM_001304717.2   c.1545+219C>T
NM_001304718.1   c.435+219C>T
NW_013171807.1   g.177126C>T
rs478839

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000672.2   g.87972113A>G
NC_000010.10   g.89731870A>G
NC_000010.11   g.87972113A>G
NG_007466.2   g.113675A>G
NM_000314.6   c.*6641A>G
NM_001304717.2   c.*6641A>G
NM_001304718.1   c.*6641A>G
NW_013171807.1   g.187902A>G
XR_001747530.1   n.1826T>C
XR_001756933.1   n.1826T>C
rs532678

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000672.2   g.87963585C>T
NC_000010.10   g.89723342C>T
NC_000010.11   g.87963585C>T
NG_007466.2   g.105147C>T
NM_000314.4   c.1027-1702C>T
NM_000314.6   c.1027-1702C>T
NM_001304717.2   c.1546-1702C>T
NM_001304718.1   c.436-1702C>T
NW_013171807.1   g.179374C>T
rs555895

Strand:    Allele origin:   Allele change: G/T   Mutation type: snp

CM000672.2   g.87961150T>G
NC_000010.10   g.89720907T>G
NC_000010.11   g.87961150T>G
NG_007466.2   g.102712T>G
NM_000314.4   c.1026+32T>G
NM_000314.6   c.1026+32T>G
NM_001304717.2   c.1545+32T>G
NM_001304718.1   c.435+32T>G
NW_013171807.1   g.176939T>G
Clinical Significance: Benign

rs701848

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000672.2   g.87966988T>C
NC_000010.10   g.89726745T>C
NC_000010.11   g.87966988T>C
NG_007466.2   g.108550T>C
NM_000314.4   c.*1516T>C
NM_000314.6   c.*1516T>C
NM_001304717.2   c.*1516T>C
NM_001304718.1   c.*1516T>C
NW_013171807.1   g.182777T>C
Clinical Significance: Benign

rs926091

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000672.2   g.87961655C>T
NC_000010.10   g.89721412C>T
NC_000010.11   g.87961655C>T
NG_007466.2   g.103217C>T
NM_000314.4   c.1026+537C>T
NM_000314.6   c.1026+537C>T
NM_001304717.2   c.1545+537C>T
NM_001304718.1   c.435+537C>T
NW_013171807.1   g.177444C>T

Protein Summary

Protein general information

P60484

Name: Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)

Length: 403 Mass: 47,166

Tissue specificity: Expressed at a relatively high level in all adult tissues, including heart, brain, placenta, lung, liver, muscle, kidney and pancreas. {ECO

Sequence

MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERH
YDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQE
ALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIY
SSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPD
HYRYSDTTDSDPENEPFDEDQHTQITKV

Structural information

Protein Domains	Phosphatase (14-185) C2 (190-350)
Interpro:	IPR017361 IPR000008 IPR000340 IPR029021 IPR014020 IPR029023 IPR016130 IPR003595
Prosite:	PS51182 PS51181
Pfam:	PF00782 PF10409
PDB:	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ
PDBsum:	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ
DIP:	35019
MINT:	127351
STRING:	ENSP00000361021;

Other Databases

GeneCards: PTEN; Malacards: PTEN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000079	regulation of cyclin-depe ndent protein serine/thre onine kinase activity	TAS	biological_process
GO:0000287	magnesium ion binding	IEA	molecular_function
GO:0001525	angiogenesis	IEA	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	ISS	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	IDA	biological_process
GO:0002902	regulation of B cell apop totic process	IEA	biological_process
GO:0004438	phosphatidylinositol-3-ph osphatase activity	IDA	molecular_function
GO:0004721	phosphoprotein phosphatas e activity	IDA	molecular_function
GO:0004722	protein serine/threonine phosphatase activity	IDA	molecular_function
GO:0004725	protein tyrosine phosphat ase activity	IDA	molecular_function
GO:0005161	platelet-derived growth f actor receptor binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0006470	protein dephosphorylation	IDA	biological_process
GO:0006470	protein dephosphorylation	TAS	biological_process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological_process
GO:0006915	apoptotic process	ISS	biological_process
GO:0007270	neuron-neuron synaptic tr ansmission	ISS	biological_process
GO:0007416	synapse assembly	ISS	biological_process
GO:0007417	central nervous system de velopment	ISS	biological_process
GO:0007507	heart development	ISS	biological_process
GO:0007568	aging	IEA	biological_process
GO:0007584	response to nutrient	IEA	biological_process
GO:0007611	learning or memory	ISS	biological_process
GO:0007613	memory	IEA	biological_process
GO:0007626	locomotory behavior	ISS	biological_process
GO:0008138	protein tyrosine/serine/t hreonine phosphatase acti vity	IEA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0008284	positive regulation of ce ll proliferation	ISS	biological_process
GO:0008285	negative regulation of ce ll proliferation	IMP	biological_process
GO:0008285	negative regulation of ce ll proliferation	IMP	biological_process
GO:0008285	negative regulation of ce ll proliferation	IDA	biological_process
GO:0008289	lipid binding	IEA	molecular_function
GO:0009749	response to glucose	IEA	biological_process
GO:0009898	cytoplasmic side of plasm a membrane	IDA	cellular_component
GO:0010043	response to zinc ion	IEA	biological_process
GO:0010975	regulation of neuron proj ection development	ISS	biological_process
GO:0010997	anaphase-promoting comple x binding	IPI	molecular_function
GO:0014067	negative regulation of ph osphatidylinositol 3-kina se signaling	TAS	biological_process
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IDA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IDA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016324	apical plasma membrane	IMP	cellular_component
GO:0016477	cell migration	ISS	biological_process
GO:0016605	PML body	IEA	cellular_component
GO:0019899	enzyme binding	IPI	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0021542	dentate gyrus development	ISS	biological_process
GO:0021955	central nervous system ne uron axonogenesis	ISS	biological_process
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030336	negative regulation of ce ll migration	IMP	biological_process
GO:0030336	negative regulation of ce ll migration	IMP	biological_process
GO:0030534	adult behavior	IEA	biological_process
GO:0031642	negative regulation of my elination	IEA	biological_process
GO:0031647	regulation of protein sta bility	IMP	biological_process
GO:0031658	negative regulation of cy clin-dependent protein se rine/threonine kinase act ivity involved in G1/S tr ansition of mitotic cell cycle	IDA	biological_process
GO:0032228	regulation of synaptic tr ansmission, GABAergic	IEA	biological_process
GO:0032286	central nervous system my elin maintenance	ISS	biological_process
GO:0032355	response to estradiol	IEA	biological_process
GO:0032535	regulation of cellular co mponent size	ISS	biological_process
GO:0033032	regulation of myeloid cel l apoptotic process	IEA	biological_process
GO:0033198	response to ATP	IEA	biological_process
GO:0033555	multicellular organismal response to stress	ISS	biological_process
GO:0035176	social behavior	ISS	biological_process
GO:0035335	peptidyl-tyrosine dephosp horylation	IEA	biological_process
GO:0035749	myelin sheath adaxonal re gion	ISS	cellular_component
GO:0042493	response to drug	IEA	biological_process
GO:0042711	maternal behavior	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042995	cell projection	IDA	cellular_component
GO:0042995	cell projection	IDA	cellular_component
GO:0043005	neuron projection	ISS	cellular_component
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043197	dendritic spine	IEA	cellular_component
GO:0043220	Schmidt-Lanterman incisur e	ISS	cellular_component
GO:0043491	protein kinase B signalin g	ISS	biological_process
GO:0043491	protein kinase B signalin g	ISS	biological_process
GO:0043542	endothelial cell migratio n	IEA	biological_process
GO:0043647	inositol phosphate metabo lic process	TAS	biological_process
GO:0045211	postsynaptic membrane	IEA	cellular_component
GO:0045471	response to ethanol	IEA	biological_process
GO:0045475	locomotor rhythm	ISS	biological_process
GO:0045792	negative regulation of ce ll size	ISS	biological_process
GO:0046621	negative regulation of or gan growth	ISS	biological_process
GO:0046685	response to arsenic-conta ining substance	IEA	biological_process
GO:0046855	inositol phosphate dephos phorylation	IDA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IMP	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IMP	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IDA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IDA	biological_process
GO:0048008	platelet-derived growth f actor receptor signaling pathway	IEA	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0048679	regulation of axon regene ration	IEA	biological_process
GO:0048738	cardiac muscle tissue dev elopment	IEA	biological_process
GO:0048853	forebrain morphogenesis	ISS	biological_process
GO:0048854	brain morphogenesis	ISS	biological_process
GO:0050680	negative regulation of ep ithelial cell proliferati on	IEA	biological_process
GO:0050765	negative regulation of ph agocytosis	IEA	biological_process
GO:0050771	negative regulation of ax onogenesis	ISS	biological_process
GO:0050821	protein stabilization	IDA	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IMP	biological_process
GO:0051717	inositol-1,3,4,5-tetrakis phosphate 3-phosphatase a ctivity	IDA	molecular_function
GO:0051717	inositol-1,3,4,5-tetrakis phosphate 3-phosphatase a ctivity	TAS	molecular_function
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	IDA	molecular_function
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	TAS	molecular_function
GO:0051895	negative regulation of fo cal adhesion assembly	IMP	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IMP	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IMP	biological_process
GO:0060024	rhythmic synaptic transmi ssion	ISS	biological_process
GO:0060070	canonical Wnt signaling p athway	IDA	biological_process
GO:0060074	synapse maturation	ISS	biological_process
GO:0060134	prepulse inhibition	ISS	biological_process
GO:0060179	male mating behavior	IEA	biological_process
GO:0060291	long-term synaptic potent iation	IEA	biological_process
GO:0060292	long term synaptic depres sion	IEA	biological_process
GO:0060736	prostate gland growth	IEA	biological_process
GO:0060997	dendritic spine morphogen esis	ISS	biological_process
GO:0061002	negative regulation of de ndritic spine morphogenes is	ISS	biological_process
GO:0070373	negative regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IEA	biological_process
GO:0071456	cellular response to hypo xia	IEA	biological_process
GO:0090071	negative regulation of ri bosome biogenesis	IEA	biological_process
GO:0090344	negative regulation of ce ll aging	IEA	biological_process
GO:0090394	negative regulation of ex citatory postsynaptic pot ential	ISS	biological_process
GO:0097105	presynaptic membrane asse mbly	ISS	biological_process
GO:0097107	postsynaptic density asse mbly	ISS	biological_process
GO:1903984	positive regulation of TR AIL-activated apoptotic s ignaling pathway	IMP	biological_process
GO:1904668	positive regulation of ub iquitin protein ligase ac tivity	IDA	biological_process
GO:2000060	positive regulation of pr otein ubiquitination invo lved in ubiquitin-depende nt protein catabolic proc ess	IDA	biological_process
GO:2000134	negative regulation of G1 /S transition of mitotic cell cycle	IDA	biological_process
GO:2000463	positive regulation of ex citatory postsynaptic pot ential	ISS	biological_process
GO:2000808	negative regulation of sy naptic vesicle clustering	ISS	biological_process
GO:0000079	regulation of cyclin-depe ndent protein serine/thre onine kinase activity	TAS	biological_process
GO:0000287	magnesium ion binding	IEA	molecular_function
GO:0001525	angiogenesis	IEA	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	IEA	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	ISS	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	IDA	biological_process
GO:0002902	regulation of B cell apop totic process	IEA	biological_process
GO:0004438	phosphatidylinositol-3-ph osphatase activity	IDA	molecular_function
GO:0004721	phosphoprotein phosphatas e activity	IEA	molecular_function
GO:0004721	phosphoprotein phosphatas e activity	IEA	molecular_function
GO:0004721	phosphoprotein phosphatas e activity	IDA	molecular_function
GO:0004722	protein serine/threonine phosphatase activity	IDA	molecular_function
GO:0004725	protein tyrosine phosphat ase activity	IEA	molecular_function
GO:0004725	protein tyrosine phosphat ase activity	IEA	molecular_function
GO:0004725	protein tyrosine phosphat ase activity	IDA	molecular_function
GO:0005161	platelet-derived growth f actor receptor binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0006470	protein dephosphorylation	IEA	biological_process
GO:0006470	protein dephosphorylation	IDA	biological_process
GO:0006470	protein dephosphorylation	TAS	biological_process
GO:0006629	lipid metabolic process	IEA	biological_process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological_process
GO:0006915	apoptotic process	ISS	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0007270	neuron-neuron synaptic tr ansmission	IEA	biological_process
GO:0007270	neuron-neuron synaptic tr ansmission	ISS	biological_process
GO:0007399	nervous system developmen t	IEA	biological_process
GO:0007416	synapse assembly	IEA	biological_process
GO:0007416	synapse assembly	ISS	biological_process
GO:0007417	central nervous system de velopment	IEA	biological_process
GO:0007417	central nervous system de velopment	ISS	biological_process
GO:0007507	heart development	IEA	biological_process
GO:0007507	heart development	ISS	biological_process
GO:0007568	aging	IEA	biological_process
GO:0007584	response to nutrient	IEA	biological_process
GO:0007611	learning or memory	IEA	biological_process
GO:0007611	learning or memory	ISS	biological_process
GO:0007613	memory	IEA	biological_process
GO:0007626	locomotory behavior	IEA	biological_process
GO:0007626	locomotory behavior	ISS	biological_process
GO:0008138	protein tyrosine/serine/t hreonine phosphatase acti vity	IEA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0008284	positive regulation of ce ll proliferation	IEA	biological_process
GO:0008284	positive regulation of ce ll proliferation	ISS	biological_process
GO:0008285	negative regulation of ce ll proliferation	IEA	biological_process
GO:0008285	negative regulation of ce ll proliferation	IEA	biological_process
GO:0008285	negative regulation of ce ll proliferation	IMP	biological_process
GO:0008285	negative regulation of ce ll proliferation	IMP	biological_process
GO:0008285	negative regulation of ce ll proliferation	IDA	biological_process
GO:0008289	lipid binding	IEA	molecular_function
GO:0009749	response to glucose	IEA	biological_process
GO:0009898	cytoplasmic side of plasm a membrane	IDA	cellular_component
GO:0010033	response to organic subst ance	IEA	biological_process
GO:0010035	response to inorganic sub stance	IEA	biological_process
GO:0010043	response to zinc ion	IEA	biological_process
GO:0010975	regulation of neuron proj ection development	IEA	biological_process
GO:0010975	regulation of neuron proj ection development	ISS	biological_process
GO:0010997	anaphase-promoting comple x binding	IPI	molecular_function
GO:0014067	negative regulation of ph osphatidylinositol 3-kina se signaling	TAS	biological_process
GO:0014070	response to organic cycli c compound	IEA	biological_process
GO:0016311	dephosphorylation	IEA	biological_process
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IEA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IEA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IEA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IDA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IDA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016324	apical plasma membrane	IMP	cellular_component
GO:0016477	cell migration	IEA	biological_process
GO:0016477	cell migration	ISS	biological_process
GO:0016605	PML body	IEA	cellular_component
GO:0016787	hydrolase activity	IEA	molecular_function
GO:0016791	phosphatase activity	IEA	molecular_function
GO:0019899	enzyme binding	IPI	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0021542	dentate gyrus development	IEA	biological_process
GO:0021542	dentate gyrus development	ISS	biological_process
GO:0021955	central nervous system ne uron axonogenesis	IEA	biological_process
GO:0021955	central nervous system ne uron axonogenesis	ISS	biological_process
GO:0030165	PDZ domain binding	IEA	molecular_function
GO:0030165	PDZ domain binding	IEA	molecular_function
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030336	negative regulation of ce ll migration	IEA	biological_process
GO:0030336	negative regulation of ce ll migration	IMP	biological_process
GO:0030336	negative regulation of ce ll migration	IMP	biological_process
GO:0030534	adult behavior	IEA	biological_process
GO:0031175	neuron projection develop ment	IEA	biological_process
GO:0031642	negative regulation of my elination	IEA	biological_process
GO:0031647	regulation of protein sta bility	IEA	biological_process
GO:0031647	regulation of protein sta bility	IMP	biological_process
GO:0031658	negative regulation of cy clin-dependent protein se rine/threonine kinase act ivity involved in G1/S tr ansition of mitotic cell cycle	IDA	biological_process
GO:0032228	regulation of synaptic tr ansmission, GABAergic	IEA	biological_process
GO:0032286	central nervous system my elin maintenance	IEA	biological_process
GO:0032286	central nervous system my elin maintenance	ISS	biological_process
GO:0032355	response to estradiol	IEA	biological_process
GO:0032535	regulation of cellular co mponent size	IEA	biological_process
GO:0032535	regulation of cellular co mponent size	ISS	biological_process
GO:0033032	regulation of myeloid cel l apoptotic process	IEA	biological_process
GO:0033198	response to ATP	IEA	biological_process
GO:0033555	multicellular organismal response to stress	IEA	biological_process
GO:0033555	multicellular organismal response to stress	ISS	biological_process
GO:0035176	social behavior	IEA	biological_process
GO:0035176	social behavior	ISS	biological_process
GO:0035335	peptidyl-tyrosine dephosp horylation	IEA	biological_process
GO:0035749	myelin sheath adaxonal re gion	IEA	cellular_component
GO:0035749	myelin sheath adaxonal re gion	ISS	cellular_component
GO:0036294	cellular response to decr eased oxygen levels	IEA	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0042711	maternal behavior	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042995	cell projection	IDA	cellular_component
GO:0042995	cell projection	IDA	cellular_component
GO:0043005	neuron projection	IEA	cellular_component
GO:0043005	neuron projection	ISS	cellular_component
GO:0043065	positive regulation of ap optotic process	IEA	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043197	dendritic spine	IEA	cellular_component
GO:0043220	Schmidt-Lanterman incisur e	IEA	cellular_component
GO:0043220	Schmidt-Lanterman incisur e	ISS	cellular_component
GO:0043491	protein kinase B signalin g	IEA	biological_process
GO:0043491	protein kinase B signalin g	ISS	biological_process
GO:0043491	protein kinase B signalin g	ISS	biological_process
GO:0043542	endothelial cell migratio n	IEA	biological_process
GO:0043647	inositol phosphate metabo lic process	TAS	biological_process
GO:0045211	postsynaptic membrane	IEA	cellular_component
GO:0045471	response to ethanol	IEA	biological_process
GO:0045475	locomotor rhythm	IEA	biological_process
GO:0045475	locomotor rhythm	ISS	biological_process
GO:0045792	negative regulation of ce ll size	IEA	biological_process
GO:0045792	negative regulation of ce ll size	ISS	biological_process
GO:0046621	negative regulation of or gan growth	IEA	biological_process
GO:0046621	negative regulation of or gan growth	ISS	biological_process
GO:0046685	response to arsenic-conta ining substance	IEA	biological_process
GO:0046855	inositol phosphate dephos phorylation	IEA	biological_process
GO:0046855	inositol phosphate dephos phorylation	IDA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IEA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IEA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IMP	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IMP	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IDA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IDA	biological_process
GO:0048008	platelet-derived growth f actor receptor signaling pathway	IEA	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0048679	regulation of axon regene ration	IEA	biological_process
GO:0048738	cardiac muscle tissue dev elopment	IEA	biological_process
GO:0048853	forebrain morphogenesis	IEA	biological_process
GO:0048853	forebrain morphogenesis	ISS	biological_process
GO:0048854	brain morphogenesis	IEA	biological_process
GO:0048854	brain morphogenesis	ISS	biological_process
GO:0050680	negative regulation of ep ithelial cell proliferati on	IEA	biological_process
GO:0050765	negative regulation of ph agocytosis	IEA	biological_process
GO:0050771	negative regulation of ax onogenesis	IEA	biological_process
GO:0050771	negative regulation of ax onogenesis	ISS	biological_process
GO:0050821	protein stabilization	IDA	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IMP	biological_process
GO:0051717	inositol-1,3,4,5-tetrakis phosphate 3-phosphatase a ctivity	IDA	molecular_function
GO:0051717	inositol-1,3,4,5-tetrakis phosphate 3-phosphatase a ctivity	TAS	molecular_function
GO:0051726	regulation of cell cycle	IEA	biological_process
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	IEA	molecular_function
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	IDA	molecular_function
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	TAS	molecular_function
GO:0051895	negative regulation of fo cal adhesion assembly	IEA	biological_process
GO:0051895	negative regulation of fo cal adhesion assembly	IMP	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IEA	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IEA	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IMP	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IMP	biological_process
GO:0060024	rhythmic synaptic transmi ssion	IEA	biological_process
GO:0060024	rhythmic synaptic transmi ssion	ISS	biological_process
GO:0060070	canonical Wnt signaling p athway	IDA	biological_process
GO:0060074	synapse maturation	IEA	biological_process
GO:0060074	synapse maturation	ISS	biological_process
GO:0060134	prepulse inhibition	IEA	biological_process
GO:0060134	prepulse inhibition	ISS	biological_process
GO:0060179	male mating behavior	IEA	biological_process
GO:0060291	long-term synaptic potent iation	IEA	biological_process
GO:0060292	long term synaptic depres sion	IEA	biological_process
GO:0060341	regulation of cellular lo calization	IEA	biological_process
GO:0060736	prostate gland growth	IEA	biological_process
GO:0060997	dendritic spine morphogen esis	IEA	biological_process
GO:0060997	dendritic spine morphogen esis	ISS	biological_process
GO:0061002	negative regulation of de ndritic spine morphogenes is	IEA	biological_process
GO:0061002	negative regulation of de ndritic spine morphogenes is	ISS	biological_process
GO:0070373	negative regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IEA	biological_process
GO:0071456	cellular response to hypo xia	IEA	biological_process
GO:0090071	negative regulation of ri bosome biogenesis	IEA	biological_process
GO:0090344	negative regulation of ce ll aging	IEA	biological_process
GO:0090394	negative regulation of ex citatory postsynaptic pot ential	IEA	biological_process
GO:0090394	negative regulation of ex citatory postsynaptic pot ential	ISS	biological_process
GO:0097105	presynaptic membrane asse mbly	IEA	biological_process
GO:0097105	presynaptic membrane asse mbly	ISS	biological_process
GO:0097107	postsynaptic density asse mbly	IEA	biological_process
GO:0097107	postsynaptic density asse mbly	ISS	biological_process
GO:1903984	positive regulation of TR AIL-activated apoptotic s ignaling pathway	IMP	biological_process
GO:1904668	positive regulation of ub iquitin protein ligase ac tivity	IDA	biological_process
GO:2000060	positive regulation of pr otein ubiquitination invo lved in ubiquitin-depende nt protein catabolic proc ess	IDA	biological_process
GO:2000134	negative regulation of G1 /S transition of mitotic cell cycle	IDA	biological_process
GO:2000463	positive regulation of ex citatory postsynaptic pot ential	IEA	biological_process
GO:2000463	positive regulation of ex citatory postsynaptic pot ential	ISS	biological_process
GO:2000808	negative regulation of sy naptic vesicle clustering	IEA	biological_process
GO:2000808	negative regulation of sy naptic vesicle clustering	ISS	biological_process
GO:2001235	positive regulation of ap optotic signaling pathway	IEA	biological_process
GO:0000079	regulation of cyclin-depe ndent protein serine/thre onine kinase activity	TAS	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	ISS	biological_process
GO:0001933	negative regulation of pr otein phosphorylation	IDA	biological_process
GO:0004438	phosphatidylinositol-3-ph osphatase activity	IDA	molecular_function
GO:0004721	phosphoprotein phosphatas e activity	IDA	molecular_function
GO:0004722	protein serine/threonine phosphatase activity	IDA	molecular_function
GO:0004725	protein tyrosine phosphat ase activity	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0006470	protein dephosphorylation	IDA	biological_process
GO:0006470	protein dephosphorylation	TAS	biological_process
GO:0006661	phosphatidylinositol bios ynthetic process	TAS	biological_process
GO:0006915	apoptotic process	ISS	biological_process
GO:0007270	neuron-neuron synaptic tr ansmission	ISS	biological_process
GO:0007416	synapse assembly	ISS	biological_process
GO:0007417	central nervous system de velopment	ISS	biological_process
GO:0007507	heart development	ISS	biological_process
GO:0007611	learning or memory	ISS	biological_process
GO:0007626	locomotory behavior	ISS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0008284	positive regulation of ce ll proliferation	ISS	biological_process
GO:0008285	negative regulation of ce ll proliferation	IMP	biological_process
GO:0008285	negative regulation of ce ll proliferation	IMP	biological_process
GO:0008285	negative regulation of ce ll proliferation	IDA	biological_process
GO:0009898	cytoplasmic side of plasm a membrane	IDA	cellular_component
GO:0010975	regulation of neuron proj ection development	ISS	biological_process
GO:0010997	anaphase-promoting comple x binding	IPI	molecular_function
GO:0014067	negative regulation of ph osphatidylinositol 3-kina se signaling	TAS	biological_process
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IDA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	IDA	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016314	phosphatidylinositol-3,4, 5-trisphosphate 3-phospha tase activity	TAS	molecular_function
GO:0016324	apical plasma membrane	IMP	cellular_component
GO:0016477	cell migration	ISS	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0021542	dentate gyrus development	ISS	biological_process
GO:0021955	central nervous system ne uron axonogenesis	ISS	biological_process
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030165	PDZ domain binding	IPI	molecular_function
GO:0030336	negative regulation of ce ll migration	IMP	biological_process
GO:0030336	negative regulation of ce ll migration	IMP	biological_process
GO:0031647	regulation of protein sta bility	IMP	biological_process
GO:0031658	negative regulation of cy clin-dependent protein se rine/threonine kinase act ivity involved in G1/S tr ansition of mitotic cell cycle	IDA	biological_process
GO:0032286	central nervous system my elin maintenance	ISS	biological_process
GO:0032535	regulation of cellular co mponent size	ISS	biological_process
GO:0033555	multicellular organismal response to stress	ISS	biological_process
GO:0035176	social behavior	ISS	biological_process
GO:0035749	myelin sheath adaxonal re gion	ISS	cellular_component
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042995	cell projection	IDA	cellular_component
GO:0042995	cell projection	IDA	cellular_component
GO:0043005	neuron projection	ISS	cellular_component
GO:0043220	Schmidt-Lanterman incisur e	ISS	cellular_component
GO:0043491	protein kinase B signalin g	ISS	biological_process
GO:0043491	protein kinase B signalin g	ISS	biological_process
GO:0043647	inositol phosphate metabo lic process	TAS	biological_process
GO:0045475	locomotor rhythm	ISS	biological_process
GO:0045792	negative regulation of ce ll size	ISS	biological_process
GO:0046621	negative regulation of or gan growth	ISS	biological_process
GO:0046855	inositol phosphate dephos phorylation	IDA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IMP	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IMP	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IDA	biological_process
GO:0046856	phosphatidylinositol deph osphorylation	IDA	biological_process
GO:0048015	phosphatidylinositol-medi ated signaling	TAS	biological_process
GO:0048853	forebrain morphogenesis	ISS	biological_process
GO:0048854	brain morphogenesis	ISS	biological_process
GO:0050771	negative regulation of ax onogenesis	ISS	biological_process
GO:0050821	protein stabilization	IDA	biological_process
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IMP	biological_process
GO:0051717	inositol-1,3,4,5-tetrakis phosphate 3-phosphatase a ctivity	IDA	molecular_function
GO:0051717	inositol-1,3,4,5-tetrakis phosphate 3-phosphatase a ctivity	TAS	molecular_function
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	IDA	molecular_function
GO:0051800	phosphatidylinositol-3,4- bisphosphate 3-phosphatas e activity	TAS	molecular_function
GO:0051895	negative regulation of fo cal adhesion assembly	IMP	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IMP	biological_process
GO:0051898	negative regulation of pr otein kinase B signaling	IMP	biological_process
GO:0060024	rhythmic synaptic transmi ssion	ISS	biological_process
GO:0060070	canonical Wnt signaling p athway	IDA	biological_process
GO:0060074	synapse maturation	ISS	biological_process
GO:0060134	prepulse inhibition	ISS	biological_process
GO:0060997	dendritic spine morphogen esis	ISS	biological_process
GO:0061002	negative regulation of de ndritic spine morphogenes is	ISS	biological_process
GO:0070373	negative regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0090394	negative regulation of ex citatory postsynaptic pot ential	ISS	biological_process
GO:0097105	presynaptic membrane asse mbly	ISS	biological_process
GO:0097107	postsynaptic density asse mbly	ISS	biological_process
GO:1903984	positive regulation of TR AIL-activated apoptotic s ignaling pathway	IMP	biological_process
GO:1904668	positive regulation of ub iquitin protein ligase ac tivity	IDA	biological_process
GO:2000060	positive regulation of pr otein ubiquitination invo lved in ubiquitin-depende nt protein catabolic proc ess	IDA	biological_process
GO:2000134	negative regulation of G1 /S transition of mitotic cell cycle	IDA	biological_process
GO:2000463	positive regulation of ex citatory postsynaptic pot ential	ISS	biological_process
GO:2000808	negative regulation of sy naptic vesicle clustering	ISS	biological_process

KEGG pathways

hsa05200  Pathways in cancer
hsa04151  PI3K-Akt signaling pathway
hsa05206  MicroRNAs in cancer
hsa04510  Focal adhesion
hsa05161  Hepatitis B
hsa05224  Breast cancer
hsa04068  FoxO signaling pathway
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  p53 pathway
hsa05215  Prostate cancer
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  Inflammation mediated by chemokine and cytokine signaling pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  p53 pathway feedback loops 2
hsa05218  Melanoma
hsa05222  Small cell lung cancer
PTHR12305:SF81  p53 pathway feedback loops 2
hsa04150  mTOR signaling pathway
PTHR12305:SF81  p53 pathway
hsa04931  Insulin resistance
hsa05230  Central carbon metabolism in cancer
hsa04071  Sphingolipid signaling pathway
hsa04140  Autophagy - animal
PTHR12305:SF81  p53 pathway
hsa04115  p53 signaling pathway
hsa05214  Glioma
hsa05213  Endometrial cancer
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  Inflammation mediated by chemokine and cytokine signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa00562  Inositol phosphate metabolism
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  Hypoxia response via HIF activation
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  Hypoxia response via HIF activation
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF32  p53 pathway feedback loops 2
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  Hypoxia response via HIF activation
PTHR12305:SF32  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF32  p53 pathway
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  Inflammation mediated by chemokine and cytokine signaling pathway
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  Inflammation mediated by chemokine and cytokine signaling pathway
PTHR12305:SF81  PI3 kinase pathway
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  PI3 kinase pathway
PTHR12305:SF81  PI3 kinase pathway
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  CCKR signaling map
PTHR12305:SF81  Hypoxia response via HIF activation
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  PI3 kinase pathway
PTHR12305:SF32  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF32  p53 pathway feedback loops 2
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  Hypoxia response via HIF activation
PTHR12305:SF32  Hypoxia response via HIF activation
PTHR12305:SF81  p53 pathway feedback loops 2
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  Hypoxia response via HIF activation
PTHR12305:SF81  Insulin/IGF pathway-protein kinase B signaling cascade
PTHR12305:SF81  PI3 kinase pathway
PTHR12305:SF81  PI3 kinase pathway
PTHR12305:SF32  p53 pathway
PTHR12305:SF81  p53 pathway
PTHR12305:SF81  Inflammation mediated by chemokine and cytokine signaling pathway
PTHR12305:SF81  Inflammation mediated by chemokine and cytokine signaling pathway

Diseases

Associated diseases	References
Alzheimer's disease	PMID: 16385451
Autism	PMID: 15805158
Breast cancer	KEGG: H00031
Cancer	PMID: 11504770
Chronic obstructive pulmonary disease (COPD)	PMID: 19625176
Craniofacial Abnormalities	PMID: 18759867
Diabetes	PMID: 14623110
Endometrial cancer	PMID: 18788685
Endometrial cancer	KEGG: H00026
Endometriosis	PMID: 12402310
Glioma	KEGG: H00042
Hepatocellular carcinoma	KEGG: H00048
Male infertility	PMID: 24269974
Malignant melanoma	KEGG: H00038
Meningioma	KEGG: H01556
Mycosis fungoides	KEGG: H01463
Endometriosis	INFBASE12402310
Polycystic ovary syndrome (PCOS)	PMID: 26802879
Premature ovarian failure ( POF)	PMID: 21370998
Primary ovarian insufficiency (POI)	PMID: 26082156
Prostate cancer	KEGG: H00024
Small cell lung cancer	KEGG: H00013
Vulvar cancer	KEGG: H00029

PubMed references

PMID	Condition	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
24154570	Endometrio sis	Indian	1252 (752 endom etriosis patien ts, 500 control s)		PTEN p-Akt p-Bad and p27	Show abstract
24154570	Endometrio sis	Indian	1252 (752 endom etriosis patien ts, 500 control s)		PTEN p-Akt p-Bad and p27	Show abstract
24154570	Endometrio sis	Indian	1252 (752 endom etriosis patien ts, 500 control s)		PTEN p-Akt p-Bad and p27	Show abstract
24018808	Endometrio sis		67 ovarian endo metrioid adenoc arcinoma(35 ass ociated with en dometriosis, 32 without endome triosis)	Female infertility	?-catenin cyclin D1 BAF250a PTEN p53 WT1	Show abstract
12402310	Endometrio sis		46 cases of end ometriosis stag es III and IV		Hmlh1 PTEN	Show abstract