Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 58985
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol IL22RA1   Gene   UCSC   Ensembl
Aliases CRF2-9, IL22R, IL22R1
Gene name interleukin 22 receptor subunit alpha 1
Alternate names interleukin-22 receptor subunit alpha-1, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, cytokine receptor class-II member 9, cytokine receptor family 2 member 9, interleukin 22 receptor, alpha 1, zcytoR11,
Gene location 1p36.11 (23835978: 24220610)     Exons: 17     NC_000016.10
Gene summary(Entrez) The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
OMIM 605457

Protein Summary

Protein general information Q8N6P7  

Name: Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)

Length: 574  Mass: 63,077

Tissue specificity: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain

Sequence MRTLLTILTVGSLAAHAPEDPSDLLQHVKFQSSNFENILTWDSGPEGTPDTVYSIEYKTYGERDWVAKKGCQRIT
RKSCNLTVETGNLTELYYARVTAVSAGGRSATKMTDRFSSLQHTTLKPPDVTCISKVRSIQMIVHPTPTPIRAGD
GHRLTLEDIFHDLFYHLELQVNRTYQMHLGGKQREYEFFGLTPDTEFLGTIMICVPTWAKESAPYMCRVKTLPDR
TWTYSFSGAFLFSMGFLVAVLCYLSYRYVTKPPAPPNSLNVQRVLTFQPLRFIQEHVLIPVFDLSGPSSLAQPVQ
YSQIRVSGPREPAGAPQRHSLSEITYLGQPDISILQPSNVPPPQILSPLSYAPNAAPEVGPPSYAPQVTPEAQFP
FYAPQAISKVQPSSYAPQATPDSWPPSYGVCMEGSGKDSPTGTLSSPKHLRPKGQLQKEPPAGSCMLGGLSLQEV
TSLAMEESQEAKSLHQPLGICTDRTSDPNVLHSGEEGTPQYLKGQLPLLSSVQIEGHPMSLPLQPPSRPCSPSDQ
GPSPWGLLESLVCPKDEAKSPAPETSDLEQPTELDSLFRGLALTVQWES
Structural information
Protein Domains
Fibronectin (17-124)
Fibronectin (141-221)
Interpro:  IPR003961 IPR036116 IPR013783 IPR015373
Prosite:   PS50853

Pfam:  
PF09294 PF01108
CDD:   cd00063

PDB:  
3DGC 3DLQ
PDBsum:   3DGC 3DLQ

DIP:  
42031
MINT:  
STRING:   ENSP00000270800;
Other Databases GeneCards:  IL22RA1;  Malacards:  IL22RA1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0004904 interferon receptor activ
ity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005886 plasma membrane
IBA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0008150 biological_process
ND biological_process
GO:0016021 integral component of mem
brane
IBA cellular_component
GO:0019221 cytokine-mediated signali
ng pathway
IEA biological_process
GO:0042015 interleukin-20 binding
IBA molecular_function
GO:0050829 defense response to Gram-
negative bacterium
IEA biological_process
GO:0004904 interferon receptor activ
ity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005886 plasma membrane
IBA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0008150 biological_process
ND biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
IEA cellular_component
GO:0016021 integral component of mem
brane
IBA cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0019221 cytokine-mediated signali
ng pathway
IEA biological_process
GO:0042015 interleukin-20 binding
IEA molecular_function
GO:0042015 interleukin-20 binding
IBA molecular_function
GO:0050829 defense response to Gram-
negative bacterium
IEA biological_process
GO:0004904 interferon receptor activ
ity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005886 plasma membrane
IBA cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0005886 plasma membrane
TAS cellular_component
GO:0008150 biological_process
ND biological_process
GO:0016021 integral component of mem
brane
IBA cellular_component
GO:0042015 interleukin-20 binding
IBA molecular_function

Diseases

Associated diseases References
Celiac disease PMID: 19240061
Endometriosis PMID: 24133578
Endometriosis INFBASE24133578
Rhinitis PMID: 19393422

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
24133578 Endometrio
sis


IL-22
IL-22R1
IL-10R2)
Show abstract