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Gene id

6171

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

RPL41 Gene UCSC Ensembl

Aliases

L41

Gene name

ribosomal protein L41

Alternate names

60S ribosomal protein L41, HG12 protein, homologue of yeast ribosomal protein YL41, large ribosomal subunit protein eL41,

Gene location

12q13.2 (56116589: 56117831) Exons: 4 NC_000012.12

Gene summary(Entrez)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

OMIM

613315

Protein Summary

Protein general information

P62945

Name: 60S ribosomal protein L41 (HG12) (Large ribosomal subunit protein eL41)

Length: 25 Mass: 3,456

Sequence

MRAKWRKKRMRRLKRKRRKMRQRSK

Structural information

Interpro:	IPR007836
Pfam:	PF05162
PDB:	4UG0 4V6X 5A2Q 5AJ0
PDBsum:	4UG0 4V6X 5A2Q 5AJ0
DIP:	46893
STRING:	ENSP00000420821;

Other Databases

GeneCards: RPL41; Malacards: RPL41

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsen se-mediated decay	TAS	biological_process
GO:0003723	RNA binding	TAS	molecular_function
GO:0003735	structural constituent of ribosome	NAS	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006364	rRNA processing	TAS	biological_process
GO:0006412	translation	NAS	biological_process
GO:0006413	translational initiation	TAS	biological_process
GO:0006614	SRP-dependent cotranslati onal protein targeting to membrane	TAS	biological_process
GO:0019083	viral transcription	TAS	biological_process
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular_component
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsen se-mediated decay	TAS	biological_process
GO:0003723	RNA binding	TAS	molecular_function
GO:0003735	structural constituent of ribosome	IEA	molecular_function
GO:0003735	structural constituent of ribosome	NAS	molecular_function
GO:0003735	structural constituent of ribosome	TAS	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005840	ribosome	IEA	cellular_component
GO:0005840	ribosome	IEA	cellular_component
GO:0006364	rRNA processing	TAS	biological_process
GO:0006412	translation	IEA	biological_process
GO:0006412	translation	NAS	biological_process
GO:0006412	translation	TAS	biological_process
GO:0006413	translational initiation	TAS	biological_process
GO:0006614	SRP-dependent cotranslati onal protein targeting to membrane	TAS	biological_process
GO:0019083	viral transcription	TAS	biological_process
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular_component
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular_component
GO:0030529	intracellular ribonucleop rotein complex	IEA	cellular_component
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsen se-mediated decay	TAS	biological_process
GO:0003723	RNA binding	TAS	molecular_function
GO:0003735	structural constituent of ribosome	NAS	molecular_function
GO:0003735	structural constituent of ribosome	TAS	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006364	rRNA processing	TAS	biological_process
GO:0006412	translation	NAS	biological_process
GO:0006412	translation	TAS	biological_process
GO:0006413	translational initiation	TAS	biological_process
GO:0006614	SRP-dependent cotranslati onal protein targeting to membrane	TAS	biological_process
GO:0019083	viral transcription	TAS	biological_process
GO:0022625	cytosolic large ribosomal subunit	IDA	cellular_component
GO:0022625	cytosolic large ribosomal subunit	TAS	cellular_component

KEGG pathways

hsa03010 Ribosome

Diseases

Associated diseases	References
Endometriosis	PMID: 16249290
Endometriosis	INFBASE16249290

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
16249290	Endometrio sis			30 (15 patients undergoing lap aroscopy or hys terectomy for e ndometriosis, 1 5 controls)		IGFBP5 PIM2 RPL41 PSAP FBLN1 SIPL DLX5 HSD11B2 SET and RHOE	Show abstract