Endometriosis Knowledgebase

Search Result

Gene id

6347

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CCL2 Gene UCSC Ensembl

Aliases

GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF

Gene name

C-C motif chemokine ligand 2

Alternate names

C-C motif chemokine 2, chemokine (C-C motif) ligand 2, monocyte chemoattractant protein-1, monocyte chemotactic and activating factor, monocyte chemotactic protein 1, monocyte secretory protein JE, small inducible cytokine A2 (monocyte chemotactic protein 1, ho,

Gene location

17q12 (34255276: 34257202) Exons: 3 NC_000017.11

Gene summary(Entrez)

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]

OMIM

158105

Protein Summary

Protein general information

P13500

Name: C C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP 1) (Monocyte secretory protein JE) (Small inducible cytokine A2)

Length: 99 Mass: 11,025

Tissue specificity: Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). {ECO

Sequence

MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEIC
ADPKQKWVQDSMDHLDKQTQTPKT

Structural information

Interpro:	IPR000827 IPR001811
Prosite:	PS00472
Pfam:	PF00048
PDB:	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDBsum:	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
DIP:	5838
MINT:	103269
STRING:	ENSP00000225831;

Other Databases

GeneCards: CCL2; Malacards: CCL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000165	MAPK cascade	IMP	biological_process
GO:0001525	angiogenesis	TAS	biological_process
GO:0001666	response to hypoxia	IEA	biological_process
GO:0001912	positive regulation of le ukocyte mediated cytotoxi city	IEA	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IEA	biological_process
GO:0002523	leukocyte migration invol ved in inflammatory respo nse	IEA	biological_process
GO:0002548	monocyte chemotaxis	IDA	biological_process
GO:0002693	positive regulation of ce llular extravasation	IEA	biological_process
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0005102	receptor binding	TAS	molecular_function
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005791	rough endoplasmic reticul um	IEA	cellular_component
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0006874	cellular calcium ion home ostasis	IEA	biological_process
GO:0006935	chemotaxis	TAS	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006959	humoral immune response	TAS	biological_process
GO:0007010	cytoskeleton organization	IDA	biological_process
GO:0007155	cell adhesion	TAS	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007179	transforming growth facto r beta receptor signaling pathway	IEA	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	TAS	biological_process
GO:0007187	G-protein coupled recepto r signaling pathway, coup led to cyclic nucleotide second messenger	TAS	biological_process
GO:0007259	JAK-STAT cascade	TAS	biological_process
GO:0007568	aging	IEA	biological_process
GO:0008009	chemokine activity	IEA	molecular_function
GO:0008201	heparin binding	IEA	molecular_function
GO:0008360	regulation of cell shape	IDA	biological_process
GO:0009408	response to heat	IEA	biological_process
GO:0009611	response to wounding	IEA	biological_process
GO:0009612	response to mechanical st imulus	IEA	biological_process
GO:0009617	response to bacterium	NAS	biological_process
GO:0009887	animal organ morphogenesi s	TAS	biological_process
GO:0010332	response to gamma radiati on	IEA	biological_process
GO:0010574	regulation of vascular en dothelial growth factor p roduction	IEA	biological_process
GO:0010759	positive regulation of ma crophage chemotaxis	IEA	biological_process
GO:0014823	response to activity	IEA	biological_process
GO:0016525	negative regulation of an giogenesis	IEA	biological_process
GO:0019079	viral genome replication	TAS	biological_process
GO:0019221	cytokine-mediated signali ng pathway	IDA	biological_process
GO:0019725	cellular homeostasis	TAS	biological_process
GO:0030139	endocytic vesicle	IEA	cellular_component
GO:0030425	dendrite	IEA	cellular_component
GO:0030593	neutrophil chemotaxis	IBA	biological_process
GO:0031100	animal organ regeneration	IEA	biological_process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological_process
GO:0031727	CCR2 chemokine receptor b inding	ISS	molecular_function
GO:0031727	CCR2 chemokine receptor b inding	TAS	molecular_function
GO:0032570	response to progesterone	IEA	biological_process
GO:0032760	positive regulation of tu mor necrosis factor produ ction	IEA	biological_process
GO:0032869	cellular response to insu lin stimulus	IEA	biological_process
GO:0032967	positive regulation of co llagen biosynthetic proce ss	IEA	biological_process
GO:0033552	response to vitamin B3	IEA	biological_process
GO:0034351	negative regulation of gl ial cell apoptotic proces s	IDA	biological_process
GO:0035684	helper T cell extravasati on	ISS	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0036006	cellular response to macr ophage colony-stimulating factor stimulus	IEA	biological_process
GO:0036120	cellular response to plat elet-derived growth facto r stimulus	IEA	biological_process
GO:0036499	PERK-mediated unfolded pr otein response	TAS	biological_process
GO:0043200	response to amino acid	IEA	biological_process
GO:0043204	perikaryon	IEA	cellular_component
GO:0043491	protein kinase B signalin g	IMP	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	IBA	biological_process
GO:0043615	astrocyte cell migration	IDA	biological_process
GO:0043679	axon terminus	IEA	cellular_component
GO:0044299	C-fiber	IEA	cellular_component
GO:0044344	cellular response to fibr oblast growth factor stim ulus	IEP	biological_process
GO:0045202	synapse	IEA	cellular_component
GO:0045471	response to ethanol	IEA	biological_process
GO:0046677	response to antibiotic	IEA	biological_process
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	IEA	biological_process
GO:0048246	macrophage chemotaxis	IDA	biological_process
GO:0048247	lymphocyte chemotaxis	IEA	biological_process
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0050729	positive regulation of in flammatory response	IBA	biological_process
GO:0050806	positive regulation of sy naptic transmission	IEA	biological_process
GO:0050870	positive regulation of T cell activation	ISS	biological_process
GO:0051770	positive regulation of ni tric-oxide synthase biosy nthetic process	ISS	biological_process
GO:0060135	maternal process involved in female pregnancy	IEA	biological_process
GO:0060137	maternal process involved in parturition	IEA	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IBA	biological_process
GO:0071222	cellular response to lipo polysaccharide	ISS	biological_process
GO:0071300	cellular response to reti noic acid	IEA	biological_process
GO:0071318	cellular response to ATP	IEA	biological_process
GO:0071346	cellular response to inte rferon-gamma	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEP	biological_process
GO:0071347	cellular response to inte rleukin-1	ISS	biological_process
GO:0071347	cellular response to inte rleukin-1	IEP	biological_process
GO:0071354	cellular response to inte rleukin-6	IEA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	ISS	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEP	biological_process
GO:0071403	cellular response to high density lipoprotein part icle stimulus	IEA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological_process
GO:0071549	cellular response to dexa methasone stimulus	IEA	biological_process
GO:0090026	positive regulation of mo nocyte chemotaxis	IEA	biological_process
GO:0090265	positive regulation of im mune complex clearance by monocytes and macrophage s	IEA	biological_process
GO:0090280	positive regulation of ca lcium ion import	IDA	biological_process
GO:0090314	positive regulation of pr otein targeting to membra ne	IEA	biological_process
GO:2000427	positive regulation of ap optotic cell clearance	ISS	biological_process
GO:2000502	negative regulation of na tural killer cell chemota xis	IDA	biological_process
GO:0000165	MAPK cascade	IMP	biological_process
GO:0001525	angiogenesis	TAS	biological_process
GO:0001664	G-protein coupled recepto r binding	IEA	molecular_function
GO:0001666	response to hypoxia	IEA	biological_process
GO:0001912	positive regulation of le ukocyte mediated cytotoxi city	IEA	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IEA	biological_process
GO:0002523	leukocyte migration invol ved in inflammatory respo nse	IEA	biological_process
GO:0002548	monocyte chemotaxis	IDA	biological_process
GO:0002687	positive regulation of le ukocyte migration	IEA	biological_process
GO:0002693	positive regulation of ce llular extravasation	IEA	biological_process
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0005102	receptor binding	TAS	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	TAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005791	rough endoplasmic reticul um	IEA	cellular_component
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0006874	cellular calcium ion home ostasis	IEA	biological_process
GO:0006935	chemotaxis	IEA	biological_process
GO:0006935	chemotaxis	TAS	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0006959	humoral immune response	TAS	biological_process
GO:0007010	cytoskeleton organization	IDA	biological_process
GO:0007155	cell adhesion	TAS	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007179	transforming growth facto r beta receptor signaling pathway	IEA	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	TAS	biological_process
GO:0007187	G-protein coupled recepto r signaling pathway, coup led to cyclic nucleotide second messenger	TAS	biological_process
GO:0007259	JAK-STAT cascade	TAS	biological_process
GO:0007568	aging	IEA	biological_process
GO:0008009	chemokine activity	IEA	molecular_function
GO:0008009	chemokine activity	IEA	molecular_function
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008201	heparin binding	IEA	molecular_function
GO:0008347	glial cell migration	IEA	biological_process
GO:0008360	regulation of cell shape	IDA	biological_process
GO:0009408	response to heat	IEA	biological_process
GO:0009611	response to wounding	IEA	biological_process
GO:0009612	response to mechanical st imulus	IEA	biological_process
GO:0009617	response to bacterium	NAS	biological_process
GO:0009887	animal organ morphogenesi s	TAS	biological_process
GO:0010332	response to gamma radiati on	IEA	biological_process
GO:0010574	regulation of vascular en dothelial growth factor p roduction	IEA	biological_process
GO:0010759	positive regulation of ma crophage chemotaxis	IEA	biological_process
GO:0014823	response to activity	IEA	biological_process
GO:0016525	negative regulation of an giogenesis	IEA	biological_process
GO:0019079	viral genome replication	TAS	biological_process
GO:0019221	cytokine-mediated signali ng pathway	IEA	biological_process
GO:0019221	cytokine-mediated signali ng pathway	IDA	biological_process
GO:0019725	cellular homeostasis	TAS	biological_process
GO:0022409	positive regulation of ce ll-cell adhesion	IEA	biological_process
GO:0030139	endocytic vesicle	IEA	cellular_component
GO:0030425	dendrite	IEA	cellular_component
GO:0030593	neutrophil chemotaxis	IEA	biological_process
GO:0030593	neutrophil chemotaxis	IBA	biological_process
GO:0031100	animal organ regeneration	IEA	biological_process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological_process
GO:0031727	CCR2 chemokine receptor b inding	IEA	molecular_function
GO:0031727	CCR2 chemokine receptor b inding	ISS	molecular_function
GO:0031727	CCR2 chemokine receptor b inding	TAS	molecular_function
GO:0032496	response to lipopolysacch aride	IEA	biological_process
GO:0032570	response to progesterone	IEA	biological_process
GO:0032760	positive regulation of tu mor necrosis factor produ ction	IEA	biological_process
GO:0032869	cellular response to insu lin stimulus	IEA	biological_process
GO:0032967	positive regulation of co llagen biosynthetic proce ss	IEA	biological_process
GO:0033552	response to vitamin B3	IEA	biological_process
GO:0034351	negative regulation of gl ial cell apoptotic proces s	IDA	biological_process
GO:0035684	helper T cell extravasati on	IEA	biological_process
GO:0035684	helper T cell extravasati on	ISS	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0036006	cellular response to macr ophage colony-stimulating factor stimulus	IEA	biological_process
GO:0036120	cellular response to plat elet-derived growth facto r stimulus	IEA	biological_process
GO:0036499	PERK-mediated unfolded pr otein response	TAS	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0043025	neuronal cell body	IEA	cellular_component
GO:0043200	response to amino acid	IEA	biological_process
GO:0043204	perikaryon	IEA	cellular_component
GO:0043491	protein kinase B signalin g	IMP	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	IBA	biological_process
GO:0043615	astrocyte cell migration	IDA	biological_process
GO:0043679	axon terminus	IEA	cellular_component
GO:0044299	C-fiber	IEA	cellular_component
GO:0044344	cellular response to fibr oblast growth factor stim ulus	IEP	biological_process
GO:0045202	synapse	IEA	cellular_component
GO:0045471	response to ethanol	IEA	biological_process
GO:0045785	positive regulation of ce ll adhesion	IEA	biological_process
GO:0046677	response to antibiotic	IEA	biological_process
GO:0048010	vascular endothelial grow th factor receptor signal ing pathway	IEA	biological_process
GO:0048246	macrophage chemotaxis	IEA	biological_process
GO:0048246	macrophage chemotaxis	IDA	biological_process
GO:0048247	lymphocyte chemotaxis	IEA	biological_process
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0050729	positive regulation of in flammatory response	IBA	biological_process
GO:0050806	positive regulation of sy naptic transmission	IEA	biological_process
GO:0050870	positive regulation of T cell activation	IEA	biological_process
GO:0050870	positive regulation of T cell activation	ISS	biological_process
GO:0051384	response to glucocorticoi d	IEA	biological_process
GO:0051770	positive regulation of ni tric-oxide synthase biosy nthetic process	IEA	biological_process
GO:0051770	positive regulation of ni tric-oxide synthase biosy nthetic process	ISS	biological_process
GO:0060135	maternal process involved in female pregnancy	IEA	biological_process
GO:0060137	maternal process involved in parturition	IEA	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IEA	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IBA	biological_process
GO:0071222	cellular response to lipo polysaccharide	IEA	biological_process
GO:0071222	cellular response to lipo polysaccharide	ISS	biological_process
GO:0071300	cellular response to reti noic acid	IEA	biological_process
GO:0071318	cellular response to ATP	IEA	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEA	biological_process
GO:0071346	cellular response to inte rferon-gamma	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEP	biological_process
GO:0071347	cellular response to inte rleukin-1	IEA	biological_process
GO:0071347	cellular response to inte rleukin-1	ISS	biological_process
GO:0071347	cellular response to inte rleukin-1	IEP	biological_process
GO:0071354	cellular response to inte rleukin-6	IEA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	ISS	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEP	biological_process
GO:0071402	cellular response to lipo protein particle stimulus	IEA	biological_process
GO:0071403	cellular response to high density lipoprotein part icle stimulus	IEA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological_process
GO:0071549	cellular response to dexa methasone stimulus	IEA	biological_process
GO:0090026	positive regulation of mo nocyte chemotaxis	IEA	biological_process
GO:0090265	positive regulation of im mune complex clearance by monocytes and macrophage s	IEA	biological_process
GO:0090280	positive regulation of ca lcium ion import	IDA	biological_process
GO:0090314	positive regulation of pr otein targeting to membra ne	IEA	biological_process
GO:2000427	positive regulation of ap optotic cell clearance	IEA	biological_process
GO:2000427	positive regulation of ap optotic cell clearance	ISS	biological_process
GO:2000502	negative regulation of na tural killer cell chemota xis	IDA	biological_process
GO:0000165	MAPK cascade	IMP	biological_process
GO:0001525	angiogenesis	TAS	biological_process
GO:0002548	monocyte chemotaxis	IDA	biological_process
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0005102	receptor binding	TAS	molecular_function
GO:0005576	extracellular region	IDA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	TAS	cellular_component
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0006935	chemotaxis	TAS	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006959	humoral immune response	TAS	biological_process
GO:0007010	cytoskeleton organization	IDA	biological_process
GO:0007155	cell adhesion	TAS	biological_process
GO:0007165	signal transduction	NAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	TAS	biological_process
GO:0007187	G-protein coupled recepto r signaling pathway, coup led to cyclic nucleotide second messenger	TAS	biological_process
GO:0007259	JAK-STAT cascade	TAS	biological_process
GO:0008009	chemokine activity	TAS	molecular_function
GO:0008360	regulation of cell shape	IDA	biological_process
GO:0009617	response to bacterium	NAS	biological_process
GO:0009887	animal organ morphogenesi s	TAS	biological_process
GO:0019079	viral genome replication	TAS	biological_process
GO:0019221	cytokine-mediated signali ng pathway	IDA	biological_process
GO:0019725	cellular homeostasis	TAS	biological_process
GO:0030593	neutrophil chemotaxis	IBA	biological_process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological_process
GO:0031727	CCR2 chemokine receptor b inding	ISS	molecular_function
GO:0031727	CCR2 chemokine receptor b inding	TAS	molecular_function
GO:0034351	negative regulation of gl ial cell apoptotic proces s	IDA	biological_process
GO:0035684	helper T cell extravasati on	ISS	biological_process
GO:0036499	PERK-mediated unfolded pr otein response	TAS	biological_process
GO:0043491	protein kinase B signalin g	IMP	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	IBA	biological_process
GO:0043615	astrocyte cell migration	IDA	biological_process
GO:0044344	cellular response to fibr oblast growth factor stim ulus	IEP	biological_process
GO:0048246	macrophage chemotaxis	IDA	biological_process
GO:0050729	positive regulation of in flammatory response	IBA	biological_process
GO:0050870	positive regulation of T cell activation	ISS	biological_process
GO:0051770	positive regulation of ni tric-oxide synthase biosy nthetic process	ISS	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IBA	biological_process
GO:0071222	cellular response to lipo polysaccharide	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEP	biological_process
GO:0071347	cellular response to inte rleukin-1	ISS	biological_process
GO:0071347	cellular response to inte rleukin-1	IEP	biological_process
GO:0071356	cellular response to tumo r necrosis factor	ISS	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IEP	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological_process
GO:0090280	positive regulation of ca lcium ion import	IDA	biological_process
GO:2000427	positive regulation of ap optotic cell clearance	ISS	biological_process
GO:2000502	negative regulation of na tural killer cell chemota xis	IDA	biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa05168  Herpes simplex infection
hsa05418  Fluid shear stress and atherosclerosis
hsa04062  Chemokine signaling pathway
hsa05164  Influenza A
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04621  NOD-like receptor signaling pathway
hsa04668  TNF signaling pathway
hsa05142  Chagas disease
hsa04657  IL-17 signaling pathway
hsa05323  Rheumatoid arthritis
hsa05144  Malaria

Diseases

Associated diseases	References
Adenomyosis	PMID: 15979992
Alopecia areata	PMID: 16479072
Alzheimer's disease	PMID: 15312962
Arthritis	PMID: 12826377
Asthma	PMID: 11544456
Atherosclerosis	PMID: 15308783
Behcet's disease	PMID: 15115316
Bipolar disorder	PMID: 15034225
Cancer	PMID: 18205260
Carpal-tunnel syndrome	PMID: 12408680
Celiac disease	PMID: 16078996
Crohn's disease	PMID: 12904997
Depression	PMID: 15296827
Dermatomyositis	PMID: 17065190
Diabetes	PMID: 15135805
Endometriosis	PMID: 18069114
Endometriosis	PMID: 20825374
Hepatopulmonary syndrome	PMID: 17934860
Intraperitoneal adhesion formation	PMID: 9647546
Macular degeneration	PMID: 18172114
Multiple sclerosis	PMID: 15191525
Nephropathy	PMID: 14767014
Ovarian endometriosis	PMID: 15005245
Ovarian endometriosis	PMID: 15005245
Ovarian hyperstimulation syndrome (OHSS)	PMID: 22344731
Pancreatitis	PMID: 15880317
Pelvic endometriosis	PMID: 26871558
Pelvic endometriosis	PMID: 26871558
Polycystic ovary syndrome (PCOS)	PMID: 17565837
Polycystic ovary syndrome (PCOS)	PMID: 25186501
Psoriasis	PMID: 18093183
Renal tubular damage	PMID: 12505750
Schizophrenia	PMID: 15389752
Sclerosis	PMID: 15654958
Unexplained infertility	INFBASE17688616
Tubal infertility	INFBASE16997300
Female infertility	INFBASE15893866
Ovarian endometriosis	INFBASE15005245
Female infertility	INFBASE12566749
Female infertility	INFBASE12372466
Endometriosis associated infertility	INFBASE7843438
Endometriosis	INFBASE7843438
Systemic lupus erythematosus	PMID: 11844145
Uveitis	PMID: 16280979

PubMed references

PMID	Condition	Mutation	Population details	Infertility_type	Associated_genes	Abstract
22265030	Endometrio sis					Show abstract
15005245	Endometrio sis (ovari an)				FCER1G PGDS IL-8 GRO1 GRO2 CXCR4 MCP1 MMP COL4A2 and COL5A2	Show abstract
17706208	Endometrio sis		141 (63 women w ith II-IV endom etriosis, 78 co ntrols)		MIF MCP-1 INFG LEP CA-127	Show abstract
23474119	Endometrio sis	MCP-1, RANTES and MCP-3	95 (54 endometr iosis, 41 contr ols)	Female infertility		Show abstract
16997300	Endometrio sis		60 (32 women wi th endometriosi s stages I-IV, 28 women withou t endometriosis )		RANTES MCP-1	Show abstract
12566749	Endometrio sis		31 (26 women wi th infertility, 5 controls )	Female infertility		Show abstract
11783354	Endometrio sis		50 (30 patients with endometri osis, 20 patien ts without endo metriosis as co ntrols)	Female infertility		Show abstract
23474119	Endometrio sis	MCP-1, RANTES and MCP-3	95 (54 patients with endometri osis, 41 contro ls)	Female infertility		Show abstract
19230876	Endometrio sis				MCP-1 MIF LEP and CA-125	Show abstract
17582674	Endometrio sis				IL-6 MCP-1 INF-gamma VEGF TNF-alpha GM-CSF IL-2 IL-8 IL-15	Show abstract
17678915	Endometrio sis		35 (20 during l uteal phase, 15 during menustr ual phase were selected for th is study based on cycle phase and presence/ab sence of endome triosis )		alpha(V) integrin IL-1 beta MCP-1 RANTES VCAM-1	Show abstract
20829186	Endometrio sis				MIF VEGF IL-8 MCP-1	Show abstract
19050323	Endometrio sis				CCR1 MCP-1 CA125	Show abstract
12840897	Endometrio sis		15 patients wit h endometriosis		IL-1 beta TNF-alpha MCP-1	Show abstract
22632541	Endometrio sis		133 PF of patie nts with endome triosis		IL-6 IL-18 eotaxin IL-12(p70) ICAM-1 GRO-? and MCP-1	Show abstract
20617440	Endometrio sis		20 (12 with end ometriosis(ePF) , 8 controls wi thout endometri osis (cPF))		MCP-1	Show abstract
9176445	Endometrio sis		78 (60 women wi th endometriosi s, 18 women wit hout endometrio sis)		MCP-1	Show abstract
12009356	Endometrio sis		23 (12 fertile women, 11 women with endometri osis)		MCP-1 MIF	Show abstract
18314120	Endometrio sis		75 (24 women wi th endometriosi s, 24 homologou s eutopic endom etrium, 27 wome n without endom etriosis)		IL-8 MCP-1	Show abstract
9422530	Endometrio sis				MCP-1	Show abstract
7843438	Endometrio sis		12 (6 women pre senting for inf ertility or pel vic pain in whi ch endometriosi s was diagnosed at laparoscopy , 6 women prese nting for tubal ligation witho ut laparoscopic evidence of th e disease)	Female infertility	MCP-1	Show abstract
8752605	Endometrio sis		57 (36 women pr esenting for in fertility, pelv ic pain, or tub al ligation in which endometri osis was diagno sed at laparosc opy, 21 normal fertile control s presenting fo r tubal ligatio n)	Female infertility	MCP-1	Show abstract
17688616	Endometrio sis		57 infertile wo men undergoing laparoscopy for unexplained in fertility	Female infertility	MCP-1 IL-8 PDGF IL-6 RANTES IL-1 beta TNF-alpha and sFas	Show abstract
15893866	Endometrio sis		55 (18 women wi th endometriosi s, 16 women wit h uterine leiom yoma, 5 unexpla ined infertilit y, 16 fertile w omen )	Female infertility		Show abstract
12372466	Endometrio sis		10 (5 women und ergoing surgery for pelvic pai n, infertility, or endometrios is; 5 women wit hout endometrio sis who were un dergoing tubal ligation were t he controls )	Female infertility		Show abstract
28433374	Endometrio sis		107 female infe rtility (56 end ometriosis pati ents, 38 patien ts without endo metriosis)	Female infertility		Show abstract