Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Search Result


Gene id 6354
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol CCL7   Gene   UCSC   Ensembl
Aliases FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
Gene name C-C motif chemokine ligand 7
Alternate names C-C motif chemokine 7, chemokine (C-C motif) ligand 7, monocyte chemoattractant protein 3, monocyte chemotactic protein 3, small inducible cytokine A7 (monocyte chemotactic protein 3), small-inducible cytokine A7,
Gene location 17q12 (34270215: 34272241)     Exons: 3     NC_000017.11
Gene summary(Entrez) This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
OMIM 158106

Protein Summary

Protein general information P80098  

Name: C C motif chemokine 7 (Monocyte chemoattractant protein 3) (Monocyte chemotactic protein 3) (MCP 3) (NC28) (Small inducible cytokine A7)

Length: 99  Mass: 11,200

Sequence MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEIC
ADPTQKWVQDFMKHLDKKTQTPKL
Structural information
Interpro:  IPR000827 IPR001811
Prosite:   PS00472

Pfam:  
PF00048

PDB:  
1BO0 1NCV 4ZKC
PDBsum:   1BO0 1NCV 4ZKC

DIP:  
5847
MINT:   103194
STRING:   ENSP00000367832;
Other Databases GeneCards:  CCL7;  Malacards:  CCL7

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0002548 monocyte chemotaxis
IBA biological_process
GO:0002548 monocyte chemotaxis
IC biological_process
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005623 cell
IEA cellular_component
GO:0006874 cellular calcium ion home
ostasis
TAS biological_process
GO:0006935 chemotaxis
TAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0007010 cytoskeleton organization
IDA biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0007267 cell-cell signaling
TAS biological_process
GO:0008009 chemokine activity
IDA molecular_function
GO:0008201 heparin binding
IEA molecular_function
GO:0008360 regulation of cell shape
IDA biological_process
GO:0010332 response to gamma radiati
on
IEA biological_process
GO:0030335 positive regulation of ce
ll migration
IDA biological_process
GO:0030593 neutrophil chemotaxis
IBA biological_process
GO:0031726 CCR1 chemokine receptor b
inding
IPI molecular_function
GO:0031726 CCR1 chemokine receptor b
inding
IPI molecular_function
GO:0031727 CCR2 chemokine receptor b
inding
IEA molecular_function
GO:0043547 positive regulation of GT
Pase activity
IBA biological_process
GO:0048245 eosinophil chemotaxis
IDA biological_process
GO:0050729 positive regulation of in
flammatory response
IBA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IBA biological_process
GO:0071346 cellular response to inte
rferon-gamma
IBA biological_process
GO:0071347 cellular response to inte
rleukin-1
IBA biological_process
GO:0071356 cellular response to tumo
r necrosis factor
IBA biological_process
GO:0071361 cellular response to etha
nol
IEA biological_process
GO:2000503 positive regulation of na
tural killer cell chemota
xis
IDA biological_process
GO:0002548 monocyte chemotaxis
IBA biological_process
GO:0002548 monocyte chemotaxis
IC biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
TAS cellular_component
GO:0005623 cell
IEA cellular_component
GO:0006874 cellular calcium ion home
ostasis
TAS biological_process
GO:0006935 chemotaxis
IEA biological_process
GO:0006935 chemotaxis
TAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0006954 inflammatory response
IEA biological_process
GO:0006955 immune response
IEA biological_process
GO:0007010 cytoskeleton organization
IDA biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0007267 cell-cell signaling
TAS biological_process
GO:0008009 chemokine activity
IEA molecular_function
GO:0008009 chemokine activity
IDA molecular_function
GO:0008009 chemokine activity
TAS molecular_function
GO:0008201 heparin binding
IEA molecular_function
GO:0008360 regulation of cell shape
IDA biological_process
GO:0010332 response to gamma radiati
on
IEA biological_process
GO:0030335 positive regulation of ce
ll migration
IDA biological_process
GO:0030593 neutrophil chemotaxis
IBA biological_process
GO:0031726 CCR1 chemokine receptor b
inding
IPI molecular_function
GO:0031726 CCR1 chemokine receptor b
inding
IPI molecular_function
GO:0031727 CCR2 chemokine receptor b
inding
IEA molecular_function
GO:0043547 positive regulation of GT
Pase activity
IBA biological_process
GO:0048245 eosinophil chemotaxis
IDA biological_process
GO:0050729 positive regulation of in
flammatory response
IBA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IBA biological_process
GO:0071346 cellular response to inte
rferon-gamma
IBA biological_process
GO:0071347 cellular response to inte
rleukin-1
IBA biological_process
GO:0071356 cellular response to tumo
r necrosis factor
IBA biological_process
GO:0071361 cellular response to etha
nol
IEA biological_process
GO:2000503 positive regulation of na
tural killer cell chemota
xis
IDA biological_process
GO:0002548 monocyte chemotaxis
IBA biological_process
GO:0002548 monocyte chemotaxis
IC biological_process
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
TAS cellular_component
GO:0006874 cellular calcium ion home
ostasis
TAS biological_process
GO:0006935 chemotaxis
TAS biological_process
GO:0006954 inflammatory response
IBA biological_process
GO:0007010 cytoskeleton organization
IDA biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0007267 cell-cell signaling
TAS biological_process
GO:0008009 chemokine activity
IDA molecular_function
GO:0008009 chemokine activity
TAS molecular_function
GO:0008360 regulation of cell shape
IDA biological_process
GO:0030335 positive regulation of ce
ll migration
IDA biological_process
GO:0030593 neutrophil chemotaxis
IBA biological_process
GO:0031726 CCR1 chemokine receptor b
inding
IPI molecular_function
GO:0031726 CCR1 chemokine receptor b
inding
IPI molecular_function
GO:0043547 positive regulation of GT
Pase activity
IBA biological_process
GO:0048245 eosinophil chemotaxis
IDA biological_process
GO:0050729 positive regulation of in
flammatory response
IBA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IBA biological_process
GO:0071346 cellular response to inte
rferon-gamma
IBA biological_process
GO:0071347 cellular response to inte
rleukin-1
IBA biological_process
GO:0071356 cellular response to tumo
r necrosis factor
IBA biological_process
GO:2000503 positive regulation of na
tural killer cell chemota
xis
IDA biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa04657  IL-17 signaling pathway

Diseases

Associated diseases References
Asthma PMID: 15715950
Endometriosis PMID: 23474119
Multiple sclerosis PMID: 12127674
Endometriosis INFBASE23474119

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
23474119 Endometrio
sis
MCP-1, RANTES and MCP-3
95 (54 endometr
iosis, 41 contr
ols)
Female infertility
Show abstract
28433374 Endometrio
sis

107 female infe
rtility (56 end
ometriosis pati
ents, 38 patien
ts without endo
metriosis)
Female infertility
Show abstract