Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Search Result


Gene id 6356
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol CCL11   Gene   UCSC   Ensembl
Aliases SCYA11
Gene name C-C motif chemokine ligand 11
Alternate names eotaxin, chemokine (C-C motif) ligand 11, eosinophil chemotactic protein, eotaxin-1, small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin),
Gene location 17q12 (34285667: 34288179)     Exons: 3     NC_000017.11
Gene summary(Entrez) This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
OMIM 601156

Protein Summary

Protein general information P51671  

Name: Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)

Length: 97  Mass: 10,732

Sequence MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICAD
PKKKWVQDSMKYLDQKSPTPKP
Structural information
Interpro:  IPR000827 IPR001811 IPR036048
Prosite:   PS00472

Pfam:  
PF00048

PDB:  
1EOT 2EOT 2MPM
PDBsum:   1EOT 2EOT 2MPM

DIP:  
5858
MINT:  
STRING:   ENSP00000302234;
Other Databases GeneCards:  CCL11;  Malacards:  CCL11

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0002544 chronic inflammatory resp
onse
IEA biological_process
GO:0002548 monocyte chemotaxis
IBA biological_process
GO:0002551 mast cell chemotaxis
IEA biological_process
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005622 intracellular
IEA cellular_component
GO:0006468 protein phosphorylation
TAS biological_process
GO:0006874 cellular calcium ion home
ostasis
TAS biological_process
GO:0006935 chemotaxis
TAS biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0007010 cytoskeleton organization
IDA biological_process
GO:0007015 actin filament organizati
on
IEA biological_process
GO:0007155 cell adhesion
TAS biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0008009 chemokine activity
IDA molecular_function
GO:0008360 regulation of cell shape
IDA biological_process
GO:0009314 response to radiation
TAS biological_process
GO:0009615 response to virus
TAS biological_process
GO:0030335 positive regulation of ce
ll migration
IDA biological_process
GO:0030593 neutrophil chemotaxis
IBA biological_process
GO:0030838 positive regulation of ac
tin filament polymerizati
on
IDA biological_process
GO:0035962 response to interleukin-1
3
IEA biological_process
GO:0043547 positive regulation of GT
Pase activity
IDA biological_process
GO:0045766 positive regulation of an
giogenesis
IEA biological_process
GO:0048020 CCR chemokine receptor bi
nding
IBA molecular_function
GO:0048245 eosinophil chemotaxis
IDA biological_process
GO:0048247 lymphocyte chemotaxis
IBA biological_process
GO:0050729 positive regulation of in
flammatory response
IBA biological_process
GO:0060444 branching involved in mam
mary gland duct morphogen
esis
IEA biological_process
GO:0060763 mammary duct terminal end
bud growth
IEA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0070371 ERK1 and ERK2 cascade
IEA biological_process
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IBA biological_process
GO:0070670 response to interleukin-4
IEA biological_process
GO:0071346 cellular response to inte
rferon-gamma
IBA biological_process
GO:0071347 cellular response to inte
rleukin-1
IBA biological_process
GO:0071356 cellular response to tumo
r necrosis factor
IBA biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0002544 chronic inflammatory resp
onse
IEA biological_process
GO:0002548 monocyte chemotaxis
IBA biological_process
GO:0002551 mast cell chemotaxis
IEA biological_process
GO:0005125 cytokine activity
IEA molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IEA cellular_component
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0005615 extracellular space
IEA cellular_component
GO:0005622 intracellular
IEA cellular_component
GO:0006468 protein phosphorylation
TAS biological_process
GO:0006874 cellular calcium ion home
ostasis
TAS biological_process
GO:0006935 chemotaxis
IEA biological_process
GO:0006935 chemotaxis
TAS biological_process
GO:0006954 inflammatory response
IEA biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0006955 immune response
IEA biological_process
GO:0007010 cytoskeleton organization
IDA biological_process
GO:0007015 actin filament organizati
on
IEA biological_process
GO:0007155 cell adhesion
TAS biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0008009 chemokine activity
IEA molecular_function
GO:0008009 chemokine activity
IEA molecular_function
GO:0008009 chemokine activity
IDA molecular_function
GO:0008360 regulation of cell shape
IDA biological_process
GO:0009314 response to radiation
TAS biological_process
GO:0009615 response to virus
TAS biological_process
GO:0030335 positive regulation of ce
ll migration
IDA biological_process
GO:0030593 neutrophil chemotaxis
IBA biological_process
GO:0030838 positive regulation of ac
tin filament polymerizati
on
IDA biological_process
GO:0035962 response to interleukin-1
3
IEA biological_process
GO:0043547 positive regulation of GT
Pase activity
IDA biological_process
GO:0045766 positive regulation of an
giogenesis
IEA biological_process
GO:0048020 CCR chemokine receptor bi
nding
IBA molecular_function
GO:0048245 eosinophil chemotaxis
IEA biological_process
GO:0048245 eosinophil chemotaxis
IDA biological_process
GO:0048247 lymphocyte chemotaxis
IBA biological_process
GO:0050729 positive regulation of in
flammatory response
IBA biological_process
GO:0060444 branching involved in mam
mary gland duct morphogen
esis
IEA biological_process
GO:0060763 mammary duct terminal end
bud growth
IEA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0070371 ERK1 and ERK2 cascade
IEA biological_process
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IBA biological_process
GO:0070670 response to interleukin-4
IEA biological_process
GO:0071346 cellular response to inte
rferon-gamma
IBA biological_process
GO:0071347 cellular response to inte
rleukin-1
IBA biological_process
GO:0071356 cellular response to tumo
r necrosis factor
IBA biological_process
GO:0001938 positive regulation of en
dothelial cell proliferat
ion
IDA biological_process
GO:0002548 monocyte chemotaxis
IBA biological_process
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005576 extracellular region
IDA cellular_component
GO:0005576 extracellular region
TAS cellular_component
GO:0005615 extracellular space
IBA cellular_component
GO:0006468 protein phosphorylation
TAS biological_process
GO:0006874 cellular calcium ion home
ostasis
TAS biological_process
GO:0006935 chemotaxis
TAS biological_process
GO:0006954 inflammatory response
TAS biological_process
GO:0007010 cytoskeleton organization
IDA biological_process
GO:0007155 cell adhesion
TAS biological_process
GO:0007165 signal transduction
TAS biological_process
GO:0007186 G-protein coupled recepto
r signaling pathway
IBA biological_process
GO:0008009 chemokine activity
IDA molecular_function
GO:0008360 regulation of cell shape
IDA biological_process
GO:0009314 response to radiation
TAS biological_process
GO:0009615 response to virus
TAS biological_process
GO:0030335 positive regulation of ce
ll migration
IDA biological_process
GO:0030593 neutrophil chemotaxis
IBA biological_process
GO:0030838 positive regulation of ac
tin filament polymerizati
on
IDA biological_process
GO:0043547 positive regulation of GT
Pase activity
IDA biological_process
GO:0048020 CCR chemokine receptor bi
nding
IBA molecular_function
GO:0048245 eosinophil chemotaxis
IDA biological_process
GO:0048247 lymphocyte chemotaxis
IBA biological_process
GO:0050729 positive regulation of in
flammatory response
IBA biological_process
GO:0070098 chemokine-mediated signal
ing pathway
IBA biological_process
GO:0070374 positive regulation of ER
K1 and ERK2 cascade
IBA biological_process
GO:0071346 cellular response to inte
rferon-gamma
IBA biological_process
GO:0071347 cellular response to inte
rleukin-1
IBA biological_process
GO:0071356 cellular response to tumo
r necrosis factor
IBA biological_process

KEGG pathways

hsa05310  Asthma
hsa04062  Chemokine signaling pathway
hsa04657  IL-17 signaling pathway
hsa04060  Cytokine-cytokine receptor interaction

Diseases

Associated diseases References
Acute coronary syndrome PMID: 18620593
Asthma PMID: 11742272
Asthma PMID: 18712274
Atherosclerosis PMID: 16510147
Atherosclerosis PMID: 19948975
Brain Ischemia PMID: 19028820
Cerebral infarct PMID: 17016617
Chronic obstructive pulmonary disease/COPD PMID: 16864713
Coronary artery disease PMID: 18612209
Dermatitis PMID: 18312459
Diabetes PMID: 19479237
Ulcerative colitis GAD16391516
Pelvic endometriosis PMID: 126871558
Restenosis GAD12082592
Ovarian cancer GAD20628624
Myocardial infarct GAD15186951
Multiple sclerosis GAD16872505
Migraine disorders GAD19559392
Metabolic syndrome GAD19056482
Meningeal cancer GAD20406964
Kidney diseases GAD19578796
Diabetes GAD20416077
Dermatitis GAD18312459
Dermatitis GAD12234713
Coronary artery disease GAD18612209
Chronic obstructive pulmonary disease (COPD) GAD16864713
Cerebral infarct GAD17016617
Bronchiolitis GAD20503287
Brain Ischemia GAD19729601
Brain Ischemia GAD19131662
Brain Ischemia GAD19028820
Atopic asthma GAD11739132
Atherosclerosis GAD16510147
Asthma GAD11742272
Acute coronary syndrome GAD18620593
Asthma OMIM600807
Endometriosis PubMed28475193
Kidney failure PMID: 19578796
Leukemia PMID: 20438785
Meningeal Neoplasms PMID: 20406964
Metabolic syndrome PMID: 19056482
Migraine disorders PMID: 19559392
Multiple sclerosis PMID: 16872505
Myocardial infarct PMID: 15186951
Ovarian cancer PMID: 20628624
Pelvic endometriosis PMID: 26871558
Pelvic endometriosis PMID: 26871558
Pelvic endometriosis PMID: 26871558
Restenosis PMID: 12082592

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
28475193 Endometrio
sis


PTX3
CXCL8
CXCL10
 CCL11 and VEGF
Show abstract