Endometriosis Knowledgebase

Search Result

Gene id

6363

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CCL19 Gene UCSC Ensembl

Aliases

CKb11, ELC, MIP-3b, MIP3B, SCYA19

Gene name

C-C motif chemokine ligand 19

Alternate names

C-C motif chemokine 19, CC chemokine ligand 19, CK beta-11, EBI1-ligand chemokine, MIP-3-beta, beta chemokine exodus-3, chemokine (C-C motif) ligand 19, epstein-Barr virus-induced molecule 1 ligand chemokine, exodus-3, macrophage inflammatory protein 3-beta, small ,

Gene location

9p13.3 (34691276: 34689569) Exons: 4 NC_000009.12

Gene summary(Entrez)

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

OMIM

602227

Protein Summary

Protein general information

Q99731

Name: C C motif chemokine 19 (Beta chemokine exodus 3) (CK beta 11) (Epstein Barr virus induced molecule 1 ligand chemokine) (EBI1 ligand chemokine) (ELC) (Macrophage inflammatory protein 3 beta) (MIP 3 beta) (Small inducible cytokine A19)

Length: 98 Mass: 10,993

Tissue specificity: Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.

Sequence

MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTTLRGRQLCAPPD
QPWVERIIQRLQRTSAKMKRRSS

Structural information

Interpro:	IPR000827 IPR034133 IPR001811
Prosite:	PS00472
Pfam:	PF00048
CDD:	cd01119
PDB:	2MP1
PDBsum:	2MP1
DIP:	5857
MINT:	123917
STRING:	ENSP00000308815;

Other Databases

GeneCards: CCL19; Malacards: CCL19

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001768	establishment of T cell p olarity	IDA	biological_process
GO:0001771	immunological synapse for mation	ISS	biological_process
GO:0002407	dendritic cell chemotaxis	IDA	biological_process
GO:0002408	myeloid dendritic cell ch emotaxis	IDA	biological_process
GO:0002548	monocyte chemotaxis	IBA	biological_process
GO:0002606	positive regulation of de ndritic cell antigen proc essing and presentation	ISS	biological_process
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0006874	cellular calcium ion home ostasis	TAS	biological_process
GO:0006954	inflammatory response	IBA	biological_process
GO:0006954	inflammatory response	NAS	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007154	cell communication	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IBA	biological_process
GO:0007257	activation of JUN kinase activity	ISS	biological_process
GO:0008009	chemokine activity	IDA	molecular_function
GO:0009615	response to virus	TAS	biological_process
GO:0010560	positive regulation of gl ycoprotein biosynthetic p rocess	ISS	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031732	CCR7 chemokine receptor b inding	ISS	molecular_function
GO:0031735	CCR10 chemokine receptor binding	IDA	molecular_function
GO:0032735	positive regulation of in terleukin-12 production	ISS	biological_process
GO:0032760	positive regulation of tu mor necrosis factor produ ction	ISS	biological_process
GO:0034695	response to prostaglandin E	IDA	biological_process
GO:0042102	positive regulation of T cell proliferation	ISS	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological_process
GO:0042379	chemokine receptor bindin g	IDA	molecular_function
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	ISS	biological_process
GO:0043547	positive regulation of GT Pase activity	IBA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0045627	positive regulation of T- helper 1 cell differentia tion	ISS	biological_process
GO:0045807	positive regulation of en docytosis	ISS	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0046330	positive regulation of JN K cascade	IDA	biological_process
GO:0048020	CCR chemokine receptor bi nding	IPI	molecular_function
GO:0048247	lymphocyte chemotaxis	IBA	biological_process
GO:0048260	positive regulation of re ceptor-mediated endocytos is	ISS	biological_process
GO:0048469	cell maturation	ISS	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	ISS	biological_process
GO:0050921	positive regulation of ch emotaxis	ISS	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060491	regulation of cell projec tion assembly	ISS	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0071346	cellular response to inte rferon-gamma	IBA	biological_process
GO:0071347	cellular response to inte rleukin-1	IBA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IBA	biological_process
GO:0071731	response to nitric oxide	IDA	biological_process
GO:0072610	interleukin-12 secretion	ISS	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	IDA	biological_process
GO:0097029	mature conventional dendr itic cell differentiation	ISS	biological_process
GO:0098586	cellular response to viru s	IMP	biological_process
GO:2000107	negative regulation of le ukocyte apoptotic process	IDA	biological_process
GO:2000147	positive regulation of ce ll motility	IDA	biological_process
GO:2000549	positive regulation of de ndritic cell dendrite ass embly	ISS	biological_process
GO:0001768	establishment of T cell p olarity	IDA	biological_process
GO:0001771	immunological synapse for mation	ISS	biological_process
GO:0002407	dendritic cell chemotaxis	IDA	biological_process
GO:0002408	myeloid dendritic cell ch emotaxis	IDA	biological_process
GO:0002548	monocyte chemotaxis	IBA	biological_process
GO:0002606	positive regulation of de ndritic cell antigen proc essing and presentation	ISS	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0005623	cell	IEA	cellular_component
GO:0006874	cellular calcium ion home ostasis	TAS	biological_process
GO:0006935	chemotaxis	IEA	biological_process
GO:0006954	inflammatory response	IBA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	NAS	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007154	cell communication	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IBA	biological_process
GO:0007257	activation of JUN kinase activity	ISS	biological_process
GO:0008009	chemokine activity	IEA	molecular_function
GO:0008009	chemokine activity	IDA	molecular_function
GO:0009615	response to virus	TAS	biological_process
GO:0010560	positive regulation of gl ycoprotein biosynthetic p rocess	ISS	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031732	CCR7 chemokine receptor b inding	ISS	molecular_function
GO:0031735	CCR10 chemokine receptor binding	IDA	molecular_function
GO:0032735	positive regulation of in terleukin-12 production	ISS	biological_process
GO:0032760	positive regulation of tu mor necrosis factor produ ction	ISS	biological_process
GO:0034695	response to prostaglandin E	IDA	biological_process
GO:0042102	positive regulation of T cell proliferation	ISS	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological_process
GO:0042379	chemokine receptor bindin g	IDA	molecular_function
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	ISS	biological_process
GO:0043547	positive regulation of GT Pase activity	IBA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0045627	positive regulation of T- helper 1 cell differentia tion	ISS	biological_process
GO:0045807	positive regulation of en docytosis	ISS	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0046330	positive regulation of JN K cascade	IDA	biological_process
GO:0048020	CCR chemokine receptor bi nding	IPI	molecular_function
GO:0048247	lymphocyte chemotaxis	IBA	biological_process
GO:0048260	positive regulation of re ceptor-mediated endocytos is	ISS	biological_process
GO:0048469	cell maturation	ISS	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	ISS	biological_process
GO:0050921	positive regulation of ch emotaxis	ISS	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060491	regulation of cell projec tion assembly	ISS	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0071346	cellular response to inte rferon-gamma	IBA	biological_process
GO:0071347	cellular response to inte rleukin-1	IBA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IBA	biological_process
GO:0071731	response to nitric oxide	IDA	biological_process
GO:0072610	interleukin-12 secretion	ISS	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	IDA	biological_process
GO:0097029	mature conventional dendr itic cell differentiation	ISS	biological_process
GO:0098586	cellular response to viru s	IMP	biological_process
GO:2000107	negative regulation of le ukocyte apoptotic process	IDA	biological_process
GO:2000147	positive regulation of ce ll motility	IDA	biological_process
GO:2000549	positive regulation of de ndritic cell dendrite ass embly	ISS	biological_process
GO:0001768	establishment of T cell p olarity	IDA	biological_process
GO:0001771	immunological synapse for mation	ISS	biological_process
GO:0002407	dendritic cell chemotaxis	IDA	biological_process
GO:0002408	myeloid dendritic cell ch emotaxis	IDA	biological_process
GO:0002548	monocyte chemotaxis	IBA	biological_process
GO:0002606	positive regulation of de ndritic cell antigen proc essing and presentation	ISS	biological_process
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0006874	cellular calcium ion home ostasis	TAS	biological_process
GO:0006954	inflammatory response	IBA	biological_process
GO:0006954	inflammatory response	NAS	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007154	cell communication	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IBA	biological_process
GO:0007257	activation of JUN kinase activity	ISS	biological_process
GO:0008009	chemokine activity	IDA	molecular_function
GO:0009615	response to virus	TAS	biological_process
GO:0010560	positive regulation of gl ycoprotein biosynthetic p rocess	ISS	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031732	CCR7 chemokine receptor b inding	ISS	molecular_function
GO:0031735	CCR10 chemokine receptor binding	IDA	molecular_function
GO:0032735	positive regulation of in terleukin-12 production	ISS	biological_process
GO:0032760	positive regulation of tu mor necrosis factor produ ction	ISS	biological_process
GO:0034695	response to prostaglandin E	IDA	biological_process
GO:0042102	positive regulation of T cell proliferation	ISS	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological_process
GO:0042379	chemokine receptor bindin g	IDA	molecular_function
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043547	positive regulation of GT Pase activity	ISS	biological_process
GO:0043547	positive regulation of GT Pase activity	IBA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0045627	positive regulation of T- helper 1 cell differentia tion	ISS	biological_process
GO:0045807	positive regulation of en docytosis	ISS	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0046330	positive regulation of JN K cascade	IDA	biological_process
GO:0048020	CCR chemokine receptor bi nding	IPI	molecular_function
GO:0048247	lymphocyte chemotaxis	IBA	biological_process
GO:0048260	positive regulation of re ceptor-mediated endocytos is	ISS	biological_process
GO:0048469	cell maturation	ISS	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	ISS	biological_process
GO:0050921	positive regulation of ch emotaxis	ISS	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060491	regulation of cell projec tion assembly	ISS	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IMP	biological_process
GO:0071346	cellular response to inte rferon-gamma	IBA	biological_process
GO:0071347	cellular response to inte rleukin-1	IBA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IBA	biological_process
GO:0071731	response to nitric oxide	IDA	biological_process
GO:0072610	interleukin-12 secretion	ISS	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	IDA	biological_process
GO:0097029	mature conventional dendr itic cell differentiation	ISS	biological_process
GO:0098586	cellular response to viru s	IMP	biological_process
GO:2000107	negative regulation of le ukocyte apoptotic process	IDA	biological_process
GO:2000147	positive regulation of ce ll motility	IDA	biological_process
GO:2000549	positive regulation of de ndritic cell dendrite ass embly	ISS	biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa04064  NF-kappa B signaling pathway

Diseases

Associated diseases	References
Endometriosis	PMID: 17357296
Endometriosis associated infertility	INFBASE17357296
Endometriosis	INFBASE17357296

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
17357296	Endometrio sis			43 (25 infertil e women with en dometriosis, 18 contro)	Female infertility	MDC/CCL22 TARC/CCL17 �MCP-1/CCL2 RANTES/CCL5 MIP-1alpha/CCL3 -1beta/CCL4 -1delta/CCL15 -3alpha/CCL20 and -3beta/CCL19.	Show abstract
28856757	Endometrio sis			70 (38 women wi th endometriosi s, 32 controls)		CCL19 CCR7	Show abstract