Endometriosis Knowledgebase

Search Result

Gene id

6647

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

SOD1 Gene UCSC Ensembl

Aliases

ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer

Gene name

superoxide dismutase 1

Alternate names

superoxide dismutase [Cu-Zn], Cu/Zn superoxide dismutase, SOD, soluble, epididymis secretory protein Li 44, indophenoloxidase A, superoxide dismutase 1, soluble, superoxide dismutase, cystolic,

Gene location

21q22.11 (31659621: 31668930) Exons: 5 NC_000021.9

Gene summary(Entrez)

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

OMIM

147450

Protein Summary

Protein general information

P00441

Name: Superoxide dismutase [Cu Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)

Length: 154 Mass: 15,936

Sequence

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGP
KDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVI
GIAQ

Structural information

Interpro:	IPR018152 IPR001424
Prosite:	PS00087 PS00332
Pfam:	PF00080
CDD:	cd00305
PDB:	1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ
PDBsum:	1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ
DIP:	44941
MINT:	204523
STRING:	ENSP00000270142;

Other Databases

GeneCards: SOD1; Malacards: SOD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000187	activation of MAPK activi ty	ISS	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0000303	response to superoxide	IDA	biological_process
GO:0001541	ovarian follicle developm ent	ISS	biological_process
GO:0001819	positive regulation of cy tokine production	IDA	biological_process
GO:0001890	placenta development	NAS	biological_process
GO:0001895	retina homeostasis	ISS	biological_process
GO:0001975	response to amphetamine	IEA	biological_process
GO:0002262	myeloid cell homeostasis	ISS	biological_process
GO:0002576	platelet degranulation	TAS	biological_process
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	EXP	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	TAS	molecular_function
GO:0005507	copper ion binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IDA	cellular_component
GO:0005758	mitochondrial intermembra ne space	TAS	cellular_component
GO:0005759	mitochondrial matrix	NAS	cellular_component
GO:0005764	lysosome	IEA	cellular_component
GO:0005777	peroxisome	ISS	cellular_component
GO:0005777	peroxisome	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006749	glutathione metabolic pro cess	ISS	biological_process
GO:0006801	superoxide metabolic proc ess	ISS	biological_process
GO:0006801	superoxide metabolic proc ess	IDA	biological_process
GO:0006879	cellular iron ion homeost asis	ISS	biological_process
GO:0007283	spermatogenesis	ISS	biological_process
GO:0007566	embryo implantation	ISS	biological_process
GO:0007566	embryo implantation	NAS	biological_process
GO:0007569	cell aging	IMP	biological_process
GO:0007605	sensory perception of sou nd	ISS	biological_process
GO:0007626	locomotory behavior	ISS	biological_process
GO:0008089	anterograde axonal transp ort	ISS	biological_process
GO:0008090	retrograde axonal transpo rt	ISS	biological_process
GO:0008217	regulation of blood press ure	ISS	biological_process
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0009408	response to heat	ISS	biological_process
GO:0010033	response to organic subst ance	IDA	biological_process
GO:0019226	transmission of nerve imp ulse	ISS	biological_process
GO:0019430	removal of superoxide rad icals	ISS	biological_process
GO:0019430	removal of superoxide rad icals	IC	biological_process
GO:0030346	protein phosphatase 2B bi nding	IDA	molecular_function
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0031045	dense core granule	IEA	cellular_component
GO:0031410	cytoplasmic vesicle	IDA	cellular_component
GO:0031667	response to nutrient leve ls	IEA	biological_process
GO:0032287	peripheral nervous system myelin maintenance	ISS	biological_process
GO:0032839	dendrite cytoplasm	IDA	cellular_component
GO:0032930	positive regulation of su peroxide anion generation	IDA	biological_process
GO:0033081	regulation of T cell diff erentiation in thymus	NAS	biological_process
GO:0034465	response to carbon monoxi de	IEA	biological_process
GO:0035865	cellular response to pota ssium ion	IEA	biological_process
GO:0040014	regulation of multicellul ar organism growth	ISS	biological_process
GO:0042493	response to drug	ISS	biological_process
GO:0042542	response to hydrogen pero xide	ISS	biological_process
GO:0042554	superoxide anion generati on	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	NAS	molecular_function
GO:0042803	protein homodimerization activity	NAS	molecular_function
GO:0043025	neuronal cell body	IDA	cellular_component
GO:0043065	positive regulation of ap optotic process	IC	biological_process
GO:0043085	positive regulation of ca talytic activity	IDA	biological_process
GO:0043087	regulation of GTPase acti vity	IDA	biological_process
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043234	protein complex	IDA	cellular_component
GO:0043524	negative regulation of ne uron apoptotic process	ISS	biological_process
GO:0045471	response to ethanol	ISS	biological_process
GO:0045541	negative regulation of ch olesterol biosynthetic pr ocess	IDA	biological_process
GO:0045859	regulation of protein kin ase activity	IDA	biological_process
GO:0046620	regulation of organ growt h	NAS	biological_process
GO:0046677	response to antibiotic	IEA	biological_process
GO:0046688	response to copper ion	IEA	biological_process
GO:0046716	muscle cell cellular home ostasis	ISS	biological_process
GO:0048365	Rac GTPase binding	IDA	molecular_function
GO:0048538	thymus development	NAS	biological_process
GO:0048678	response to axon injury	ISS	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	ISS	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	IDA	biological_process
GO:0051087	chaperone binding	IPI	molecular_function
GO:0051881	regulation of mitochondri al membrane potential	IMP	biological_process
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0060047	heart contraction	IDA	biological_process
GO:0060052	neurofilament cytoskeleto n organization	ISS	biological_process
GO:0060087	relaxation of vascular sm ooth muscle	ISS	biological_process
GO:0060088	auditory receptor cell st ereocilium organization	ISS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071276	cellular response to cadm ium ion	IEA	biological_process
GO:0071318	cellular response to ATP	IEA	biological_process
GO:0072593	reactive oxygen species m etabolic process	IDA	biological_process
GO:0097332	response to antipsychotic drug	IEA	biological_process
GO:1902177	positive regulation of ox idative stress-induced in trinsic apoptotic signali ng pathway	IMP	biological_process
GO:1904115	axon cytoplasm	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0000187	activation of MAPK activi ty	IEA	biological_process
GO:0000187	activation of MAPK activi ty	ISS	biological_process
GO:0000302	response to reactive oxyg en species	IEA	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0000303	response to superoxide	IEA	biological_process
GO:0000303	response to superoxide	IDA	biological_process
GO:0001541	ovarian follicle developm ent	IEA	biological_process
GO:0001541	ovarian follicle developm ent	ISS	biological_process
GO:0001819	positive regulation of cy tokine production	IDA	biological_process
GO:0001890	placenta development	NAS	biological_process
GO:0001895	retina homeostasis	IEA	biological_process
GO:0001895	retina homeostasis	ISS	biological_process
GO:0001975	response to amphetamine	IEA	biological_process
GO:0002262	myeloid cell homeostasis	IEA	biological_process
GO:0002262	myeloid cell homeostasis	ISS	biological_process
GO:0002576	platelet degranulation	TAS	biological_process
GO:0004784	superoxide dismutase acti vity	IEA	molecular_function
GO:0004784	superoxide dismutase acti vity	IEA	molecular_function
GO:0004784	superoxide dismutase acti vity	IEA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	EXP	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	TAS	molecular_function
GO:0005507	copper ion binding	IEA	molecular_function
GO:0005507	copper ion binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005739	mitochondrion	IDA	cellular_component
GO:0005758	mitochondrial intermembra ne space	IEA	cellular_component
GO:0005758	mitochondrial intermembra ne space	TAS	cellular_component
GO:0005759	mitochondrial matrix	NAS	cellular_component
GO:0005764	lysosome	IEA	cellular_component
GO:0005777	peroxisome	IEA	cellular_component
GO:0005777	peroxisome	ISS	cellular_component
GO:0005777	peroxisome	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006749	glutathione metabolic pro cess	IEA	biological_process
GO:0006749	glutathione metabolic pro cess	ISS	biological_process
GO:0006801	superoxide metabolic proc ess	IEA	biological_process
GO:0006801	superoxide metabolic proc ess	IEA	biological_process
GO:0006801	superoxide metabolic proc ess	ISS	biological_process
GO:0006801	superoxide metabolic proc ess	IDA	biological_process
GO:0006879	cellular iron ion homeost asis	IEA	biological_process
GO:0006879	cellular iron ion homeost asis	ISS	biological_process
GO:0006979	response to oxidative str ess	IEA	biological_process
GO:0007283	spermatogenesis	IEA	biological_process
GO:0007283	spermatogenesis	ISS	biological_process
GO:0007566	embryo implantation	IEA	biological_process
GO:0007566	embryo implantation	ISS	biological_process
GO:0007566	embryo implantation	NAS	biological_process
GO:0007568	aging	IEA	biological_process
GO:0007569	cell aging	IMP	biological_process
GO:0007605	sensory perception of sou nd	IEA	biological_process
GO:0007605	sensory perception of sou nd	ISS	biological_process
GO:0007626	locomotory behavior	IEA	biological_process
GO:0007626	locomotory behavior	ISS	biological_process
GO:0008089	anterograde axonal transp ort	IEA	biological_process
GO:0008089	anterograde axonal transp ort	ISS	biological_process
GO:0008090	retrograde axonal transpo rt	IEA	biological_process
GO:0008090	retrograde axonal transpo rt	ISS	biological_process
GO:0008217	regulation of blood press ure	IEA	biological_process
GO:0008217	regulation of blood press ure	ISS	biological_process
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0009408	response to heat	IEA	biological_process
GO:0009408	response to heat	ISS	biological_process
GO:0010033	response to organic subst ance	IDA	biological_process
GO:0016209	antioxidant activity	IEA	molecular_function
GO:0016491	oxidoreductase activity	IEA	molecular_function
GO:0019226	transmission of nerve imp ulse	IEA	biological_process
GO:0019226	transmission of nerve imp ulse	ISS	biological_process
GO:0019430	removal of superoxide rad icals	IEA	biological_process
GO:0019430	removal of superoxide rad icals	ISS	biological_process
GO:0019430	removal of superoxide rad icals	IC	biological_process
GO:0019899	enzyme binding	IEA	molecular_function
GO:0030141	secretory granule	IEA	cellular_component
GO:0030346	protein phosphatase 2B bi nding	IEA	molecular_function
GO:0030346	protein phosphatase 2B bi nding	IDA	molecular_function
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0031045	dense core granule	IEA	cellular_component
GO:0031410	cytoplasmic vesicle	IDA	cellular_component
GO:0031667	response to nutrient leve ls	IEA	biological_process
GO:0032287	peripheral nervous system myelin maintenance	IEA	biological_process
GO:0032287	peripheral nervous system myelin maintenance	ISS	biological_process
GO:0032839	dendrite cytoplasm	IDA	cellular_component
GO:0032930	positive regulation of su peroxide anion generation	IDA	biological_process
GO:0033081	regulation of T cell diff erentiation in thymus	NAS	biological_process
GO:0034465	response to carbon monoxi de	IEA	biological_process
GO:0034599	cellular response to oxid ative stress	IEA	biological_process
GO:0035865	cellular response to pota ssium ion	IEA	biological_process
GO:0040014	regulation of multicellul ar organism growth	IEA	biological_process
GO:0040014	regulation of multicellul ar organism growth	ISS	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0042493	response to drug	ISS	biological_process
GO:0042542	response to hydrogen pero xide	IEA	biological_process
GO:0042542	response to hydrogen pero xide	ISS	biological_process
GO:0042554	superoxide anion generati on	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	NAS	molecular_function
GO:0042803	protein homodimerization activity	NAS	molecular_function
GO:0043005	neuron projection	IEA	cellular_component
GO:0043025	neuronal cell body	IEA	cellular_component
GO:0043025	neuronal cell body	IDA	cellular_component
GO:0043065	positive regulation of ap optotic process	IC	biological_process
GO:0043066	negative regulation of ap optotic process	IEA	biological_process
GO:0043085	positive regulation of ca talytic activity	IEA	biological_process
GO:0043085	positive regulation of ca talytic activity	IDA	biological_process
GO:0043087	regulation of GTPase acti vity	IDA	biological_process
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043234	protein complex	IEA	cellular_component
GO:0043234	protein complex	IDA	cellular_component
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	ISS	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0045471	response to ethanol	ISS	biological_process
GO:0045541	negative regulation of ch olesterol biosynthetic pr ocess	IDA	biological_process
GO:0045859	regulation of protein kin ase activity	IDA	biological_process
GO:0046620	regulation of organ growt h	NAS	biological_process
GO:0046677	response to antibiotic	IEA	biological_process
GO:0046688	response to copper ion	IEA	biological_process
GO:0046716	muscle cell cellular home ostasis	IEA	biological_process
GO:0046716	muscle cell cellular home ostasis	ISS	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0046872	metal ion binding	IEA	molecular_function
GO:0048365	Rac GTPase binding	IDA	molecular_function
GO:0048538	thymus development	NAS	biological_process
GO:0048678	response to axon injury	IEA	biological_process
GO:0048678	response to axon injury	ISS	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	IEA	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	ISS	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	IDA	biological_process
GO:0051087	chaperone binding	IPI	molecular_function
GO:0051881	regulation of mitochondri al membrane potential	IMP	biological_process
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0060047	heart contraction	IEA	biological_process
GO:0060047	heart contraction	IDA	biological_process
GO:0060052	neurofilament cytoskeleto n organization	IEA	biological_process
GO:0060052	neurofilament cytoskeleto n organization	ISS	biological_process
GO:0060087	relaxation of vascular sm ooth muscle	IEA	biological_process
GO:0060087	relaxation of vascular sm ooth muscle	ISS	biological_process
GO:0060088	auditory receptor cell st ereocilium organization	IEA	biological_process
GO:0060088	auditory receptor cell st ereocilium organization	ISS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071276	cellular response to cadm ium ion	IEA	biological_process
GO:0071318	cellular response to ATP	IEA	biological_process
GO:0072593	reactive oxygen species m etabolic process	IDA	biological_process
GO:0097332	response to antipsychotic drug	IEA	biological_process
GO:1902177	positive regulation of ox idative stress-induced in trinsic apoptotic signali ng pathway	IMP	biological_process
GO:1904115	axon cytoplasm	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0000187	activation of MAPK activi ty	ISS	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0000303	response to superoxide	IDA	biological_process
GO:0001541	ovarian follicle developm ent	ISS	biological_process
GO:0001819	positive regulation of cy tokine production	IDA	biological_process
GO:0001890	placenta development	NAS	biological_process
GO:0001895	retina homeostasis	ISS	biological_process
GO:0002262	myeloid cell homeostasis	ISS	biological_process
GO:0002576	platelet degranulation	TAS	biological_process
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	EXP	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	IDA	molecular_function
GO:0004784	superoxide dismutase acti vity	TAS	molecular_function
GO:0005507	copper ion binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IDA	cellular_component
GO:0005758	mitochondrial intermembra ne space	TAS	cellular_component
GO:0005759	mitochondrial matrix	NAS	cellular_component
GO:0005777	peroxisome	ISS	cellular_component
GO:0005777	peroxisome	IDA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006749	glutathione metabolic pro cess	ISS	biological_process
GO:0006801	superoxide metabolic proc ess	ISS	biological_process
GO:0006801	superoxide metabolic proc ess	IDA	biological_process
GO:0006879	cellular iron ion homeost asis	ISS	biological_process
GO:0007283	spermatogenesis	ISS	biological_process
GO:0007566	embryo implantation	ISS	biological_process
GO:0007566	embryo implantation	NAS	biological_process
GO:0007569	cell aging	IMP	biological_process
GO:0007605	sensory perception of sou nd	ISS	biological_process
GO:0007626	locomotory behavior	ISS	biological_process
GO:0008089	anterograde axonal transp ort	ISS	biological_process
GO:0008090	retrograde axonal transpo rt	ISS	biological_process
GO:0008217	regulation of blood press ure	ISS	biological_process
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0009408	response to heat	ISS	biological_process
GO:0010033	response to organic subst ance	IDA	biological_process
GO:0019226	transmission of nerve imp ulse	ISS	biological_process
GO:0019430	removal of superoxide rad icals	ISS	biological_process
GO:0019430	removal of superoxide rad icals	IC	biological_process
GO:0030346	protein phosphatase 2B bi nding	IDA	molecular_function
GO:0031012	extracellular matrix	IDA	cellular_component
GO:0031410	cytoplasmic vesicle	IDA	cellular_component
GO:0032287	peripheral nervous system myelin maintenance	ISS	biological_process
GO:0032839	dendrite cytoplasm	IDA	cellular_component
GO:0032930	positive regulation of su peroxide anion generation	IDA	biological_process
GO:0033081	regulation of T cell diff erentiation in thymus	NAS	biological_process
GO:0040014	regulation of multicellul ar organism growth	ISS	biological_process
GO:0042493	response to drug	ISS	biological_process
GO:0042542	response to hydrogen pero xide	ISS	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042803	protein homodimerization activity	NAS	molecular_function
GO:0042803	protein homodimerization activity	NAS	molecular_function
GO:0043025	neuronal cell body	IDA	cellular_component
GO:0043065	positive regulation of ap optotic process	IC	biological_process
GO:0043085	positive regulation of ca talytic activity	IDA	biological_process
GO:0043087	regulation of GTPase acti vity	IDA	biological_process
GO:0043234	protein complex	IDA	cellular_component
GO:0043524	negative regulation of ne uron apoptotic process	ISS	biological_process
GO:0045471	response to ethanol	ISS	biological_process
GO:0045541	negative regulation of ch olesterol biosynthetic pr ocess	IDA	biological_process
GO:0045859	regulation of protein kin ase activity	IDA	biological_process
GO:0046620	regulation of organ growt h	NAS	biological_process
GO:0046716	muscle cell cellular home ostasis	ISS	biological_process
GO:0048365	Rac GTPase binding	IDA	molecular_function
GO:0048538	thymus development	NAS	biological_process
GO:0048678	response to axon injury	ISS	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	ISS	biological_process
GO:0050665	hydrogen peroxide biosynt hetic process	IDA	biological_process
GO:0051087	chaperone binding	IPI	molecular_function
GO:0051881	regulation of mitochondri al membrane potential	IMP	biological_process
GO:0060047	heart contraction	IDA	biological_process
GO:0060052	neurofilament cytoskeleto n organization	ISS	biological_process
GO:0060087	relaxation of vascular sm ooth muscle	ISS	biological_process
GO:0060088	auditory receptor cell st ereocilium organization	ISS	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0072593	reactive oxygen species m etabolic process	IDA	biological_process
GO:1902177	positive regulation of ox idative stress-induced in trinsic apoptotic signali ng pathway	IMP	biological_process
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component

KEGG pathways

hsa05016  Huntington's disease
hsa04213  Longevity regulating pathway
hsa05014  Amyotrophic lateral sclerosis
hsa05020  Prion diseases
hsa04146  Peroxisome

Diseases

Associated diseases	References
Adenomyosis	PMID: 8372889
Alzheimer's disease	PMID: 16036425
Amyotrophic lateral sclerosis (ALS)	PMID: 15623718
Asthenoteratozoospermia	PMID: 17540046
Asthenozoospermia	PMID: 17540046
Cancer	PMID: 17646272
Diabetes	PMID: 11440784
Diabetic nephropathy	PMID: 17914031
Endometriosis	PMID: 25947891
Female infertility	PMID: 24444339
Idiopathic oligoasthenozoospermia	PMID: 19517995
Leukocytospermia	PMID: 7789553
Male infertility	PMID: 24444339
Female infertility	INFBASE22578534
Endometriosis associated infertility	INFBASE11523228
Female infertility	INFBASE10428161
Endometriosis	INFBASE10428161
Oligoasthenoteratozoospermia	PMID: 22211112
Polycystic ovary syndrome (PCOS)	PMID: 24526356
Polyzoospermia	PMID: 14579418
Preeclampsia	PMID: 19399816
Semen quality	PMID: 24658925
Unexplained infertility	PMID: 11002563
Varicocele	PMID: 18264794
Varicocele	PMID: 18294306

PubMed references

PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
24283168	Endometrio sis	42 (20 endometr iosis, 22 patie nts with tubal factor infertil ity)	Female infertility		Show abstract
10428161	Endometrio sis	121 (36 patient s with endometr iosis, 38 patie nts with histol ogically proven adenomyosis, a nd 47 fertile c ontrols)	Female infertility		Show abstract
11523228	Endometrio sis		Female infertility	LPO SOD	Show abstract
22578534	Endometrio sis	91 infertile wo men (23 inferti le women with e ndometriosis an d 68 controls i ncluding infert ile women due t o tubal factor, male factor, o r healthy egg d onors)	Female infertility		Show abstract
25947891	Endometrio sis	81 (26 infertil e patients with minimal/mild e ndometriosis, 1 4 patients with moderate/sever e endometriosis , and 41 contro ls undergoing c ontrolled ovari an stimulation for ICSI)	Female infertility	SOD2 GPX4	Show abstract