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Gene id

6665

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

SOX15 Gene UCSC Ensembl

Aliases

SOX20, SOX26, SOX27

Gene name

SRY-box 15

Alternate names

protein SOX-15, SRY (sex determining region Y)-box 15, SRY (sex determining region Y)-box 20,

Gene location

17p13.1 (7590169: 7588179) Exons: 2 NC_000017.11

Gene summary(Entrez)

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]

OMIM

601297

Protein Summary

Protein general information

O60248

Name: Protein SOX-15 (Protein SOX-12) (Protein SOX-20)

Length: 233 Mass: 25,251

Tissue specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. {ECO

Sequence

MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMH
NSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGP
GYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAG
APMPLTHL

Structural information

Interpro:	IPR009071 IPR036910 IPR031269
Prosite:	PS50118
Pfam:	PF00505
STRING:	ENSP00000355354;

Other Databases

GeneCards: SOX15; Malacards: SOX15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	ISS	biological_process
GO:0000981	RNA polymerase II transcr iption factor activity, s equence-specific DNA bind ing	IEA	molecular_function
GO:0003677	DNA binding	NAS	molecular_function
GO:0003682	chromatin binding	IEA	molecular_function
GO:0003700	transcription factor acti vity, sequence-specific D NA binding	NAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	NAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006325	chromatin organization	NAS	biological_process
GO:0006355	regulation of transcripti on, DNA-templated	NAS	biological_process
GO:0006357	regulation of transcripti on from RNA polymerase II promoter	TAS	biological_process
GO:0008584	male gonad development	TAS	biological_process
GO:0014718	positive regulation of sa tellite cell activation i nvolved in skeletal muscl e regeneration	ISS	biological_process
GO:0030154	cell differentiation	ISS	biological_process
GO:0043403	skeletal muscle tissue re generation	IEA	biological_process
GO:0044798	nuclear transcription fac tor complex	IEA	cellular_component
GO:0045843	negative regulation of st riated muscle tissue deve lopment	ISS	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	ISS	biological_process
GO:0046982	protein heterodimerizatio n activity	IEA	molecular_function
GO:0048627	myoblast development	ISS	biological_process
GO:0070318	positive regulation of G0 to G1 transition	ISS	biological_process
GO:2000288	positive regulation of my oblast proliferation	ISS	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IEA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	ISS	biological_process
GO:0000981	RNA polymerase II transcr iption factor activity, s equence-specific DNA bind ing	IEA	molecular_function
GO:0003677	DNA binding	IEA	molecular_function
GO:0003677	DNA binding	IEA	molecular_function
GO:0003677	DNA binding	NAS	molecular_function
GO:0003682	chromatin binding	IEA	molecular_function
GO:0003700	transcription factor acti vity, sequence-specific D NA binding	NAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	NAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006325	chromatin organization	NAS	biological_process
GO:0006355	regulation of transcripti on, DNA-templated	NAS	biological_process
GO:0006357	regulation of transcripti on from RNA polymerase II promoter	TAS	biological_process
GO:0008584	male gonad development	TAS	biological_process
GO:0014718	positive regulation of sa tellite cell activation i nvolved in skeletal muscl e regeneration	IEA	biological_process
GO:0014718	positive regulation of sa tellite cell activation i nvolved in skeletal muscl e regeneration	ISS	biological_process
GO:0030154	cell differentiation	IEA	biological_process
GO:0030154	cell differentiation	ISS	biological_process
GO:0043403	skeletal muscle tissue re generation	IEA	biological_process
GO:0044798	nuclear transcription fac tor complex	IEA	cellular_component
GO:0045843	negative regulation of st riated muscle tissue deve lopment	IEA	biological_process
GO:0045843	negative regulation of st riated muscle tissue deve lopment	ISS	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IEA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	ISS	biological_process
GO:0046982	protein heterodimerizatio n activity	IEA	molecular_function
GO:0048627	myoblast development	IEA	biological_process
GO:0048627	myoblast development	ISS	biological_process
GO:0070318	positive regulation of G0 to G1 transition	IEA	biological_process
GO:0070318	positive regulation of G0 to G1 transition	ISS	biological_process
GO:2000288	positive regulation of my oblast proliferation	IEA	biological_process
GO:2000288	positive regulation of my oblast proliferation	ISS	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	ISS	biological_process
GO:0003677	DNA binding	NAS	molecular_function
GO:0003700	transcription factor acti vity, sequence-specific D NA binding	NAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	NAS	cellular_component
GO:0006325	chromatin organization	NAS	biological_process
GO:0006355	regulation of transcripti on, DNA-templated	NAS	biological_process
GO:0006357	regulation of transcripti on from RNA polymerase II promoter	TAS	biological_process
GO:0008584	male gonad development	TAS	biological_process
GO:0014718	positive regulation of sa tellite cell activation i nvolved in skeletal muscl e regeneration	ISS	biological_process
GO:0030154	cell differentiation	ISS	biological_process
GO:0045843	negative regulation of st riated muscle tissue deve lopment	ISS	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	ISS	biological_process
GO:0048627	myoblast development	ISS	biological_process
GO:0070318	positive regulation of G0 to G1 transition	ISS	biological_process
GO:2000288	positive regulation of my oblast proliferation	ISS	biological_process

Diseases

Associated diseases	References
Endometriosis	PMID: 27881125
Glomerulonephritis	PMID: 22197929
Endometriosis	INFBASE27881125

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
27881125	Endometrio sis			209 (69 endomet riosis patient, 90 endometriot ic tissue, 50 c ontrol endometr ium )		OCT4 SOX15 TWIST1 DCAMLK1	Show abstract