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Gene id

673

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

BRAF Gene UCSC Ensembl

Aliases

B-RAF1, B-raf, BRAF1, NS7, RAFB1

Gene name

B-Raf proto-oncogene, serine/threonine kinase

Alternate names

serine/threonine-protein kinase B-raf, 94 kDa B-raf protein, B-Raf proto-oncogene serine/threonine-protein kinase (p94), murine sarcoma viral (v-raf) oncogene homolog B1, proto-oncogene B-Raf, v-raf murine sarcoma viral oncogene homolog B, v-raf murine sarcoma ,

Gene location

7q34 (140924763: 140719330) Exons: 21 NC_000007.14

Gene summary(Entrez)

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]

OMIM

164757

Protein Summary

Protein general information

P15056

Name: Serine/threonine protein kinase B raf (EC 2.7.11.1) (Proto oncogene B Raf) (p94) (v Raf murine sarcoma viral oncogene homolog B1)

Length: 766 Mass: 84,437

Tissue specificity: Brain and testis.

Sequence

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPP
SIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPK
SPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVE
VLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIE
PVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDW
EIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQL
AIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS
PDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACAS
PKTPIQAGGYGAFPVH

Structural information

Protein Domains	RBD. (155-227) Protein (457-717)
Interpro:	IPR020454 IPR011009 IPR002219 IPR000719 IPR017441 IPR003116 IPR001245 IPR008271 IPR029071
Prosite:	PS00107 PS50011 PS00108 PS50898 PS00479 PS50081
Pfam:	PF00130 PF07714 PF02196
CDD:	cd00029
PDB:	1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4CQE 4DBN 4E26 4E4X 4EHE 4EHG 4FC0 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ 4MNE 4MNF 4PP7 4R5Y 4RZV 4RZW 4WO5 4XV1 4XV2 4XV3 4XV9 4YHT 5C9C 5CSW 5CSX
PDBsum:	1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4CQE 4DBN 4E26 4E4X 4EHE 4EHG 4FC0 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ 4MNE 4MNF 4PP7 4R5Y 4RZV 4RZW 4WO5 4XV1 4XV2 4XV3 4XV9 4YHT 5C9C 5CSW 5CSX
DIP:	1045
MINT:	1574728
STRING:	ENSP00000288602;

Other Databases

GeneCards: BRAF; Malacards: BRAF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000165	MAPK cascade	TAS	biological_process
GO:0000186	activation of MAPKK activ ity	IEA	biological_process
GO:0002318	myeloid progenitor cell d ifferentiation	IEA	biological_process
GO:0004672	protein kinase activity	IDA	molecular_function
GO:0004674	protein serine/threonine kinase activity	IDA	molecular_function
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular_function
GO:0005509	calcium ion binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0008542	visual learning	IEA	biological_process
GO:0009887	animal organ morphogenesi s	TAS	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010764	negative regulation of fi broblast migration	IEA	biological_process
GO:0015758	glucose transport	IDA	biological_process
GO:0030878	thyroid gland development	IEA	biological_process
GO:0031434	mitogen-activated protein kinase kinase binding	IEA	molecular_function
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0035019	somatic stem cell populat ion maintenance	IEA	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0042127	regulation of cell prolif eration	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0043005	neuron projection	IEA	cellular_component
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043231	intracellular membrane-bo unded organelle	IDA	cellular_component
GO:0043367	CD4-positive, alpha-beta T cell differentiation	IEA	biological_process
GO:0043368	positive T cell selection	IEA	biological_process
GO:0043434	response to peptide hormo ne	IEA	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological_process
GO:0044297	cell body	IEA	cellular_component
GO:0046982	protein heterodimerizatio n activity	IEA	molecular_function
GO:0048538	thymus development	IEA	biological_process
GO:0048680	positive regulation of ax on regeneration	IEA	biological_process
GO:0050772	positive regulation of ax onogenesis	IEA	biological_process
GO:0051291	protein heterooligomeriza tion	IEA	biological_process
GO:0051496	positive regulation of st ress fiber assembly	IEA	biological_process
GO:0051591	response to cAMP	IEA	biological_process
GO:0060291	long-term synaptic potent iation	IEA	biological_process
GO:0060323	head morphogenesis	IEA	biological_process
GO:0060324	face development	IEA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071277	cellular response to calc ium ion	IDA	biological_process
GO:0090150	establishment of protein localization to membrane	IDA	biological_process
GO:1900026	positive regulation of su bstrate adhesion-dependen t cell spreading	IEA	biological_process
GO:2000301	negative regulation of sy naptic vesicle exocytosis	IEA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IEA	biological_process
GO:0031267	small GTPase binding	IPI	molecular_function
GO:0000165	MAPK cascade	IEA	biological_process
GO:0000165	MAPK cascade	TAS	biological_process
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0000186	activation of MAPKK activ ity	IEA	biological_process
GO:0002318	myeloid progenitor cell d ifferentiation	IEA	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0004672	protein kinase activity	IDA	molecular_function
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0004674	protein serine/threonine kinase activity	IDA	molecular_function
GO:0004709	MAP kinase kinase kinase activity	IEA	molecular_function
GO:0005057	signal transducer activit y, downstream of receptor	IEA	molecular_function
GO:0005509	calcium ion binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0007165	signal transduction	IEA	biological_process
GO:0008542	visual learning	IEA	biological_process
GO:0009887	animal organ morphogenesi s	TAS	biological_process
GO:0010628	positive regulation of ge ne expression	IEA	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010764	negative regulation of fi broblast migration	IEA	biological_process
GO:0015758	glucose transport	IDA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016301	kinase activity	IEA	molecular_function
GO:0016310	phosphorylation	IEA	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0030154	cell differentiation	IEA	biological_process
GO:0030878	thyroid gland development	IEA	biological_process
GO:0031434	mitogen-activated protein kinase kinase binding	IEA	molecular_function
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0035019	somatic stem cell populat ion maintenance	IEA	biological_process
GO:0035556	intracellular signal tran sduction	IEA	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0042127	regulation of cell prolif eration	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0043005	neuron projection	IEA	cellular_component
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process
GO:0043231	intracellular membrane-bo unded organelle	IDA	cellular_component
GO:0043367	CD4-positive, alpha-beta T cell differentiation	IEA	biological_process
GO:0043368	positive T cell selection	IEA	biological_process
GO:0043434	response to peptide hormo ne	IEA	biological_process
GO:0043524	negative regulation of ne uron apoptotic process	IEA	biological_process
GO:0044297	cell body	IEA	cellular_component
GO:0046632	alpha-beta T cell differe ntiation	IEA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0046982	protein heterodimerizatio n activity	IEA	molecular_function
GO:0048538	thymus development	IEA	biological_process
GO:0048679	regulation of axon regene ration	IEA	biological_process
GO:0048680	positive regulation of ax on regeneration	IEA	biological_process
GO:0050772	positive regulation of ax onogenesis	IEA	biological_process
GO:0051291	protein heterooligomeriza tion	IEA	biological_process
GO:0051496	positive regulation of st ress fiber assembly	IEA	biological_process
GO:0051591	response to cAMP	IEA	biological_process
GO:0060291	long-term synaptic potent iation	IEA	biological_process
GO:0060323	head morphogenesis	IEA	biological_process
GO:0060324	face development	IEA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IEA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071277	cellular response to calc ium ion	IDA	biological_process
GO:0090150	establishment of protein localization to membrane	IDA	biological_process
GO:1900026	positive regulation of su bstrate adhesion-dependen t cell spreading	IEA	biological_process
GO:2000301	negative regulation of sy naptic vesicle exocytosis	IEA	biological_process
GO:2000352	negative regulation of en dothelial cell apoptotic process	IEA	biological_process
GO:0031267	small GTPase binding	IPI	molecular_function
GO:0000165	MAPK cascade	TAS	biological_process
GO:0004672	protein kinase activity	IDA	molecular_function
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0004674	protein serine/threonine kinase activity	IDA	molecular_function
GO:0005509	calcium ion binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0009887	animal organ morphogenesi s	TAS	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0015758	glucose transport	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043066	negative regulation of ap optotic process	TAS	biological_process
GO:0043231	intracellular membrane-bo unded organelle	IDA	cellular_component
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071277	cellular response to calc ium ion	IDA	biological_process
GO:0090150	establishment of protein localization to membrane	IDA	biological_process
GO:0031267	small GTPase binding	IPI	molecular_function

KEGG pathways

hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa04010  MAPK signaling pathway
hsa04015  Rap1 signaling pathway
hsa04510  Focal adhesion
hsa04062  Chemokine signaling pathway
hsa05224  Breast cancer
hsa04068  FoxO signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05215  Prostate cancer
hsa01522  Endocrine resistance
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04650  Natural killer cell mediated cytotoxicity
hsa04024  cAMP signaling pathway
hsa05160  Hepatitis C
hsa04722  Neurotrophin signaling pathway
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05212  Pancreatic cancer
hsa05210  Colorectal cancer
hsa04012  ErbB signaling pathway
hsa04910  Insulin signaling pathway
hsa04150  mTOR signaling pathway
hsa05034  Alcoholism
hsa05219  Bladder cancer
hsa05211  Renal cell carcinoma
hsa04914  Progesterone-mediated oocyte maturation
hsa05214  Glioma
hsa05213  Endometrial cancer
hsa05223  Non-small cell lung cancer
hsa05221  Acute myeloid leukemia
hsa04726  Serotonergic synapse
hsa04270  Vascular smooth muscle contraction
hsa04730  Long-term depression
hsa05216  Thyroid cancer
hsa04320  Dorso-ventral axis formation
hsa04720  Long-term potentiation

Diseases

Associated diseases	References
Adenocarcinoma	OMIM: 164757
Cardiofaciocutaneous syndrome	OMIM: 164757
Colorectal cancer	OMIM: 164757
Endometriosis	PMID: 16973828
LEOPARD syndrome	OMIM: 164757
Malignant melanoma	KEGG: H00038
Melanoma	OMIM: 164757
Non-small cell lung cancer	OMIM: 164757
Noonan syndrome	OMIM: 164757, KEGG: H00523
Endometriosis	INFBASE22276910
Thyroid cancer	KEGG: H00032

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
22276910	Endometrio sis			100 (50 endomet riosis, 50 cont rols)		COX-2 BRAF NRAS CFL1 MAT2A SEPT9 ATAD3A CADM2 NAA15 and CCDC21	Show abstract