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A repository for genes associated with endometriosis

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Gene id 6790
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol AURKA   Gene   UCSC   Ensembl
Aliases AIK, ARK1, AURA, BTAK, PPP1R47, STK15, STK6, STK7
Gene name aurora kinase A
Alternate names aurora kinase A, aurora 2, aurora/IPL1-like kinase, aurora/IPL1-related kinase 1, breast tumor-amplified kinase, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase a,
Gene location 20q13.2 (56392336: 56369388)     Exons: 12     NC_000020.11
Gene summary(Entrez) The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OMIM 603072

Protein Summary

Protein general information O14965  

Name: Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1 related kinase 1) (ARK 1) (Aurora related kinase 1) (hARK1) (Breast tumor amplified kinase) (Serine/threonine protein kinase 15) (Serine/threonine protein kinase 6) (Serine/threonine protein kinase aur

Length: 403  Mass: 45,809

Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Sequence MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQK
QKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLA
REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLR
EVLEHPWITANSSKPSNCQNKESASKQS
Structural information
Protein Domains
Protein (133-383)
Interpro:  IPR030616 IPR030611 IPR011009 IPR000719 IPR017441 IPR008271
Prosite:   PS00107 PS50011 PS00108

Pfam:  
PF00069
CDD:   cd14116

PDB:  
1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH
PDBsum:   1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH

DIP:  
33068
MINT:   254096
STRING:   ENSP00000216911;
Other Databases GeneCards:  AURKA;  Malacards:  AURKA

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0000086 G2/M transition of mitoti
c cell cycle
TAS biological_process
GO:0000780 condensed nuclear chromos
ome, centromeric region
IBA cellular_component
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
TAS molecular_function
GO:0004712 protein serine/threonine/
tyrosine kinase activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005813 centrosome
TAS cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005814 centriole
IEA cellular_component
GO:0005819 spindle
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005929 cilium
IEA cellular_component
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006977 DNA damage response, sign
al transduction by p53 cl
ass mediator resulting in
cell cycle arrest
TAS biological_process
GO:0007051 spindle organization
IMP biological_process
GO:0007052 mitotic spindle organizat
ion
IBA biological_process
GO:0007057 spindle assembly involved
in female meiosis I
IEA biological_process
GO:0007067 mitotic nuclear division
TAS biological_process
GO:0007100 mitotic centrosome separa
tion
IEA biological_process
GO:0009948 anterior/posterior axis s
pecification
IEA biological_process
GO:0015630 microtubule cytoskeleton
IDA cellular_component
GO:0019901 protein kinase binding
IPI molecular_function
GO:0030496 midbody
TAS cellular_component
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
TAS biological_process
GO:0031616 spindle pole centrosome
IDA cellular_component
GO:0031625 ubiquitin protein ligase
binding
IEA molecular_function
GO:0031647 regulation of protein sta
bility
IMP biological_process
GO:0032091 negative regulation of pr
otein binding
IDA biological_process
GO:0032133 chromosome passenger comp
lex
IBA cellular_component
GO:0032355 response to estradiol
IEA biological_process
GO:0032436 positive regulation of pr
oteasomal ubiquitin-depen
dent protein catabolic pr
ocess
IEA biological_process
GO:0032465 regulation of cytokinesis
IBA biological_process
GO:0035174 histone serine kinase act
ivity
IBA molecular_function
GO:0035404 histone-serine phosphoryl
ation
IEA biological_process
GO:0042585 germinal vesicle
IEA cellular_component
GO:0042787 protein ubiquitination in
volved in ubiquitin-depen
dent protein catabolic pr
ocess
TAS biological_process
GO:0043066 negative regulation of ap
optotic process
IEA biological_process
GO:0043203 axon hillock
IEA cellular_component
GO:0045120 pronucleus
IEA cellular_component
GO:0045840 positive regulation of mi
totic nuclear division
TAS biological_process
GO:0046605 regulation of centrosome
cycle
TAS biological_process
GO:0046777 protein autophosphorylati
on
TAS biological_process
GO:0048471 perinuclear region of cyt
oplasm
IDA cellular_component
GO:0051233 spindle midzone
IBA cellular_component
GO:0051301 cell division
IEA biological_process
GO:0051642 centrosome localization
IEA biological_process
GO:0071539 protein localization to c
entrosome
IEA biological_process
GO:0072686 mitotic spindle
IEA cellular_component
GO:0072687 meiotic spindle
IEA cellular_component
GO:1900195 positive regulation of oo
cyte maturation
IEA biological_process
GO:1901796 regulation of signal tran
sduction by p53 class med
iator
TAS biological_process
GO:1990138 neuron projection extensi
on
IEA biological_process
GO:0005876 spindle microtubule
IDA cellular_component
GO:0000086 G2/M transition of mitoti
c cell cycle
TAS biological_process
GO:0000166 nucleotide binding
IEA molecular_function
GO:0000212 meiotic spindle organizat
ion
IEA biological_process
GO:0000212 meiotic spindle organizat
ion
IEA biological_process
GO:0000226 microtubule cytoskeleton
organization
IEA biological_process
GO:0000226 microtubule cytoskeleton
organization
IEA biological_process
GO:0000278 mitotic cell cycle
IEA biological_process
GO:0000278 mitotic cell cycle
IEA biological_process
GO:0000780 condensed nuclear chromos
ome, centromeric region
IBA cellular_component
GO:0000922 spindle pole
IEA cellular_component
GO:0004672 protein kinase activity
IEA molecular_function
GO:0004672 protein kinase activity
IEA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular_function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
TAS molecular_function
GO:0004712 protein serine/threonine/
tyrosine kinase activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005524 ATP binding
IEA molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005813 centrosome
IEA cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005813 centrosome
TAS cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005814 centriole
IEA cellular_component
GO:0005815 microtubule organizing ce
nter
IEA cellular_component
GO:0005815 microtubule organizing ce
nter
IEA cellular_component
GO:0005819 spindle
IEA cellular_component
GO:0005819 spindle
TAS cellular_component
GO:0005819 spindle
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005856 cytoskeleton
IEA cellular_component
GO:0005874 microtubule
IEA cellular_component
GO:0005929 cilium
IEA cellular_component
GO:0006468 protein phosphorylation
IEA biological_process
GO:0006468 protein phosphorylation
IEA biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
TAS biological_process
GO:0006977 DNA damage response, sign
al transduction by p53 cl
ass mediator resulting in
cell cycle arrest
TAS biological_process
GO:0007049 cell cycle
IEA biological_process
GO:0007049 cell cycle
IEA biological_process
GO:0007051 spindle organization
IMP biological_process
GO:0007052 mitotic spindle organizat
ion
IEA biological_process
GO:0007052 mitotic spindle organizat
ion
IEA biological_process
GO:0007052 mitotic spindle organizat
ion
IBA biological_process
GO:0007057 spindle assembly involved
in female meiosis I
IEA biological_process
GO:0007067 mitotic nuclear division
IEA biological_process
GO:0007067 mitotic nuclear division
IEA biological_process
GO:0007067 mitotic nuclear division
TAS biological_process
GO:0007100 mitotic centrosome separa
tion
IEA biological_process
GO:0007100 mitotic centrosome separa
tion
IEA biological_process
GO:0007126 meiotic nuclear division
IEA biological_process
GO:0009948 anterior/posterior axis s
pecification
IEA biological_process
GO:0015630 microtubule cytoskeleton
IDA cellular_component
GO:0016301 kinase activity
IEA molecular_function
GO:0016310 phosphorylation
IEA biological_process
GO:0016740 transferase activity
IEA molecular_function
GO:0019901 protein kinase binding
IPI molecular_function
GO:0030030 cell projection organizat
ion
IEA biological_process
GO:0030496 midbody
TAS cellular_component
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
TAS biological_process
GO:0031616 spindle pole centrosome
IDA cellular_component
GO:0031625 ubiquitin protein ligase
binding
IEA molecular_function
GO:0031647 regulation of protein sta
bility
IMP biological_process
GO:0032091 negative regulation of pr
otein binding
IDA biological_process
GO:0032133 chromosome passenger comp
lex
IBA cellular_component
GO:0032355 response to estradiol
IEA biological_process
GO:0032436 positive regulation of pr
oteasomal ubiquitin-depen
dent protein catabolic pr
ocess
IEA biological_process
GO:0032465 regulation of cytokinesis
IBA biological_process
GO:0035174 histone serine kinase act
ivity
IEA molecular_function
GO:0035174 histone serine kinase act
ivity
IBA molecular_function
GO:0035404 histone-serine phosphoryl
ation
IEA biological_process
GO:0042585 germinal vesicle
IEA cellular_component
GO:0042787 protein ubiquitination in
volved in ubiquitin-depen
dent protein catabolic pr
ocess
TAS biological_process
GO:0042995 cell projection
IEA cellular_component
GO:0043066 negative regulation of ap
optotic process
IEA biological_process
GO:0043203 axon hillock
IEA cellular_component
GO:0045120 pronucleus
IEA cellular_component
GO:0045840 positive regulation of mi
totic nuclear division
TAS biological_process
GO:0046605 regulation of centrosome
cycle
TAS biological_process
GO:0046777 protein autophosphorylati
on
TAS biological_process
GO:0048471 perinuclear region of cyt
oplasm
IDA cellular_component
GO:0051233 spindle midzone
IBA cellular_component
GO:0051297 centrosome organization
IEA biological_process
GO:0051297 centrosome organization
IEA biological_process
GO:0051301 cell division
IEA biological_process
GO:0051321 meiotic cell cycle
IEA biological_process
GO:0051642 centrosome localization
IEA biological_process
GO:0071539 protein localization to c
entrosome
IEA biological_process
GO:0072686 mitotic spindle
IEA cellular_component
GO:0072687 meiotic spindle
IEA cellular_component
GO:1900195 positive regulation of oo
cyte maturation
IEA biological_process
GO:1901796 regulation of signal tran
sduction by p53 class med
iator
TAS biological_process
GO:1990138 neuron projection extensi
on
IEA biological_process
GO:0005876 spindle microtubule
IDA cellular_component
GO:0000086 G2/M transition of mitoti
c cell cycle
TAS biological_process
GO:0000780 condensed nuclear chromos
ome, centromeric region
IBA cellular_component
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004672 protein kinase activity
IDA molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
EXP molecular_function
GO:0004674 protein serine/threonine
kinase activity
TAS molecular_function
GO:0004712 protein serine/threonine/
tyrosine kinase activity
TAS molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005515 protein binding
IPI molecular_function
GO:0005634 nucleus
IDA cellular_component
GO:0005634 nucleus
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005654 nucleoplasm
TAS cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005813 centrosome
TAS cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005813 centrosome
IDA cellular_component
GO:0005819 spindle
TAS cellular_component
GO:0005819 spindle
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0005829 cytosol
TAS cellular_component
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
IDA biological_process
GO:0006468 protein phosphorylation
TAS biological_process
GO:0006977 DNA damage response, sign
al transduction by p53 cl
ass mediator resulting in
cell cycle arrest
TAS biological_process
GO:0007051 spindle organization
IMP biological_process
GO:0007052 mitotic spindle organizat
ion
IBA biological_process
GO:0007067 mitotic nuclear division
TAS biological_process
GO:0015630 microtubule cytoskeleton
IDA cellular_component
GO:0019901 protein kinase binding
IPI molecular_function
GO:0030496 midbody
TAS cellular_component
GO:0031145 anaphase-promoting comple
x-dependent catabolic pro
cess
TAS biological_process
GO:0031616 spindle pole centrosome
IDA cellular_component
GO:0031647 regulation of protein sta
bility
IMP biological_process
GO:0032091 negative regulation of pr
otein binding
IDA biological_process
GO:0032133 chromosome passenger comp
lex
IBA cellular_component
GO:0032465 regulation of cytokinesis
IBA biological_process
GO:0035174 histone serine kinase act
ivity
IBA molecular_function
GO:0042787 protein ubiquitination in
volved in ubiquitin-depen
dent protein catabolic pr
ocess
TAS biological_process
GO:0045840 positive regulation of mi
totic nuclear division
TAS biological_process
GO:0046605 regulation of centrosome
cycle
TAS biological_process
GO:0046777 protein autophosphorylati
on
TAS biological_process
GO:0048471 perinuclear region of cyt
oplasm
IDA cellular_component
GO:0051233 spindle midzone
IBA cellular_component
GO:1901796 regulation of signal tran
sduction by p53 class med
iator
TAS biological_process
GO:0005876 spindle microtubule
IDA cellular_component

KEGG pathways

hsa04114  Oocyte meiosis

Diseases

Associated diseases References
Colon cancer OMIM: 603072
Endometriosis PMID: 21840910
Endometriosis INFBASE21840910

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21840910 Endometrio
sis

222 (438 sample
s obtained from
194 patients a
ffected by endo
metriosis, 28 s
amples from 28
patients with n
ormal endometri
um)
Female infertility Aurora A kinases
Show abstract