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Search Result

Gene id

7124

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

TNF Gene UCSC Ensembl

Aliases

DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F

Gene name

tumor necrosis factor

Alternate names

tumor necrosis factor, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha,

Gene location

6p21.33 (31575566: 31578335) Exons: 4 NC_000006.12

Gene summary(Entrez)

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]

OMIM

191160

SNPs

rs1800610

Strand:    Allele origin:   Allele change: C/T   Mutation type: snp

CM000668.2   g.31576050G>A
NC_000006.11   g.31543827G>A
NC_000006.12   g.31576050G>A
NG_007462.1   g.5478G>A
NG_012010.1   g.8952G>A
NM_000594.3   c.186+123G>A
NT_113891.2   g.3053443G>A
NT_113891.3   g.3053337G>A
NT_167244.1   g.2858545G>A
NT_167244.2   g.2908629G>A
NT_167245.1   g.2829368G>A
NT_167245.2   g.2823783G>A
NT_167246.1   g.2886711G>A
NT_167246.2   g.2881091G>A
NT_167247.1   g.2923533G>A
NT_167247.2   g.2917948G>A
NT_167248.1   g.2837465G>A
NT_167248.2   g.2831869G>A
NT_167249.1   g.2874628G>A
NT_167249.2   g.2875330G>A
rs1800750

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000668.2   g.31575186G>A
NC_000006.11   g.31542963G>A
NC_000006.12   g.31575186G>A
NG_007462.1   g.4614G>A
NG_012010.1   g.8088G>A
NM_000594.3   c.-556G>A
NT_113891.2   g.3052579G>A
NT_113891.3   g.3052473G>A
NT_167245.1   g.2828504G>A
NT_167245.2   g.2822919G>A
NT_167246.1   g.2885847G>A
NT_167246.2   g.2880227G>A
NT_167247.1   g.2922669G>A
NT_167247.2   g.2917084G>A
NT_167248.1   g.2836601A=
NT_167248.1   g.2836601A>G
NT_167248.2   g.2831005A=
NT_167248.2   g.2831005A>G
NT_167249.1   g.2873764G>A
NT_167249.2   g.2874466G>A
rs3093661

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000668.2   g.31575981G>A
NC_000006.11   g.31543758G>A
NC_000006.12   g.31575981G>A
NG_007462.1   g.5409G>A
NG_012010.1   g.8883G>A
NM_000594.3   c.186+54G>A
NT_113891.2   g.3053374G>A
NT_113891.3   g.3053268G>A
NT_167244.1   g.2858476G>A
NT_167244.2   g.2908560G>A
NT_167245.1   g.2829299A=
NT_167245.1   g.2829299A>G
NT_167245.2   g.2823714A=
NT_167245.2   g.2823714A>G
NT_167246.1   g.2886642G>A
NT_167246.2   g.2881022G>A
NT_167247.1   g.2923464G>A
NT_167247.2   g.2917879G>A
NT_167248.1   g.2837396G>A
NT_167248.2   g.2831800G>A
NT_167249.1   g.2874559G>A
NT_167249.2   g.2875261G>A
rs3093662

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000668.2   g.31576412A>G
NC_000006.11   g.31544189A>G
NC_000006.12   g.31576412A>G
NG_007462.1   g.5840A>G
NM_000594.3   c.187-122A>G
NT_113891.2   g.3053805A>G
NT_113891.3   g.3053699A>G
NT_167244.1   g.2858907A>G
NT_167244.2   g.2908991A>G
NT_167245.1   g.2829730G=
NT_167245.1   g.2829730G>A
NT_167245.2   g.2824145G=
NT_167245.2   g.2824145G>A
NT_167246.1   g.2887073A>G
NT_167246.2   g.2881453A>G
NT_167247.1   g.2923895A>G
NT_167247.2   g.2918310A>G
NT_167248.1   g.2837829G=
NT_167248.1   g.2837829G>A
NT_167248.2   g.2832233G=
NT_167248.2   g.2832233G>A
NT_167249.1   g.2874990A>G
NT_167249.2   g.2875692A>G
rs3093664

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000668.2   g.31576865A>G
NC_000006.11   g.31544642A>G
NC_000006.12   g.31576865A>G
NG_007462.1   g.6293A>G
NM_000594.3   c.280+51A>G
NT_113891.2   g.3054258A>G
NT_113891.3   g.3054152A>G
NT_167244.1   g.2859360A>G
NT_167244.2   g.2909444A>G
NT_167245.1   g.2830183G=
NT_167245.1   g.2830183G>A
NT_167245.2   g.2824598G=
NT_167245.2   g.2824598G>A
NT_167246.1   g.2887526A>G
NT_167246.2   g.2881906A>G
NT_167247.1   g.2924348A>G
NT_167247.2   g.2918763A>G
NT_167248.1   g.2838282A>G
NT_167248.2   g.2832686A>G
NT_167249.1   g.2875443A>G
NT_167249.2   g.2876145A>G
rs361525

Strand:    Allele origin:   Allele change: A/G   Mutation type: snp

CM000668.2   g.31575324G>A
NC_000006.11   g.31543101G>A
NC_000006.12   g.31575324G>A
NG_007462.1   g.4752G>A
NG_012010.1   g.8226G>A
NM_000594.3   c.-418G>A
NT_113891.2   g.3052717G>A
NT_113891.3   g.3052611G>A
NT_167245.1   g.2828642A=
NT_167245.1   g.2828642A>G
NT_167245.2   g.2823057A=
NT_167245.2   g.2823057A>G
NT_167246.1   g.2885985G>A
NT_167246.2   g.2880365G>A
NT_167247.1   g.2922807G>A
NT_167247.2   g.2917222G>A
NT_167248.1   g.2836739A=
NT_167248.1   g.2836739A>G
NT_167248.2   g.2831143A=
NT_167248.2   g.2831143A>G
NT_167249.1   g.2873902G>A
NT_167249.2   g.2874604G>A
rs4645843

Strand:    Allele origin:   Allele change: C/G/T   Mutation type: snp

CM000668.2   g.31576785C>G
CM000668.2   g.31576785C>T
NC_000006.11   g.31544562C>T
NC_000006.12   g.31576785C>G
NC_000006.12   g.31576785C>T
NG_007462.1   g.6213C>G
NG_007462.1   g.6213C>T
NM_000594.3   c.251C>G
NM_000594.3   c.251C>T
NP_000585.2   p.Pro84Arg
NP_000585.2   p.Pro84Leu
NT_113891.2   g.3054178C>T
NT_113891.3   g.3054072C>G
NT_113891.3   g.3054072C>T
NT_167244.1   g.2859280C>T
NT_167244.2   g.2909364C>G
NT_167244.2   g.2909364C>T
NT_167245.1   g.2830103C>T
NT_167245.2   g.2824518C>G
NT_167245.2   g.2824518C>T
NT_167246.1   g.2887446C>T
NT_167246.2   g.2881826C>G
NT_167246.2   g.2881826C>T
NT_167247.1   g.2924268C>T
NT_167247.2   g.2918683C>G
NT_167247.2   g.2918683C>T
NT_167248.1   g.2838202C>T
NT_167248.2   g.2832606C>G
NT_167248.2   g.2832606C>T
NT_167249.1   g.2875363C>T
NT_167249.2   g.2876065C>G
NT_167249.2   g.2876065C>T

Protein Summary

Protein general information

P01375

Name: Tumor necrosis factor (Cachectin) (TNF alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF a) [Cleaved into: Tumor necrosis factor, membrane form (N terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C doma

Length: 233 Mass: 25,644

Sequence

MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQ
AVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHV
LLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQ
VYFGIIAL

Structural information

Interpro:	IPR006053 IPR002959 IPR021184 IPR006052 IPR008983
Prosite:	PS00251 PS50049
Pfam:	PF00229
PDB:	1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 5MU8 5TSW
PDBsum:	1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 5MU8 5TSW
DIP:	2895
MINT:	1131842
STRING:	ENSP00000398698;

Other Databases

GeneCards: TNF; Malacards: TNF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000060	protein import into nucle us, translocation	IDA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0000165	MAPK cascade	IMP	biological_process
GO:0000185	activation of MAPKKK acti vity	IDA	biological_process
GO:0000187	activation of MAPK activi ty	IDA	biological_process
GO:0001819	positive regulation of cy tokine production	IDA	biological_process
GO:0001891	phagocytic cup	ISS	cellular_component
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0002020	protease binding	IPI	molecular_function
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological_process
GO:0002740	negative regulation of cy tokine secretion involved in immune response	IDA	biological_process
GO:0002876	positive regulation of ch ronic inflammatory respon se to antigenic stimulus	IEA	biological_process
GO:0002925	positive regulation of hu moral immune response med iated by circulating immu noglobulin	IEA	biological_process
GO:0005125	cytokine activity	IDA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	IDA	cellular_component
GO:0006006	glucose metabolic process	IEA	biological_process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006959	humoral immune response	IEA	biological_process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological_process
GO:0007254	JNK cascade	IEA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological_process
GO:0008630	intrinsic apoptotic signa ling pathway in response to DNA damage	IEA	biological_process
GO:0009615	response to virus	IDA	biological_process
GO:0009651	response to salt stress	TAS	biological_process
GO:0009897	external side of plasma m embrane	ISS	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010693	negative regulation of al kaline phosphatase activi ty	IEA	biological_process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological_process
GO:0010888	negative regulation of li pid storage	NAS	biological_process
GO:0030198	extracellular matrix orga nization	IEA	biological_process
GO:0030316	osteoclast differentiatio n	IEA	biological_process
GO:0030730	sequestering of triglycer ide	IDA	biological_process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological_process
GO:0031334	positive regulation of pr otein complex assembly	IDA	biological_process
GO:0031622	positive regulation of fe ver generation	ISS	biological_process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological_process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological_process
GO:0032722	positive regulation of ch emokine production	IDA	biological_process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological_process
GO:0032755	positive regulation of in terleukin-6 production	IEA	biological_process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological_process
GO:0032800	receptor biosynthetic pro cess	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological_process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological_process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological_process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological_process
GO:0042802	identical protein binding	IDA	molecular_function
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IMP	biological_process
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological_process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043242	negative regulation of pr otein complex disassembly	IDA	biological_process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological_process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043491	protein kinase B signalin g	IMP	biological_process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological_process
GO:0044130	negative regulation of gr owth of symbiont in host	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0045071	negative regulation of vi ral genome replication	IDA	biological_process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological_process
GO:0045121	membrane raft	IDA	cellular_component
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological_process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological_process
GO:0045662	negative regulation of my oblast differentiation	IEA	biological_process
GO:0045668	negative regulation of os teoblast differentiation	IEA	biological_process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological_process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IGI	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0045994	positive regulation of tr anslational initiation by iron	IEA	biological_process
GO:0046325	negative regulation of gl ucose import	IEA	biological_process
GO:0048566	embryonic digestive tract development	IEP	biological_process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological_process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050766	positive regulation of ph agocytosis	IMP	biological_process
GO:0050796	regulation of insulin sec retion	IDA	biological_process
GO:0050830	defense response to Gram- positive bacterium	IEA	biological_process
GO:0050901	leukocyte tethering or ro lling	IDA	biological_process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological_process
GO:0051023	regulation of immunoglobu lin secretion	IEA	biological_process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological_process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological_process
GO:0051222	positive regulation of pr otein transport	IDA	biological_process
GO:0051384	response to glucocorticoi d	IDA	biological_process
GO:0051533	positive regulation of NF AT protein import into nu cleus	IDA	biological_process
GO:0051798	positive regulation of ha ir follicle development	IEA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological_process
GO:0055037	recycling endosome	ISS	cellular_component
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological_process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological_process
GO:0060664	epithelial cell prolifera tion involved in salivary gland morphogenesis	IEA	biological_process
GO:0060693	regulation of branching i nvolved in salivary gland morphogenesis	IEA	biological_process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological_process
GO:0071230	cellular response to amin o acid stimulus	IEA	biological_process
GO:0071316	cellular response to nico tine	IDA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological_process
GO:0071550	death-inducing signaling complex assembly	TAS	biological_process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological_process
GO:0071803	positive regulation of po dosome assembly	IDA	biological_process
GO:0090002	establishment of protein localization to plasma me mbrane	IDA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological_process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological_process
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological_process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological_process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological_process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological_process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological_process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological_process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological_process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological_process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological_process
GO:0000060	protein import into nucle us, translocation	IDA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IEA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0000165	MAPK cascade	IMP	biological_process
GO:0000185	activation of MAPKKK acti vity	IDA	biological_process
GO:0000187	activation of MAPK activi ty	IDA	biological_process
GO:0001819	positive regulation of cy tokine production	IDA	biological_process
GO:0001891	phagocytic cup	IEA	cellular_component
GO:0001891	phagocytic cup	ISS	cellular_component
GO:0001932	regulation of protein pho sphorylation	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0002020	protease binding	IEA	molecular_function
GO:0002020	protease binding	IPI	molecular_function
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological_process
GO:0002740	negative regulation of cy tokine secretion involved in immune response	IDA	biological_process
GO:0002876	positive regulation of ch ronic inflammatory respon se to antigenic stimulus	IEA	biological_process
GO:0002925	positive regulation of hu moral immune response med iated by circulating immu noglobulin	IEA	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005125	cytokine activity	IDA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	IDA	cellular_component
GO:0006006	glucose metabolic process	IEA	biological_process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IEA	biological_process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological_process
GO:0006952	defense response	IEA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0006959	humoral immune response	IEA	biological_process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological_process
GO:0007254	JNK cascade	IEA	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IEA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological_process
GO:0008630	intrinsic apoptotic signa ling pathway in response to DNA damage	IEA	biological_process
GO:0009615	response to virus	IDA	biological_process
GO:0009651	response to salt stress	TAS	biological_process
GO:0009887	animal organ morphogenesi s	IEA	biological_process
GO:0009897	external side of plasma m embrane	IEA	cellular_component
GO:0009897	external side of plasma m embrane	ISS	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010033	response to organic subst ance	IEA	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010693	negative regulation of al kaline phosphatase activi ty	IEA	biological_process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological_process
GO:0010888	negative regulation of li pid storage	NAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0030198	extracellular matrix orga nization	IEA	biological_process
GO:0030316	osteoclast differentiatio n	IEA	biological_process
GO:0030730	sequestering of triglycer ide	IDA	biological_process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological_process
GO:0031334	positive regulation of pr otein complex assembly	IDA	biological_process
GO:0031622	positive regulation of fe ver generation	IEA	biological_process
GO:0031622	positive regulation of fe ver generation	ISS	biological_process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological_process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological_process
GO:0032722	positive regulation of ch emokine production	IDA	biological_process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological_process
GO:0032755	positive regulation of in terleukin-6 production	IEA	biological_process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological_process
GO:0032800	receptor biosynthetic pro cess	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IEA	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological_process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological_process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological_process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological_process
GO:0042127	regulation of cell prolif eration	IEA	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IEA	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological_process
GO:0042742	defense response to bacte rium	IEA	biological_process
GO:0042802	identical protein binding	IDA	molecular_function
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IMP	biological_process
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological_process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IEA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043242	negative regulation of pr otein complex disassembly	IDA	biological_process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological_process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043491	protein kinase B signalin g	IMP	biological_process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological_process
GO:0044130	negative regulation of gr owth of symbiont in host	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0045071	negative regulation of vi ral genome replication	IDA	biological_process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological_process
GO:0045121	membrane raft	IEA	cellular_component
GO:0045121	membrane raft	IDA	cellular_component
GO:0045123	cellular extravasation	IEA	biological_process
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological_process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological_process
GO:0045662	negative regulation of my oblast differentiation	IEA	biological_process
GO:0045668	negative regulation of os teoblast differentiation	IEA	biological_process
GO:0045670	regulation of osteoclast differentiation	IEA	biological_process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological_process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IEA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IEA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IGI	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0045994	positive regulation of tr anslational initiation by iron	IEA	biological_process
GO:0046325	negative regulation of gl ucose import	IEA	biological_process
GO:0046330	positive regulation of JN K cascade	IEA	biological_process
GO:0048566	embryonic digestive tract development	IEP	biological_process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological_process
GO:0050708	regulation of protein sec retion	IEA	biological_process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050766	positive regulation of ph agocytosis	IMP	biological_process
GO:0050796	regulation of insulin sec retion	IDA	biological_process
GO:0050830	defense response to Gram- positive bacterium	IEA	biological_process
GO:0050900	leukocyte migration	IEA	biological_process
GO:0050901	leukocyte tethering or ro lling	IDA	biological_process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological_process
GO:0051023	regulation of immunoglobu lin secretion	IEA	biological_process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological_process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological_process
GO:0051222	positive regulation of pr otein transport	IDA	biological_process
GO:0051384	response to glucocorticoi d	IDA	biological_process
GO:0051533	positive regulation of NF AT protein import into nu cleus	IDA	biological_process
GO:0051798	positive regulation of ha ir follicle development	IEA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological_process
GO:0055037	recycling endosome	IEA	cellular_component
GO:0055037	recycling endosome	ISS	cellular_component
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological_process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological_process
GO:0060664	epithelial cell prolifera tion involved in salivary gland morphogenesis	IEA	biological_process
GO:0060693	regulation of branching i nvolved in salivary gland morphogenesis	IEA	biological_process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological_process
GO:0071222	cellular response to lipo polysaccharide	IEA	biological_process
GO:0071230	cellular response to amin o acid stimulus	IEA	biological_process
GO:0071316	cellular response to nico tine	IDA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological_process
GO:0071550	death-inducing signaling complex assembly	TAS	biological_process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological_process
GO:0071803	positive regulation of po dosome assembly	IDA	biological_process
GO:0090002	establishment of protein localization to plasma me mbrane	IDA	biological_process
GO:0097190	apoptotic signaling pathw ay	IEA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IEA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IEA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological_process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological_process
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological_process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological_process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological_process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological_process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological_process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological_process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological_process
GO:2000377	regulation of reactive ox ygen species metabolic pr ocess	IEA	biological_process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological_process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological_process
GO:0000060	protein import into nucle us, translocation	IDA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0000165	MAPK cascade	IMP	biological_process
GO:0000185	activation of MAPKKK acti vity	IDA	biological_process
GO:0000187	activation of MAPK activi ty	IDA	biological_process
GO:0001819	positive regulation of cy tokine production	IDA	biological_process
GO:0001891	phagocytic cup	ISS	cellular_component
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological_process
GO:0002020	protease binding	IPI	molecular_function
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological_process
GO:0002740	negative regulation of cy tokine secretion involved in immune response	IDA	biological_process
GO:0005125	cytokine activity	IDA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	IDA	cellular_component
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological_process
GO:0006927	obsolete transformed cell apoptotic process	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0006954	inflammatory response	IDA	biological_process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological_process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological_process
GO:0009615	response to virus	IDA	biological_process
GO:0009651	response to salt stress	TAS	biological_process
GO:0009897	external side of plasma m embrane	ISS	cellular_component
GO:0009986	cell surface	IDA	cellular_component
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010628	positive regulation of ge ne expression	IMP	biological_process
GO:0010628	positive regulation of ge ne expression	IDA	biological_process
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010629	negative regulation of ge ne expression	IDA	biological_process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological_process
GO:0010888	negative regulation of li pid storage	NAS	biological_process
GO:0030730	sequestering of triglycer ide	IDA	biological_process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological_process
GO:0031334	positive regulation of pr otein complex assembly	IDA	biological_process
GO:0031622	positive regulation of fe ver generation	ISS	biological_process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological_process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological_process
GO:0032722	positive regulation of ch emokine production	IDA	biological_process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological_process
GO:0032800	receptor biosynthetic pro cess	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological_process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological_process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological_process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological_process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological_process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological_process
GO:0042802	identical protein binding	IDA	molecular_function
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043065	positive regulation of ap optotic process	IMP	biological_process
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological_process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043242	negative regulation of pr otein complex disassembly	IDA	biological_process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological_process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological_process
GO:0043491	protein kinase B signalin g	IMP	biological_process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0045071	negative regulation of vi ral genome replication	IDA	biological_process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological_process
GO:0045121	membrane raft	IDA	cellular_component
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological_process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological_process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological_process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological_process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IGI	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological_process
GO:0048566	embryonic digestive tract development	IEP	biological_process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological_process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050766	positive regulation of ph agocytosis	IMP	biological_process
GO:0050796	regulation of insulin sec retion	IDA	biological_process
GO:0050901	leukocyte tethering or ro lling	IDA	biological_process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological_process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological_process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological_process
GO:0051222	positive regulation of pr otein transport	IDA	biological_process
GO:0051384	response to glucocorticoi d	IDA	biological_process
GO:0051533	positive regulation of NF AT protein import into nu cleus	IDA	biological_process
GO:0055037	recycling endosome	ISS	cellular_component
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological_process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological_process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological_process
GO:0071316	cellular response to nico tine	IDA	biological_process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological_process
GO:0071550	death-inducing signaling complex assembly	TAS	biological_process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological_process
GO:0071803	positive regulation of po dosome assembly	IDA	biological_process
GO:0090002	establishment of protein localization to plasma me mbrane	IDA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological_process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:0097527	necroptotic signaling pat hway	IDA	biological_process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological_process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological_process
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological_process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological_process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological_process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological_process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological_process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological_process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological_process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological_process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa05166  HTLV-I infection
hsa05205  Proteoglycans in cancer
hsa04010  MAPK signaling pathway
hsa05152  Tuberculosis
hsa05168  Herpes simplex infection
hsa05418  Fluid shear stress and atherosclerosis
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05145  Toxoplasmosis
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04210  Apoptosis
hsa04621  NOD-like receptor signaling pathway
hsa04668  TNF signaling pathway
hsa05142  Chagas disease
hsa04657  IL-17 signaling pathway
hsa04380  Osteoclast differentiation
hsa04932  Non-alcoholic fatty liver disease
hsa04650  Natural killer cell mediated cytotoxicity
hsa05160  Hepatitis C
hsa05323  Rheumatoid arthritis
hsa05321  Inflammatory bowel disease
hsa04640  Hematopoietic cell lineage
hsa04620  Toll-like receptor signaling pathway
hsa05146  Amoebiasis
hsa04660  T cell receptor signaling pathway
hsa05140  Leishmaniasis
hsa04217  Necroptosis
hsa05133  Pertussis
hsa04612  Antigen processing and presentation
hsa04064  NF-kappa B signaling pathway
hsa04150  mTOR signaling pathway
hsa04350  TGF-beta signaling pathway
hsa05010  Alzheimer's disease
hsa04931  Insulin resistance
hsa05134  Legionellosis
hsa04071  Sphingolipid signaling pathway
hsa05144  Malaria
hsa04920  Adipocytokine signaling pathway
hsa05410  Hypertrophic cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05332  Graft-versus-host disease
hsa05322  Systemic lupus erythematosus
hsa05330  Allograft rejection
hsa04940  Type I diabetes mellitus
hsa04664  Fc epsilon RI signaling pathway
hsa05143  African trypanosomiasis
hsa04930  Type II diabetes mellitus
hsa05014  Amyotrophic lateral sclerosis
hsa04622  RIG-I-like receptor signaling pathway
hsa01523  Antifolate resistance
hsa05310  Asthma
PTHR11471:SF29  Apoptosis signaling pathway
PTHR11471:SF23  Apoptosis signaling pathway
PTHR11471:SF31  Apoptosis signaling pathway

Diseases

Associated diseases	References
Actinic prurigo	PMID: 11722460
Adenomyosis	PMID: 12069392
Adenomyosis	PMID: 14597251
Allergic rhinitis	PMID: 15120189
Alveolar Bone Loss	PMID: 17356374
Alzheimer's disease	PMID: 12434654
Amyloidosis	PMID: 14696796
Amyotrophic lateral sclerosis (ALS)	PMID: 18083240
Anemia	PMID: 12424537
Ankylosing spondylitis	PMID: 12118167
Antiphospholipid syndrome	PMID: 11246532
Arthritis	PMID: 12492251
Asthenoteratozoospermia	PMID: 23465534
Asthenozoospermia	PMID: 24029665
Asthma	PMID: 12392859
Atherosclerosis	PMID: 12899665
Atopy	PMID: 10371104
Autoimmune diseases	PMID: 17712006
Azoospermia	PMID: 19811461
Behcet's disease	PMID: 14727453
Bronchial hyperresponsiveness	PMID: 10469028
Bronchitis	PMID: 15686588
Bronchopulmonary dysplasia	PMID: 17123322
Bullous pemphigoid	PMID: 16403098
Celiac disease	PMID: 25915602
Cerebral palsy	PMID: 16522396
Chagas Disease	PMID: 17712635
Cholangitis	PMID: 14567462
Chorioamnionitis	PMID: 12850624
Chronic bronchitis	PMID: 9372657
Chronic immune thrombocytopenic purpura	PMID: 15009068
Chronic obstructive pulmonary disease (COPD)	PMID: 12149538
Chronic periodontitis	PMID: 12828656
Chronic prostatitis	PMID: 19800664
Chronic renal failure	PMID: 15086488
Chronic ulcerative colitis	PMID: 14617036
Cystic fibrosis	PMID: 17336597
Dementia	OMIM: 191160
Dermatitis	PMID: 12694213
Dermatomyositis	PMID: 12173300
Diabetic nephropathy	PMID: 17428349
Diabetic retinopathy	PMID: 12090088
Down syndrome	PMID: 15308304
Emphysema	PMID: 12661999
Endometriosis	PMID: 20008415
Endometriosis	PMID: 9392916
Endometriosis	PMID: 20655530
Endometriosis	PMID: 8653926
Endotoxemia	PMID: 18307517
Enterocolitis	PMID: 11697432
Fabry disease	PMID: 17353161
Female infertility	PMID: 24476398, PMID: 19105467
Female infertility	PMID: 19579970
Female infertility	PMID: 21463377
Female infertility	PMID: 18490014
Fertilization capacity	PMID: 3364508
Fibrosis	PMID: 17395331
Fuchs heterochromic cyclitis	PMID: 17287608
Gingivitis	PMID: 17953695
Glaucoma	PMID: 12579167
Glomerulonephritis	PMID: 16391465
Glossitis	PMID: 17850436
Gout	PMID: 17631734
Graves disease	PMID: 16313297
Guillain-Barre Syndrome	PMID: 17483581
Hashimoto's thyroiditis	PMID: 17115419
Hemochromatosis	PMID: 12940442
Hemophilia A	PMID: 16926287
Henoch-Schonlein purpura	PMID: 15257453
Hyperandrogenism	PMID: 11502808
Hypergonadotropic hypogonadism	PMID: 17507040
Hyperlipidemia	PMID: 17981921
Hypersensitivity	PMID: 15127972
Hypertension	PMID: 11735091
Hypothyroidism	PMID: 15236755
Idiopathic infertility	PMID: 17977210
Immune�infertility	PMID: 25032981
Impaired spermatogenesis	PMID: 19527232
Inflammation	PMID: 15306845
Insulin resistance	PMID: 11319665
Juvenile arthritis	PMID: 15901906
Kawasaki disease	PMID: 14744383
Kidney disease	PMID: 15036247
Leiomyoma	PMID: 14597251
Leucocytospermia	PMID: 25081128
Leukocytospermia	PMID: 21218642
Liver disease	PMID: 12682890
Lung disease	PMID: 15486341
Lupus	PMID: 9098928
Lymphohistiocytosis	PMID: 17166738
Female infertility	INFBASE27337799
Endometriosis (ovarian)	INFBASE27337799
Endometriosis	INFBASE26054109
Ovulatory dysfunction in endometriosis	INFBASE23427178
Male infertility	PMID: 19811461
Polycystic ovary syndrome (PCOS)	INFBASE22007253
Endometriosis associated infertility	INFBASE20825374
Dysmenorrhea	INFBASE19903048
Female infertility	INFBASE16154044
Female infertility	INFBASE12845737
Female infertility	INFBASE10831551
Female infertility	INFBASE10831550
Ectopic endometriosis	INFBASE10087426
Female infertility	INFBASE8607944
Sperm functional defects	INFBASE7835127
Primary infertility	INFBASE2971579
Metabolic syndrome	PMID: 15978856
Migraine disorders	PMID: 17063315
Mucocutaneous lymph node syndrome	PMID: 12783130
Multiple implantation failure	PMID: 12660269
Multiple sclerosis	PMID: 16183136
Myasthenia gravis	PMID: 16075747
Myelopathy	PMID: 11163081
Myocardial infarction	PMID: 11113269
Nasal polyposis	PMID: 17638785
Nephropathy	PMID: 11748357
Neutropenia	PMID: 15986200
Obesity	PMID: 12395215
Oligoasthenoteratozoospermia	PMID: 23465534
Oligozoospermia	PMID: 21218642
Omenn syndrome	PMID: 17572155
Oocyte development	PMID: 9513849
Oocyte maturation	PMID: 9513849
Ophthalmia	PMID: 16249504
Oral cancer	PMID: 11808761
Osteoarthritis	PMID: 11083263
Osteolysis	PMID: 14606512
Osteoporosis	PMID: 15927351
Otitis media	PMID: 17142509
Ovarian dysfunction	PMID: 16579166
Ovarian endometriosis	PMID: 27337799
Ovarian endometriosis	PMID: 27337799
Ovarian hyperstimulation syndrome (OHSS)	PMID: 25200828
Palmoplantar pustulosis	PMID: 12691703
Pancreatitis	PMID: 15220553
Parkinson's disease	PMID: 15279067
Pelvic adhesions	PMID: 11756364
Pelvic endometriosis	PMID: 26871558
Pemphigus	PMID: 14617046
Perianal disease	PMID: 17509030
Periodontal disease	PMID: 15341923
Polycystic ovary syndrome (PCOS)	PMID: 22316276
Polycystic ovary syndrome (PCOS)	PMID: 12396555
Polycystic ovaries (PCO)	PMID: 7593494
Polymyositis	PMID: 15022353
Preeclampsia	PMID: 24444293
Preeclampsia	PMID: 11349201
Premature adenarche	PMID: 22654787
Premature ovarian failure ( POF)	PMID: 8561874
Preterm delivery	PMID: 15507967
Primary biliary cirrhosis	PMID: 12911663
Primary ovarian insufficiency (POI)	PMID: 22884017
Psoriasis	PMID: 17388919
Pterygium	PMID: 15184943
Puerperal disorders	PMID: 11324946
Recurrent aphthous stomatitis	PMID: 12477062
Recurrent miscarriage	PMID: 22349103
Renal syndrome	PMID: 11427627
Respiratory distress syndrome	PMID: 16135717
Respiratory tract diseases	PMID: 16688007
Rheumatic diseases	PMID: 17763205
Rheumatoid arthritis	PMID: 15077289
Sarcoidosis	PMID: 11243953
Scarring trachoma	PMID: 9038309
Schizophrenia	PMID: 14563376
Scleroderma	PMID: 14872499
Sepsis	PMID: 10450735
Sickle cell anemia	PMID: 17600229
Silicosis	PMID: 11264025
Sinusitis	PMID: 11037831
Sleep apnea	PMID: 16204600
Spermatogenetic defects	PMID: 8723440
Stomatitis	PMID: 17052682
Syncytial virus bronchiolitis	PMID: 14722888
Systemic inflammatory response syndrome	PMID: 12607668
Systemic lupus erythematosus	PMID: 12126589
Systemic sclerosis	PMID: 15585313
Thryoiditis	PMID: 11506478
Ulcerative colitis	PMID: 16116311
Ullrich-Turner syndrome (UTS)	PMID: 3165234
Unexplained infertility	PMID: 12607776
Uterine cervical incompetence	PMID: 12802709
Varicocele	PMID: 25351208
Vitiligo	PMID: 16691430
Wegener granulomatosis	PMID: 15708894

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
25376627	Endometrio sis			65 (31 patients with endometri osis, 34 patien ts without endo metriosis)	Female infertility	GPX3 IL6 IL8 TNF TXN TBPL2	Show abstract
25331066	Endometrio sis			35 (23 infertil e women with St age III or IV e ndometriosis, 1 2 controls )	Female infertility		Show abstract
18096563	Endometrio sis			58 (33 patients affected by en dometriosis (6 with stage I di sease, 14 with stage II diseas e, 7 with stage III disease an d 6 with stage IV disease))			Show abstract
17997748	Endometrio sis			70 (46 had hist ology-proven en dometriosis, 24 patients witho ut endometriosi s participated as controls)			Show abstract
16128129	Endometrio sis			30 patients wit h endometriosis , 31 without en dometriosis			Show abstract
14745563	Endometrio sis			100 (65 endomet riosis, 35 cont rols)			Show abstract
12845737	Endometrio sis			25 (14 infertil e patients with endometriosis (EMT group) and 11 infertile w omen with norma l pelvis (contr ol group))	Female infertility	IL6 TNF	Show abstract
19401003	Endometrio sis			72 (34 with end ometriosis, 38 without endomet riosis)		AMH FSH TNF GM-CSF VEGF	Show abstract
19661147	Endometrio sis					ICAM1 MMP9 TNF MMP1	Show abstract
7835127	Endometrio sis			34 (16 infertil e women, 11 wom en without endo metriosis, 7 no rmal fertile wo men)		TNF	Show abstract
10597959	Endometrio sis			23 (10 patients with endometri osis, 13 withou t endometriosis )		TNFA IL-1	Show abstract
8612850	Endometrio sis			25 (17 women wi th endometriosi s, 8 fertile co ntrols undergoi ng tubal ligati on)		TNF alpha IL-8 IL-10	Show abstract
23293332	Endometrio sis			72 (38 women wi th endometriosi s, 34 women wit h carcinoma in situ of the ute rine cervix as controls)		TNF PAK4	Show abstract
20339793	Endometrio sis			98 (65 patients with endometri osis (Group A) and 33 without the disease (Gr oup B))		IL 2 4 and 10 �TNF-alpha and IFN-gamma	Show abstract
24495049	Endometrio sis			49 (21 women wi th endometriosi s undergoing la paroscopic surg ery, 20 control s without endom etriosis)		NKp46 TNF-alpha and IFN-gamma	Show abstract
25218120	Endometrio sis			17 (10 women wi th endometriosi s, 7 women with out endometrios is)	Female infertility	TNF VEGFA	Show abstract
23952049	Endometrio sis	TNFA (-1031T/C), VEGFA(+450G/C)	Iranian	308 (135 women with diagnosis of endometriosi s, 173 women wi th no evidence of the disease)		TNFA VEGF	Show abstract
26054109	Endometrio sis			98 (46 with end ometriosis, 52 with benign tum ors)		IL-1 TNF IgG IgA Bcl-6 Blimp-1	Show abstract
22883518	Endometrio sis	TNFA -1031T/C, IL-6 -634C/G		931 (432 endome triosis patient s, 499 non-endo metriosis women )		TNF-?	Show abstract
21640344	Endometrio sis					TNF	Show abstract
22563871	Endometrio sis					IL-6 TNF-alpha glycodelin A	Show abstract
23269356	Endometrio sis			50 women includ ing EMS patient s undergoing la paroscopic ovar ian cystectomy, non-EMS patien ts undergoing h ysterectomy for uterine fibroi ds		hBD-2 TNFA IL-1b	Show abstract
20825374	Endometrio sis			28 infertile wo men with endome triosis (study group), 23 wome n with fallopia n-associated in fertility (cont rols), and 24 w omen with myoma (controls)	Female infertility	Leptin MCP-1 andTNF-alpha levels	Show abstract
27337799	Endometrio sis (ovari an)			122 (64 patient s with ovarian endometriosis, 58 infertility cases caused by male side were used as contro l group)	Female infertility	IL-6 TNFA	Show abstract
23427178	Endometrio sis					TNFA EGR1	Show abstract
22007253	Endometrio sis			157 women under going in vitro fertilization ( IVF)	Female infertility	IL-1 IL-6 IL-18 IFN-gamma TNF-alpha IL-12 IL-23 MIP-1? MIP-1? MCP-1 RANTES IL-8 CD47	Show abstract
16154044	Endometrio sis			79 women belong ing to four sel ected subgroups according to t heir endometrio sis and/or�infe rtility	Female infertility	IL-1beta TNF-alpha IL-6 IL-8 ICAM-1	Show abstract
11821289	Endometrio sis			130 (56 with en dometriosis, 8 with idiopathic infertility, 2 7 controls (tub al ligation), 3 9 were excluded due to bloody PF)		IL-1beta �IL-6 IL-8 IL-12 IL-13 TNF-alpha	Show abstract
10831550	Endometrio sis				Female infertility		Show abstract
11834864	Endometrio sis				Female infertility	IL-6 TNF-alpha	Show abstract
19394608	Endometrio sis	TNFA (C850T)	Asian I ndian	245 (110 surgic ally confirmed cases of endome triosis, 50 ult rasonographical ly confirmed ca ses of fibroid tumors, 85 heal thy female volu nteers)		TNFA	Show abstract
15212671	Endometrio sis	TNFA (polymorphisms at positions -1031, -863, -857, HLA-B*0702 )		288 (123 patien ts with endomet riosis, 165 fer tile healthy wo men )		TNFA TNFR2	Show abstract
16641167	Endometrio sis			73 (61 patients with endometri osis, 12 patien ts without endo metriosis)		TNFalpha IL-6	Show abstract
16006475	Endometrio sis			30 (18 infertil e women with en dometriosis, 12 women without endometriosis)		IL-6 TNFalpha	Show abstract
19260858	Endometrio sis					cIAP2 IL-8 NFkappaB TNFalpha	Show abstract
17509205	Endometrio sis			75 (17 endometr iosis patients with ovarian in volvement, 33 p atients without ovarian involv ement, 25 witho ut endometriosi s)		IL-8 TNFalpha	Show abstract
10831551	Endometrio sis			86 (Infertile w omen with minim al or mild endo metriosis (11 p atients with re d lesions, 36 p atients with no n-red lesions), 39 infertile n ormo-ovulatory patients with n ormal pelvic an atomy as contro ls)	Female infertility	TNFalpha	Show abstract
10087426	Endometrio sis					TNF-alpha IL-8	Show abstract
8607944	Endometrio sis					IL-1 beta IL-2 and�TNF- alpha�	Show abstract
1442940	Endometrio sis			50 (21 infertil e women with no endometriosis, 19 untreated e ndometriosis, 1 0 undergoing tr eatment for end ometriosis )	Female infertility, Endometriosis associated infertility	IL-1 TNF	Show abstract
20677482	Endometrio sis					NF-kappaB COX-2 TNF-alpha	Show abstract
11526787	Endometrio sis			19 (9 infertile women with min imal or mild en dometriosis and 10 patients wi th tubal occlus ion (the refere nce group))	Female infertility	TNF-alpha IFN-gamma	Show abstract
18684450	Endometrio sis			45 (35 patients with ovarian e ndometrioma, 10 patients with uterine myoma)		IL-10 IL-6 TNF-alpha	Show abstract
18272527	Endometrio sis	TNF:g.[-1031T > C], [-863C > A]	Korean	494 (246 women with endometrio sis, 248 women without endomet riosis)		TNF-alpha	Show abstract
15319381	Endometrio sis	TNF-alpha (-238G/A, -308G/A, -857C/T, -863C/A and -1031T/C)	Japanes e	315 (130 endome triosis cases, 185 controls)		TNF-alpha	Show abstract
12840897	Endometrio sis			15 patients wit h endometriosis		IL-1 beta TNF-alpha MCP-1	Show abstract
16553183	Endometrio sis			326 (47 women w ith endometrios is, 279 women w ithout endometr iosis)		IL-6 TNF-alpha ENA-78	Show abstract
16045019	Endometrio sis			150 (82 patient s with EMS, 68 controls)		TNF-alpha TNF-beta	Show abstract
12372447	Endometrio sis			52 (35 women wi th endometriosi s, 17 controls without endomet riosis)		TNF-alpha	Show abstract
9703655	Endometrio sis			40 women underw ent diagnostic laparoscopy (14 endometriosis- free pelvic sit us, 26 subgroup s characterized by the increas ing stage of th e disease)	Female infertility	TNF-alpha	Show abstract
19903048	Endometrio sis			68 (41 endometr iosis, 27 contr ols )		IL-8 RANTES OPG PAPP-A TNF-alpha and glycodelin	Show abstract
2971579	Endometrio sis			74 women underg oing laparoscop y was determine d	Female infertility	TNF	Show abstract
19410630	Endometrio sis					ICAM-3 IL-6 IL-8 TAK1 JNK2 RelA and TLR4 TNFalpha	Show abstract
19238748	Endometrio sis	TNF-alpha C((-857)T, C(-863)A and T(-1031)C), TNFR1 (A(36)G. TNFR2 T(676)G, A(1663)G, T(1668)G and C(1690)T)	Korean	206 (105 women with endometrio sis, 101 women without endomet riosis)		TNT-alpha TNFR2 TNFR	Show abstract