Endometriosis Knowledgebase

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Gene id

7295

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

TXN Gene UCSC Ensembl

Aliases

TRDX, TRX, TRX1

Gene name

thioredoxin

Alternate names

thioredoxin, ADF, ATL-derived factor, SASP, TXN delta 3, surface-associated sulphydryl protein, testicular tissue protein Li 199, thioredoxin delta 3,

Gene location

9q31.3 (110256639: 110243811) Exons: 5 NC_000009.12

Gene summary(Entrez)

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

OMIM

187700

Protein Summary

Protein general information

P10599

Name: Thioredoxin (Trx) (ATL derived factor) (ADF) (Surface associated sulphydryl protein) (SASP)

Length: 105 Mass: 11,737

Sequence

MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMP
TFQFFKKGQKVGEFSGANKEKLEATINELV

Structural information

Protein Domains	Thioredoxin. (2-105)
Interpro:	IPR005746 IPR012336 IPR017937 IPR013766
Prosite:	PS00194 PS51352
Pfam:	PF00085
PDB:	1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY
PDBsum:	1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY
DIP:	6129
MINT:	1522967
STRING:	ENSP00000363641;

Other Databases

GeneCards: TXN; Malacards: TXN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000103	sulfate assimilation	IBA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IEA	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IBA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006351	transcription, DNA-templa ted	IEA	biological_process
GO:0006457	protein folding	IBA	biological_process
GO:0006662	glycerol ether metabolic process	IEA	biological_process
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0009314	response to radiation	IDA	biological_process
GO:0015035	protein disulfide oxidore ductase activity	IBA	molecular_function
GO:0015037	peptide disulfide oxidore ductase activity	IEA	molecular_function
GO:0015949	nucleobase-containing sma ll molecule interconversi on	TAS	biological_process
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as a cceptor	IBA	molecular_function
GO:0030091	protein repair	TAS	biological_process
GO:0032148	activation of protein kin ase B activity	IC	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IGI	biological_process
GO:0033158	regulation of protein imp ort into nucleus, translo cation	IDA	biological_process
GO:0043388	positive regulation of DN A binding	IDA	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045454	cell redox homeostasis	IBA	biological_process
GO:0046826	negative regulation of pr otein export from nucleus	IEA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IC	biological_process
GO:0055114	oxidation-reduction proce ss	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:1903206	negative regulation of hy drogen peroxide-induced c ell death	IGI	biological_process
GO:0000103	sulfate assimilation	IBA	biological_process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IEA	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005739	mitochondrion	IBA	cellular_component
GO:0005829	cytosol	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006351	transcription, DNA-templa ted	IEA	biological_process
GO:0006355	regulation of transcripti on, DNA-templated	IEA	biological_process
GO:0006457	protein folding	IBA	biological_process
GO:0006662	glycerol ether metabolic process	IEA	biological_process
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0009314	response to radiation	IDA	biological_process
GO:0015035	protein disulfide oxidore ductase activity	IEA	molecular_function
GO:0015035	protein disulfide oxidore ductase activity	IBA	molecular_function
GO:0015037	peptide disulfide oxidore ductase activity	IEA	molecular_function
GO:0015949	nucleobase-containing sma ll molecule interconversi on	TAS	biological_process
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as a cceptor	IBA	molecular_function
GO:0030091	protein repair	TAS	biological_process
GO:0032148	activation of protein kin ase B activity	IC	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IGI	biological_process
GO:0033158	regulation of protein imp ort into nucleus, translo cation	IDA	biological_process
GO:0043388	positive regulation of DN A binding	IDA	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045454	cell redox homeostasis	IEA	biological_process
GO:0045454	cell redox homeostasis	IEA	biological_process
GO:0045454	cell redox homeostasis	IBA	biological_process
GO:0046826	negative regulation of pr otein export from nucleus	IEA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IC	biological_process
GO:0055114	oxidation-reduction proce ss	IEA	biological_process
GO:0055114	oxidation-reduction proce ss	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:1903206	negative regulation of hy drogen peroxide-induced c ell death	IGI	biological_process
GO:0000103	sulfate assimilation	IBA	biological_process
GO:0000302	response to reactive oxyg en species	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005739	mitochondrion	IBA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006457	protein folding	IBA	biological_process
GO:0006928	movement of cell or subce llular component	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0009314	response to radiation	IDA	biological_process
GO:0015035	protein disulfide oxidore ductase activity	IBA	molecular_function
GO:0015949	nucleobase-containing sma ll molecule interconversi on	TAS	biological_process
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as a cceptor	IBA	molecular_function
GO:0030091	protein repair	TAS	biological_process
GO:0032148	activation of protein kin ase B activity	IC	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IGI	biological_process
GO:0033158	regulation of protein imp ort into nucleus, translo cation	IDA	biological_process
GO:0043388	positive regulation of DN A binding	IDA	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0045454	cell redox homeostasis	IBA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IC	biological_process
GO:0055114	oxidation-reduction proce ss	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:1903206	negative regulation of hy drogen peroxide-induced c ell death	IGI	biological_process

KEGG pathways

hsa05418 Fluid shear stress and atherosclerosis
hsa04621 NOD-like receptor signaling pathway

Diseases

Associated diseases	References
Cancer	PMID: 16424062
Endometriosis	PMID: 20172870
Gonad development	PMID: 15120973
Endometriosis	INFBASE20172870

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
25376627	Endometrio sis			65 (31 patients with endometri osis, 34 patien ts without endo metriosis)	Female infertility	GPX3 IL6 IL8 TNF TXN TBPL2	Show abstract
20172870	Endometrio sis			66 (35 patients with histologi cally confirmed endometriosis, 31 patients wi thout endometri osis)		TRX TBP-2	Show abstract