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Gene id

7442

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

TRPV1 Gene UCSC Ensembl

Aliases

VR1

Gene name

transient receptor potential cation channel subfamily V member 1

Alternate names

transient receptor potential cation channel subfamily V member 1, OTRPC1, capsaicin receptor, osm-9-like TRP channel 1, transient receptor potential vanilloid 1a, transient receptor potential vanilloid 1b, vanilloid receptor subtype 1,

Gene location

17p13.2 (3609410: 3565445) Exons: 19 NC_000017.11

Gene summary(Entrez)

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

OMIM

602076

Protein Summary

Protein general information

Q8NER1

Name: Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm 9 like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)

Length: 839 Mass: 94,956

Tissue specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum o

Sequence

MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPT
ITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFK
DPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENG
ADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY
GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFT
MAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLA
TVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILL
LNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNW
TTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPE
DAEVFKSPAASGEK

Structural information

Motifs	Selectivity filter.(644-647)
Interpro:	IPR002110 IPR020683 IPR005821 IPR004729 IPR024862 IPR008347 IPR024863
Prosite:	PS50297 PS50088
Pfam:	PF12796 PF00520
MINT:	4721979
STRING:	ENSP00000459962;

Other Databases

GeneCards: TRPV1; Malacards: TRPV1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004888	transmembrane signaling r eceptor activity	ISS	molecular_function
GO:0005231	excitatory extracellular ligand-gated ion channel activity	ISS	molecular_function
GO:0005262	calcium channel activity	TAS	molecular_function
GO:0005516	calmodulin binding	IEA	molecular_function
GO:0005524	ATP binding	ISS	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0006810	transport	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007635	chemosensory behavior	TAS	biological_process
GO:0015278	calcium-release channel a ctivity	ISS	molecular_function
GO:0016021	integral component of mem brane	IDA	cellular_component
GO:0030054	cell junction	IEA	cellular_component
GO:0031226	intrinsic component of pl asma membrane	ISS	cellular_component
GO:0032591	dendritic spine membrane	IEA	cellular_component
GO:0045211	postsynaptic membrane	ISS	cellular_component
GO:0050955	thermoception	IDA	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IEA	biological_process
GO:0051219	phosphoprotein binding	IPI	molecular_function
GO:0070588	calcium ion transmembrane transport	ISS	biological_process
GO:0070588	calcium ion transmembrane transport	TAS	biological_process
GO:0071312	cellular response to alka loid	ISS	biological_process
GO:0071318	cellular response to ATP	ISS	biological_process
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0004888	transmembrane signaling r eceptor activity	ISS	molecular_function
GO:0005216	ion channel activity	IEA	molecular_function
GO:0005231	excitatory extracellular ligand-gated ion channel activity	ISS	molecular_function
GO:0005262	calcium channel activity	IEA	molecular_function
GO:0005262	calcium channel activity	TAS	molecular_function
GO:0005262	calcium channel activity	TAS	molecular_function
GO:0005516	calmodulin binding	IEA	molecular_function
GO:0005524	ATP binding	ISS	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0006810	transport	IEA	biological_process
GO:0006810	transport	TAS	biological_process
GO:0006811	ion transport	IEA	biological_process
GO:0006811	ion transport	IEA	biological_process
GO:0006816	calcium ion transport	IEA	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007635	chemosensory behavior	TAS	biological_process
GO:0015278	calcium-release channel a ctivity	ISS	molecular_function
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016021	integral component of mem brane	IDA	cellular_component
GO:0030054	cell junction	IEA	cellular_component
GO:0031226	intrinsic component of pl asma membrane	ISS	cellular_component
GO:0032591	dendritic spine membrane	IEA	cellular_component
GO:0042995	cell projection	IEA	cellular_component
GO:0045202	synapse	IEA	cellular_component
GO:0045211	postsynaptic membrane	ISS	cellular_component
GO:0045211	postsynaptic membrane	IEA	cellular_component
GO:0045211	postsynaptic membrane	IEA	cellular_component
GO:0050955	thermoception	IDA	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IEA	biological_process
GO:0051219	phosphoprotein binding	IPI	molecular_function
GO:0055085	transmembrane transport	IEA	biological_process
GO:0070588	calcium ion transmembrane transport	ISS	biological_process
GO:0070588	calcium ion transmembrane transport	IEA	biological_process
GO:0070588	calcium ion transmembrane transport	TAS	biological_process
GO:0071312	cellular response to alka loid	ISS	biological_process
GO:0071318	cellular response to ATP	ISS	biological_process
GO:0004888	transmembrane signaling r eceptor activity	ISS	molecular_function
GO:0005231	excitatory extracellular ligand-gated ion channel activity	ISS	molecular_function
GO:0005262	calcium channel activity	TAS	molecular_function
GO:0005262	calcium channel activity	TAS	molecular_function
GO:0005524	ATP binding	ISS	molecular_function
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0006810	transport	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007635	chemosensory behavior	TAS	biological_process
GO:0015278	calcium-release channel a ctivity	ISS	molecular_function
GO:0016021	integral component of mem brane	IDA	cellular_component
GO:0031226	intrinsic component of pl asma membrane	ISS	cellular_component
GO:0045211	postsynaptic membrane	ISS	cellular_component
GO:0050955	thermoception	IDA	biological_process
GO:0051219	phosphoprotein binding	IPI	molecular_function
GO:0070588	calcium ion transmembrane transport	ISS	biological_process
GO:0070588	calcium ion transmembrane transport	TAS	biological_process
GO:0071312	cellular response to alka loid	ISS	biological_process
GO:0071318	cellular response to ATP	ISS	biological_process

KEGG pathways

hsa04080 Neuroactive ligand-receptor interaction
hsa04750 Inflammatory mediator regulation of TRP channels

Diseases

Associated diseases	References
Dysmenorrhea	PMID: 20096818
Endometriosis	PMID: 21160085
Peritoneal endometriosis	INFBASE21160085
Peritoneal endometriosis	PMID: 21160085

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
21160085	Endometrio sis (Perit oneal)			49 (28 of whom had chronic pel vic pain (CPP) and 21 without chronic pelvic pain (CPP))		TRPV1	Show abstract