Endometriosis Knowledgebase

Search Result

Gene id

7474

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

WNT5A Gene UCSC Ensembl

Aliases

hWNT5A

Gene name

Wnt family member 5A

Alternate names

protein Wnt-5a, WNT-5A protein, wingless-type MMTV integration site family, member 5A,

Gene location

3p14.3 (55505260: 55465714) Exons: 15 NC_000003.12

Gene summary(Entrez)

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

OMIM

164975

Protein Summary

Protein general information

P41221

Name: Protein Wnt 5a

Length: 380 Mass: 42,339

Tissue specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protei

Sequence

MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGL
SQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAM
SRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEA
GRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLV
YIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVD
QFVCK

Structural information

Interpro:	IPR005817 IPR026538 IPR018161
Prosite:	PS00246
Pfam:	PF00110
DIP:	29735
STRING:	ENSP00000264634;

Other Databases

GeneCards: WNT5A; Malacards: WNT5A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000187	activation of MAPK activi ty	IDA	biological_process
GO:0001736	establishment of planar p olarity	IEA	biological_process
GO:0001756	somitogenesis	IEA	biological_process
GO:0001837	epithelial to mesenchymal transition	IEP	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IMP	biological_process
GO:0001947	heart looping	IEA	biological_process
GO:0002053	positive regulation of me senchymal cell proliferat ion	IEA	biological_process
GO:0002088	lens development in camer a-type eye	ISS	biological_process
GO:0002741	positive regulation of cy tokine secretion involved in immune response	IMP	biological_process
GO:0003323	type B pancreatic cell de velopment	IEA	biological_process
GO:0003402	planar cell polarity path way involved in axis elon gation	IEA	biological_process
GO:0003408	optic cup formation invol ved in camera-type eye de velopment	ISS	biological_process
GO:0003700	transcription factor acti vity, sequence-specific D NA binding	IMP	molecular_function
GO:0005109	frizzled binding	IPI	molecular_function
GO:0005110	frizzled-2 binding	IEA	molecular_function
GO:0005115	receptor tyrosine kinase- like orphan receptor bind ing	IPI	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005788	endoplasmic reticulum lum en	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IMP	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IDA	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	NAS	biological_process
GO:0007257	activation of JUN kinase activity	IMP	biological_process
GO:0007257	activation of JUN kinase activity	IDA	biological_process
GO:0007411	axon guidance	ISS	biological_process
GO:0007416	synapse assembly	TAS	biological_process
GO:0007442	hindgut morphogenesis	IEA	biological_process
GO:0007494	midgut development	IEA	biological_process
GO:0008584	male gonad development	IEP	biological_process
GO:0008595	anterior/posterior axis s pecification, embryo	IEA	biological_process
GO:0009986	cell surface	IEA	cellular_component
GO:0010033	response to organic subst ance	IEP	biological_process
GO:0010595	positive regulation of en dothelial cell migration	IMP	biological_process
GO:0010595	positive regulation of en dothelial cell migration	IMP	biological_process
GO:0010800	positive regulation of pe ptidyl-threonine phosphor ylation	IEA	biological_process
GO:0010820	positive regulation of T cell chemotaxis	IMP	biological_process
GO:0010976	positive regulation of ne uron projection developme nt	ISS	biological_process
GO:0016055	Wnt signaling pathway	IDA	biological_process
GO:0016055	Wnt signaling pathway	TAS	biological_process
GO:0019904	protein domain specific b inding	IEA	molecular_function
GO:0021891	olfactory bulb interneuro n development	ISS	biological_process
GO:0030182	neuron differentiation	ISS	biological_process
GO:0030216	keratinocyte differentiat ion	IEP	biological_process
GO:0030514	negative regulation of BM P signaling pathway	IEA	biological_process
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030825	positive regulation of cG MP metabolic process	IDA	biological_process
GO:0030850	prostate gland developmen t	IEA	biological_process
GO:0032092	positive regulation of pr otein binding	IEA	biological_process
GO:0032148	activation of protein kin ase B activity	IDA	biological_process
GO:0032355	response to estradiol	IEA	biological_process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological_process
GO:0032755	positive regulation of in terleukin-6 production	IMP	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological_process
GO:0033574	response to testosterone	IEA	biological_process
GO:0034613	cellular protein localiza tion	IDA	biological_process
GO:0035567	non-canonical Wnt signali ng pathway	TAS	biological_process
GO:0036342	post-anal tail morphogene sis	IEA	biological_process
GO:0036517	chemoattraction of seroto nergic neuron axon	IEA	biological_process
GO:0036518	chemorepulsion of dopamin ergic neuron axon	IEA	biological_process
GO:0038031	non-canonical Wnt signali ng pathway via JNK cascad e	IEA	biological_process
GO:0040037	negative regulation of fi broblast growth factor re ceptor signaling pathway	IEA	biological_process
GO:0042060	wound healing	IDA	biological_process
GO:0042733	embryonic digit morphogen esis	IEA	biological_process
GO:0043032	positive regulation of ma crophage activation	IMP	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0044849	estrous cycle	IEA	biological_process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IMP	biological_process
GO:0045165	cell fate commitment	IBA	biological_process
GO:0045198	establishment of epitheli al cell apical/basal pola rity	IEA	biological_process
GO:0045599	negative regulation of fa t cell differentiation	IMP	biological_process
GO:0045732	positive regulation of pr otein catabolic process	IGI	biological_process
GO:0045766	positive regulation of an giogenesis	IMP	biological_process
GO:0045778	positive regulation of os sification	IMP	biological_process
GO:0045807	positive regulation of en docytosis	IEA	biological_process
GO:0045836	positive regulation of me iotic nuclear division	IEA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IMP	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IMP	biological_process
GO:0048018	receptor agonist activity	IC	molecular_function
GO:0048022	negative regulation of me lanin biosynthetic proces s	IEA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0048286	lung alveolus development	IEA	biological_process
GO:0048341	paraxial mesoderm formati on	IEA	biological_process
GO:0048570	notochord morphogenesis	IEA	biological_process
GO:0048706	embryonic skeletal system development	IMP	biological_process
GO:0048806	genitalia development	IMP	biological_process
GO:0048843	negative regulation of ax on extension involved in axon guidance	IEA	biological_process
GO:0048850	hypophysis morphogenesis	IEA	biological_process
GO:0050680	negative regulation of ep ithelial cell proliferati on	IEA	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	IMP	biological_process
GO:0050729	positive regulation of in flammatory response	IMP	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051216	cartilage development	IEA	biological_process
GO:0051384	response to glucocorticoi d	IEA	biological_process
GO:0051964	negative regulation of sy napse assembly	IEA	biological_process
GO:0055093	response to hyperoxia	IEA	biological_process
GO:0060021	palate development	IMP	biological_process
GO:0060028	convergent extension invo lved in axis elongation	IEA	biological_process
GO:0060029	convergent extension invo lved in organogenesis	IEA	biological_process
GO:0060065	uterus development	IEA	biological_process
GO:0060067	cervix development	IEA	biological_process
GO:0060068	vagina development	IEA	biological_process
GO:0060070	canonical Wnt signaling p athway	IEA	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	TAS	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	TAS	biological_process
GO:0060157	urinary bladder developme nt	IEA	biological_process
GO:0060324	face development	IMP	biological_process
GO:0060340	positive regulation of ty pe I interferon-mediated signaling pathway	IDA	biological_process
GO:0060599	lateral sprouting involve d in mammary gland duct m orphogenesis	IEA	biological_process
GO:0060638	mesenchymal-epithelial ce ll signaling	IEA	biological_process
GO:0060686	negative regulation of pr ostatic bud formation	IEA	biological_process
GO:0060744	mammary gland branching i nvolved in thelarche	IEA	biological_process
GO:0060750	epithelial cell prolifera tion involved in mammary gland duct elongation	IEA	biological_process
GO:0060760	positive regulation of re sponse to cytokine stimul us	IDA	biological_process
GO:0060762	regulation of branching i nvolved in mammary gland duct morphogenesis	IEA	biological_process
GO:0060775	planar cell polarity path way involved in gastrula mediolateral intercalatio n	IEA	biological_process
GO:0060809	mesodermal to mesenchymal transition involved in g astrulation	IEA	biological_process
GO:0060907	positive regulation of ma crophage cytokine product ion	IMP	biological_process
GO:0061036	positive regulation of ca rtilage development	IEA	biological_process
GO:0061347	planar cell polarity path way involved in outflow t ract morphogenesis	IEA	biological_process
GO:0061348	planar cell polarity path way involved in ventricul ar septum morphogenesis	IEA	biological_process
GO:0061349	planar cell polarity path way involved in cardiac r ight atrium morphogenesis	IEA	biological_process
GO:0061350	planar cell polarity path way involved in cardiac m uscle tissue morphogenesi s	IEA	biological_process
GO:0061354	planar cell polarity path way involved in pericardi um morphogenesis	IEA	biological_process
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070245	positive regulation of th ymocyte apoptotic process	IEA	biological_process
GO:0071222	cellular response to lipo polysaccharide	IEP	biological_process
GO:0071277	cellular response to calc ium ion	IEP	biological_process
GO:0071300	cellular response to reti noic acid	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEP	biological_process
GO:0071425	hematopoietic stem cell p roliferation	IDA	biological_process
GO:0071560	cellular response to tran sforming growth factor be ta stimulus	IEP	biological_process
GO:0072201	negative regulation of me senchymal cell proliferat ion	IDA	biological_process
GO:0090009	primitive streak formatio n	IEA	biological_process
GO:0090037	positive regulation of pr otein kinase C signaling	IMP	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IGI	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IDA	biological_process
GO:0090103	cochlea morphogenesis	IEA	biological_process
GO:0090179	planar cell polarity path way involved in neural tu be closure	IEA	biological_process
GO:0090630	activation of GTPase acti vity	IEA	biological_process
GO:0097325	melanocyte proliferation	IEA	biological_process
GO:1900020	positive regulation of pr otein kinase C activity	IMP	biological_process
GO:1902379	chemoattractant activity involved in axon guidance	IEA	molecular_function
GO:1902474	positive regulation of pr otein localization to syn apse	TAS	biological_process
GO:1903827	regulation of cellular pr otein localization	IEA	biological_process
GO:1904861	excitatory synapse assemb ly	TAS	biological_process
GO:1904862	inhibitory synapse assemb ly	TAS	biological_process
GO:1904934	negative regulation of ce ll proliferation in midbr ain	NAS	biological_process
GO:1904953	Wnt signaling pathway inv olved in midbrain dopamin ergic neuron differentiat ion	NAS	biological_process
GO:1904955	planar cell polarity path way involved in midbrain dopaminergic neuron diffe rentiation	TAS	biological_process
GO:2000049	positive regulation of ce ll-cell adhesion mediated by cadherin	IEA	biological_process
GO:2000052	positive regulation of no n-canonical Wnt signaling pathway	IEA	biological_process
GO:2000484	positive regulation of in terleukin-8 secretion	IEA	biological_process
GO:0000187	activation of MAPK activi ty	IDA	biological_process
GO:0001667	ameboidal-type cell migra tion	IEA	biological_process
GO:0001736	establishment of planar p olarity	IEA	biological_process
GO:0001756	somitogenesis	IEA	biological_process
GO:0001819	positive regulation of cy tokine production	IEA	biological_process
GO:0001837	epithelial to mesenchymal transition	IEP	biological_process
GO:0001843	neural tube closure	IEA	biological_process
GO:0001934	positive regulation of pr otein phosphorylation	IEA	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IMP	biological_process
GO:0001947	heart looping	IEA	biological_process
GO:0002009	morphogenesis of an epith elium	IEA	biological_process
GO:0002053	positive regulation of me senchymal cell proliferat ion	IEA	biological_process
GO:0002088	lens development in camer a-type eye	ISS	biological_process
GO:0002741	positive regulation of cy tokine secretion involved in immune response	IMP	biological_process
GO:0003323	type B pancreatic cell de velopment	IEA	biological_process
GO:0003344	pericardium morphogenesis	IEA	biological_process
GO:0003401	axis elongation	IEA	biological_process
GO:0003402	planar cell polarity path way involved in axis elon gation	IEA	biological_process
GO:0003408	optic cup formation invol ved in camera-type eye de velopment	ISS	biological_process
GO:0003700	transcription factor acti vity, sequence-specific D NA binding	IMP	molecular_function
GO:0005102	receptor binding	IEA	molecular_function
GO:0005102	receptor binding	IEA	molecular_function
GO:0005109	frizzled binding	IEA	molecular_function
GO:0005109	frizzled binding	IPI	molecular_function
GO:0005110	frizzled-2 binding	IEA	molecular_function
GO:0005115	receptor tyrosine kinase- like orphan receptor bind ing	IPI	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	IEA	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	IEA	cellular_component
GO:0005578	proteinaceous extracellul ar matrix	IEA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005788	endoplasmic reticulum lum en	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IEA	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IMP	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IDA	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	NAS	biological_process
GO:0007254	JNK cascade	IEA	biological_process
GO:0007257	activation of JUN kinase activity	IMP	biological_process
GO:0007257	activation of JUN kinase activity	IDA	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0007368	determination of left/rig ht symmetry	IEA	biological_process
GO:0007409	axonogenesis	IEA	biological_process
GO:0007411	axon guidance	IEA	biological_process
GO:0007411	axon guidance	ISS	biological_process
GO:0007416	synapse assembly	TAS	biological_process
GO:0007442	hindgut morphogenesis	IEA	biological_process
GO:0007494	midgut development	IEA	biological_process
GO:0008284	positive regulation of ce ll proliferation	IEA	biological_process
GO:0008584	male gonad development	IEA	biological_process
GO:0008584	male gonad development	IEP	biological_process
GO:0008595	anterior/posterior axis s pecification, embryo	IEA	biological_process
GO:0009952	anterior/posterior patter n specification	IEA	biological_process
GO:0009986	cell surface	IEA	cellular_component
GO:0010033	response to organic subst ance	IEA	biological_process
GO:0010033	response to organic subst ance	IEP	biological_process
GO:0010595	positive regulation of en dothelial cell migration	IMP	biological_process
GO:0010595	positive regulation of en dothelial cell migration	IMP	biological_process
GO:0010800	positive regulation of pe ptidyl-threonine phosphor ylation	IEA	biological_process
GO:0010820	positive regulation of T cell chemotaxis	IMP	biological_process
GO:0010976	positive regulation of ne uron projection developme nt	IEA	biological_process
GO:0010976	positive regulation of ne uron projection developme nt	ISS	biological_process
GO:0014070	response to organic cycli c compound	IEA	biological_process
GO:0016055	Wnt signaling pathway	IEA	biological_process
GO:0016055	Wnt signaling pathway	IEA	biological_process
GO:0016055	Wnt signaling pathway	IEA	biological_process
GO:0016055	Wnt signaling pathway	IDA	biological_process
GO:0016055	Wnt signaling pathway	TAS	biological_process
GO:0016477	cell migration	IEA	biological_process
GO:0019904	protein domain specific b inding	IEA	molecular_function
GO:0021891	olfactory bulb interneuro n development	IEA	biological_process
GO:0021891	olfactory bulb interneuro n development	ISS	biological_process
GO:0021915	neural tube development	IEA	biological_process
GO:0022008	neurogenesis	IEA	biological_process
GO:0022409	positive regulation of ce ll-cell adhesion	IEA	biological_process
GO:0030154	cell differentiation	IEA	biological_process
GO:0030154	cell differentiation	IEA	biological_process
GO:0030182	neuron differentiation	IEA	biological_process
GO:0030182	neuron differentiation	ISS	biological_process
GO:0030216	keratinocyte differentiat ion	IEP	biological_process
GO:0030324	lung development	IEA	biological_process
GO:0030326	embryonic limb morphogene sis	IEA	biological_process
GO:0030514	negative regulation of BM P signaling pathway	IEA	biological_process
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030825	positive regulation of cG MP metabolic process	IDA	biological_process
GO:0030850	prostate gland developmen t	IEA	biological_process
GO:0030901	midbrain development	IEA	biological_process
GO:0032092	positive regulation of pr otein binding	IEA	biological_process
GO:0032148	activation of protein kin ase B activity	IDA	biological_process
GO:0032355	response to estradiol	IEA	biological_process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological_process
GO:0032755	positive regulation of in terleukin-6 production	IEA	biological_process
GO:0032755	positive regulation of in terleukin-6 production	IMP	biological_process
GO:0032880	regulation of protein loc alization	IEA	biological_process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IEA	biological_process
GO:0033574	response to testosterone	IEA	biological_process
GO:0034613	cellular protein localiza tion	IEA	biological_process
GO:0034613	cellular protein localiza tion	IDA	biological_process
GO:0035108	limb morphogenesis	IEA	biological_process
GO:0035567	non-canonical Wnt signali ng pathway	IEA	biological_process
GO:0035567	non-canonical Wnt signali ng pathway	TAS	biological_process
GO:0036342	post-anal tail morphogene sis	IEA	biological_process
GO:0036517	chemoattraction of seroto nergic neuron axon	IEA	biological_process
GO:0036518	chemorepulsion of dopamin ergic neuron axon	IEA	biological_process
GO:0038031	non-canonical Wnt signali ng pathway via JNK cascad e	IEA	biological_process
GO:0040037	negative regulation of fi broblast growth factor re ceptor signaling pathway	IEA	biological_process
GO:0042060	wound healing	IDA	biological_process
GO:0042472	inner ear morphogenesis	IEA	biological_process
GO:0042733	embryonic digit morphogen esis	IEA	biological_process
GO:0043032	positive regulation of ma crophage activation	IMP	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0043507	positive regulation of JU N kinase activity	IEA	biological_process
GO:0043547	positive regulation of GT Pase activity	IEA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0044849	estrous cycle	IEA	biological_process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IMP	biological_process
GO:0045165	cell fate commitment	IBA	biological_process
GO:0045198	establishment of epitheli al cell apical/basal pola rity	IEA	biological_process
GO:0045599	negative regulation of fa t cell differentiation	IMP	biological_process
GO:0045732	positive regulation of pr otein catabolic process	IGI	biological_process
GO:0045766	positive regulation of an giogenesis	IMP	biological_process
GO:0045778	positive regulation of os sification	IMP	biological_process
GO:0045807	positive regulation of en docytosis	IEA	biological_process
GO:0045836	positive regulation of me iotic nuclear division	IEA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IEA	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IEA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IMP	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IMP	biological_process
GO:0046330	positive regulation of JN K cascade	IEA	biological_process
GO:0046546	development of primary ma le sexual characteristics	IEA	biological_process
GO:0048018	receptor agonist activity	IC	molecular_function
GO:0048022	negative regulation of me lanin biosynthetic proces s	IEA	biological_process
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0048286	lung alveolus development	IEA	biological_process
GO:0048341	paraxial mesoderm formati on	IEA	biological_process
GO:0048546	digestive tract morphogen esis	IEA	biological_process
GO:0048570	notochord morphogenesis	IEA	biological_process
GO:0048706	embryonic skeletal system development	IMP	biological_process
GO:0048806	genitalia development	IMP	biological_process
GO:0048812	neuron projection morphog enesis	IEA	biological_process
GO:0048843	negative regulation of ax on extension involved in axon guidance	IEA	biological_process
GO:0048850	hypophysis morphogenesis	IEA	biological_process
GO:0050679	positive regulation of ep ithelial cell proliferati on	IEA	biological_process
GO:0050680	negative regulation of ep ithelial cell proliferati on	IEA	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	IEA	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	IMP	biological_process
GO:0050729	positive regulation of in flammatory response	IMP	biological_process
GO:0050919	negative chemotaxis	IEA	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0051216	cartilage development	IEA	biological_process
GO:0051384	response to glucocorticoi d	IEA	biological_process
GO:0051964	negative regulation of sy napse assembly	IEA	biological_process
GO:0055093	response to hyperoxia	IEA	biological_process
GO:0060021	palate development	IMP	biological_process
GO:0060026	convergent extension	IEA	biological_process
GO:0060028	convergent extension invo lved in axis elongation	IEA	biological_process
GO:0060029	convergent extension invo lved in organogenesis	IEA	biological_process
GO:0060065	uterus development	IEA	biological_process
GO:0060067	cervix development	IEA	biological_process
GO:0060068	vagina development	IEA	biological_process
GO:0060070	canonical Wnt signaling p athway	IEA	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	IEA	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	TAS	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	TAS	biological_process
GO:0060157	urinary bladder developme nt	IEA	biological_process
GO:0060324	face development	IMP	biological_process
GO:0060340	positive regulation of ty pe I interferon-mediated signaling pathway	IDA	biological_process
GO:0060599	lateral sprouting involve d in mammary gland duct m orphogenesis	IEA	biological_process
GO:0060606	tube closure	IEA	biological_process
GO:0060638	mesenchymal-epithelial ce ll signaling	IEA	biological_process
GO:0060686	negative regulation of pr ostatic bud formation	IEA	biological_process
GO:0060744	mammary gland branching i nvolved in thelarche	IEA	biological_process
GO:0060750	epithelial cell prolifera tion involved in mammary gland duct elongation	IEA	biological_process
GO:0060760	positive regulation of re sponse to cytokine stimul us	IDA	biological_process
GO:0060762	regulation of branching i nvolved in mammary gland duct morphogenesis	IEA	biological_process
GO:0060775	planar cell polarity path way involved in gastrula mediolateral intercalatio n	IEA	biological_process
GO:0060809	mesodermal to mesenchymal transition involved in g astrulation	IEA	biological_process
GO:0060907	positive regulation of ma crophage cytokine product ion	IMP	biological_process
GO:0061036	positive regulation of ca rtilage development	IEA	biological_process
GO:0061053	somite development	IEA	biological_process
GO:0061347	planar cell polarity path way involved in outflow t ract morphogenesis	IEA	biological_process
GO:0061348	planar cell polarity path way involved in ventricul ar septum morphogenesis	IEA	biological_process
GO:0061349	planar cell polarity path way involved in cardiac r ight atrium morphogenesis	IEA	biological_process
GO:0061350	planar cell polarity path way involved in cardiac m uscle tissue morphogenesi s	IEA	biological_process
GO:0061354	planar cell polarity path way involved in pericardi um morphogenesis	IEA	biological_process
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070245	positive regulation of th ymocyte apoptotic process	IEA	biological_process
GO:0071219	cellular response to mole cule of bacterial origin	IEA	biological_process
GO:0071222	cellular response to lipo polysaccharide	IEP	biological_process
GO:0071277	cellular response to calc ium ion	IEP	biological_process
GO:0071300	cellular response to reti noic acid	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEP	biological_process
GO:0071425	hematopoietic stem cell p roliferation	IEA	biological_process
GO:0071425	hematopoietic stem cell p roliferation	IDA	biological_process
GO:0071542	dopaminergic neuron diffe rentiation	IEA	biological_process
GO:0071560	cellular response to tran sforming growth factor be ta stimulus	IEP	biological_process
GO:0072201	negative regulation of me senchymal cell proliferat ion	IDA	biological_process
GO:0090009	primitive streak formatio n	IEA	biological_process
GO:0090037	positive regulation of pr otein kinase C signaling	IMP	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IEA	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IGI	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IDA	biological_process
GO:0090103	cochlea morphogenesis	IEA	biological_process
GO:0090179	planar cell polarity path way involved in neural tu be closure	IEA	biological_process
GO:0090630	activation of GTPase acti vity	IEA	biological_process
GO:0097325	melanocyte proliferation	IEA	biological_process
GO:1900020	positive regulation of pr otein kinase C activity	IMP	biological_process
GO:1902379	chemoattractant activity involved in axon guidance	IEA	molecular_function
GO:1902474	positive regulation of pr otein localization to syn apse	TAS	biological_process
GO:1903827	regulation of cellular pr otein localization	IEA	biological_process
GO:1904861	excitatory synapse assemb ly	TAS	biological_process
GO:1904862	inhibitory synapse assemb ly	TAS	biological_process
GO:1904934	negative regulation of ce ll proliferation in midbr ain	NAS	biological_process
GO:1904953	Wnt signaling pathway inv olved in midbrain dopamin ergic neuron differentiat ion	NAS	biological_process
GO:1904955	planar cell polarity path way involved in midbrain dopaminergic neuron diffe rentiation	TAS	biological_process
GO:2000049	positive regulation of ce ll-cell adhesion mediated by cadherin	IEA	biological_process
GO:2000052	positive regulation of no n-canonical Wnt signaling pathway	IEA	biological_process
GO:2000484	positive regulation of in terleukin-8 secretion	IEA	biological_process
GO:0000187	activation of MAPK activi ty	IDA	biological_process
GO:0001837	epithelial to mesenchymal transition	IEP	biological_process
GO:0001938	positive regulation of en dothelial cell proliferat ion	IMP	biological_process
GO:0002088	lens development in camer a-type eye	ISS	biological_process
GO:0002741	positive regulation of cy tokine secretion involved in immune response	IMP	biological_process
GO:0003408	optic cup formation invol ved in camera-type eye de velopment	ISS	biological_process
GO:0003700	transcription factor acti vity, sequence-specific D NA binding	IMP	molecular_function
GO:0005109	frizzled binding	IPI	molecular_function
GO:0005115	receptor tyrosine kinase- like orphan receptor bind ing	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005615	extracellular space	IDA	cellular_component
GO:0005788	endoplasmic reticulum lum en	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005796	Golgi lumen	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IMP	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	IDA	biological_process
GO:0007223	Wnt signaling pathway, ca lcium modulating pathway	NAS	biological_process
GO:0007257	activation of JUN kinase activity	IMP	biological_process
GO:0007257	activation of JUN kinase activity	IDA	biological_process
GO:0007411	axon guidance	ISS	biological_process
GO:0007416	synapse assembly	TAS	biological_process
GO:0008584	male gonad development	IEP	biological_process
GO:0010033	response to organic subst ance	IEP	biological_process
GO:0010595	positive regulation of en dothelial cell migration	IMP	biological_process
GO:0010595	positive regulation of en dothelial cell migration	IMP	biological_process
GO:0010820	positive regulation of T cell chemotaxis	IMP	biological_process
GO:0010976	positive regulation of ne uron projection developme nt	ISS	biological_process
GO:0016055	Wnt signaling pathway	IDA	biological_process
GO:0016055	Wnt signaling pathway	TAS	biological_process
GO:0021891	olfactory bulb interneuro n development	ISS	biological_process
GO:0030182	neuron differentiation	ISS	biological_process
GO:0030216	keratinocyte differentiat ion	IEP	biological_process
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030666	endocytic vesicle membran e	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	cellular_component
GO:0030825	positive regulation of cG MP metabolic process	IDA	biological_process
GO:0032148	activation of protein kin ase B activity	IDA	biological_process
GO:0032755	positive regulation of in terleukin-6 production	IMP	biological_process
GO:0034613	cellular protein localiza tion	IDA	biological_process
GO:0035567	non-canonical Wnt signali ng pathway	TAS	biological_process
GO:0042060	wound healing	IDA	biological_process
GO:0043032	positive regulation of ma crophage activation	IMP	biological_process
GO:0043066	negative regulation of ap optotic process	IDA	biological_process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular_function
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IMP	biological_process
GO:0045165	cell fate commitment	IBA	biological_process
GO:0045599	negative regulation of fa t cell differentiation	IMP	biological_process
GO:0045732	positive regulation of pr otein catabolic process	IGI	biological_process
GO:0045766	positive regulation of an giogenesis	IMP	biological_process
GO:0045778	positive regulation of os sification	IMP	biological_process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological_process
GO:0045893	positive regulation of tr anscription, DNA-template d	IMP	biological_process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IMP	biological_process
GO:0048018	receptor agonist activity	IC	molecular_function
GO:0048146	positive regulation of fi broblast proliferation	IDA	biological_process
GO:0048706	embryonic skeletal system development	IMP	biological_process
GO:0048806	genitalia development	IMP	biological_process
GO:0050718	positive regulation of in terleukin-1 beta secretio n	IMP	biological_process
GO:0050729	positive regulation of in flammatory response	IMP	biological_process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological_process
GO:0060021	palate development	IMP	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	TAS	biological_process
GO:0060071	Wnt signaling pathway, pl anar cell polarity pathwa y	TAS	biological_process
GO:0060324	face development	IMP	biological_process
GO:0060340	positive regulation of ty pe I interferon-mediated signaling pathway	IDA	biological_process
GO:0060760	positive regulation of re sponse to cytokine stimul us	IDA	biological_process
GO:0060907	positive regulation of ma crophage cytokine product ion	IMP	biological_process
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0070062	extracellular exosome	TAS	cellular_component
GO:0071222	cellular response to lipo polysaccharide	IEP	biological_process
GO:0071277	cellular response to calc ium ion	IEP	biological_process
GO:0071300	cellular response to reti noic acid	ISS	biological_process
GO:0071346	cellular response to inte rferon-gamma	IEP	biological_process
GO:0071425	hematopoietic stem cell p roliferation	IDA	biological_process
GO:0071560	cellular response to tran sforming growth factor be ta stimulus	IEP	biological_process
GO:0072201	negative regulation of me senchymal cell proliferat ion	IDA	biological_process
GO:0090037	positive regulation of pr otein kinase C signaling	IMP	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IGI	biological_process
GO:0090090	negative regulation of ca nonical Wnt signaling pat hway	IDA	biological_process
GO:1900020	positive regulation of pr otein kinase C activity	IMP	biological_process
GO:1902474	positive regulation of pr otein localization to syn apse	TAS	biological_process
GO:1904861	excitatory synapse assemb ly	TAS	biological_process
GO:1904862	inhibitory synapse assemb ly	TAS	biological_process
GO:1904934	negative regulation of ce ll proliferation in midbr ain	NAS	biological_process
GO:1904953	Wnt signaling pathway inv olved in midbrain dopamin ergic neuron differentiat ion	NAS	biological_process
GO:1904955	planar cell polarity path way involved in midbrain dopaminergic neuron diffe rentiation	TAS	biological_process

KEGG pathways

hsa05200  Pathways in cancer
hsa05166  HTLV-I infection
hsa05205  Proteoglycans in cancer
hsa05224  Breast cancer
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04390  Hippo signaling pathway
hsa04360  Axon guidance
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04916  Melanogenesis
hsa05217  Basal cell carcinoma

Diseases

Associated diseases	References
Endometriosis	PMID: 24661731
Female infertility	PMID: 26667040
Endometriosis	INFBASE24661731
Polycystic ovary syndrome (PCOS)	PMID: 25303486
Preeclampsia	PMID: 26848991
Robinow syndrome	KEGG: H00485, OMIM: 164975

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
24661731	Endometrio sis			69 (30 with end ometriosis, 39 women undergoin g ICSI for male infertility)		WNT4 WNT5a WNT1 ?-catenin BMP4	Show abstract