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Gene id

8743

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

TNFSF10 Gene UCSC Ensembl

Aliases

APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL

Gene name

TNF superfamily member 10

Alternate names

tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, TNF-related apoptosis inducing ligand TRAIL, chemokine tumor necrosis factor ligand superfamily member 10, tumor necrosis factor (ligand) family, member 10, tumor necrosis factor (ligand) superf,

Gene location

3q26.31 (172523506: 172505507) Exons: 6 NC_000003.12

Gene summary(Entrez)

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

OMIM

603598

Protein Summary

Protein general information

P50591

Name: Tumor necrosis factor ligand superfamily member 10 (Apo 2 ligand) (Apo 2L) (TNF related apoptosis inducing ligand) (Protein TRAIL) (CD antigen CD253)

Length: 281 Mass: 32,509

Tissue specificity: Widespread; most predominant in spleen, lung and prostate.

Sequence

MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNS
PCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRK
INSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKS
ARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Structural information

Interpro:	IPR021184 IPR006052 IPR017355 IPR008983
Prosite:	PS00251 PS50049
Pfam:	PF00229
PDB:	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
PDBsum:	1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
DIP:	6230
MINT:	109168
STRING:	ENSP00000241261;

Other Databases

GeneCards: TNFSF10; Malacards: TNFSF10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005102	receptor binding	TAS	molecular_function
GO:0005102	receptor binding	TAS	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	TAS	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IEP	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0090200	positive regulation of re lease of cytochrome c fro m mitochondria	IDA	biological_process
GO:0097296	activation of cysteine-ty pe endopeptidase activity involved in apoptotic si gnaling pathway	TAS	biological_process
GO:1902041	regulation of extrinsic a poptotic signaling pathwa y via death domain recept ors	TAS	biological_process
GO:1902042	negative regulation of ex trinsic apoptotic signali ng pathway via death doma in receptors	TAS	biological_process
GO:1902042	negative regulation of ex trinsic apoptotic signali ng pathway via death doma in receptors	TAS	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:0005102	receptor binding	TAS	molecular_function
GO:0005102	receptor binding	TAS	molecular_function
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0006915	apoptotic process	IEA	biological_process
GO:0006915	apoptotic process	TAS	biological_process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	TAS	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0032813	tumor necrosis factor rec eptor superfamily binding	IEA	molecular_function
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IEP	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0090200	positive regulation of re lease of cytochrome c fro m mitochondria	IDA	biological_process
GO:0097296	activation of cysteine-ty pe endopeptidase activity involved in apoptotic si gnaling pathway	TAS	biological_process
GO:1902041	regulation of extrinsic a poptotic signaling pathwa y via death domain recept ors	TAS	biological_process
GO:1902042	negative regulation of ex trinsic apoptotic signali ng pathway via death doma in receptors	TAS	biological_process
GO:1902042	negative regulation of ex trinsic apoptotic signali ng pathway via death doma in receptors	TAS	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IEA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:0005102	receptor binding	TAS	molecular_function
GO:0005102	receptor binding	TAS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	TAS	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007165	signal transduction	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0043065	positive regulation of ap optotic process	IDA	biological_process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IEP	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0090200	positive regulation of re lease of cytochrome c fro m mitochondria	IDA	biological_process
GO:0097296	activation of cysteine-ty pe endopeptidase activity involved in apoptotic si gnaling pathway	TAS	biological_process
GO:1902041	regulation of extrinsic a poptotic signaling pathwa y via death domain recept ors	TAS	biological_process
GO:1902042	negative regulation of ex trinsic apoptotic signali ng pathway via death doma in receptors	TAS	biological_process
GO:1902042	negative regulation of ex trinsic apoptotic signali ng pathway via death doma in receptors	TAS	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process
GO:2001238	positive regulation of ex trinsic apoptotic signali ng pathway	IDA	biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa05164  Influenza A
hsa04068  FoxO signaling pathway
hsa04210  Apoptosis
hsa05162  Measles
hsa04650  Natural killer cell mediated cytotoxicity
hsa04217  Necroptosis

Diseases

Associated diseases	References
Endometriosis	PMID: 22392486
Endometriosis	INFBASE22392486
Male Infertility	PMID: 21317160
Male infertility	PMID: 24825910
Multiple sclerosis	PMID: 16040132
Systemic lupus erythematosus	PMID: 18174230

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
15242994	Endometrio sis			64		OPG TRAIL	Show abstract
22392486	Endometrio sis	TRAIL (c.49G>A, c.592A>G, c.615A>G, and c.662T>C; DR4 c.626G>C and c.1322A>G; DR5 c.95C>T, c.200C>T, and c.72T>G), OPG -(245T>G, c.9C>G, c.788A>C, and c.9938G>T)	Korean	352 (138 women with endometrio sis, 214 women without endomet riosis)		TRAIL OPG	Show abstract