Endometriosis Knowledgebase

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Gene id

8844

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

KSR1 Gene UCSC Ensembl

Aliases

KSR, RSU2

Gene name

kinase suppressor of ras 1

Alternate names

kinase suppressor of Ras 1,

Gene location

17q11.2 (27456440: 27626437) Exons: 31 NC_000017.11

OMIM

601132

Protein Summary

Protein general information

Q8IVT5

Name: Kinase suppressor of Ras 1

Length: 923 Mass: 102,160

Sequence

MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRT
LEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEIPRDLTLDALLEMNEAKVKETLRRC
GASGDECGRLQYALTCLRKVTGLGGEHKEDSSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGP
RSISVSALPASDSPTPSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVCHVCQKSMIFGVKCKH
CRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAEPHFGTLPKALTKKEHPPAMNHLDSSSNPSS
TTSSTPSSPAPFPTSSNPSSATTPPNPSPGQRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAF
NISAFAHAAPLPEAADGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLFMGA
CMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITD
FGLFGISGVVREGRRENQLKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQA
AEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
SSKVVPRFERFGLGVLESSNPKM

Structural information

Protein Domains	Protein (613-883)
Interpro:	IPR011009 IPR025561 IPR002219 IPR000719 IPR001245 IPR008271
Prosite:	PS50011 PS00108 PS00479 PS50081
Pfam:	PF13543 PF07714
CDD:	cd00029
DIP:	32619
MINT:	87143
STRING:	ENSP00000323178;

Other Databases

GeneCards: KSR1; Malacards: KSR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000165	MAPK cascade	TAS	biological_process
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0005078	MAP-kinase scaffold activ ity	ISS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005783	endoplasmic reticulum	IDA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0007265	Ras protein signal transd uction	ISS	biological_process
GO:0007265	Ras protein signal transd uction	NAS	biological_process
GO:0008022	protein C-terminus bindin g	IDA	molecular_function
GO:0016020	membrane	IDA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0019933	cAMP-mediated signaling	ISS	biological_process
GO:0031434	mitogen-activated protein kinase kinase binding	IEA	molecular_function
GO:0043234	protein complex	IDA	cellular_component
GO:0043410	positive regulation of MA PK cascade	ISS	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0000165	MAPK cascade	TAS	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0005078	MAP-kinase scaffold activ ity	IEA	molecular_function
GO:0005078	MAP-kinase scaffold activ ity	ISS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0005783	endoplasmic reticulum	IDA	cellular_component
GO:0005789	endoplasmic reticulum mem brane	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0007265	Ras protein signal transd uction	ISS	biological_process
GO:0007265	Ras protein signal transd uction	NAS	biological_process
GO:0008022	protein C-terminus bindin g	IDA	molecular_function
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0019933	cAMP-mediated signaling	ISS	biological_process
GO:0031434	mitogen-activated protein kinase kinase binding	IEA	molecular_function
GO:0035556	intracellular signal tran sduction	IEA	biological_process
GO:0043234	protein complex	IDA	cellular_component
GO:0043410	positive regulation of MA PK cascade	IEA	biological_process
GO:0043410	positive regulation of MA PK cascade	ISS	biological_process
GO:0046872	metal ion binding	IEA	molecular_function
GO:0000165	MAPK cascade	TAS	biological_process
GO:0004672	protein kinase activity	NAS	molecular_function
GO:0005078	MAP-kinase scaffold activ ity	ISS	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005783	endoplasmic reticulum	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0007265	Ras protein signal transd uction	ISS	biological_process
GO:0007265	Ras protein signal transd uction	NAS	biological_process
GO:0008022	protein C-terminus bindin g	IDA	molecular_function
GO:0016020	membrane	IDA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0019933	cAMP-mediated signaling	ISS	biological_process
GO:0043234	protein complex	IDA	cellular_component
GO:0043410	positive regulation of MA PK cascade	ISS	biological_process

KEGG pathways

hsa04014 Ras signaling pathway
hsa05152 Tuberculosis

Diseases

Associated diseases	References
Endometriosis	PMID: 16210010
Endometriosis	INFBASE16210010

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
16210010	Endometrio sis					RON SOS 14-3-3 protein eta KSR PI3K p85and uPAR	Show abstract