Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Search Result


Gene id 94025
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol MUC16   Gene   UCSC   Ensembl
Aliases CA125
Gene name mucin 16, cell surface associated
Alternate names mucin-16, CA125 ovarian cancer antigen, ovarian cancer-related tumor marker CA125, ovarian carcinoma antigen CA125,
Gene location 19p13.2 (9010389: 8848839)     Exons: 88     NC_000019.10
OMIM 606154

Protein Summary
Protein general information Q8WXI7  

Name: Mucin 16 (MUC 16) (Ovarian cancer related tumor marker CA125) (CA 125) (Ovarian carcinoma antigen CA125)

Length: 14507  Mass: 1,519,175

Tissue specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO

Sequence MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLSPKTSTGAIVVTEHTLPFTSPDKTLASPTSSVVGRT
TQSLGVMSSALPESTSRGMTHSEQRTSPSLSPQVNGTPSRNYPATSMVSGLSSPRTRTSSTEGNFTKEASTYTLT
VETTSGPVTEKYTVPTETSTTEGDSTETPWDTRYIPVKITSPMKTFADSTASKENAPVSMTPAETTVTDSHTPGR
TNPSFGTLYSSFLDLSPKGTPNSRGETSLELILSTTGYPFSSPEPGSAGHSRISTSAPLSSSASVLDNKISETSI
FSGQSLTSPLSPGVPEARASTMPNSAIPFSMTLSNAETSAERVRSTISSLGTPSISTKQTAETILTFHAFAETMD
IPSTHIAKTLASEWLGSPGTLGGTSTSALTTTSPSTTLVSEETNTHHSTSGKETEGTLNTSMTPLETSAPGEESE
MTATLVPTLGFTTLDSKIRSPSQVSSSHPTRELRTTGSTSGRQSSSTAAHGSSDILRATTSSTSKASSWTSESTA
QQFSEPQHTQWVETSPSMKTERPPASTSVAAPITTSVPSVVSGFTTLKTSSTKGIWLEETSADTLIGESTAGPTT
HQFAVPTGISMTGGSSTRGSQGTTHLLTRATASSETSADLTLATNGVPVSVSPAVSKTAAGSSPPGGTKPSYTMV
SSVIPETSSLQSSAFREGTSLGLTPLNTRHPFSSPEPDSAGHTKISTSIPLLSSASVLEDKVSATSTFSHHKATS
SITTGTPEISTKTKPSSAVLSSMTLSNAATSPERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPNIHPTG
TLTSESSESPSTLSLPSVSGVKTTFSSSTPSTHLFTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPTPVFPT
MDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALPKISHLTGTATMSQTNRDTFNDSAAPQSTTWPETSPRFK
TGLPSATTTVSTSATSLSATVMVSKFTSPATSSMEATSIREPSTTILTTETTNGPGSMAVASTNIPIGKGYITEG
RLDTSHLPIGTTASSETSMDFTMAKESVSMSVSPSQSMDAAGSSTPGRTSQFVDTFSDDVYHLTSREITIPRDGT
SSALTPQMTATHPPSPDPGSARSTWLGILSSSPSSPTPKVTMSSTFSTQRVTTSMIMDTVETSRWNMPNLPSTTS
LTPSNIPTSGAIGKSTLVPLDTPSPATSLEASEGGLPTLSTYPESTNTPSIHLGAHASSESPSTIKLTMASVVKP
GSYTPLTFPSIETHIHVSTARMAYSSGSSPEMTAPGETNTGSTWDPTTYITTTDPKDTSSAQVSTPHSVRTLRTT
ENHPKTESATPAAYSGSPKISSSPNLTSPATKAWTITDTTEHSTQLHYTKLAEKSSGFETQSAPGPVSVVIPTSP
TIGSSTLELTSDVPGEPLVLAPSEQTTITLPMATWLSTSLTEEMASTDLDISSPSSPMSTFAIFPPMSTPSHELS
KSEADTSAIRNTDSTTLDQHLGIRSLGRTGDLTTVPITPLTTTWTSVIEHSTQAQDTLSATMSPTHVTQSLKDQT
SIPASASPSHLTEVYPELGTQGRSSSEATTFWKPSTDTLSREIETGPTNIQSTPPMDNTTTGSSSSGVTLGIAHL
PIGTSSPAETSTNMALERRSSTATVSMAGTMGLLVTSAPGRSISQSLGRVSSVLSESTTEGVTDSSKGSSPRLNT
QGNTALSSSLEPSYAEGSQMSTSIPLTSSPTTPDVEFIGGSTFWTKEVTTVMTSDISKSSARTESSSATLMSTAL
GSTENTGKEKLRTASMDLPSPTPSMEVTPWISLTLSNAPNTTDSLDLSHGVHTSSAGTLATDRSLNTGVTRASRL
ENGSDTSSKSLSMGNSTHTSMTYTEKSEVSSSIHPRPETSAPGAETTLTSTPGNRAISLTLPFSSIPVEEVISTG
ITSGPDINSAPMTHSPITPPTIVWTSTGTIEQSTQPLHAVSSEKVSVQTQSTPYVNSVAVSASPTHENSVSSGSS
TSSPYSSASLESLDSTISRRNAITSWLWDLTTSLPTTTWPSTSLSEALSSGHSGVSNPSSTTTEFPLFSAASTSA
AKQRNPETETHGPQNTAASTLNTDASSVTGLSETPVGASISSEVPLPMAITSRSDVSGLTSESTANPSLGTASSA
GTKLTRTISLPTSESLVSFRMNKDPWTVSIPLGSHPTTNTETSIPVNSAGPPGLSTVASDVIDTPSDGAESIPTV
SFSPSPDTEVTTISHFPEKTTHSFRTISSLTHELTSRVTPIPGDWMSSAMSTKPTGASPSITLGERRTITSAAPT
TSPIVLTASFTETSTVSLDNETTVKTSDILDARKTNELPSDSSSSSDLINTSIASSTMDVTKTASISPTSISGMT
ASSSPSLFSSDRPQVPTSTTETNTATSPSVSSNTYSLDGGSNVGGTPSTLPPFTITHPVETSSALLAWSRPVRTF
STMVSTDTASGENPTSSNSVVTSVPAPGTWTSVGSTTDLPAMGFLKTSPAGEAHSLLASTIEPATAFTPHLSAAV
VTGSSATSEASLLTTSESKAIHSSPQTPTTPTSGANWETSATPESLLVVTETSDTTLTSKILVTDTILFSTVSTP
PSKFPSTGTLSGASFPTLLPDTPAIPLTATEPTSSLATSFDSTPLVTIASDSLGTVPETTLTMSETSNGDALVLK
TVSNPDRSIPGITIQGVTESPLHPSSTSPSKIVAPRNTTYEGSITVALSTLPAGTTGSLVFSQSSENSETTALVD
SSAGLERASVMPLTTGSQGMASSGGIRSGSTHSTGTKTFSSLPLTMNPGEVTAMSEITTNRLTATQSTAPKGIPV
KPTSAESGLLTPVSASSSPSKAFASLTTAPPTWGIPQSTLTFEFSEVPSLDTKSASLPTPGQSLNTIPDSDASTA
SSSLSKSPEKNPRARMMTSTKAISASSFQSTGFTETPEGSASPSMAGHEPRVPTSGTGDPRYASESMSYPDPSKA
SSAMTSTSLASKLTTLFSTGQAARSGSSSSPISLSTEKETSFLSPTASTSRKTSLFLGPSMARQPNILVHLQTSA
LTLSPTSTLNMSQEEPPELTSSQTIAEEEGTTAETQTLTFTPSETPTSLLPVSSPTEPTARRKSSPETWASSISV
PAKTSLVETTDGTLVTTIKMSSQAAQGNSTWPAPAEETGSSPAGTSPGSPEMSTTLKIMSSKEPSISPEIRSTVR
NSPWKTPETTVPMETTVEPVTLQSTALGSGSTSISHLPTGTTSPTKSPTENMLATERVSLSPSPPEAWTNLYSGT
PGGTRQSLATMSSVSLESPTARSITGTGQQSSPELVSKTTGMEFSMWHGSTGGTTGDTHVSLSTSSNILEDPVTS
PNSVSSLTDKSKHKTETWVSTTAIPSTVLNNKIMAAEQQTSRSVDEAYSSTSSWSDQTSGSDITLGASPDVTNTL
YITSTAQTTSLVSLPSGDQGITSLTNPSGGKTSSASSVTSPSIGLETLRANVSAVKSDIAPTAGHLSQTSSPAEV
SILDVTTAPTPGISTTITTMGTNSISTTTPNPEVGMSTMDSTPATERRTTSTEHPSTWSSTAASDSWTVTDMTSN
LKVARSPGTISTMHTTSFLASSTELDSMSTPHGRITVIGTSLVTPSSDASAVKTETSTSERTLSPSDTTASTPIS
TFSRVQRMSISVPDILSTSWTPSSTEAEDVPVSMVSTDHASTKTDPNTPLSTFLFDSLSTLDWDTGRSLSSATAT
TSAPQGATTPQELTLETMISPATSQLPFSIGHITSAVTPAAMARSSGVTFSRPDPTSKKAEQTSTQLPTTTSAHP
GQVPRSAATTLDVIPHTAKTPDATFQRQGQTALTTEARATSDSWNEKEKSTPSAPWITEMMNSVSEDTIKEVTSS
SSVLRTLNTLDINLESGTTSSPSWKSSPYERIAPSESTTDKEAIHPSTNTVETTGWVTSSEHASHSTIPAHSASS
KLTSPVVTTSTREQAIVSMSTTTWPESTRARTEPNSFLTIELRDVSPYMDTSSTTQTSIISSPGSTAITKGPRTE
ITSSKRISSSFLAQSMRSSDSPSEAITRLSNFPAMTESGGMILAMQTSPPGATSLSAPTLDTSATASWTGTPLAT
TQRFTYSEKTTLFSKGPEDTSQPSPPSVEETSSSSSLVPIHATTSPSNILLTSQGHSPSSTPPVTSVFLSETSGL
GKTTDMSRISLEPGTSLPPNLSSTAGEALSTYEASRDTKAIHHSADTAVTNMEATSSEYSPIPGHTKPSKATSPL
VTSHIMGDITSSTSVFGSSETTEIETVSSVNQGLQERSTSQVASSATETSTVITHVSSGDATTHVTKTQATFSSG
TSISSPHQFITSTNTFTDVSTNPSTSLIMTESSGVTITTQTGPTGAATQGPYLLDTSTMPYLTETPLAVTPDFMQ
SEKTTLISKGPKDVSWTSPPSVAETSYPSSLTPFLVTTIPPATSTLQGQHTSSPVSATSVLTSGLVKTTDMLNTS
MEPVTNSPQNLNNPSNEILATLAATTDIETIHPSINKAVTNMGTASSAHVLHSTLPVSSEPSTATSPMVPASSMG
DALASISIPGSETTDIEGEPTSSLTAGRKENSTLQEMNSTTESNIILSNVSVGAITEATKMEVPSFDATFIPTPA
QSTKFPDIFSVASSRLSNSPPMTISTHMTTTQTGSSGATSKIPLALDTSTLETSAGTPSVVTEGFAHSKITTAMN
NDVKDVSQTNPPFQDEASSPSSQAPVLVTTLPSSVAFTPQWHSTSSPVSMSSVLTSSLVKTAGKVDTSLETVTSS
PQSMSNTLDDISVTSAATTDIETTHPSINTVVTNVGTTGSAFESHSTVSAYPEPSKVTSPNVTTSTMEDTTISRS
IPKSSKTTRTETETTSSLTPKLRETSISQEITSSTETSTVPYKELTGATTEVSRTDVTSSSSTSFPGPDQSTVSL
DISTETNTRLSTSPIMTESAEITITTQTGPHGATSQDTFTMDPSNTTPQAGIHSAMTHGFSQLDVTTLMSRIPQD
VSWTSPPSVDKTSSPSSFLSSPAMTTPSLISSTLPEDKLSSPMTSLLTSGLVKITDILRTRLEPVTSSLPNFSST
SDKILATSKDSKDTKEIFPSINTEETNVKANNSGHESHSPALADSETPKATTQMVITTTVGDPAPSTSMPVHGSS
ETTNIKREPTYFLTPRLRETSTSQESSFPTDTSFLLSKVPTGTITEVSSTGVNSSSKISTPDHDKSTVPPDTFTG
EIPRVFTSSIKTKSAEMTITTQASPPESASHSTLPLDTSTTLSQGGTHSTVTQGFPYSEVTTLMGMGPGNVSWMT
TPPVEETSSVSSLMSSPAMTSPSPVSSTSPQSIPSSPLPVTALPTSVLVTTTDVLGTTSPESVTSSPPNLSSITH
ERPATYKDTAHTEAAMHHSTNTAVTNVGTSGSGHKSQSSVLADSETSKATPLMSTTSTLGDTSVSTSTPNISQTN
QIQTEPTASLSPRLRESSTSEKTSSTTETNTAFSYVPTGAITQASRTEISSSRTSISDLDRPTIAPDISTGMITR
LFTSPIMTKSAEMTVTTQTTTPGATSQGILPWDTSTTLFQGGTHSTVSQGFPHSEITTLRSRTPGDVSWMTTPPV
EETSSGFSLMSPSMTSPSPVSSTSPESIPSSPLPVTALLTSVLVTTTNVLGTTSPEPVTSSPPNLSSPTQERLTT
YKDTAHTEAMHASMHTNTAVANVGTSISGHESQSSVPADSHTSKATSPMGITFAMGDTSVSTSTPAFFETRIQTE
STSSLIPGLRDTRTSEEINTVTETSTVLSEVPTTTTTEVSRTEVITSSRTTISGPDHSKMSPYISTETITRLSTF
PFVTGSTEMAITNQTGPIGTISQATLTLDTSSTASWEGTHSPVTQRFPHSEETTTMSRSTKGVSWQSPPSVEETS
SPSSPVPLPAITSHSSLYSAVSGSSPTSALPVTSLLTSGRRKTIDMLDTHSELVTSSLPSASSFSGEILTSEAST
NTETIHFSENTAETNMGTTNSMHKLHSSVSIHSQPSGHTPPKVTGSMMEDAIVSTSTPGSPETKNVDRDSTSPLT
PELKEDSTALVMNSTTESNTVFSSVSLDAATEVSRAEVTYYDPTFMPASAQSTKSPDISPEASSSHSNSPPLTIS
THKTIATQTGPSGVTSLGQLTLDTSTIATSAGTPSARTQDFVDSETTSVMNNDLNDVLKTSPFSAEEANSLSSQA
PLLVTTSPSPVTSTLQEHSTSSLVSVTSVPTPTLAKITDMDTNLEPVTRSPQNLRNTLATSEATTDTHTMHPSIN
TAVANVGTTSSPNEFYFTVSPDSDPYKATSAVVITSTSGDSIVSTSMPRSSAMKKIESETTFSLIFRLRETSTSQ
KIGSSSDTSTVFDKAFTAATTEVSRTELTSSSRTSIQGTEKPTMSPDTSTRSVTMLSTFAGLTKSEERTIATQTG
PHRATSQGTLTWDTSITTSQAGTHSAMTHGFSQLDLSTLTSRVPEYISGTSPPSVEKTSSSSSLLSLPAITSPSP
VPTTLPESRPSSPVHLTSLPTSGLVKTTDMLASVASLPPNLGSTSHKIPTTSEDIKDTEKMYPSTNIAVTNVGTT
TSEKESYSSVPAYSEPPKVTSPMVTSFNIRDTIVSTSMPGSSEITRIEMESTFSLAHGLKGTSTSQDPIVSTEKS
AVLHKLTTGATETSRTEVASSRRTSIPGPDHSTESPDISTEVIPSLPISLGITESSNMTIITRTGPPLGSTSQGT
FTLDTPTTSSRAGTHSMATQEFPHSEMTTVMNKDPEILSWTIPPSIEKTSFSSSLMPSPAMTSPPVSSTLPKTIH
TTPSPMTSLLTPSLVMTTDTLGTSPEPTTSSPPNLSSTSHEILTTDEDTTAIEAMHPSTSTAATNVETTSSGHGS
QSSVLADSEKTKATAPMDTTSTMGHTTVSTSMSVSSETTKIKRESTYSLTPGLRETSISQNASFSTDTSIVLSEV
PTGTTAEVSRTEVTSSGRTSIPGPSQSTVLPEISTRTMTRLFASPTMTESAEMTIPTQTGPSGSTSQDTLTLDTS
TTKSQAKTHSTLTQRFPHSEMTTLMSRGPGDMSWQSSPSLENPSSLPSLLSLPATTSPPPISSTLPVTISSSPLP
VTSLLTSSPVTTTDMLHTSPELVTSSPPKLSHTSDERLTTGKDTTNTEAVHPSTNTAASNVEIPSSGHESPSSAL
ADSETSKATSPMFITSTQEDTTVAISTPHFLETSRIQKESISSLSPKLRETGSSVETSSAIETSAVLSEVSIGAT
TEISRTEVTSSSRTSISGSAESTMLPEISTTRKIIKFPTSPILAESSEMTIKTQTSPPGSTSESTFTLDTSTTPS
LVITHSTMTQRLPHSEITTLVSRGAGDVPRPSSLPVEETSPPSSQLSLSAMISPSPVSSTLPASSHSSSASVTSL
LTPGQVKTTEVLDASAEPETSSPPSLSSTSVEILATSEVTTDTEKIHPFSNTAVTKVGTSSSGHESPSSVLPDSE
TTKATSAMGTISIMGDTSVSTLTPALSNTRKIQSEPASSLTTRLRETSTSEETSLATEANTVLSKVSTGATTEVS
RTEAISFSRTSMSGPEQSTMSQDISIGTIPRISASSVLTESAKMTITTQTGPSESTLESTLNLNTATTPSWVETH
SIVIQGFPHPEMTTSMGRGPGGVSWPSPPFVKETSPPSSPLSLPAVTSPHPVSTTFLAHIPPSPLPVTSLLTSGP
ATTTDILGTSTEPGTSSSSSLSTTSHERLTTYKDTAHTEAVHPSTNTGGTNVATTSSGYKSQSSVLADSSPMCTT
STMGDTSVLTSTPAFLETRRIQTELASSLTPGLRESSGSEGTSSGTKMSTVLSKVPTGATTEISKEDVTSIPGPA
QSTISPDISTRTVSWFSTSPVMTESAEITMNTHTSPLGATTQGTSTLDTSSTTSLTMTHSTISQGFSHSQMSTLM
RRGPEDVSWMSPPLLEKTRPSFSLMSSPATTSPSPVSSTLPESISSSPLPVTSLLTSGLAKTTDMLHKSSEPVTN
SPANLSSTSVEILATSEVTTDTEKTHPSSNRTVTDVGTSSSGHESTSFVLADSQTSKVTSPMVITSTMEDTSVST
STPGFFETSRIQTEPTSSLTLGLRKTSSSEGTSLATEMSTVLSGVPTGATAEVSRTEVTSSSRTSISGFAQLTVS
PETSTETITRLPTSSIMTESAEMMIKTQTDPPGSTPESTHTVDISTTPNWVETHSTVTQRFSHSEMTTLVSRSPG
DMLWPSQSSVEETSSASSLLSLPATTSPSPVSSTLVEDFPSASLPVTSLLNPGLVITTDRMGISREPGTSSTSNL
SSTSHERLTTLEDTVDTEDMQPSTHTAVTNVRTSISGHESQSSVLSDSETPKATSPMGTTYTMGETSVSISTSDF
FETSRIQIEPTSSLTSGLRETSSSERISSATEGSTVLSEVPSGATTEVSRTEVISSRGTSMSGPDQFTISPDIST
EAITRLSTSPIMTESAESAITIETGSPGATSEGTLTLDTSTTTFWSGTHSTASPGFSHSEMTTLMSRTPGDVPWP
SLPSVEEASSVSSSLSSPAMTSTSFFSTLPESISSSPHPVTALLTLGPVKTTDMLRTSSEPETSSPPNLSSTSAE
ILATSEVTKDREKIHPSSNTPVVNVGTVIYKHLSPSSVLADLVTTKPTSPMATTSTLGNTSVSTSTPAFPETMMT
QPTSSLTSGLREISTSQETSSATERSASLSGMPTGATTKVSRTEALSLGRTSTPGPAQSTISPEISTETITRIST
PLTTTGSAEMTITPKTGHSGASSQGTFTLDTSSRASWPGTHSAATHRSPHSGMTTPMSRGPEDVSWPSRPSVEKT
SPPSSLVSLSAVTSPSPLYSTPSESSHSSPLRVTSLFTPVMMKTTDMLDTSLEPVTTSPPSMNITSDESLATSKA
TMETEAIQLSENTAVTQMGTISARQEFYSSYPGLPEPSKVTSPVVTSSTIKDIVSTTIPASSEITRIEMESTSTL
TPTPRETSTSQEIHSATKPSTVPYKALTSATIEDSMTQVMSSSRGPSPDQSTMSQDISTEVITRLSTSPIKTEST
EMTITTQTGSPGATSRGTLTLDTSTTFMSGTHSTASQGFSHSQMTALMSRTPGDVPWLSHPSVEEASSASFSLSS
PVMTSSSPVSSTLPDSIHSSSLPVTSLLTSGLVKTTELLGTSSEPETSSPPNLSSTSAEILAITEVTTDTEKLEM
TNVVTSGYTHESPSSVLADSVTTKATSSMGITYPTGDTNVLTSTPAFSDTSRIQTKSKLSLTPGLMETSISEETS
SATEKSTVLSSVPTGATTEVSRTEAISSSRTSIPGPAQSTMSSDTSMETITRISTPLTRKESTDMAITPKTGPSG
ATSQGTFTLDSSSTASWPGTHSATTQRFPQSVVTTPMSRGPEDVSWPSPLSVEKNSPPSSLVSSSSVTSPSPLYS
TPSGSSHSSPVPVTSLFTSIMMKATDMLDASLEPETTSAPNMNITSDESLAASKATTETEAIHVFENTAASHVET
TSATEELYSSSPGFSEPTKVISPVVTSSSIRDNMVSTTMPGSSGITRIEIESMSSLTPGLRETRTSQDITSSTET
STVLYKMPSGATPEVSRTEVMPSSRTSIPGPAQSTMSLDISDEVVTRLSTSPIMTESAEITITTQTGYSLATSQV
TLPLGTSMTFLSGTHSTMSQGLSHSEMTNLMSRGPESLSWTSPRFVETTRSSSSLTSLPLTTSLSPVSSTLLDSS
PSSPLPVTSLILPGLVKTTEVLDTSSEPKTSSSPNLSSTSVEIPATSEIMTDTEKIHPSSNTAVAKVRTSSSVHE
SHSSVLADSETTITIPSMGITSAVDDTTVFTSNPAFSETRRIPTEPTFSLTPGFRETSTSEETTSITETSAVLYG
VPTSATTEVSMTEIMSSNRIHIPDSDQSTMSPDIITEVITRLSSSSMMSESTQMTITTQKSSPGATAQSTLTLAT
TTAPLARTHSTVPPRFLHSEMTTLMSRSPENPSWKSSLFVEKTSSSSSLLSLPVTTSPSVSSTLPQSIPSSSFSV
TSLLTPGMVKTTDTSTEPGTSLSPNLSGTSVEILAASEVTTDTEKIHPSSSMAVTNVGTTSSGHELYSSVSIHSE
PSKATYPVGTPSSMAETSISTSMPANFETTGFEAEPFSHLTSGFRKTNMSLDTSSVTPTNTPSSPGSTHLLQSSK
TDFTSSAKTSSPDWPPASQYTEIPVDIITPFNASPSITESTGITSFPESRFTMSVTESTHHLSTDLLPSAETIST
GTVMPSLSEAMTSFATTGVPRAISGSGSPFSRTESGPGDATLSTIAESLPSSTPVPFSSSTFTTTDSSTIPALHE
ITSSSATPYRVDTSLGTESSTTEGRLVMVSTLDTSSQPGRTSSSPILDTRMTESVELGTVTSAYQVPSLSTRLTR
TDGIMEHITKIPNEAAHRGTIRPVKGPQTSTSPASPKGLHTGGTKRMETTTTALKTTTTALKTTSRATLTTSVYT
PTLGTLTPLNASMQMASTIPTEMMITTPYVFPDVPETTSSLATSLGAETSTALPRTTPSVFNRESETTASLVSRS
GAERSPVIQTLDVSSSEPDTTASWVIHPAETIPTVSKTTPNFFHSELDTVSSTATSHGADVSSAIPTNISPSELD
ALTPLVTISGTDTSTTFPTLTKSPHETETRTTWLTHPAETSSTIPRTIPNFSHHESDATPSIATSPGAETSSAIP
IMTVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGEPKTIASLVTHPEAQTSSAIPTSTISPAVSRLVTSMVTSL
AAKTSTTNRALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFHSKSDTTPSMTTSHGAESSSAVPTPTVSTEVP
GVVTPLVTSSRAVISTTIPILTLSPGEPETTPSMATSHGEEASSAIPTPTVSPGVPGVVTSLVTSSRAVTSTTIP
ILTFSLGEPETTPSMATSHGTEAGSAVPTVLPEVPGMVTSLVASSRAVTSTTLPTLTLSPGEPETTPSMATSHGA
EASSTVPTVSPEVPGVVTSLVTSSSGVNSTSIPTLILSPGELETTPSMATSHGAEASSAVPTPTVSPGVSGVVTP
LVTSSRAVTSTTIPILTLSSSEPETTPSMATSHGVEASSAVLTVSPEVPGMVTSLVTSSRAVTSTTIPTLTISSD
EPETTTSLVTHSEAKMISAIPTLAVSPTVQGLVTSLVTSSGSETSAFSNLTVASSQPETIDSWVAHPGTEASSVV
PTLTVSTGEPFTNISLVTHPAESSSTLPRTTSRFSHSELDTMPSTVTSPEAESSSAISTTISPGIPGVLTSLVTS
SGRDISATFPTVPESPHESEATASWVTHPAVTSTTVPRTTPNYSHSEPDTTPSIATSPGAEATSDFPTITVSPDV
PDMVTSQVTSSGTDTSITIPTLTLSSGEPETTTSFITYSETHTSSAIPTLPVSPGASKMLTSLVISSGTDSTTTF
PTLTETPYEPETTAIQLIHPAETNTMVPRTTPKFSHSKSDTTLPVAITSPGPEASSAVSTTTISPDMSDLVTSLV
PSSGTDTSTTFPTLSETPYEPETTATWLTHPAETSTTVSGTIPNFSHRGSDTAPSMVTSPGVDTRSGVPTTTIPP
SIPGVVTSQVTSSATDTSTAIPTLTPSPGEPETTASSATHPGTQTGFTVPIRTVPSSEPDTMASWVTHPPQTSTP
VSRTTSSFSHSSPDATPVMATSPRTEASSAVLTTISPGAPEMVTSQITSSGAATSTTVPTLTHSPGMPETTALLS
THPRTETSKTFPASTVFPQVSETTASLTIRPGAETSTALPTQTTSSLFTLLVTGTSRVDLSPTASPGVSAKTAPL
STHPGTETSTMIPTSTLSLGLLETTGLLATSSSAETSTSTLTLTVSPAVSGLSSASITTDKPQTVTSWNTETSPS
VTSVGPPEFSRTVTGTTMTLIPSEMPTPPKTSHGEGVSPTTILRTTMVEATNLATTGSSPTVAKTTTTFNTLAGS
LFTPLTTPGMSTLASESVTSRTSYNHRSWISTTSSYNRRYWTPATSTPVTSTFSPGISTSSIPSSTAATVPFMVP
FTLNFTITNLQYEEDMRHPGSRKFNATERELQGLLKPLFRNSSLEYLYSGCRLASLRPEKDSSATAVDAICTHRP
DPEDLGLDRERLYWELSNLTNGIQELGPYTLDRNSLYVNGFTHRSSMPTTSTPGTSTVDVGTSGTPSSSPSPTTA
GPLLMPFTLNFTITNLQYEEDMRRTGSRKFNTMESVLQGLLKPLFKNTSVGPLYSGCRLTLLRPEKDGAATGVDA
ICTHRLDPKSPGLNREQLYWELSKLTNDIEELGPYTLDRNSLYVNGFTHQSSVSTTSTPGTSTVDLRTSGTPSSL
SSPTIMAAGPLLVPFTLNFTITNLQYGEDMGHPGSRKFNTTERVLQGLLGPIFKNTSVGPLYSGCRLTSLRSEKD
GAATGVDAICIHHLDPKSPGLNRERLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHRTSVPTSSTPGTSTVDLG
TSGTPFSLPSPATAGPLLVLFTLNFTITNLKYEEDMHRPGSRKFNTTERVLQTLLGPMFKNTSVGLLYSGCRLTL
LRSEKDGAATGVDAICTHRLDPKSPGVDREQLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHWIPVPTSSTPGT
STVDLGSGTPSSLPSPTTAGPLLVPFTLNFTITNLKYEEDMHCPGSRKFNTTERVLQSLLGPMFKNTSVGPLYSG
CRLTLLRSEKDGAATGVDAICTHRLDPKSPGVDREQLYWELSQLTNGIKELGPYTLDRNSLYVNGFTHQTSAPNT
STPGTSTVDLGTSGTPSSLPSPTSAGPLLVPFTLNFTITNLQYEEDMHHPGSRKFNTTERVLQGLLGPMFKNTSV
GLLYSGCRLTLLRPEKNGAATGMDAICSHRLDPKSPGLNREQLYWELSQLTHGIKELGPYTLDRNSLYVNGFTHR
SSVAPTSTPGTSTVDLGTSGTPSSLPSPTTAVPLLVPFTLNFTITNLQYGEDMRHPGSRKFNTTERVLQGLLGPL
FKNSSVGPLYSGCRLISLRSEKDGAATGVDAICTHHLNPQSPGLDREQLYWQLSQMTNGIKELGPYTLDRNSLYV
NGFTHRSSGLTTSTPWTSTVDLGTSGTPSPVPSPTTTGPLLVPFTLNFTITNLQYEENMGHPGSRKFNITESVLQ
GLLKPLFKSTSVGPLYSGCRLTLLRPEKDGVATRVDAICTHRPDPKIPGLDRQQLYWELSQLTHSITELGPYTLD
RDSLYVNGFTQRSSVPTTSTPGTFTVQPETSETPSSLPGPTATGPVLLPFTLNFTITNLQYEEDMRRPGSRKFNT
TERVLQGLLMPLFKNTSVSSLYSGCRLTLLRPEKDGAATRVDAVCTHRPDPKSPGLDRERLYWKLSQLTHGITEL
GPYTLDRHSLYVNGFTHQSSMTTTRTPDTSTMHLATSRTPASLSGPMTASPLLVLFTINFTITNLRYEENMHHPG
SRKFNTTERVLQGLLRPVFKNTSVGPLYSGCRLTLLRPKKDGAATKVDAICTYRPDPKSPGLDREQLYWELSQLT
HSITELGPYTLDRDSLYVNGFTQRSSVPTTSIPGTPTVDLGTSGTPVSKPGPSAASPLLVLFTLNFTITNLRYEE
NMQHPGSRKFNTTERVLQGLLRSLFKSTSVGPLYSGCRLTLLRPEKDGTATGVDAICTHHPDPKSPRLDREQLYW
ELSQLTHNITELGPYALDNDSLFVNGFTHRSSVSTTSTPGTPTVYLGASKTPASIFGPSAASHLLILFTLNFTIT
NLRYEENMWPGSRKFNTTERVLQGLLRPLFKNTSVGPLYSGCRLTLLRPEKDGEATGVDAICTHRPDPTGPGLDR
EQLYLELSQLTHSITELGPYTLDRDSLYVNGFTHRSSVPTTSTGVVSEEPFTLNFTINNLRYMADMGQPGSLKFN
ITDNVMQHLLSPLFQRSSLGARYTGCRVIALRSVKNGAETRVDLLCTYLQPLSGPGLPIKQVFHELSQQTHGITR
LGPYSLDKDSLYLNGYNEPGPDEPPTTPKPATTFLPPLSEATTAMGYHLKTLTLNFTISNLQYSPDMGKGSATFN
STEGVLQHLLRPLFQKSSMGPFYLGCQLISLRPEKDGAATGVDTTCTYHPDPVGPGLDIQQLYWELSQLTHGVTQ
LGFYVLDRDSLFINGYAPQNLSIRGEYQINFHIVNWNLSNPDPTSSEYITLLRDIQDKVTTLYKGSQLHDTFRFC
LVTNLTMDSVLVTVKALFSSNLDPSLVEQVFLDKTLNASFHWLGSTYQLVDIHVTEMESSVYQPTSSSSTQHFYL
NFTITNLPYSQDKAQPGTTNYQRNKRNIEDALNQLFRNSSIKSYFSDCQVSTFRSVPNRHHTGVDSLCNFSPLAR
RVDRVAIYEEFLRMTRNGTQLQNFTLDRSSVLVDGYSPNRNEPLTGNSDLPFWAVILIGLAGLLGVITCLICGVL
VTTRRRKKEGEYNVQQQCPGYYQSHLDLEDLQ
Structural information
Protein Domains
 SEA (12072-12193)
SEA (12228-12349)
SEA (12386-12507)
SEA (12542-12663)
Interpro:  IPR028850 IPR000082
Prosite:   PS50024

Pfam:  		 PF01390
STRING:   ENSP00000381008;
Other Databases GeneCards:  MUC16;  Malacards:  MUC16

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0005515 protein binding
 IPI molecular_function
GO:0005615 extracellular space
 IEA cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0007155 cell adhesion
 NAS biological_process
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0016266 O-glycan processing
 TAS biological_process
GO:0016266 O-glycan processing
 TAS biological_process
GO:0019898 extrinsic component of me
mbrane
 IDA cellular_component
GO:0031982 vesicle
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0005515 protein binding
 IPI molecular_function
GO:0005576 extracellular region
 IEA cellular_component
GO:0005615 extracellular space
 IEA cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0007155 cell adhesion
 NAS biological_process
GO:0016020 membrane
 IEA cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0016266 O-glycan processing
 TAS biological_process
GO:0016266 O-glycan processing
 TAS biological_process
GO:0019898 extrinsic component of me
mbrane
 IDA cellular_component
GO:0031982 vesicle
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component
GO:0005515 protein binding
 IPI molecular_function
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0005796 Golgi lumen
 TAS cellular_component
GO:0007155 cell adhesion
 NAS biological_process
GO:0016266 O-glycan processing
 TAS biological_process
GO:0016266 O-glycan processing
 TAS biological_process
GO:0019898 extrinsic component of me
mbrane
 IDA cellular_component
GO:0031982 vesicle
 IDA cellular_component
GO:0070062 extracellular exosome
 IDA cellular_component

Diseases

Associated diseases References
Adenomyosis PMID: 19921231
Endometrial cancer PMID: 25197000
Endometriosis PMID: 17706208
Endometriosis PMID: 24939955
Male infertility PMID: 7524922
Ovarian endometriomas PMID: 15890727
Ovarian function PMID: 1936874
Ovarian hyperstimulation syndrome (OHSS) PMID: 3115839
Peritoneal endometriosis INFBASE26583603
Endometriosis (Peritoneal) INFBASE26583603
Endometriosis INFBASE26246541
Epithelial ovarian carcinoma INFBASE25197000
Female infertility INFBASE24813083
Dysmenorrhea INFBASE24813083
Pelvic endometriosis INFBASE24813083
Pelvic endometriosis INFBASE22392313
Endometrioma INFBASE20074813
Endometriosis,Infertility INFBASE20007161
Pelvic endometriosis INFBASE17086305
Endometriosis (Pelvic) INFBASE17086305
Subfertility INFBASE16708809
Leiomyomas INFBASE15890727
Adenomyosis INFBASE15890727
Ovarian endometriosis INFBASE15890727
Female infertility INFBASE15294374
Female infertility INFBASE15243756
Female infertility INFBASE12870230
Pelvic endometriosis INFBASE9436699
Endometriosis associated infertility INFBASE8988701
Chronic pelvic pain INFBASE2910718
Pelvic endometriosis PMID: 9436699
Pelvic endometriosis PMID: 9436699
Pelvic endometriosis PMID: 22392313
Pelvic endometriosis PMID: 17086305
Peritoneal endometriosis PMID: 26583603

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
23850516 Endometrio
sis
710 (299 premen
opausal women w
ho underwent la
paroscopic surg
ery, 197 patien
ts with moderat
e to severe end
ometriosis, 102
patients with
benign tumor, 1
12 healthy subj
ects)
 CA 125
 Show abstract
19230253 Endometrio
sis
50 (15 women wi
thout endometri
osis, as confir
med by laparosc
opy (group A),
35 patients wit
h pelvic endome
triosis)
 Ca 125 II
C-reactive protein (CRP)
serum amyloid A (SAA)
anticardiolipin antibody (aCL)
 Show abstract
9436699 Endometrio
sis (pelvi
c)
50 (15 women wi
thout endometri
osis, as confir
med by laparosc
opy (group A),
35 patients wit
h pelvic endome
triosis diagnos
ed by laparosco
py or laparotom
y (group B))
 CRP
CA 125 II
SAA
Acl
 Show abstract
8988701 Endometrio
sis
368 consecutive
patients suffe
ring from benig
n gynaecologica
l diseases (e.g
. pelvic pain,i
nfertility, ele
ctive sterilisa
tion, uterine f
ibroids and pel
vic masses) wit
h (n = 71) and
without (n = 29
7) endometriosi
s
 Female infertility
Show abstract
21075501 Endometrio
sis
48 (24 cases of
endometriosis,
24 controls)
 Female infertility CA125
TNF
IL-1
IL-6 and IL-8
 Show abstract
24813083 Endometrio
sis
80 (60 women wi
th confirmed pe
lvic endometrio
sis constituted
the endometrio
sis group, 20 w
omen without en
dometriosis)
 Female infertility CA125
syntaxin-5 and laminin-1
 Show abstract
10993101 Endometrio
sis
45 (26 cases we
re stage III an
d 19 were stage
IV endometrios
is)
Show abstract
24339876 Endometrio
sis
 rs1970801, rs1434536, and rs11097457 Taiwane
se
 395 (193 endome
triosis patient
s, 202 healthy
controls)
Show abstract
19050323 Endometrio
sis

CCR1
MCP-1
CA125
Show abstract
26246541 Endometrio
sis
 Caucasi
an, Asi
an
 1818 (963 cases
, 855 controls)
Show abstract
22065163 Endometrio
sis
60 (20 cases of
ovarian, 20 ca
ses of deep end
ometriosis)
 CA125
Survivin
CA19
 Show abstract
15294374 Endometrio
sis
28 patients who
underwent lapa
roscopy to chec
k for pelvic ca
uses of inferti
lity
 Female infertility CA125
 Show abstract
10755799 Endometrio
sis

CA125
 Show abstract
9455858 Endometrio
sis
34 (24 women wi
th endometriosi
s (12 early sta
ge women with e
ndometriosis, 1
2 advanced stag
e women with en
dometriosis,) 1
0 fertile women
without endome
triosis)
 CA125
 Show abstract
16708809 Endometrio
sis
58 (36 endometr
iosis women, 22
non-endometrio
sis but subfert
ility or pelvic
pain women ser
ved as controls
)
 Female infertility P450
CA125
 Show abstract
25197000 Endometrio
sis
95 (59 patients
with endometri
osis, 36 patien
ts with epithel
ial ovarian car
cinoma (EOC))
Show abstract
25446542 Endometrio
sis (Endom
etriomas (
OMAs), dee
p infiltra
ting lesio
ns (DIE),
and superf
icial endo
metriosis
(SUP))
685 (406 women
with histologic
ally proven end
ometriosis, 279
women without
endometriosis.)
Show abstract
17706208 Endometrio
sis
141 (63 women w
ith surgically
confirmed stage
II-IV endometr
iosis, 78 women
who were surgi
cally confirmed
to be free of
endometriosis)
 MIF
MCP-1
INFG
LEP
CA-127
 Show abstract
17706208 Endometrio
sis
141 (63 women w
ith II-IV endom
etriosis, 78 co
ntrols)
 Female infertility MIF
MCP-1
INF-?
LEP
CA-129
 Show abstract
19230876 Endometrio
sis

MCP-1
MIF
LEP
and CA-125
 Show abstract
17706208 Endometrio
sis
141 (63 women w
ith surgically
confirmed stage
II-IV endometr
iosis, 78 women
who were surgi
cally confirmed
to be free of
endometriosis)
 Female infertility
Show abstract
24283984 Endometrio
sis
59 (39 patients
with histologi
cally confirmed
endometriosis,
20 patients wi
thout endometri
osis)
 Female infertility EnolaseI
CA-125
 Show abstract
15243756 Endometrio
sis
108 (65 women w
ith endometrios
is, 43 women wi
thout pelvic di
sease)
 Female infertility CA-125
CA 19-9
CA 15-3
 Show abstract
22736326 Endometrio
sis
353 (121 contro
ls without endo
metriosis at la
paroscopy and f
rom 232 women w
ith endometrios
is (minimal-mil
d n = 148; mode
rate-severe n =
84))
 Annexin V
VEGF
CA-125 and sICAM-1
glycodelin
 Show abstract
20007161 Endometrio
sis
294 (93 women w
ith a normal pe
lvis, 201 women
with endometri
osis)
 Female infertility IL-6
IL-8
CA-125
 Show abstract
18555226 Endometrio
sis
760 (231 patien
ts with endomet
riosis, 145 pat
ients with beni
gn ovarian tumo
rs, and 384 hea
lthy controls )
 CA-125
 Show abstract
8059614 Endometrio
sis
91 consecutive
women undergoin
g laparoscopy f
or infertility,
pelvic pain an
d/or annexial c
ysts (53 endome
triosis patient
s)
 CA-125
 Show abstract
12870230 Endometrio
sis
117 women parti
cipants (Patien
ts with endomet
riosis, Patient
s without endom
etriosis)
 Female infertility CA-125
 Show abstract
2910718 Endometrio
sis
326 (163 women
who had had pel
vic pain, 82 wo
men with endome
triosis, 81 wom
en without endo
metriosis)
 Female infertility CA-125
 Show abstract
20074813 Endometrio
sis

IL-6
IL-8
IL-13
IL-17 and CA-125
 Show abstract
17062580 Endometrio
sis
119 (38 control
s, 47 endometri
osis sufferers,
11 minimal-mil
d endometriosis
, 36 moderate-s
evere endometri
osis, 13 uterin
e myomas, 21 be
nign ovarian pa
thologies)
 IL-6
Ca-125
 Show abstract
22392313 Endometrio
sis (Pelvi
c)
102 (44 women w
ith endometrios
is, 58 without
endometriosis)
 CA-125
 Show abstract
17086305 Endometrio
sis (Pelvi
c)
52 (35 patients
with biopsy-co
nfirmed pelvic
endometriosis,
17 patients wi
thout endometri
osis)
 CA-125
 Show abstract
26583603 Endometrio
sis (Perit
oneal)

CA-125
Prolactin
 Show abstract
15890727 Endometrio
sis
775 consecutive
women diagnose
d by laparoscop
y or laparotomy
with endometri
osis, adenomyos
is, leiomyomas,
or normal pelv
is.
 CA-125
 Show abstract
17611835 Endometrio
sis
32 (18 patients
with endometri
osis, 14 contro
ls without endo
metriosis)
 Lactoferrin
myeloperoxidase
cancer antigen 125
 Show abstract