Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Search Result


Gene id 9536
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary

Gene Symbol PTGES   Gene   UCSC   Ensembl
Aliases MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1
Gene name prostaglandin E synthase
Alternate names prostaglandin E synthase, MGST1-like 1, glutathione S-transferase 1-like 1, microsomal glutathione S-transferase 1-like 1, microsomal prostaglandin E synthase-1, p53-induced apoptosis protein 12, p53-induced gene 12 protein, tumor protein p53 inducible protein 1,
Gene location 9q34.11 (129777578: 129738335)     Exons: 4     NC_000009.12
Gene summary(Entrez) The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
OMIM 605172

Protein Summary

Protein general information O14684  

Name: Prostaglandin E synthase (EC 5.3.99.3) (Microsomal glutathione S transferase 1 like 1) (MGST1 L1) (Microsomal prostaglandin E synthase 1) (MPGES 1) (p53 induced gene 12 protein)

Length: 152  Mass: 17,102

Sequence MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRND
METIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAAR
HL
Structural information
Interpro:  IPR023352 IPR001129

Pfam:  
PF01124

PDB:  
3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
PDBsum:   3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
STRING:   ENSP00000342385;
Other Databases GeneCards:  PTGES;  Malacards:  PTGES

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001516 prostaglandin biosyntheti
c process
IDA biological_process
GO:0002526 acute inflammatory respon
se
IEA biological_process
GO:0002544 chronic inflammatory resp
onse
IEA biological_process
GO:0005641 nuclear envelope lumen
IEA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006693 prostaglandin metabolic p
rocess
TAS biological_process
GO:0007165 signal transduction
NAS biological_process
GO:0008285 negative regulation of ce
ll proliferation
IEA biological_process
GO:0014070 response to organic cycli
c compound
IEA biological_process
GO:0016020 membrane
TAS cellular_component
GO:0016021 integral component of mem
brane
IDA cellular_component
GO:0019371 cyclooxygenase pathway
TAS biological_process
GO:0032496 response to lipopolysacch
aride
IEA biological_process
GO:0032526 response to retinoic acid
IEA biological_process
GO:0034097 response to cytokine
IEA biological_process
GO:0043295 glutathione binding
IDA molecular_function
GO:0048471 perinuclear region of cyt
oplasm
IEA cellular_component
GO:0050220 prostaglandin-E synthase
activity
EXP molecular_function
GO:0050220 prostaglandin-E synthase
activity
IDA molecular_function
GO:0051592 response to calcium ion
IEA biological_process
GO:0001516 prostaglandin biosyntheti
c process
IEA biological_process
GO:0001516 prostaglandin biosyntheti
c process
IEA biological_process
GO:0001516 prostaglandin biosyntheti
c process
IDA biological_process
GO:0002526 acute inflammatory respon
se
IEA biological_process
GO:0002544 chronic inflammatory resp
onse
IEA biological_process
GO:0005641 nuclear envelope lumen
IEA cellular_component
GO:0005737 cytoplasm
IEA cellular_component
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006629 lipid metabolic process
IEA biological_process
GO:0006631 fatty acid metabolic proc
ess
IEA biological_process
GO:0006633 fatty acid biosynthetic p
rocess
IEA biological_process
GO:0006693 prostaglandin metabolic p
rocess
IEA biological_process
GO:0006693 prostaglandin metabolic p
rocess
IEA biological_process
GO:0006693 prostaglandin metabolic p
rocess
TAS biological_process
GO:0007165 signal transduction
NAS biological_process
GO:0008285 negative regulation of ce
ll proliferation
IEA biological_process
GO:0014070 response to organic cycli
c compound
IEA biological_process
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
IEA cellular_component
GO:0016020 membrane
TAS cellular_component
GO:0016021 integral component of mem
brane
IEA cellular_component
GO:0016021 integral component of mem
brane
IDA cellular_component
GO:0016853 isomerase activity
IEA molecular_function
GO:0019371 cyclooxygenase pathway
TAS biological_process
GO:0032496 response to lipopolysacch
aride
IEA biological_process
GO:0032526 response to retinoic acid
IEA biological_process
GO:0034097 response to cytokine
IEA biological_process
GO:0043231 intracellular membrane-bo
unded organelle
IEA cellular_component
GO:0043295 glutathione binding
IDA molecular_function
GO:0048471 perinuclear region of cyt
oplasm
IEA cellular_component
GO:0050220 prostaglandin-E synthase
activity
IEA molecular_function
GO:0050220 prostaglandin-E synthase
activity
IEA molecular_function
GO:0050220 prostaglandin-E synthase
activity
EXP molecular_function
GO:0050220 prostaglandin-E synthase
activity
IDA molecular_function
GO:0051592 response to calcium ion
IEA biological_process
GO:0001516 prostaglandin biosyntheti
c process
IDA biological_process
GO:0005789 endoplasmic reticulum mem
brane
TAS cellular_component
GO:0006693 prostaglandin metabolic p
rocess
TAS biological_process
GO:0007165 signal transduction
NAS biological_process
GO:0016020 membrane
TAS cellular_component
GO:0016021 integral component of mem
brane
IDA cellular_component
GO:0019371 cyclooxygenase pathway
TAS biological_process
GO:0043295 glutathione binding
IDA molecular_function
GO:0050220 prostaglandin-E synthase
activity
EXP molecular_function
GO:0050220 prostaglandin-E synthase
activity
IDA molecular_function

KEGG pathways

hsa01100  Metabolic pathways
hsa00590  Arachidonic acid metabolism

Diseases

Associated diseases References
Alzheimer's disease PMID: 19141999
Endometriosis PMID: 17295901
Endometriosis PMID: 24035605
Hypertension PMID: 15167446
Endometriosis INFBASE17295901

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
23239446 Endometrio
sis


COX-2
PGE
Show abstract
17295901 Endometrio
sis

28 patients wit
h endometriosis
PGES
COX-2
Show abstract
24035605 Endometrio
sis

74 (45 women wi
th endometriosi
s, 29 normal co
ntrols)
Female infertility Cox-2
mPGES-1
mPGES-2
cPGES
and AKR-1C3
Show abstract
23252918 Endometrio
sis

37 patients wit
h endometrial c
ysts
COX-2
mPGES-1
and TLR4
Show abstract