Results
| PMID | 10357985 |
| Gene Name | IL6 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 76 |
| Population details | 76 (36 women with endometriosis, 40 women without endometriosis) |
| Sex | Female |
| Associated genes | HGF |
| Other associated phenotypes |
Endometriosis |
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Hum Reprod. 1999 Jun;14(6):1611-3. Osuga, Y| Tsutsumi, O| Okagaki, R| Takai, Y| Fujimoto, A| Suenaga, A| Maruyama, M| Momoeda, M| Yano, T| Taketani, Y Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113-8655, Japan. The concentrations of hepatocyte growth factor (HGF) in peritoneal fluid (PF) from women with endometriosis (n = 36) and without endometriosis (n = 40) were measured. All of the PF samples examined contained detectable concentrations of HGF. The HGF concentrations in PF from women with stage III/IV endometriosis (0.906 ng/ml, 0. 561-1.185; median, interquartile range) were significantly higher (P < 0.0001) than those from women without endometriosis (0.315 ng/ml, 0.251-0.472). The HGF concentrations from women with stage I/II endometriosis (0.417 ng/ml, 0.310-1.023) appeared to be intermediate. There were no apparent variations detected among the HGF concentrations in women in the follicular or luteal phases regardless of the presence of endometriosis. Interestingly, HGF concentrations in PF from women on gonadotrophin releasing hormone analogues, independent of the presence of endometriosis, were comparable with those from untreated women. Given the known mitogenic property of HGF in human endometrial cells, these results suggest that HGF might play a role in the progression of endometriosis. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Endometriosis/*metabolism/pathology| Female| Follicular Phase/metabolism| Gonadotropin-Releasing Hormone/analogs & derivatives| Hepatocyte Growth Factor/*analysis| Humans| Luteal Phase/metabolism|DA 1999/06/08 00:0 |
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