Results
| PMID | 10682450 |
| Gene Name | IL2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 28 |
| Population details | 28 (15 infertile patients with endometriosis, 13 normal fertile women as controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Female infertility, endometriosis |
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Zhonghua Fu Chan Ke Za Zhi. 1998 Jan;33(1):17-9. Zhang, S| Wang, H| Meng, C Second Hospital of Hebei Medical University, Shijiazhuang. OBJECTIVE: To study the relationship between alteration of peritoneal lymphocyte transformation activity, its interleukin-2 (IL-2) release and infertility associated with endometriosis. METHODS: Peritoneal fluid was collected from 15 infertile patients with endometriosis (endometriosis group) and 13 normal fertile women (control group). Lymphocyte transformation activity were determined in peritoneal fluid by morphometry. IL-2 contents were determined in peritoneal fluid and supernatants of cultured pelvic lymphocytes by biological method. RESULTS: Lymphocyte transformation activity reinforced (P < 0.001) and IL-2 contents increased in peritoneal fluid and supernatant of cultured pelvic lymphocyte in the endometriosis group than those in the control group (P < 0.01, P < 0.001 respectively). There is significant positive correlation between lymphocyte transformation rate and IL-2 activity of cultured supernatant in endometriosis group (P < 0.001). CONCLUSION: The increase of IL-2 content in the samples of endometriosis may play an important role in infertility with endometriosis. Mesh Terms: Adult| Ascitic Fluid/cytology/metabolism| Endometriosis/complications/*immunology| Female| Humans| Infertility, Female/etiology/*immunology| Interleukin-2/*metabolism| *Lymphocyte Activation| Lymphocytes/immunology| Random Allocation|DA 2000/05/2 |
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