Results
| PMID | 10785227 |
| Gene Name | IGFBP3 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 63 |
| Population details | 63 (43 with endometriosis, 20 patients without endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IGF-I, IGF-II, IGFBP-1, IGFBP-3, IGFBP-4 |
| Other associated phenotypes |
Endometriosis related infertility |
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Fertil Steril. 2000 May;73(5):996-1000. Kim, J G| Suh, C S| Kim, S H| Choi, Y M| Moon, S Y| Lee, J Y Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, South Korea. kimjg@plaza.snu.ac.kr OBJECTIVE: To compare levels of insulin-like growth factor (IGF) components in the peritoneal fluid of patients with and without endometriosis. DESIGN: Patients with endometriosis were compared with control patients. SETTING: Seoul National University Hospital, Korea. PATIENT(S): Forty-three patients with endometriosis and 20 patients without endometriosis. INTERVENTION(S): Peritoneal fluid specimens were collected. MAIN OUTCOME MEASURE(S): Insulin-like growth factors, IGF binding protein (IGFBP) profiles and IGFBP-3 protease activity. RESULT(S): The IGF-I levels in peritoneal fluid were significantly higher in patients with endometriosis than in control patients, while the IGFBP-3 levels and the relative proportion of IGFBP-2 in peritoneal fluid were significantly lower in patients with endometriosis than in control patients. However, IGF-II levels, IGFBP-4 profiles, and IGFBP-3 protease activity did not differ significantly between the two groups. No correlation between these IGF components in peritoneal fluid and the stage of endometriosis was noted. CONCLUSION(S): The profiles of IGF components in peritoneal fluid of patients with pelvic endometriosis may play an important role in the growth of ectopic endometrium and endometriosis-induced infertility. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Body Mass Index| Endometriosis/*metabolism| Endopeptidases/*metabolism| Humans| Insulin-Like Growth Factor Binding Proteins/*analysis| Insulin-Like Growth Factor I/*analysis| Insulin-Like Growth Factor II/*analysi |
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