Results
| PMID | 11301163 |
| Gene Name | IL1B |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 51 |
| Population details | 51 (19 regularly cycling women, 32 without endometriosis) |
| Sex | Female |
| Associated genes | MMP-3, IL-1, TIMP-1, TIMP-2, MMP 1, MMP 2, MMP 9 |
| Other associated phenotypes |
Endometriosis |
|
Eur J Obstet Gynecol Reprod Biol. 2001 Apr;95(2):167-74. Sillem, M| Prifti, S| Koch, A| Neher, M| Jauckus, J| Runnebaum, B Department of Obstetrics and Gynaecology, Division of Gynecological Endocrinology and Reproductive Medicine, Heidelberg, Germany. gin.sillem@dkd-wiesbaden.de OBJECTIVE: To determine whether alterations in the secretion and regulation of matrix metalloproteinases (MMPs) and their inhibitors are present in uterine endometrial cells from endometriosis patients. STUDY DESIGN: In an in vitro study, uterine endometrial cells from 19 regularly cycling women with and 32 without endometriosis were treated with diethyl stilbestrol, promegestone (R5020), interleukin-1 (IL-1) and tumor necrosis factor a (TNF-alpha). Culture supernatants were assayed for MMPs 1, 2, 3, and 9, and for tissue inhibitors of MMP (TIMP-1 and TIMP-2) by ELISA. RESULTS: MMP-3 was secreted in high concentrations, moderate concentrations were seen for MMP-1 and MMP-2, and very low concentrations for MMP-9. Substantially more TIMP-1 than TIMP-2 was secreted. MMP-1 and MMP-3 were uniformly attenuated by R5020, while MMP-2 was not influenced by hormone treatment. MMP-3 was upregulated by TNF-alpha in all samples while IL-1 only increased secretion in cells from endometriosis patients. CONCLUSION: The upregulation of MMP-3 by IL-1 may contribute to an increased invasiveness of uterine endometrial fragments in endometriosis patients. Mesh Terms: Adult| Cells, Cultured| Diethylstilbestrol/pharmacology| Endometriosis/*enzymology| Endometrium/*enzymology| Female| Humans| Interleukin-1/pharmacology| Matrix Metalloproteinase 1/metabolism| Matrix Metalloproteinase 2/metabolism| Matrix Metallo |
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