Results
| PMID | 11326914 |
| Gene Name | ITGB3 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 45 |
| Population details | 45 (15 endometriotic tissues of patients with endometriosis and 30 endometrium from non-endometriosis subjects during the same menstrual phase) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | Integrin beta 3, ICAM |
| Other associated phenotypes |
Endometriosis, Female infertility |
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Zhonghua Fu Chan Ke Za Zhi. 1999 Apr;34(4):204-6. Wu, J| Zhang, J| Liu, Y Obstetrics and Gynecology Hospital of Shanghai Medical University, Shanghai 200011. OBJECTIVE: To study the relationship between integrin beta 3, intracellular adhesion molecule (ICAM) and endometriosis. METHODS: The expression of integrin beta 3 and ICAM protein were determined in 3 batches by immunoblotting method in 15 endometrium and 15 endometriotic tissues of patients with endometriosis and 30 endometrium from non-endometriosis subjects during the same menstrual phase. The results were scanned and semi-quantified, and then analysed by F test and t test. RESULTS: The results from 3 measurements showed the same trend. Endometrium from patients with endometriosis expressed significantly fewer integrin beta 3 and ICAM protein than those without endometriosis. On the other hand, the expression of integrin beta 3 in endometriotic tissue was significantly lower while the ICAM expression was significantly higher than those in controls. CONCLUSIONS: In patients with endometriosis, integrin beta 3 and ICAM expression changed significantly from eutopic to ectopic endometrium which may be related to the development of endometriosis and infertility. Mesh Terms: Adult| Antigens, CD/*biosynthesis| Endometriosis/*metabolism| Endometrium/*metabolism| Female| Humans| Integrin beta3| Intercellular Adhesion Molecule-1/*biosynthesis| Middle Aged| Platelet Membrane Glycoproteins/*biosynthesis| Uterine Diseases/ |
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