Results
| PMID | 11331669 |
| Gene Name | CTSD |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 54 |
| Population details | 54 (33 women with endometriosis, 21 without endometriosis) |
| Sex | Female |
| Associated genes | cathepsin D |
| Other associated phenotypes |
Endometriosis |
|
Mol Hum Reprod. 2001 May;7(5):459-62. Suzumori, N| Ozaki, Y| Ogasawara, M| Suzumori, K Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan. suzumori@bcm.tmc.edu To assess the release of the proteolytic enzyme cathepsin D in endometriosis, concentrations in peritoneal fluid and serum were measured by ELISA in 54 women with (n = 33) and without (n = 21) endometriosis. Surgery was scheduled in either the proliferative or secretory phase of the menstrual cycle. The concentrations of cathepsin D in the peritoneal fluid were markedly elevated in the endometriosis patients (median 58 ng/ml, interquartile range 0-166 ng/ml) as compared to the controls (5 ng/ml, 0-86 ng/ml), especially in women with late stage disease (n = 19, stages III/IV) and in those not undergoing gonadotrophin-releasing hormone (GnRH) agonist therapy (n = 15). No significant difference was determined in cathepsin D concentrations of the serum from women with and without endometriosis. We conclude that cathepsin D is an important factor that may contribute to the pathogenesis of endometriosis, possibly by promoting digestion of extracellular matrix proteins. These results have implications for the therapeutic efficacy of GnRH agonists. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Cathepsin D/blood/*metabolism| Endometriosis/blood/*metabolism| Female| Humans| Middle Aged|DA 2001/08/31 10:01 |
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