Results
| PMID | 11775942 |
| Gene Name | HLA-A |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Fu Chan Ke Za Zhi. 2000 Sep;35(9):530-2. Xin, Y| Xu, X| Ling, H Department of Obstetrics and Gynecology, First Affiliated Hospital, Chongqing University of Medical Sciences, 400016 Chongqing, China. OBJECTIVE: To study the possible effect of major histocompatibility complex-class I (MHC-I) antigen on endometrial stromal cells in endometriosis patients. METHODS: The stromal cells of endometrium was separated and cultured in vitro. gamma-interferon (gamma-IFN) was added to modulate the MHC-I antigen level which was assessed by flowcytometry, and the sensitivity of endometrial stromal cells to cytotoxic lymphocytes was examined by methyl thiazolyl tetrazolium (MTT). RESULTS: Our study demonstrated that in vitro cultured stromal cells with significant reduced MHC-I antigen levels showed enhanced susceptibility to lysis (51.28%) mediated by lymphokine-activated killer (LAK) cells, whereas gamma-IFN treated in vitro cultured stromal cells with restored MHC-I antigen levels showed more resistance to lysis (28.64%). CONCLUSIONS: MHC-I antigen on endometrial stromal cells may inhibit the cytotoxicity of natural killer (NK) cells and NK-like T cells, which might play a key role in the pathogenesis of endometriosis. The level of MHC-I antigen could be regulated by culture or some biologic factors such as gamma-IFN. Mesh Terms: Cells, Cultured| Endometriosis/etiology/*immunology| Endometrium/cytology/*immunology| Female| Histocompatibility Antigens Class I/*analysis| Humans| Interferon-gamma/pharmacology| Stromal Cells/immunology|DA 2002/01/31 10:01 |
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