Results
| PMID | 11836687 |
| Gene Name | HLA-DRB1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | HLA-DQA1*0301 and *0401 |
| Population size | 140 |
| Population details | 140 (51 cases of endometriosis, 45 cases of adenomyosis, 44 normal individuals as the control) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis, adenomyosis |
|
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Feb;19(1):49-51. Zong, Lili| Pan, Dejing| Chen, Weiming| He, Yuanli| Liu, Zehuan| Lin, Jianghai| Xu, Anlong Department of Gynecology and Obstetrics, Zhujiang Hospital, First Military Medical University, Guangzhou, Guangdong, 510282 P. R. China. Houwm@gdvnet.com OBJECTIVE: To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis. METHODS: The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control. RESULTS: The frequencies of HLA-DQA1*0401(7.8%, 10.0%) were significantly increased in the endometriosis group and the adenomyosis group (Pc=0.03, Pc=0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups (Pc=0.00, Pc=0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis. CONCLUSION: The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies. Mesh Terms: Asian Continental Ancestry Group/genetics| Endometriosis/*genetics| Female| *Gene Frequency| Genetic Predisposition to Disease| Genotype| HLA-DQ Antigens/*genetics| HLA-DQ alpha-Chains| HLA-DR Antigens/*genetics| HLA-DRB1 Chains| Humans| Polyme |
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