Results
| PMID | 11870103 |
| Gene Name | HLA-DRB1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | HLA-DRB1*1403 |
| Population size | 83 |
| Population details | 83 patients with endometriosis |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Hum Reprod. 2002 Mar;17(3):560-3. Ishii, Keisuke| Takakuwa, Koichi| Mitsui, Takuya| Tanaka, Kenichi Department of Obstetrics and Gynecology, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan. keisui28@med.niigata-u.ac.jp BACKGROUND: An increasing number of reports suggest that endometriosis is associated with abnormal immune function involving changes in both cell-mediated and humoral immunity, although the aetiology of the disease remains undefined. The human leukocyte antigen system (HLA) is known to play a role in the aetiology of a number of diseases. This study examines the possible association between the HLA-DR and endometriosis. METHODS: Eighty-three patients diagnosed with endometriosis by laparoscopic examination were typed for HLA-DR antigens using a PCR-restriction fragment length polymorphism analysis. The frequency of HLA-DR genotypes in this patient population was compared with that in a population of general controls. RESULTS: The incidence of HLA-DRB1*1403 in the patient group was 6.0% (10/166 alleles) compared with 1.4% in the control group (6/444 alleles), and the incidence of the HLA-DRB1*1403 allele was significantly greater in patients with endometriosis compared with the control population [odds ratio 4.68, 95% confidence interval 1.67-13.09, P = 0.0013 (chi(2) analysis), (corrected P values: Pc = 0.0494)]. No significant difference was found between the two groups with regards to the frequency of the other HLA-DR alleles. CONCLUSIONS: The results from this study may be helpful to implicate a role of HLA-DR antigens in the development of endometriosis, although further investigation is required. Mesh Terms: *Alleles| Endometriosis/*genetics/*immunology| Female| Gene Frequency| Genotype| HLA-DR Antigens/*genetics| HLA-DRB1 Chains| Humans| Male| Reference Values|DA 2002/08/31 10:01 |
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