Results
| PMID | 12126569 |
| Gene Name | HLA-DRB1 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | HLA-DRB1 * 15 |
| Population size | 90 |
| Population details | 90 (40 surgically proven Endometriosis patients, 50 normal control) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Fu Chan Ke Za Zhi. 2002 Jun 18;37(6):346-8. Wang, Xin| Liu, Chunyu| Lin, Qiuhua| Fang, Xiaoling| Lin, Li| Mei, Qiyuan Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China. OBJECTIVE: To study the possibility of a correlation between occurrence of endometriosis (EM) and polymorphism of human leukocyte antigen (HLA) DRB1 allele. METHODS: Polymorphism of HLA-DRB1 allele were detected by polymerase chain reaction- sequence specific primers (PCR-SSP) testing 40 surgically proven EM patients and 50 normal control. RESULTS: At HLA-DRB1 15 allele, positive frequency of EM group was significant higher as compared with those of the normal control group [45.0% vs 26.0%, P < 0.05, relative risk (RR) = 2.1]. Other HLA-DRB1 allele positive frequency of EM group and control group had no significant difference. But for Polymorphism of DRB1 * 15 allele, positive frequency of EM group and control group had no significant difference [1501 : 35.0% vs 20.0%; 1502 : 10.0% vs 6.0%; P > 0.05]. CONCLUSIONS: The occurrence of EM may be associated with the presence of HLA-DRB1 allele, but hasn't associated about polymorphism of DRB1* 15 allele. HLA-DRB1 * 15 maybe one of some factors for the pathogenesis of endometriosis. Mesh Terms: Adult| Alleles| Endometriosis/*genetics/immunology| Female| Gene Frequency| HLA-DR Antigens/*genetics| HLA-DRB1 Chains| Humans| Middle Aged| Polymerase Chain Reaction/methods| *Polymorphism, Genetic|DA 2005/01/26 09:00 |
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