Results
| PMID | 12372458 |
| Gene Name | TIMP2 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | MMP-2, MT1-MMP, TIMP-2 |
| Population size | 53 |
| Population details | 53 (23 with endometriosis and 30 without endometriosis) |
| Sex | Female |
| Associated genes | MMP-2, MT1-MMP, TIMP-2 |
| Other associated phenotypes |
Endometriosis |
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Fertil Steril. 2002 Oct;78(4):787-95. Chung, Hye Won| Lee, Ji Young| Moon, Hye-Sung| Hur, Sung Eun| Park, Mi Hye| Wen, Yan| Polan, Mary Lake Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea. hyewon@mm.ewha.ac.kr OBJECTIVE: To investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in ectopic and eutopic endometrium from women with and without endometriosis throughout the menstrual cycle. DESIGN: Molecular studies in human tissue. SETTING: Reproductive immunology laboratory of a university medical center. PATIENT(S): Fifty-three premenopausal woman (23 with endometriosis and 30 without endometriosis) undergoing laparoscopic surgery. Endometrium and ectopic endometriosis tissue were obtained at the time of surgery. MAIN OUTCOME MEASURE(S): Messenger RNA and protein expression from eutopic and ectopic endometrium was analyzed by using quantitative competitive polymerase chain reaction, zymography, and Western blot assay. RESULT(S): Uterine endometrium from women with endometriosis expressed higher levels of MMP-2 and MT1-MMP and lower levels of TIMP-2 than did endometrium from normal women. CONCLUSION(S): Eutopic endometrium from patients with endometriosis may be more invasive and prone to peritoneal implantation because of greater expression of MMP-2 and MT1-MMP and lower expression of TIMP-2 messenger RNA, compared with endometrium from women without endometriosis. Thus, increased proteolytic activity may help to explain the invasive factors that result in endometriosis. Mesh Terms: Adult| Blotting, Western| Electrophoresis, Polyacrylamide Gel| Endometriosis/*enzymology/surgery| Endometrium/*enzymology/surgery| Female| *Gene Expression| Humans| Laparoscopy| Matrix Metalloproteinase 2/analysis/*genetics| Matrix Metalloprotei |
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