Results
| PMID | 12372465 |
| Gene Name | IL1R2 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | IL-1RII, IL-1alpha, IL-1beta, MCP-1 |
| Population size | 117 |
| Population details | 117 (79 women with endometriosis, 38 control women) |
| Sex | Female |
| Associated genes | IL-1RII |
| Other associated phenotypes |
Endometriosis |
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Fertil Steril. 2002 Oct;78(4):836-42. Kharfi, Abdelaziz| Akoum, Ali Departement d'Obstetrique-Gynecologie, Faculte de Medecine, Universite Laval, Quebec, Quebec, Canada. OBJECTIVE: To assess the ability of peripheral blood serum from women with endometriosis to induce monocyte chemotactic protein-1 (MCP-1) secretion by monocytes and the putative role of the interleukin-1 (IL-1) system in endometriosis-associated monocyte activation. DESIGN: Cultures of U937 monocytic cells exposed to serum from normal women (control group) or women with endometriosis. SETTING: Gynecology clinic and human reproduction research laboratory. PATIENT(S): Seventy-nine women with endometriosis and 38 control women with no evidence of endometriosis at laparoscopy. INTERVENTION(S): Peripheral blood obtained a few days before laparoscopy. MAIN OUTCOME MEASURE(S): MCP-1 secretion in the culture medium and serum concentrations of soluble IL-1 receptor type II (sIL-1RII), IL-1beta, and IL-1alpha by ELISA or by enzyme immunometric assay. RESULT(S): Serum concentrations of sIL-1RII were significantly lower in women with stage I-II endometriosis than in control women, whereas serum concentrations of IL-1beta and IL-1alpha were comparable between the two groups. The serum of women with endometriosis induced higher secretion of MCP-1 by U937 cells than that of control women, particularly in the initial stages of endometriosis (stages I-II), and recombinant IL-1RII (rIL-1RII) significantly blocked that secretion. CONCLUSION(S): These findings point toward a deficiency in the mechanisms involved in the down-regulation of IL-1 actions at the systemic level and reveal sIL-1RII as a key factor involved in that process. Mesh Terms: Chemokine CCL2/*secretion| Culture Media| Endometriosis/*blood| Enzyme-Linked Immunosorbent Assay| Female| Humans| Immunoenzyme Techniques| Monocytes/*physiology| Receptors, Interleukin-1/blood/genetics/*physiology| Receptors, Interleukin-1 Type |
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