Results
| PMID | 12615822 |
| Gene Name | LAMA1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 107 |
| Population details | 107 (68 infertile patients who underwent laparoscopy or laparotomy, 39 healthy non-pregnant women) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | Laminin-1 |
| Other associated phenotypes |
Endometriosis, Infertile |
|
Hum Reprod. 2003 Mar;18(3):544-9. Inagaki, Junko| Sugiura-Ogasawara, Mayumi| Nomizu, Motoyoshi| Nakatsuka, Mikiya| Ikuta, Katsuo| Suzuki, Nobuharu| Kaihara, Keiko| Kobayashi, Kazuko| Yasuda, Tatsuji| Shoenfeld, Yehuda| Aoki, Koji| Matsuura, Eiji Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. BACKGROUND: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. METHODS: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. RESULTS: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-alpha1 chain G domain. mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions. CONCLUSIONS: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis. Mesh Terms: Adult| Autoantibodies/*blood| Case-Control Studies| Endometriosis/*complications/metabolism| Female| Humans| Immunoglobulin G/*blood| Infertility, Female/*complications/*immunology| Laminin/genetics/*immunology| RNA, Messenger/metabolism|DA 2003/ |
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