Results
| PMID | 12754129 |
| Gene Name | GSTM1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 156 |
| Population details | 156 (76 patients with endometriosis, 80 controls (surgical patients for gynecological problems other than endometriosis)) |
| Sex | Female |
| Associated genes | GSTM1 |
| Other associated phenotypes |
Endometriosis |
|
Di Yi Jun Yi Da Xue Xue Bao. 2003 May;23(5):458-9, 462. Peng, Dong-xian| He, Yuan-li| Qiu, Li-wen| Yang, Fang| Lin, Jing-ming Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. pdx@fimmu.com OBJECTIVE: To evaluate the possible association of the glutathione S-transferase M1 (GSTM1) gene polymorphism with the susceptibility to endometriosis in women of Han nationality in Guangdong Province. METHODS: Polymerase chain reaction was used to identify the GSTM1 genotypes in 76 patients with endometriosis and 80 controls (surgical patients for gynecological problems other than endometriosis). RESULTS: The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 65.8% and 46.3%, respectively, showing a significant difference between the endometriotic cohort and the control group (X(2)=6.03, P < 0.05). Individuals with GSTM1 null genotype were exposed to risks for endometriosis 2.24 times that of subjects without these genotypes OR=2.24, 95% CI=1.17-4.27 . CONCLUSION: GSTM1 gene deletion might bea risk factor for endometriosis in women of Han nationality who are native residents in Guangdong Province. Mesh Terms: Adult| Endometriosis/enzymology/*genetics| Female| *Genetic Predisposition to Disease| Glutathione Transferase/*genetics| Humans| Middle Aged|DA 2004/04/17 05:00 |
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