Results
| PMID | 12765344 |
| Gene Name | PAPPA |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 98 |
| Population details | 98 (60 women with endometriosis, 38 women without endometriosis) |
| Sex | Female |
| Associated genes | PAPP-A |
| Other associated phenotypes |
Endometriosis |
|
Am J Reprod Immunol. 2003 Feb;49(2):70-4. Arici, Aydin| Matalliotakis, Ioannis| Goumenou, Anastasia| Koumantakis, Georgios| Fragouli, Yvoni| Mahutte, Neal G Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, New Haven, CT 06520-8063, USA. aydin.arici@yale.edu PROBLEM: Pregnancy-associated plasma protein-A (PAPP-A) belongs to a group of glycoproteins isolated from extracts of human placenta. Healthy ovarian and uterine tissues are also known to express PAPP-A. We hypothesized that PAPP-A levels might also be elevated in the peritoneal fluid (PF) of women with endometriosis, and examined variations in PF PAPP-A during the menstrual cycle and with the severity of the disease. METHOD OF STUDY: PF PAPP-A were measured in 60 women with endometriosis and 38 women without endometriosis using a high-sensitivity immunofluorometric assay. RESULTS: We found that the mean level of PAPP-A was higher in PF from patients with endometriosis than controls (p = 0.003). Furthermore, significant correlation was found between the stages of endometriosis and the levels of PAPP-A in these patients (r = 0.39, p = 0.009). The concentrations of PAPP-A in PF were significantly higher in the secretory phase than the proliferative phase of the menstrual cycle in both women with and without endometriosis (p = 0.009 and P = 0.002, respectively). Finally, among the controls, women undergoing tubal ligation had significantly lower mean PF levels of PAPP-A than women with infertility or pelvic pain (p = 0.001). CONCLUSION: We conclude that PF levels of PAPP-A vary during the menstrual cycle, and are highest in the secretory phase. We also find that PF PAPP-A levels are significantly increased in women with endometriosis, and that the degree of elevation corresponds to the extent of disease. Mesh Terms: Adult| Ascitic Fluid/*metabolism| Endometriosis/*metabolism| Female| Fluorescent Antibody Technique| Humans| Menstrual Cycle/metabolism| Pregnancy-Associated Plasma Protein-A/*metabolism|DA 2003/10/24 05:00 |
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