Results
| PMID | 14505259 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 13 |
| Population details | 13 women with rectal and vaginal endometriosis, scar endometriosis and endometriosis of the omentum majus |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):252-5. Bartley, J| Mechsner, S| Beutler, C| Halis, G| Lange, J| Ebert, A D Deutsches Endometriose Kompetenz- und Experten-Netzwerk, Frauenklinik, Charite-Universitatsmedizin Berlin, FU Berlin. OBJECTIVE: Extragenital endometriosis is a rare form of endometriosis. Due to its invasive and metastatic properties it resembles some features of malignant tumours. Cyclooxygenase (COX)-2 is a rate-limiting enzyme in the biosynthesis of prostaglandins and is mainly expressed in inflammatory and malignant processes. In this study we investigated the COX-2 expression in extragenital endometriosis. MATERIAL AND METHODS: Tissue was obtained of 13 women with rectal and vaginal endometriosis, scar endometriosis and endometriosis of the omentum majus. The COX-2 expression was investigated by immunohistochemistry. RESULTS: In the glandular epithelium a COX-2 overexpression was found in all cases and in the stroma a weak to moderate COX-2 expression was found in half of the cases. A hormonal therapy at the time of surgery had no influence on the COX-2 expression in extragenital endometriosis. CONCLUSION: The high COX-2 expression in extragenital endometriosis is believed to be strongly correlated with the pathological abnormalities this of disease. Mesh Terms: Cyclooxygenase 2| Cyclooxygenase 2 Inhibitors| Cyclooxygenase Inhibitors/*therapeutic use| Endometriosis/drug therapy/*enzymology/surgery| Female| Gene Expression Regulation, Enzymologic| Humans| Isoenzymes/*genetics| Membrane Proteins| Prostagla |
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