Results
| PMID | 14506926 |
| Gene Name | TNFRSF1B |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | TNF-RII |
| Other associated phenotypes |
Endometriosis |
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Am J Reprod Immunol. 2003 Jul;50(1):33-40. Kharfi, Abdelaziz| Labelle, Yves| Mailloux, Jacques| Akoum, Ali Centre de Recherche, Hopital Saint-Francois d'Assise, Centre Hospitalier Universitaire de Quebec, Faculte de Medecine, Universite Laval, Quebec, Canada. PROBLEM: Tumor necrosis factor-alpha (TNF-alpha) is secreted mainly during the menstrual phase and has been suggested to play a role in induction of apoptosis in endometrial cells and menstrual shedding. TNF-alpha receptor type 2 (TNF-RII) is believed to play a central role in TNFalpha-mediated cytotoxic, mitogenic, anti-proliferative and apoptotic effects. The aim of this study was to assess whether TNF-RII maybe expressed differentially in the endometrium of women with different degrees of endometriosis. METHOD OF STUDY: TNF-RII expression in the endometrial tissue of women with and without endometriosis was investigated by immunohistochemical techniques and in situ hybridization. RESULTS: In histological sections, we observed TNF-RII mRNA and the corresponding protein localized mainly in endometrial glandular cells, with only very faint immunostaining in the surrounding stromal cells. Statistical analysis of our data showed a significant decrease in protein and mRNA expression of TNF-RII in endometrial glandular cells of patients with stages I and II endometriosis compared to normal subjects. TNF-RII expression was also found to decrease significantly in the secretory phase of the menstrual cycle in women with early endometriosis stages (I and II). CONCLUSIONS: In view of the relevant role of TNF-RII in the modulation of the inflammatory and the proapoptotic effects of TNFalpha, deficient expression of TNF-RII mRNA in the endometrium of women at the earliest stages of endometriosis may play a significant role in the pathophysiology of this disease. Mesh Terms: Adult| Antigens, CD/genetics/*metabolism| Endometriosis/*metabolism/pathology| Endometrium/chemistry/*metabolism/pathology| Female| Gene Expression| Humans| Immunohistochemistry/methods| In Situ Hybridization, Fluorescence/methods| RNA, Messenger |
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