Results
| PMID | 14747187 |
| Gene Name | PTGS2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 136 |
| Population details | 136 samples of endometriotic tissue from 103 patients affected by endometriosis. |
| Age | Mean age: 31.4 +- 6.03 years |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Hum Reprod. 2004 Feb;19(2):393-7. Fagotti, Anna| Ferrandina, Gabriella| Fanfani, Francesco| Legge, Francesco| Lauriola, Libero| Gessi, Marco| Castelli, Paola| Barbieri, Fabrizio| Minelli, Luca| Scambia, Giovanni Department of Gynecological Oncology, Catholic University of the Sacred Heart, Campobasso, Italy. BACKGROUND: Recent studies have demonstrated the overexpression of cyclooxygenase-2 (COX-2) in endometriosis. The aim of this study was to investigate the expression of COX-2 in different anatomical sites of endometriosis and its association with clinico-pathological parameters in a single institutional series of patients undergoing operative treatment. METHODS: COX-2 expression was analysed by immunohistochemistry in 136 samples of endometriotic tissue from 103 patients affected by endometriosis. RESULTS: COX-2 immunoreaction was observed in 78.5% of ovarian endometriotic cysts, in 11.1% of peritoneal implants and 13.3% of recto-vaginal nodules. COX-2 positivity was not distributed differently according to age, pre-operative serum levels of CA125 and AFS score. Moreover, COX-2 positivity did not show any significant variation according to the subjective intensity of pain, as dysmenorrhoea, chronic pelvic pain, lower urinary tract or gastrointestinal symptoms, or according to infertility. CONCLUSIONS: Increased COX-2 expression in the endometriotic ovarian cyst wall was observed with respect to other extraovarian localizations. No relevant correlations between COX-2 positivity and clinico-pathological characteristics and symptoms of patients were observed. Mesh Terms: Adult| CA-125 Antigen/blood| Cyclooxygenase 2| Endometriosis/*enzymology/*pathology/surgery| Female| Humans| Immunohistochemistry| Isoenzymes/*analysis| Membrane Proteins| Ovarian Cysts/enzymology/pathology| Peritoneum/enzymology/pathology| Pro |
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