Results
| PMID | 14967364 |
| Gene Name | CXCL5 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 59 |
| Population details | 59 (35 women with endometriosis, 24 women without endometriosis) |
| Sex | Female |
| Associated genes | ENA-78 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2004 Feb;81(2):305-8. Suzumori, Nobuhiro| Katano, Kinue| Suzumori, Kaoru Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, Nagoya, Japan. og.n.suz@med.nagoya-cu.ac.jp OBJECTIVE: To assess the release of epithelial neutrophil-activating peptide-78 (ENA-78) into peritoneal fluid in women with and without endometriosis. DESIGN: Retrospective study. SETTING: Nagoya City University Hospital. PATIENT(S): Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 59 women with (n = 35) and without (n = 24) endometriosis. INTERVENTION(S): Peritoneal fluid samples were obtained at laparotomy or laparoscopy. MAIN OUTCOME MEASURE(S): The ENA-78 concentrations in the peritoneal fluid were measured using enzyme-linked immunosorbent assay (ELISA). RESULT(S): The concentrations of ENA-78 in the peritoneal fluid were markedly elevated in the endometriosis patients as compared with the controls, especially in women with severe stage disease. CONCLUSION(S): We conclude that ENA-78 is an important factor that may contribute to the pathogenesis of endometriosis, possibly promoting neovascularization. Mesh Terms: Ascitic Fluid/*chemistry| Biomarkers/analysis| Chemokine CXCL5| *Chemokines, CXC| Chemotaxis, Leukocyte| Endometriosis/pathology/*physiopathology| Endometrium/blood supply| Female| Humans| Interleukin-8/analogs & derivatives/*analysis| Neovascul |
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