Results
| PMID | 15136083 |
| Gene Name | MMP2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 58 |
| Population details | 58 (40 patients with endometriosis-associated infertility undergoing laparoscopy, 18 women undergoing tubal ligation) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis associated infertility |
|
Fertil Steril. 2004 May;81(5):1235-9. Huang, He-Feng| Hong, Li-Hua| Tan, Yi| Sheng, Jian-Zhong Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China. huanghefg@hotmail.com OBJECTIVE: To determine matrix metalloproteinase 2 (MMP-2) levels in sera and peritoneal fluids of women with or without endometriosis-associated infertility and to determine whether MMP-2 had correlation with 17beta-E(2) and P in the sera and peritoneal fluids of the patients with endometriosis. DESIGN: A case-control study. SETTING: A women's hospital in China. PATIENT(S): Forty patients with endometriosis-associated infertility undergoing laparoscopy and 18 women undergoing tubal ligation. INTERVENTION(S): Sera and peritoneal fluids were collected from women with or without endometriosis. MAIN OUTCOME MEASURE(S): Matrix metalloproteinase 2, 17beta-E(2), and P concentration. RESULT(S): Compared with the control women, the patients with endometriosis had higher MMP-2 levels in their sera and peritoneal fluids. Serum and peritoneal fluid MMP-2 levels were higher in the proliferative phase than in the secretory phase. The level of MMP-2 in the patients was correlated positively with 17beta-E(2) in serum and peritoneal fluid and negatively with P. CONCLUSION(S): The results demonstrated a correlation between MMP-2 concentrations and steroid hormones in sera and peritoneal fluids of the patients with endometriosis-associated infertility. Estradiol might up-regulate MMP-2, resulting in the formation of endometriosis. Progesterone might down-regulate MMP-2 to inhibit the formation and development of endometriosis. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Case-Control Studies| Endometriosis/*metabolism| Estradiol/*analysis/blood| Female| Follicular Fluid/chemistry| Humans| Matrix Metalloproteinase 2/*analysis/blood| Menstrual Cycle| Progesterone/*analysis/blood|DA |
|