Results
| PMID | 15242994 |
| Gene Name | TNFSF10 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 64 |
| Population details | 64 |
| Sex | Female |
| Associated genes | OPG, TRAIL |
| Other associated phenotypes |
Endometriosis |
|
Hum Reprod. 2004 Oct;19(10):2188-91. Epub 2004 Jul 8. Harada, Miyuki| Osuga, Yutaka| Hirata, Tetsuya| Hirota, Yasushi| Koga, Kaori| Yoshino, Osamu| Morimoto, Chieko| Fujiwara, Toshihiro| Momoeda, Mikio| Yano, Tetsu| Tsutsumi, Osamu| Taketani, Yuji Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. BACKGROUND: Failure of apoptosis of refluxed endometrial cells within the peritoneal cavity is a possible etiologic factor for development of endometriosis. Osteoprotegerin (OPG) is a survival factor that exerts its effect by binding to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), thus preventing TRAIL from binding to the apoptosis receptors DR4 and DR5. In the present study, we addressed the possibility that the TRAIL/OPG system is involved in the pathogenesis of endometriosis. METHODS: Concentrations of OPG and TRAIL in the peritoneal fluid (PF) of women with or without endometriosis were measured using specific enzyme-linked immunoabsorbent assay. The expression of DR4 and DR5 in the endometriotic tissue was examined by reverse transcription-polymerase chain reaction. RESULTS: OPG concentrations in PF of women with endometriosis were significantly higher than those of women without endometriosis (P=0.006). With respect to the stages of the disease, the concentrations of OPG in women with stage III/IV endometriosis were significantly higher than in those without endometriosis and those with stage I/II endometriosis. On the other hand, the ratios of TRAIL/OPG concentrations were significantly lower in stage III/IV endometriosis compared to those in non-endometriosis and stage I/II endometriosis. DR5 mRNA expression was clearly detected in all the endometriotic tissues studied. CONCLUSIONS: These findings suggest that the TRAIL/OPG system is involved in the pathophysiology of endometriosis, possibly affecting the apoptosis of endometriotic cells. Mesh Terms: Adult| Apoptosis Regulatory Proteins| Ascitic Fluid/*metabolism| Case-Control Studies| Endometriosis/*metabolism/pathology| Female| Glycoproteins/*metabolism| Humans| Infertility, Female/metabolism| Membrane Glycoproteins/metabolism| Osmolar Con |
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